Recommendations of the Spanish Group on Crohn’s Disease and Ulcerative Colitis on the importance, screening and vaccination in inflammatory bowel disease patients | Gastroenterología y Hepatología (English Edition)

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Spanish Group on Crohn’s Disease and Ulcerative Colitis on the importance, screening and vaccination in inflammatory bowel disease patients" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "805" "paginaFinal" => "818" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Rocío Ferreiro-Iglesias, Marta Piqueras, Elena Ricart, Laura Sempere, Mariona Roca, Javier Martín de Carpi, Olga Benítez, Yamile Zabana, Míriam Mañosa, Francisco Rodríguez-Moranta, Manuel Barreiro-de Acosta" "autores" => array:12 [ 0 => array:3 [ "nombre" => "Rocío" "apellidos" => "Ferreiro-Iglesias" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "1" "identificador" => "fn0005" ] ] ] 1 => array:4 [ "nombre" => "Marta" "apellidos" => "Piqueras" "email" => array:1 [ 0 => "mpiqueras@cst.cat" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" 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"aff0045" ] ] ] 7 => array:3 [ "nombre" => "Yamile" "apellidos" => "Zabana" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] 1 => array:2 [ "etiqueta" => "i" "identificador" => "aff0045" ] ] ] 8 => array:3 [ "nombre" => "Míriam" "apellidos" => "Mañosa" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] 1 => array:2 [ "etiqueta" => "j" "identificador" => "aff0050" ] ] ] 9 => array:3 [ "nombre" => "Francisco" "apellidos" => "Rodríguez-Moranta" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "k" "identificador" => "aff0055" ] ] ] 10 => array:3 [ "nombre" => "Manuel" "apellidos" => "Barreiro-de Acosta" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 11 => array:1 [ "colaborador" => "on behalf of GETECCU" ] ] "afiliaciones" => array:11 [ 0 => array:3 [ "entidad" => "Servicio de Gastroenterología, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, A Coruña, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Gastroenterología, Consorci Sanitari de Terrassa (CST), Terrassa, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Gastroenterología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Servicio de Gastroenterología, Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Servicio de Farmacia, Consorci Sanitari de Terrassa (CST), Responsable del Servicio de Gestión Integral de Vacunas (SEGIV), Terrassa, Barcelona, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Unidad para el Cuidado Integral de la Enfermedad Inflamatoria Intestinal Pediátrica (UCIEII-P), Servicio de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital Sant Joan de Déu, Barcelona, Spain" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología, Hospital Mútua de Terrassa (HMT), Terrassa, Barcelona, Spain" "etiqueta" => "i" "identificador" => "aff0045" ] 9 => array:3 [ "entidad" => "Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain" "etiqueta" => "j" "identificador" => "aff0050" ] 10 => array:3 [ "entidad" => "Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología, Hospital Universitario de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "k" "identificador" => "aff0055" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa sobre la importancia, el cribado y la vacunación en pacientes con enfermedad inflamatoria intestinal" ] ] "textoCompleto" => "IntroductionPatients with inflammatory bowel disease (IBD) have a higher predisposition to infections than the general population,<a class="elsevierStyleCrossRef" href="#bib0005">1</a> some of which can be prevented with vaccinations.<a class="elsevierStyleCrossRef" href="#bib0010">2</a> Despite the existence of specific recommendations,<a class="elsevierStyleCrossRefs" href="#bib0015">3,4</a> IBD patients have low immunisation rates.<a class="elsevierStyleCrossRefs" href="#bib0025">5–7</a> In addition, vaccination schedules can vary by country and in the different clinical settings, hence recommendations should be adapted taking all these characteristics into account. For all these reasons, this consensus document endorsed by the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) has been produced and which establishes clear vaccination guidelines applied to our setting.Epidemiology: the risk of infection and immunisation rates in IBD patientsTreatment for Crohn's disease (CD) and ulcerative colitis has progressed significantly over the last 20 years. Many of the available drugs work by suppressing the immune system to a greater or lesser degree. These drugs include biological agents (infliximab, adalimumab, golimumab, vedolizumab and ustekinumab), corticosteroids, immunosuppressants (azathioprine, mercaptopurine, methotrexate, cyclosporine, tacrolimus) and Janus kinase (JAK) inhibitors (tofacitinib). In addition, the risk of developing infections increases when different immunosuppressive treatments that act on different targets are combined.<a class="elsevierStyleCrossRef" href="#bib0005">1</a>Patients with IBD have an increased risk of any infection, especially opportunistic infections.<a class="elsevierStyleCrossRefs" href="#bib0005">1,8</a> In the TREAT (Crohn's Therapy, Resource, Evaluation, and Assessment Tool) registry, after a follow-up of more than five years, an increased risk of infection was observed in patients with moderate-severe disease, those who were treated with infliximab, narcotic analgesics, or corticosteroids.<a class="elsevierStyleCrossRef" href="#bib0045">9</a> In addition, the risk of serious infections is higher in patients receiving combination treatment with thiopurines and TNF inhibitors compared to TNF inhibitor monotherapy.<a class="elsevierStyleCrossRef" href="#bib0050">10</a>Many infections, which can be serious or even fatal, are immunopreventable with vaccinations. However, some studies have shown low seroprotection and adherence to vaccination programmes in patients with immunosuppressed IBD versus the general population. Some of the main reasons for these low immunisation rates are poor adherence to vaccination protocols, concerns about possible adverse effects and vaccine safety in immunocompromised patients, or high costs of some unfunded vaccines.<a class="elsevierStyleCrossRefs" href="#bib0035">7,11,12</a> Thus, a recent survey of GETECCU partners reported that 3.5% of gastroenterologists specialising in IBD would currently recommend live attenuated vaccines in immunosuppressed patients, and 4.5% would not recommend inactivated vaccines during the first year of life of children born of mothers treated with biologics during pregnancy.<a class="elsevierStyleCrossRef" href="#bib0065">13</a>Degree of immunosuppression and risk factors. Vaccine safetyDegree of immunosuppression and infection risk factorsThe risk factors associated with the appearance of opportunistic infections include the use of immunosuppressive agents, particularly in combination with TNF inhibitors, advanced age, comorbidities, malnutrition, parenteral nutrition, intestinal surgery, IBD severity, and treatment with narcotics.The main causes of immunosuppression in IBD are immunosuppressive and/or biological drugs used to control the disease, and malnutrition. Thus, the treatments used in IBD patients can be classified, according to the degree of immunosuppression, into:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">1Non-immunosuppressants: aminosalicylates.</li><li class="elsevierStyleListItem" id="lsti0010">2Selective immunosuppressants: vedolizumab.</li><li class="elsevierStyleListItem" id="lsti0015">3Low degree of immunosuppression: azathioprine at doses under 3 mg/kg/day, mercaptopurine at doses under 1.5 mg/kg/day, systemic corticosteroids at doses under 20 mg/kg/day for under two weeks and methotrexate at doses under 20 mg/week (<0.4 mg/kg/week). Maintenance treatment with budesonide up to a dose of 6 mg/day has no increased risk of infection compared with placebo.</li><li class="elsevierStyleListItem" id="lsti0020">4High degree of immunosuppression: cyclosporine, tacrolimus, TNF inhibitors, tofacitinib, ustekinumab.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> Azathioprine, mercaptopurine, systemic corticosteroids and methotrexate produce a high degree of immunosuppression at doses higher than those discussed in the previous section.</li></ul>This classification makes it possible to establish the potential risk of opportunistic infections and the possibility or not of administration of live attenuated vaccines.Are vaccines safe during immunosuppression?The risk of adverse effects from vaccines depends on the degree of immunosuppression and the type of vaccine.<a class="elsevierStyleCrossRefs" href="#bib0070">14–17</a> With the exception of live attenuated vaccines, vaccines have the same safety profile in the immunocompromised population as in the immunocompetent population, so immunosuppressive treatment should not be altered because of vaccination. There are five types of vaccines (the main two are summarised in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). <ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025">-Inactivated vaccines. They contain particles of viruses, bacteria or toxins that have lost the ability to produce diseases as a result of chemical agents or physical processes.</li><li class="elsevierStyleListItem" id="lsti0030">-Live attenuated vaccines (live attenuated viruses or bacteria). Although these vaccines are based on attenuated microorganisms, they are still alive and are contraindicated in people receiving treatments that involve high immunosuppression. In this situation, there are two premises: <ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0035">•If immunosuppressive treatment is essential to control the underlying disease, it should not be delayed for vaccination. In this situation, treatment, and not vaccination, of the underlying disease is indicated.</li><li class="elsevierStyleListItem" id="lsti0040">•If immunosuppressive treatment is not essential to control the underlying disease, vaccination can be carried out with a safety period prior to and after vaccination.</li></ul></li></ul><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Patients treated with selective or low-dose immunosuppressive therapy should be assessed on an individual basis, taking into account the risks and benefits, and vaccination without the application of interruption intervals should be considered.<a class="elsevierStyleCrossRefs" href="#bib0015">3,18</a><ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0045">-Antigenic subunit vaccines consist only of specific fragments of the virus or bacteria that are essential for the immune system to recognise.</li><li class="elsevierStyleListItem" id="lsti0050">-Viral vector-based vaccines introduce small fragments of RNA or DNA containing instructions for the body to directly produce a pathogen-specific protein. The innocuous virus serves as a platform for introducing the protein into the body.</li><li class="elsevierStyleListItem" id="lsti0055">-DNA or RNA vaccines consist of plasmids or liposomes containing a fragment of RNA or DNA of the infectious agent with genetic information for making a specific protein.</li></ul>Screening and protocol prior to vaccination in patients on immunosuppressive and/or biologic treatment. When and how to vaccinate?It is recommended that the immunisation status of patients with IBD be assessed at the time of diagnosis and the appropriate vaccines be administered to avoid infections.