Article information
Resumen
En la Digestive Disease Week 2011 se han presentado numerosos estudios que muestran cómo todos los conceptos sobre enfermedad inflamatoria cambian a gran velocidad. Aunque se presta habitualmente más atención a los estudios sobre tratamiento, los cambios en las definiciones y en los procesos diagnósticos son, si cabe, más llamativos. Los estudios genéticos están empezando a delimitar subgrupos diferentes de pacientes. Cada vez son más los datos que demuestran que la mera evaluación clínica no es suficiente para estimar la situación real del paciente y que es necesario progresar tanto en los índices objetivos de actividad de la enfermedad (biomarcadores, técnicas de imagen, cuantificación y validación de los índices) como en completar las perspectivas definiendo las consecuencias económicas, personales y sociales de la enfermedad, así como valorando otros aspectos como los riesgos de otras afecciones, a veces consecuencia directa de los tratamientos.
Palabras clave:
Biomarcador
Calprotectina
Colitis ulcerosa
Diagnóstico
Ecografía
Endoscopia
Enfermedad de Crohn
Resonancia magnética
Abstract
A large number of new studies on all the concepts of inflammatory bowel disease were presented at Digestive Disease Week 2011, showing a rapidly changing scenario. Although therapeutic trials usually receive the lion's share of attention, the changes in definitions and diagnostic processes were, if anything, more striking. Genetic studies are starting to define new subgroups of patients. More and more data show that traditional clinical evaluation is insufficient to assess patients’ real status. Both objective indexes of disease activity (biomarkers, imaging techniques, quantification and validation of indexes) and new perspectives are required. These new perspectives include gaining greater insight into the economic, personal and social consequences of the disease, as well as assessing other issues such as the risks of other diseases, which are sometimes the direct consequence of treatments.
Keywords:
Biomarker
Calprotectin
Ulcerative colitis
Diagnosis
Ultrasound
Endoscopy
Crohn's disease
Magnetic resonance imaging
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