Pancreatitis crónica | Gastroenterología y Hepatología

Article information

Resumen

La pancreatitis crónica es una enfermedad multifactorial. Las mutaciones en el gen de la quimotripsina C pueden favorecer el desarrollo de pancreatitis crónica. El hábito de fumar es un importante factor asociado al desarrollo y evolución de la pancreatitis crónica. Es necesario categorizar los signos identificados en la ecoendoscopia a la hora de diagnosticar una pancreatitis crónica, ya que no todos tienen el mismo valor diagnóstico. La pancreatitis autoinmunitaria tiene manifestaciones clínicas más variadas que las descritas inicialmente y varían según la población estudiada. Los criterios utilizados para el diagnóstico de la pancreatitis autoinmunitaria no son del todo precisos y su tratamiento puede requerir del uso de inmunomoduladores. El tratamiento con antioxidantes tiene efectos beneficiosos a largo plazo en pacientes con pancreatitis crónica. Algunas manifestaciones clínicas en pacientes con síndrome del intestino irritable pueden tener su origen en una insuficiencia pancreática no identificada. Un estudio con cápsula endoscópica muestra que la fibrosis quística presenta signos de enteropatía en el intestino delgado.

Palabras clave:

Pancreatitis crónica

Pancreatitis autoinmunitaria

Ecoendoscopia

Antioxidantes

Fibrosis quística

Abstract

Chronic pancreatitis is a multifactorial disease. Mutations in the chymotrypsin C gene may encourage the development of chronic pancreatitis. Smoking is an important factor in the development and progression of chronic pancreatitis. The signs identified in endoscopic ultrasound should be categorized when diagnosing chronic pancreatitis, since not all have the same diagnostic value. The clinical manifestations of autoimmune pancreatitis are more varied than initially described and depend on the population studied. The criteria used for the diagnosis of autoimmune pancreatitis have not been well defined and treatment may require the use of immunomodulators. Antioxidant therapy has beneficial effects in the long term in patients with chronic pancreatitis. Some clinical manifestations found in patients with irritable bowel syndrome may be caused by unidentified pancreatic insufficiency. Capsule endoscopy shows that cystic fibrosis presents signs of small bowel enteropathy.

Key words:

Chronic pancreatitis

autoimmune pancreatitis

endoscopic ultrasound

antioxidants

cystic fibrosis

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