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> A fact sheet on vaccines that can be administered to patients with IBD is provided in <a class="elsevierStyleCrossRef" href="#sec0130">Annex 1</a>.The best time to vaccinate patients is at diagnosis or before the initiation of immunosuppressive therapy, since the response to vaccines may decrease with immunosuppression. In clinical practice this is not always possible and vaccination does not justify delaying the start of treatment. The response rate without immunosuppressive treatment is similar to the response rate in the general population. <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarises the recommended time intervals for withdrawal and the introduction of immunosuppression prior to and after vaccination, respectively.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Going through the following checklist is recommended for all patients, although it is mandatory before the start of any biologic or immunosuppressive treatment.<a class="elsevierStyleCrossRefs" href="#bib0095">19,20</a><ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0060">•Screening for viral infections at IBD diagnosis: hepatitis A virus, hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Epstein-Barr virus, cytomegalovirus, herpes simplex virus, varicella zoster virus (VZV), mumps, rubella and measles (<a class="elsevierStyleCrossRef" href="#sec0130">Annex 2</a>).</li></ul>At diagnosis, it is important to be aware of the serological situation regarding different infections such as HBV, HCV, HIV, mumps, rubella, measles,<a class="elsevierStyleCrossRef" href="#bib0105">21</a> Epstein-Barr virus, VZV (a history of varicella does not necessarily mean there is no need for serological determination) and cytomegalovirus (not essential, it indicates whether or not infection has passed in view of the risk of cytomegalovirus reactivation in immunosuppressed patients).<a class="elsevierStyleCrossRefs" href="#bib0110">22,23</a>The study and vaccination of hepatitis A virus is not always mandatory and will depend on the patient's individual risk factors (profession, underlying liver disease, coagulation disorder, administration of hepatotoxic drugs or indication for solid organ transplantation, community where the patient lives and if they travel to endemic areas).HBV serology should be performed because of the risk of reactivation with immunosuppressive therapy. More importantly, when positive serology is present, the possibility of occult HBV infection should be considered. It is also important to determine HCV serology, as patients with HCV infection on immunosuppressive therapy may present worsened liver disease.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> Administration of immunosuppressants may also increase the risk of serious infections in patients with poorly controlled HIV infection.<a class="elsevierStyleCrossRef" href="#bib0125">25</a><ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0065">•Human papillomavirus (HPV) screening.</li></ul>HPV cytology is recommended at the time of IBD diagnosis.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> Immunosuppressed patients should have an annual cytology.<a class="elsevierStyleCrossRef" href="#bib0015">3</a><ul class="elsevierStyleList" id="lis0035"><li class="elsevierStyleListItem" id="lsti0070">•SARS-CoV-2 screening.</li></ul>Current studies show that IBD patients (including immunosuppressed patients) are not at greater risk of infection or more serious infection than the general population.<a class="elsevierStyleCrossRefs" href="#bib0130">26–29</a><ul class="elsevierStyleList" id="lis0040"><li class="elsevierStyleListItem" id="lsti0075">•Immune response to vaccines</li></ul>The immune response to different vaccines may vary depending on the type of vaccine administered and the treatment the patient is receiving. The recommended vaccine dosage is listed in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Live attenuated vaccinesHerpes zoster virusThe infection may occur in the form of VZV or herpes zoster. There is an approximately 50% higher risk of herpes zoster in IBD patients compared to the general population. The risk is higher in patients receiving combined TNF inhibitors and thiopurines.<a class="elsevierStyleCrossRef" href="#bib0150">30</a> Tofacitinib may be associated with a higher risk of herpes zoster infection than TNF inhibitors, with the risk being greater with higher doses of tofacitinib.<a class="elsevierStyleCrossRef" href="#bib0155">31</a> Vedolizumab and ustekinumab have not been associated with an increased risk of herpes infection.Zostavax® is a live attenuated virus vaccine, administered subcutaneously, with an efficacy of 50%–60%. It is indicated in patients older than 50 years and contraindicated in immunosuppressed patients, except those on low doses of immunosuppressants. In this case, it could be administered by assessing the risk on an individual basis. Short- and long-term studies have found that vaccine efficacy tends to decline over time (up to 21% at 11 years post-administration).<a class="elsevierStyleCrossRef" href="#bib0160">32</a>Recently, the Shingrix vaccine has become available in Spain®. This is an inactivated recombinant vaccine, administered intramuscularly, with an effectiveness of more than 95%, sustained over the first four years.<a class="elsevierStyleCrossRefs" href="#bib0165">33,34</a> Two doses are administered two months apart, if possible, before starting immunosuppressive therapy. It is currently only approved for patients ≥ 18 years of age who are starting JAK inhibitors or are on active therapy.<a class="elsevierStyleCrossRef" href="#bib0175">35</a>MMR vaccineAlthough most patients have already received the MMR vaccination (and some children have received the VZV vaccination), the absence of antibodies against these infections or against vaccination in a screening analysis renders its administration advisable before the start of immunosuppressive treatment, ideally at the diagnosis of IBD.<a class="elsevierStyleCrossRef" href="#bib0015">3</a>In Spain, since 1995, two doses separated by at least four weeks have been recommended. Available data from 2018 indicate that 97% of Spanish children are vaccinated with the first dose, which guarantees good immunity, although only 94% of Spanish children are vaccinated with the second dose. In September 2018, in view of the increase in the number of measles cases, mainly outside Spain, the Ministerio de Sanidad, Consumo y Bienestar [Ministry of Health, Consumption and Welfare] recommended MMR vaccination (against mumps, measles and rubella, since there is no exclusive vaccine for measles) for all those born in 1970 or later who had not received both doses of the vaccine or had not had the disease. It is accepted that those born before 1970 had measles or were in contact with the wild virus and are therefore excluded from these general recommendations.Inactivated vaccinesRoutine vaccination against influenza, pneumococcus, and HBV (regardless of age and immunosuppression status) is recommended for IBD patients.Flu (influenza) and pneumococcus (Streptococcus pneumoniae)A retrospective cohort study compared the risk of influenza infection among 140,480 patients with IBD and controls without IBD. The IBD patients had a higher risk of infection and hospitalisation than the controls.<a class="elsevierStyleCrossRefs" href="#bib0180">36,37</a> Seroconversion after vaccination against influenza and pneumococcus has been seen to be lower in patients on immunosuppressive treatment, especially in those with combined treatment (TNF inhibitors and immunosuppressive drugs). For this reason, the withdrawal of methotrexate for two weeks after vaccination and the administration of high doses of influenza vaccine in patients receiving TNF inhibitors are recommended to optimise vaccination outcomes.<a class="elsevierStyleCrossRefs" href="#bib0190">38,39</a>Among the risk groups likely to receive influenza and pneumococcal vaccinations, subjects on immunosuppressant therapy and patients with IBD (regardless of whether or not they are immunosuppressed) have been considered. With regard to the new biologic treatments, a recent study reports adequate immunogenicity following influenza vaccination in CD patients treated with ustekinumab.<a class="elsevierStyleCrossRef" href="#bib0200">40</a> In addition, ustekinumab does not appear to influence the response to the HBV or pneumococcal vaccine (although published studies do not include IBD patients). Similarly, treatment with vedolizumab does not appear to decrease the effectiveness of the influenza and pneumococcal vaccines.<a class="elsevierStyleCrossRef" href="#bib0205">41</a> In patients treated with tofacitinib, it has been observed that the effectiveness of the pneumococcal vaccine PPSV23 may be diminished, but not the influenza vaccine.Sequential vaccination with both vaccines, conjugate (PCV13 or Prevenar® or 13-valent conjugate) and polysaccharide (PPSV23 or 23-valent polysaccharide), is recommended, respecting the minimum intervals between doses and type of vaccine. The vaccination schedule depends on the person's age and on whether they have been vaccinated before. After age six years, the sequential regimen (PCV13 + PPSV23) is administered with a recommended interval of at least eight weeks. In all situations, a dose of PPSV23 is administered and should be repeated every five years.Human papilloma virusThe HPV vaccine is recommended for women under 26 years.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> In addition, national guidelines are considering including boys of school age.The HPV vaccine is inactivated and highly effective in preventing HPV infection, precursor lesions of cervical, vaginal, and vulvar cancer, and genital warts caused by serotypes 6, 11, 16 or 18 in women who have not been infected with these serotypes. It is administered in three doses (at zero, two and six months). In 2017 Gardasil9®, a novel vaccine that includes nine serotypes: 6, 11, 16, 18, 31, 33, 45, 52 and 58, was marketed. It is funded by the Spanish National Health System (according to the systematic schedule) for school-age girls, for HIV-infected men and women <26 years, and for women diagnosed with advanced-grade cervical intraepithelial neoplasia (CIN II or III) or endocervical adenocarcinoma in situ. For other patients this should be consulted, since, although recommended, the vaccine is not funded in most autonomous communities in immunosuppressed patients. There are exceptions, such as in the Autonomous Community of the Canary Islands, where funding for 18−65-year-old women with a history of IBD is approved. For the screening and diagnosis of HPV infection, an annual cytology is recommended in women with IBD, especially if they are on immunosuppressive therapy. A history of old infection or an active HPV infection does not contraindicate immunosuppressive treatment, since most infections are transient and disappear within two years.<a class="elsevierStyleCrossRefs" href="#bib0015">3,42,43</a>Hepatitis B virusPatients with IBD are not at increased risk of HBV infection. Conversely, HBV reactivation has been observed in 7.5% of patients with a history of HBV infection treated with infliximab.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> All reactivations in IBD patients have occurred in those who were on immunosuppressive or biologic treatment, with the use of two or more immunosuppressants entailing a higher risk. HBV vaccine efficacy is 95% in the general population. However, immunosuppressed IBD patients may have a low response rate (about 50%).<a class="elsevierStyleCrossRef" href="#bib0220">44</a>Vaccination is recommended due to the potentially fatal consequences of infection. In patients on immunosuppressive treatment, the rapid, double-dose regimen results in increased immunisation and seroconversion. When there are anti-HBs antibody (Ab) levels > 100 IU, higher response percentages are also obtained.<a class="elsevierStyleCrossRefs" href="#bib0225">45,46</a> However, although the recommendation is to achieve anti-HBs levels > 100 IU in IBD patients, in some autonomous communities it is not funded if anti-HBs levels are higher than 10 IU. In patients who are already vaccinated, anti-HBs Ab levels should be determined every one to two years to assess whether they have <100 IU/l. In such a case, a booster dose could be considered and new anti-HBs Ab level determinations at two to three months to check efficacy. If the titres are low, a new vaccination regimen will be necessary.Attention should be paid to the recommended guidelines for each vaccine available (antigen quantity or number of doses). For example, vaccine overdose errors have been reported with the Engerix® 20 µg vaccine due to it being presumed equal to Fendrix® 20 µg. The Fendrix® vaccine contains 20 µg but it is adjuvanted, so it is considered an immunity-enhanced vaccine and the antigenic response is much greater. A study was recently published that randomised 173 IBD patients to receive a double dose of Engerix®-B (53%) or a single dose of Fendrix® at months zero, one, two and six (46%). Forty-five percent of patients responded (anti-HBs ≥ 100 IU/l) after three doses and 71% after the fourth dose. The response rate after the fourth dose, was 75% with Fendrix® compared to 68% with Engerix®-B. Advanced age and treatment with steroids, immunosuppressants or TNF inhibitors were associated with a lower likelihood of response. However, Fendrix® was not superior to Engerix®, so either one may be recommended. This study highlights the importance of the fourth dose (more effective than the three-dose regimen) and the importance of taking into account the >100 IU/l anti-HBs Ab threshold, because the rate of antibody loss during the first year is very rapid (20%/patient-year).<a class="elsevierStyleCrossRef" href="#bib0235">47</a> In contrast, a recent study in patients treated with vedolizumab obtained a response similar to that observed in the vaccination of non-immunosuppressed patients.<a class="elsevierStyleCrossRef" href="#bib0205">41</a>The following scenarios are considered:<ul class="elsevierStyleList" id="lis0045"><li class="elsevierStyleListItem" id="lsti0080">-Immunocompetent patient: standard dose and normal regimen: HBVaxPro® 10 µg or Engerix® 20 µg 0-1-6 months.</li><li class="elsevierStyleListItem" id="lsti0085">-Patient with immunosuppression or not responding to a first vaccination regimen: double dose intensified with fourth dose: HBVaxPro® 40 µ or Fendrix® 20 µg 0-1-2-6/12 months. Subsequent annual or six-monthly anti-HBs Abs monitoring. In the case of low Abs (in previously responsive patients), administer a booster dose (Fendrix® 20 µg or HBVaxPro® 40 µg) and serological control 1−3 months. If there is no response, start a re-vaccination regimen (maximum two rounds of re-vaccination).</li></ul>Recommendations for vaccination against SARS-CoV-2 infectionThe approval and availability of Pfizer-BioNTech and Moderna vaccines, messenger RNA (mRNA) vaccines, and AstraZeneca and Janssen (modified adenovirus) vaccines, with information provided by the Agencia Española de Medicamentos y Productos Sanitarios [Spanish Agency for Medicines and Medical Devices] confirms that the vaccines are safe and effective.<a class="elsevierStyleCrossRefs" href="#bib0240">48,49</a>Recent articles recommend vaccination against SARS-CoV-2 in IBD patients with any available vaccine, regardless of the underlying immunosuppressive treatment.<a class="elsevierStyleCrossRefs" href="#bib0250">50,51</a> Vaccination against SARS-CoV-2 should not be delayed if the patient is on immunosuppressive treatment, although it may decrease the immune response to the vaccine.<a class="elsevierStyleCrossRef" href="#bib0260">52</a> In the vaccine trials, no patient had a worsening of a pre-existing autoimmune disease. As in the general population, vaccinated IBD patients may present the infection, although it is less likely and with a milder course. Patients who have had the infection should also be vaccinated.Serological responses following SARS-CoV-2 vaccination may be weaker in immunosuppressed individuals. Recently, a study of 6935 IBD patients with symptomatic SARS-CoV-2 infection was published showing that patients treated with infliximab have a lower seroprevalence, seroconversion, and anti-SARS-CoV-2 antibody reactivity magnitude compared to patients treated with vedolizumab. In addition, only one third of patients receiving concomitant immunosuppressive treatment (thiopurines or methotrexate) with infliximab had post-infection anti-SARS-CoV-2 antibodies.<a class="elsevierStyleCrossRef" href="#bib0265">53</a> Another recent systematic review of 46 studies evaluating seroconversion rates after full vaccination against SARS-CoV-2 in patients with IBD found that with the mRNA vaccines seroconversion rates are similar in patients with IBD and controls (healthy population). Although seroconversion rates are lower in patients treated with corticosteroids and the combination of TNF inhibitors and immunosuppressants, seroconversion >90% is observed after full vaccination. Treatment with TNF inhibitors, vedolizumab, ustekinumab, and JAK inhibitors were all associated with good seroconversion rates with the complete vaccination regimen. The lifespan of antibody response after full vaccination against SARS-CoV-2 is a matter of ongoing evaluation. Many studies point to a decrease in antibody titres from the fourth week post-vaccination, it being greater in patients who are on treatment with TNF inhibitors alone or in combination with immunosuppressants. This systematic review shows that there is a decrease in antibody responses after vaccination against SARS-CoV-2 in patients with IBD, more rapid in patients treated with TNF inhibitors, immunosuppressants or a combination thereof, meaning that additional doses could be considered in these patients.<a class="elsevierStyleCrossRef" href="#bib0270">54</a>Interactions with other inactivated vaccines have not been demonstrated. It is therefore recommended that patients with IBD follow the same vaccination regimen established by the competent bodies as the general population.<a class="elsevierStyleCrossRef" href="#bib0275">55</a>Are there vaccines specifically recommended for IBD patients? For cohabitants as well?Routine mandatory vaccinations are part of the Spanish Public Health programme, whether or not a person has an IBD. Specific mandatory vaccines are those that are not given to the general population on a regular basis, but are mandatory in patients with IBD. Optional vaccines are indicated according to the individual patient's risk (comorbidities, risky contacts, etc.). Recommendations for routine and IBD-specific mandatory vaccines are defined in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>.Cohabitants of patients with diseases who are at risk of infection should have received all the vaccines recommended for their age, including live attenuated vaccines. Vaccination will prevent the disease in contacts and prevent potential transmission to the immunocompromised patient. No vaccine marketed in Spain is contraindicated in cohabitants of at-risk patients.<a class="elsevierStyleCrossRef" href="#bib0280">56</a> Annual influenza vaccination is recommended for cohabitants. The MMR vaccine should be administered according to the usual recommendations and without requiring any special precautions, since the transmission of any of the viruses contained in the vaccine has not been described. Although precautions should be taken, the administration of VZV, MMR, Zostavax® and rotavirus vaccinations to cohabitants of immunosuppressed people has been shown to be safe and effective.<a class="elsevierStyleCrossRef" href="#bib0285">57</a>The patient should be informed of the risk of live attenuated vaccines (oral typhoid, VZV, yellow fever, rotavirus, BCG).Vaccines abroadBefore going on a trip, an individualised vaccination schedule assessment is recommended, taking into account personal characteristics and the destination, at least four to eight weeks before departure, as there are vaccines that cannot be administered together, or multiple doses or a latency time are required until they are effective.<a class="elsevierStyleCrossRef" href="#bib0290">58</a> Travellers with IBD should go to their referral centre and consult their IBD specialist and travel prevention specialist.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> Travellers with IBD are advised to be aware of the guidelines to follow in the event of an outbreak and to request a medical report specifying their disease, treatment (generic name of drug) and dose. They can submit queries or enquiries to the IBDPassport<a class="elsevierStyleCrossRef" href="#bib0295">59</a> website, which has a Spanish version, or the World Health Organization and the U.S. Centers for Disease Control and Prevention prevention guidelines,<a class="elsevierStyleCrossRef" href="#bib0300">60</a> which provide country-specific risk information. If patients are not immunosuppressed, the recommendations are the same as those for the general population. If they are immunosuppressed, live attenuated viral vaccines should be avoided.Three types of vaccinations can be administered (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>):<ul class="elsevierStyleList" id="lis0050"><li class="elsevierStyleListItem" id="lsti0090">-Mandatory vaccinations: vaccinations that are not part of the Spanish vaccination schedule but may be required by the health authorities of the destination country. This type of vaccination may vary depending on the country visited, the type of trip and the age of the traveller. Yellow fever, meningococcal disease and poliomyelitis vaccinations are included.</li><li class="elsevierStyleListItem" id="lsti0095">-Recommended vaccinations: vaccinations that are not mandatory or part of the Spanish public health programme, but are recommended in case of an individual or environmental risk of contracting the disease. These include typhoid, hepatitis, cholera, rabies, Japanese encephalitis, central European borne encephalitis, influenza and rabies, but also poliomyelitis and meningococcal meningitis (already discussed).</li><li class="elsevierStyleListItem" id="lsti0100">-Routine or universal vaccination: vaccinations recommended for the entire population to protect susceptible people from the disease but also the general population. This type of vaccination includes tetanus, diphtheria, hepatitis B, measles, mumps, rubella and VZV.</li></ul><elsevierMultimedia ident="tbl0020"></elsevierMultimedia>The simultaneous administration of vaccines is safe and effective, with certain exceptions<a class="elsevierStyleCrossRef" href="#bib0290">58</a>:<ul class="elsevierStyleList" id="lis0055"><li class="elsevierStyleListItem" id="lsti0105">•Different vaccine formulations against the same disease should not be administered simultaneously, such as meningococcal or pneumococcal conjugate vaccines.</li><li class="elsevierStyleListItem" id="lsti0110">•If the oral cholera vaccine is administered and others are to be administered, an least an interval of one hour should be allowed to elapse between them.</li><li class="elsevierStyleListItem" id="lsti0115">•The oral poliomyelitis vaccine may reduce the response to the rotavirus vaccine, so it is advisable to administer them separately.</li><li class="elsevierStyleListItem" id="lsti0120">•The simultaneous administration of the MMR and yellow fever vaccines conditions a reduction in humoral response to yellow fever, rubella and mumps and it is therefore advisable to separate them by a minimum of four weeks.</li></ul>Vaccinations in IBD patients during pregnancy and breast-feeding. Which vaccinations, and when can they be given to children of mothers who have received biologic treatment during pregnancy?Pregnancy and breast-feeding in IBD patientsThe indications for vaccination in pregnancy are summarised in <a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>.<elsevierMultimedia ident="tbl0025"></elsevierMultimedia>Vaccination during breast-feeding has two main objectives: to protect the mother from vaccine-preventable diseases and to protect the infant by protecting the mother (cocooning) and transferring antibodies through breast milk (>90% IgA secretory). Breastfeeding does not adversely affect vaccination the success or safety.<a class="elsevierStyleCrossRefs" href="#bib0305">61,62</a>Vaccination of the newborn of a mother with IBDThe vaccination of a newborn of a mother with IBD should follow the same recommendations as for other newborns and should be performed according to the schedule established in the common vaccination schedule (see the peculiarities of each autonomous community). However, if the mother is exposed to biologic therapy, it is recommended that live attenuated vaccines be avoided for the first 12 months of life (or newborn drug levels for mothers treated with TNF inhibitors be obtained).<a class="elsevierStyleCrossRefs" href="#bib0315">63,64</a> Biologics are actively transported through the placenta, especially in the second half of pregnancy. Drug levels are detected in the newborn and, in the case of TNF inhibitors, can remain detectable for up to six to 12 months. The detection of these immunosuppressive drugs in the plasma of the newborn with a possible involvement of the immune system prompts the recommendation not to administer live attenuated vaccines during the first year of life.Live attenuated vaccines should be avoided during the first 6–12 months of life in children who have been exposed to biologic treatment in the uterus during the third trimester, including: MMR, VZV, BCG, intranasal influenza, oral polio (not used in Spain, replaced by intramuscular inactivated), yellow fever and typhoid fever.<a class="elsevierStyleCrossRef" href="#bib0325">65</a>The Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes (PIANO) is a US data registry of children of mothers with IBD from 2007 to 2016 that compares the response to vaccination of children exposed during pregnancy to treatment with: 5-aminosalicylates, steroids, azathioprine, mercaptopurine, infliximab, adalimumab, golimumab, certolizumab, natalizumab, vedolizumab, or ustekinumab, and it concludes that there are no differences in immune response to the vaccinations received and that neither is there a greater number of adverse reactions. However, overall response was slightly lower than the figure reported in the general population. Data from this registry showed that rotavirus vaccine administration is safe, albeit with a sample of only 43 newborns from mothers on biologic treatment (19 infliximab, 12 certolizumab, 7 adalimumab, 1 infliximab and certolizumab, 1 ustekinumab), with the appearance of mild adverse effects: 26% fever and 5% diarrhoea (vs. 42% and 19%, respectively, in the general population).<a class="elsevierStyleCrossRef" href="#bib0330">66</a>Orally-administered rotavirus vaccine is the only live attenuated vaccine administered before six months of age. The rotavirus vaccine Summaries of Product Characteristics warn of the need to assess the potential benefits and risks of vaccine administration in children who have been exposed to immunosuppressive and/or biologic treatment in the uterus. A French retrospective abstract study evaluated the administration of live attenuated vaccines < 12 months (BCG, rotavirus, and MMR) in 143 mothers with IBD who received TNF inhibitors treatment during pregnancy, without observing any complications.<a class="elsevierStyleCrossRef" href="#bib0335">67</a>Vaccines in paediatric IBDIncreased diagnosis of paediatric IBD<a class="elsevierStyleCrossRefs" href="#bib0340">68,69</a> is accompanied by an increased use of drugs with immunomodulatory capacity in these patients. Specific guidelines for the treatment of paediatric CD and ulcerative colitis recommend the early use of immunosuppressive drugs and biologic treatments.<a class="elsevierStyleCrossRefs" href="#bib0350">70–72</a>The Vaccines Committee of the Asociación Española de Pediatría [Spanish Association of Paediatrics] defines and periodically reviews the vaccination schedule, regarded as being of universal compliance for children to stay healthy in the initial years of life. This vaccination schedule undergoes modifications in the different autonomous communities. Immunisation with live attenuated virus vaccines should be completed by the age of four years. Diagnosing the classical forms of IBD at this stage of life is quite rare. Therefore, most patients diagnosed with IBD in paediatric age should have already received all the live attenuated virus vaccines listed in the vaccine schedule. For cases in which vaccination has not been carried out at the established ages, the Asociación Española de Pediatría also establishes recommendations through the so-called rescue or accelerated guidelines. Two models have been established for these recommendations: one for children up to 6 years of age and one for children and adolescents between 7 and 18 years of age.<a class="elsevierStyleCrossRef" href="#bib0365">73</a>In this regard, and as reflected in a document from the IBD Working Group of the European Society for Paediatric Gastroenterology Hepatology and Nutrition ‒ESPGHAN‒, published in 2012, children with IBD should have live attenuated virus vaccinations at least three to four weeks before starting treatment with immunosuppressants or TNF inhibitors.<a class="elsevierStyleCrossRef" href="#bib0370">74</a> The nutritional treatment phase at the onset of paediatric CD or initial salicylate treatment in mild-to-moderate ulcerative colitis are the most appropriate periods for initiating these rescue strategies in incorrectly vaccinated patients or those with inadequate immunisation. If, due to the specific needs of these patients, such a plan cannot be carried out, the administration of these vaccines should be postponed at least until three months after cessation, which will not always be feasible.<a class="elsevierStyleCrossRef" href="#bib0375">75</a>As in the adult population, it is recommended that the vaccination history of patients be assessed at the time of diagnosis and the most appropriate strategy for correct immunisation be established. However, the data currently available indicate that follow-up to these recommendations in the paediatric community is frankly suboptimal. A retrospective survey published in 2020 by the ESPGHAN analysed immunisation rates in paediatric patients with IBD, showing vaccination rates of 89% for MMR, 82% for Haemophilus influenzae Type B, 23% for meningococcal C, 18% for VZV, 19% for pneumococcus, 5.9% for HPV and 1.9% for rotavirus. The rate of patients with full immunisation was only 8.8%.<a class="elsevierStyleCrossRef" href="#bib0380">76</a> With regard to vaccine safety, the rate of adverse effects in IBD patients did not differ from that of healthy controls, regardless of the base treatment.<a class="elsevierStyleCrossRef" href="#bib0385">77</a>How can adherence to vaccination programmes by patients and healthcare workers be improved?Adherence is defined by the World Health Organization “the degree to which the person's behaviour corresponds with the agreed recommendations from a health care provider”.<a class="elsevierStyleCrossRef" href="#bib0390">78</a> Lack of adherence to vaccination is common in patients with IBD, mainly due to fear of side effects and as it is not seen as necessary despite medical recommendations.<a class="elsevierStyleCrossRef" href="#bib0395">79</a> It is important to individualise the intervention so that the IBD patient feels heard, welcomed and understood with a view to building a trust-based relationship.<a class="elsevierStyleCrossRef" href="#bib0400">80</a> Health education about vaccines, demystifying and explaining their side effects, and informing about the importance of having the vaccine schedule up to date, especially in immunosuppressed patients, is an important task of the IBD unit team. Harmonising criteria in vaccination guidelines is important in providing the same coverage to patients. This also reduces administration errors in different vaccination regimens.GETECCU recommendations on the importance of screening and vaccination in IBD patientsBased on the review in this document, the following GETECCU recommendations on the importance, screening and vaccination of IBD patients (adult and paediatric populations) are summarised below: <ul class="elsevierStyleList" id="lis0060"><li class="elsevierStyleListItem" id="lsti0125">1Patients with IBD are at higher risk of infection than the general population.</li><li class="elsevierStyleListItem" id="lsti0130">2A vaccination programme is part of the initial standardised checklist to be performed with IBD patients. Possible risk factors for infection, demographic and epidemiological variables, disease history and comorbidities should be considered before initiating immunosuppressive therapy.</li><li class="elsevierStyleListItem" id="lsti0135">3The best time to vaccinate patients, both adult and paediatric, is before the start of immunosuppressive therapy, if possible when IBD is diagnosed. Otherwise, the risk-benefit ratio of vaccination during treatment should be assessed.</li><li class="elsevierStyleListItem" id="lsti0140">4At the time of diagnosis of IBD, hepatitis B, influenza, pneumococcus, VZV, HPV, diphtheria-tetanus-pertussis, poliomyelitis and MMR vaccinations are recommended.</li><li class="elsevierStyleListItem" id="lsti0145">5Live attenuated vaccines in both the paediatric and adult populations should be administered at least four weeks before starting treatment with immunosuppressants, JAK (tofacitinib) inhibitors or biologics. If this is not possible, it is recommended that the administration of these vaccines be postponed at least until three months after cessation of immunosuppressive therapy and one month after termination of steroids.</li><li class="elsevierStyleListItem" id="lsti0150">6In patients on low-dose immunosuppression or selective immunosuppressants, live attenuated vaccines can be considered on an individual basis by assessing the risk-benefit ratio.</li><li class="elsevierStyleListItem" id="lsti0155">7The live attenuated vaccines that are contraindicated in immunosuppressed patients are: yellow fever, VZV, BCG, MMR, rotavirus, oral polio, nasal influenza and oral typhoid fever.</li><li class="elsevierStyleListItem" id="lsti0160">8Influenza vaccination is recommended annually and pneumococcal vaccination is recommended sequentially with a PPSV23 booster at five years.</li><li class="elsevierStyleListItem" id="lsti0165">9The baseline serological study and vaccination against the hepatitis A virus is not always mandatory and depends on the risk factors and the community in which the patient resides.</li><li class="elsevierStyleListItem" id="lsti0170">10All HBV seronegative patients should be vaccinated. In immunocompetent patients, the standard hepatitis B vaccination regimen may be used. In immunosuppressed patients with titres <100 IU/mL, a double, rapid-dose regimen should be recommended. Four-dose regimens are more effective than 3-dose regimens.</li><li class="elsevierStyleListItem" id="lsti0175">11In patients vaccinated against hepatitis B, anti-HBs Ab levels should be determined every one to two years. If the anti-HBs Ab levels are <100 IU/l a booster dose should be considered and new level determinations performed at two to three months to check efficacy. If the titres are low, a new vaccination regimen will be necessary.</li><li class="elsevierStyleListItem" id="lsti0180">12HPV vaccination does not exclude cytology and gynaecological screening for cervical cancer. Vaccination is always recommended in patients who have had a history of HPV infection, CIN II-III, or cervical cancer. Having been infected with one HPV type does not protect against infection with another serotype, and vaccination would continue to be recommended. Administration in men is recommended, although it is not funded in Spain.</li><li class="elsevierStyleListItem" id="lsti0185">13The vaccine (Zostavax®) against herpes zoster is recombinant with live attenuated viruses and should be recommended in patients >50 years. It is contraindicated in immunosuppressed patients, except those on low-dose immunosuppressants. The inactivated virus vaccine (Shingrix®) is now authorised in Spain for patients ≥ 18 years who are going to start or are already on treatment with JAK inhibitors.</li><li class="elsevierStyleListItem" id="lsti0190">14There is no evidence of an increased risk of SARS-CoV-2 vaccine in IBD patients, so it is recommended that all IBD patients be vaccinated against SARS-CoV-2 regardless of their baseline treatment. Full vaccination against SARS-CoV-2 is associated with seroconversion in most IBD patients. The decrease in antibody titres over time requires the consideration of additional doses, particularly in patients on certain therapies (TNF inhibitors, immunosuppressants or a combination thereof). As understanding of the management of this pandemic is increasing rapidly, recommendations could change.</li><li class="elsevierStyleListItem" id="lsti0195">15The patient should be informed if they are to travel to areas of endemic diseases, especially those on immunosuppressive treatment. IBD patients going on a trip should consult one to two months before the trip.</li><li class="elsevierStyleListItem" id="lsti0200">16As a rule, live attenuated virus vaccines in the children of mothers who have received biologic treatment during pregnancy should be avoided within the first 6–12 months or be assessed, according to drug levels in the blood, prior to vaccination.</li><li class="elsevierStyleListItem" id="lsti0205">17Low immunisation rates in IBD could be explained by scant awareness in the medical profession, lack of protocolisation of vaccination circuits and concern about possible adverse effects and vaccine safety in immunocompromised patients.</li></ul>Conflicts of interestRocío Ferreiro-Iglesias has been a speaker for or received research funding from Takeda, MSD, AbbVie, Janssen, Pfizer, Palex, Shire Pharmaceuticals, Tillotts Pharma and Casen Recordati.Marta Piqueras has been a speaker for or received research funding from Takeda, AbbVie and Janssen.Elena Ricart has been a speaker for or has received research funding from MSD, AbbVie, Janssen, Takeda, Ferring, Pfizer, Amgen and Fresenius Kabi.Laura Sampere has been a speaker for or received research funding from Pfizer and Janssen.Mariona Roca has been a speaker for or received research funding from Pfizer, MSD, GSK, Fresenius Kabi, Braun, Nutricia, Abbott and Nestlé.Javier Martín de Carpi has been a speaker for or received research funding from MSD, AbbVie, Janssen, Fresenius Kabi, Adacyte, Nestlé, Abbott, Lactalis, Ferrer, Kern and Celltrion.Olga Benítez has been a speaker for or received research funding from Janssen, Biogen and MSD.Yamile Zabana has been a speaker for or has received research funding from AbbVie, MSD, Ferring, Amgen, Janssen, Pfizer, Dr. Falk, Tillotts, Galapagos and Takeda.Miriam Mañosa has been a speaker for or has received research funding from AbbVie, MSD, Takeda, Ferring, Janssen, Pfizer, Tillotts, Faes Farma, Gilead, Fresenius, Dr. Falk, Kern and Adacyte.Francisco Rodríguez-Moranta has been a speaker for or has received research funding from AbbVie, MSD, Takeda, Ferring, Janssen, Pfizer and Dr. Falk.Manuel Barreiro-de Acosta has been a speaker for or has received research funding from Pfizer, MSD, Takeda, AbbVie, Kern, Janssen, Fresenius Kabi, Biogen, Sandoz, Ferring, Faes Farma, Shire Pharmaceuticals, Dr. Falk, Chiesi, Gebro Pharma, Adacyte and Tillotts.None of these activities by the authors were related to this study." 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"secciones" => array:5 [ 0 => array:3 [ "identificador" => "sec0035" "titulo" => "Live attenuated vaccines" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Herpes zoster virus" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "MMR vaccine" ] ] ] 1 => array:3 [ "identificador" => "sec0050" "titulo" => "Inactivated vaccines" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Flu (influenza) and pneumococcus (Streptococcus pneumoniae)" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Human papilloma virus" ] ] ] 2 => array:2 [ "identificador" => "sec0065" "titulo" => "Hepatitis B virus" ] 3 => array:2 [ "identificador" => "sec0070" "titulo" => "Recommendations for vaccination against SARS-CoV-2 infection" ] 4 => array:2 [ "identificador" => "sec0075" "titulo" => "Are there vaccines specifically recommended for IBD patients? For cohabitants as well?" ] ] ] 8 => array:2 [ "identificador" => "sec0080" "titulo" => "Vaccines abroad" ] 9 => array:3 [ "identificador" => "sec0085" "titulo" => "Vaccinations in IBD patients during pregnancy and breast-feeding. Which vaccinations, and when can they be given to children of mothers who have received biologic treatment during pregnancy?" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0090" "titulo" => "Pregnancy and breast-feeding in IBD patients" ] 1 => array:2 [ "identificador" => "sec0095" "titulo" => "Vaccination of the newborn of a mother with IBD" ] ] ] 10 => array:2 [ "identificador" => "sec0100" "titulo" => "Vaccines in paediatric IBD" ] 11 => array:2 [ "identificador" => "sec0105" "titulo" => "How can adherence to vaccination programmes by patients and healthcare workers be improved?" ] 12 => array:2 [ "identificador" => "sec0110" "titulo" => "GETECCU recommendations on the importance of screening and vaccination in IBD patients" ] 13 => array:2 [ "identificador" => "sec0115" "titulo" => "Conflicts of interest" ] 14 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1602317" "palabras" => array:5 [ 0 => "Vaccination" 1 => "Inflammatory bowel disease" 2 => "Screening" 3 => "Prevention" 4 => "Infection" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1602318" "palabras" => array:5 [ 0 => "Vacuna" 1 => "Enfermedad inflamatoria intestinal" 2 => "Cribado" 3 => "Prevención" 4 => "Infección" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Patients with inflammatory bowel disease (IBD) may require different immunosuppressive treatments throughout their illness. It is essential to assess the immunization status of patients at diagnosis or, if this is not possible, at least before the beginning of immunosuppressive therapy and, subsequently, administering the appropriate vaccines.Therefore, the aim of this work is to establish clear and concise recommendations on vaccination in patients with IBD in the different settings of our clinical practice including vaccination in children, during pregnancy, breastfeeding or on trips. This consensus document emphasizes the differences between inactivated and attenuated vaccines and the different degrees of immunosuppression and correlates them with the administration of both mandatory and optional vaccines recommended to our patients with IBD. Finally, as a summary, 17 recommendations are established based on the available scientific evidence and expert opinion. A multidisciplinary team with extensive experience in IBD and vaccination, made up of specialists in gastroenterology, paediatrics, nursing and pharmacy, has participated in the preparation of these recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU)." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Los pacientes con enfermedad inflamatoria intestinal (EII) pueden requerir diferentes tratamientos inmunosupresores a lo largo del curso de su enfermedad. Por ello, es fundamental evaluar el estado de inmunización en el momento del diagnóstico o, si no es posible, siempre antes de iniciar un tratamiento inmunosupresor y administrar las vacunas apropiadas.El objetivo del presente documento es establecer unas recomendaciones claras y concisas sobre la vacunación en pacientes con EII en diferentes escenarios de práctica clínica, incluyendo situaciones especiales como la vacunación en la edad pediátrica, el embarazo, la lactancia o en viajes al extranjero. Se presentan las diferencias entre vacunas inactivadas y atenuadas, los diferentes grados de inmunosupresión y su relación con las pautas de administración de las diferentes vacunas (tanto obligatorias como opcionales) recomendadas a los pacientes con EII. En el documento, se establecen 17 recomendaciones basadas en la evidencia científica disponible y opinión de expertos. En la elaboración de estas recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU) ha participado un equipo multidisciplinar con amplia experiencia en EII y vacunación formado por especialistas de gastroenterología, pediatría, enfermería y farmacia." ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "Marta Piqueras and Rocío Ferreiro-Iglesias share co-authorship." "identificador" => "fn0005" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "The following are Supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia><elsevierMultimedia ident="upi0010"></elsevierMultimedia>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0130" ] ] ] ] "multimedia" => array:7 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Types of vaccine \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Live attenuated \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Inactivated \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mandatory in IBD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MMR (measles, mumps and rubella) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pneumococcus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Varicella \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Influenza \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hepatitis B \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Optional in IBD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rotavirus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hepatitis A \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oral polio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Meningococcal group B (Bexsero®)<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yellow fever \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Meningococcal groups A, C, W, Y<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diphtheria, tetanus, whooping cough \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Menveo® or Nimenrix® \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bacillus Calmette–Guérin<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Haemophilus influenzae type B \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Herpes zoster<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> (Zostavax®) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Human papilloma virus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Herpes zoster (Shingrix®) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Currently, the vaccine against TB (Bacillus Calmette-Guérin) is not indicated in Spain. It is only indicated in people who will reside in high-prevalence countries for more than three months (especially children)." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "Zostavax® is less effective than Shingrix®." ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "Meningococcal B, Menveo® or Nimenrix® (A, C, W, Y) in the case of a risk group (splenic dysfunction)." ] ] ] "descripcion" => array:1 [ "en" => "Classification of vaccines according to the technology used in their manufacture." ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Source: Kucharzik et al.<a class="elsevierStyleCrossRef" href="#bib0015">3</a>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">From treatment interruption to vaccination (weeks) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">From vaccination to restart of treatment (weeks) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Corticosteroids: ≥20 mg/day prednisone or equivalent > 2 weeks in adults and >1 mg/kg >2 weeks in the paediatric age group \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bolus corticosteroids \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Azathioprine/6-mercaptopurine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Methotrexate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TNF inhibitors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ustekinumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vedolizumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12−16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tofacitinib \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cyclosporine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tacrolimus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Immunosuppressive treatment interruption intervals for administration of live attenuated vaccines based on the half-life of each treatment." ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccinations \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients who are not on IMS treatment (like the general population) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients who are on IMS treatment \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pneumococcus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One dose of conjugate vaccine (Prevenar® 13), followed at 2 months by a dose of PPSV23. After 5 years, 2nd and last dose of PPSV23. If the patient has already received a dose of PPSV23, they must wait a year for PCV13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One dose of conjugate vaccine (Prevenar® 13), followed at 2 months by a dose of PPSV23. After 5 years, 2nd and last dose of PPSV23. If the patient has already received a dose of PPSV23, they must wait a year for PCV13 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hepatitis B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not immunised \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses 0-1-6 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">If anti-HBs < 100 IU \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 double doses (0-1-2 months) with booster between 6−12 m. Re-vaccination if anti-HBs < 100 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Re-vaccination if anti-HBs < 100 IU \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Influenza \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated in the current year \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One annual dose \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated in the current year \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One annual dose \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Measles, mumps, rubella \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not immunised \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One or 2 doses (interval > 28 days) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Contraindicated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Varicella \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not immunised \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 doses (0, 1−2 months) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Contraindicated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tetanus-diphtheria \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 initial doses (0, 1 and 7 months) + one dose/10 years until completion of 5 doses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 initial doses (0, 1 and 7 months) + one dose/10 years until completion of 5 doses \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DTaP (Diphtheria, tetanus, whooping cough) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pregnancy (week 28−36, preferably 32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One dose in each pregnancy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pregnancy (week 28−36, preferably 32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One dose in each pregnancy \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Human papilloma virus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Females (males<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a>) 11−14 years old (up to age 26 or having sexual intercourse) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses (0, 2, 6 months) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Females (males<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a>) 11−14 years old (up to age 26 or having sexual intercourse) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses (0, 2, 6 months) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Women > 26 years with a history of CIN II-III or conisation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Women > 26 years with a history of CIN II-III or conisation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Poliomyelitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses (0, 1−2, 6−12 months) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses (0, 1−2, 6−12 months) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Meningococcal group C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single dose \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Meningococcal group B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 doses (0, 2 months) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Meningococcal ACWY \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single dose \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Haemophilus influenzae type B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unvaccinated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single dose \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Herpes zoster \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients ≥ 50 years old \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single dose (Zostavax®) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients ≥ 18 years on JAK inhibitors (funded) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Two doses (0, 2−6 months) (Shingrix®) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Two doses (Shingrix®)<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "a" "nota" => "Not funded in non-immunosuppressed patients." ] ] ] "descripcion" => array:1 [ "en" => "Dosage of mandatory and optional vaccinations in patients with IBD." ] ] 3 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccinations in travellers</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Non-immunosuppressed patients</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Immunosuppressed patients</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yellow fever \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas in South America and Africa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single dose \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Contraindicated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Typhoid fever \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas in India and South Africa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 oral doses (0, 2, 4 days) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas in India and South Africa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single intramuscular dose \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hepatitis A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not immunised \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 doses (0, 6−12 months) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not immunised \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 doses (0, 6−12 months) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cholera \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas with insufficient access to clean water sources \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 doses (0, 1 week) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas with insufficient access to clean water sources \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 doses (0, 1 week) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Japanese encephalitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas of Asia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 doses (0, 1 month) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas of Asia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 doses (0, 1 month) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Central European encephalitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas of central and north-eastern Europe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses (0, 1−3, 9−18 months) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas of central and north-eastern Europe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses (0, 1−3, 9−18 months) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rabies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses (0, 7, 21−28 days) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endemic areas \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 doses (0, 7, 21−28 days) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Vaccination recommendations abroad." ] ] 4 => array:8 [ "identificador" => "tbl0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccine \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Indication \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DTaP (diphtheria, tetanus, whooping cough) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pregnant (week 28−36, preferably 32<a class="elsevierStyleCrossRef" href="#tblfn0025">a</a>) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Influenza \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Any trimester \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Other inactivated vaccines: HAV, HBV, meningococcal, pneumococcal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Selective vaccination if there are associated risk factors<a class="elsevierStyleCrossRef" href="#tblfn0030">b</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Measles, mumps and rubella (MMR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Contraindicated because it is a live attenuated virus vaccine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Varicella \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Contraindicated because it is a live attenuated virus vaccine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Herpes zoster \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Zostavax® contraindicated because it is a live attenuated virus vaccine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SARS-CoV-2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Recommended \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "a" "nota" => "The body takes two weeks to synthesise protective antibodies against whooping cough that are transferred to the foetus via the placenta. Vaccination must be performed sufficiently in advance of labour to meet this criterion." ] 1 => array:3 [ "identificador" => "tblfn0030" "etiqueta" => "b" "nota" => "Risk factors: HAV: occupational risk, chronic liver disease; meningococcus: occupational exposure, asplenia, complement deficiencies, HIV up to 26 years or in post-exposure prophylaxis; HBV: occupational risk, advanced chronic kidney disease, liver disease, HIV; pneumococcus: HIV, asplenia, advanced chronic kidney disease." ] ] ] "descripcion" => array:1 [ "en" => "Type of vaccine and indication in pregnant patients with IBD." ] ] 5 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.doc" "ficheroTamanyo" => 44340 ] ] 6 => array:5 [ "identificador" => "upi0010" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc2.pdf" "ficheroTamanyo" => 82490 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:81 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relevant infections in inflammatory bowel disease, and their relationship with immunosuppressive therapy and their effects on disease mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. 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Statistics

Clinical practice guidelines

Recommendations of the Spanish Group on Crohn’s Disease and Ulcerative Colitis on the importance, screening and vaccination in inflammatory bowel disease patients

Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa sobre la importancia, el cribado y la vacunación en pacientes con enfermedad inflamatoria intestinal

Rocío Ferreiro-Iglesiasa,b,1, Marta Piquerasc,

,1, Elena Ricartd,e, Laura Semperef, Mariona Rocag, Javier Martín de Carpih, Olga Benítezi, Yamile Zabanae,i, Míriam Mañosae,j, Francisco Rodríguez-Morantak, Manuel Barreiro-de Acostaa,b, on behalf of GETECCU

a Servicio de Gastroenterología, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, Spain

b Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, A Coruña, Spain

c Servicio de Gastroenterología, Consorci Sanitari de Terrassa (CST), Terrassa, Barcelona, Spain

d Servicio de Gastroenterología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain

e Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain

f Servicio de Gastroenterología, Hospital General Universitario de Alicante, Alicante, Spain

g Servicio de Farmacia, Consorci Sanitari de Terrassa (CST), Responsable del Servicio de Gestión Integral de Vacunas (SEGIV), Terrassa, Barcelona, Spain

h Unidad para el Cuidado Integral de la Enfermedad Inflamatoria Intestinal Pediátrica (UCIEII-P), Servicio de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital Sant Joan de Déu, Barcelona, Spain

i Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología, Hospital Mútua de Terrassa (HMT), Terrassa, Barcelona, Spain

j Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain

k Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología, Hospital Universitario de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain

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        "titulo" => "Recomendaciones del Grupo Espa&#241;ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa sobre la importancia&#44; el cribado y la vacunaci&#243;n en pacientes con enfermedad inflamatoria intestinal"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Patients with inflammatory bowel disease &#40;IBD&#41; have a higher predisposition to infections than the general population&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> some of which can be prevented with vaccinations&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Despite the existence of specific recommendations&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> IBD patients have low immunisation rates&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a> In addition&#44; vaccination schedules can vary by country and in the different clinical settings&#44; hence recommendations should be adapted taking all these characteristics into account&#46; For all these reasons&#44; this consensus document endorsed by the Spanish Working Group on Crohn&#39;s Disease and Ulcerative Colitis &#40;GETECCU&#41; has been produced and which establishes clear vaccination guidelines applied to our setting&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Epidemiology&#58; the risk of infection and immunisation rates in IBD patients</span><p id="par0010" class="elsevierStylePara elsevierViewall">Treatment for Crohn&#39;s disease &#40;CD&#41; and ulcerative colitis has progressed significantly over the last 20 years&#46; Many of the available drugs work by suppressing the immune system to a greater or lesser degree&#46; These drugs include biological agents &#40;infliximab&#44; adalimumab&#44; golimumab&#44; vedolizumab and ustekinumab&#41;&#44; corticosteroids&#44; immunosuppressants &#40;azathioprine&#44; mercaptopurine&#44; methotrexate&#44; cyclosporine&#44; tacrolimus&#41; and Janus kinase &#40;JAK&#41; inhibitors &#40;tofacitinib&#41;&#46; In addition&#44; the risk of developing infections increases when different immunosuppressive treatments that act on different targets are combined&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Patients with IBD have an increased risk of any infection&#44; especially opportunistic infections&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;8</span></a> In the TREAT &#40;Crohn&#39;s Therapy&#44; Resource&#44; Evaluation&#44; and Assessment Tool&#41; registry&#44; after a follow-up of more than five years&#44; an increased risk of infection was observed in patients with moderate-severe disease&#44; those who were treated with infliximab&#44; narcotic analgesics&#44; or corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In addition&#44; the risk of serious infections is higher in patients receiving combination treatment with thiopurines and TNF inhibitors compared to TNF inhibitor monotherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Many infections&#44; which can be serious or even fatal&#44; are immunopreventable with vaccinations&#46; However&#44; some studies have shown low seroprotection and adherence to vaccination programmes in patients with immunosuppressed IBD versus the general population&#46; Some of the main reasons for these low immunisation rates are poor adherence to vaccination protocols&#44; concerns about possible adverse effects and vaccine safety in immunocompromised patients&#44; or high costs of some unfunded vaccines&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;11&#44;12</span></a> Thus&#44; a recent survey of GETECCU partners reported that 3&#46;5&#37; of gastroenterologists specialising in IBD would currently recommend live attenuated vaccines in immunosuppressed patients&#44; and 4&#46;5&#37; would not recommend inactivated vaccines during the first year of life of children born of mothers treated with biologics during pregnancy&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Degree of immunosuppression and risk factors&#46; Vaccine safety</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Degree of immunosuppression and infection risk factors</span><p id="par0025" class="elsevierStylePara elsevierViewall">The risk factors associated with the appearance of opportunistic infections include the use of immunosuppressive agents&#44; particularly in combination with TNF inhibitors&#44; advanced age&#44; comorbidities&#44; malnutrition&#44; parenteral nutrition&#44; intestinal surgery&#44; IBD severity&#44; and treatment with narcotics&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The main causes of immunosuppression in IBD are immunosuppressive and&#47;or biological drugs used to control the disease&#44; and malnutrition&#46; Thus&#44; the treatments used in IBD patients can be classified&#44; according to the degree of immunosuppression&#44; into&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0035" class="elsevierStylePara elsevierViewall">Non-immunosuppressants&#58; aminosalicylates&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2</span><p id="par0040" class="elsevierStylePara elsevierViewall">Selective immunosuppressants&#58; vedolizumab&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3</span><p id="par0045" class="elsevierStylePara elsevierViewall">Low degree of immunosuppression&#58; azathioprine at doses under 3&#8239;mg&#47;kg&#47;day&#44; mercaptopurine at doses under 1&#46;5&#8239;mg&#47;kg&#47;day&#44; systemic corticosteroids at doses under 20&#8239;mg&#47;kg&#47;day for under two weeks and methotrexate at doses under 20&#8239;mg&#47;week &#40;&#60;0&#46;4&#8239;mg&#47;kg&#47;week&#41;&#46; Maintenance treatment with budesonide up to a dose of 6&#8239;mg&#47;day has no increased risk of infection compared with placebo&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4</span><p id="par0050" class="elsevierStylePara elsevierViewall">High degree of immunosuppression&#58; cyclosporine&#44; tacrolimus&#44; TNF inhibitors&#44; tofacitinib&#44; ustekinumab&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Azathioprine&#44; mercaptopurine&#44; systemic corticosteroids and methotrexate produce a high degree of immunosuppression at doses higher than those discussed in the previous section&#46;</p></li></ul></p><p id="par0055" class="elsevierStylePara elsevierViewall">This classification makes it possible to establish the potential risk of opportunistic infections and the possibility or not of administration of live attenuated vaccines&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Are vaccines safe during immunosuppression&#63;</span><p id="par0060" class="elsevierStylePara elsevierViewall">The risk of adverse effects from vaccines depends on the degree of immunosuppression and the type of vaccine&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#8211;17</span></a> With the exception of live attenuated vaccines&#44; vaccines have the same safety profile in the immunocompromised population as in the immunocompetent population&#44; so immunosuppressive treatment should not be altered because of vaccination&#46; There are five types of vaccines &#40;the main two are summarised in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; <ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">Inactivated vaccines&#46; They contain particles of viruses&#44; bacteria or toxins that have lost the ability to produce diseases as a result of chemical agents or physical processes&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0070" class="elsevierStylePara elsevierViewall">Live attenuated vaccines &#40;live attenuated viruses or bacteria&#41;&#46; Although these vaccines are based on attenuated microorganisms&#44; they are still alive and are contraindicated in people receiving treatments that involve high immunosuppression&#46; In this situation&#44; there are two premises&#58; <ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0075" class="elsevierStylePara elsevierViewall">If immunosuppressive treatment is essential to control the underlying disease&#44; it should not be delayed for vaccination&#46; In this situation&#44; treatment&#44; and not vaccination&#44; of the underlying disease is indicated&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0080" class="elsevierStylePara elsevierViewall">If immunosuppressive treatment is not essential to control the underlying disease&#44; vaccination can be carried out with a safety period prior to and after vaccination&#46;</p></li></ul></p></li></ul></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Patients treated with selective or low-dose immunosuppressive therapy should be assessed on an individual basis&#44; taking into account the risks and benefits&#44; and vaccination without the application of interruption intervals should be considered&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;18</span></a><ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0090" class="elsevierStylePara elsevierViewall">Antigenic subunit vaccines consist only of specific fragments of the virus or bacteria that are essential for the immune system to recognise&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">-</span><p id="par0095" class="elsevierStylePara elsevierViewall">Viral vector-based vaccines introduce small fragments of RNA or DNA containing instructions for the body to directly produce a pathogen-specific protein&#46; The innocuous virus serves as a platform for introducing the protein into the body&#46;</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">-</span><p id="par0100" class="elsevierStylePara elsevierViewall">DNA or RNA vaccines consist of plasmids or liposomes containing a fragment of RNA or DNA of the infectious agent with genetic information for making a specific protein&#46;</p></li></ul></p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Screening and protocol prior to vaccination in patients on immunosuppressive and&#47;or biologic treatment&#46; When and how to vaccinate&#63;</span><p id="par0105" class="elsevierStylePara elsevierViewall">It is recommended that the immunisation status of patients with IBD be assessed at the time of diagnosis and the appropriate vaccines be administered to avoid infections&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> A fact sheet on vaccines that can be administered to patients with IBD is provided in <a class="elsevierStyleCrossRef" href="#sec0130">Annex 1</a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The best time to vaccinate patients is at diagnosis or before the initiation of immunosuppressive therapy&#44; since the response to vaccines may decrease with immunosuppression&#46; In clinical practice this is not always possible and vaccination does not justify delaying the start of treatment&#46; The response rate without immunosuppressive treatment is similar to the response rate in the general population&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarises the recommended time intervals for withdrawal and the introduction of immunosuppression prior to and after vaccination&#44; respectively&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Going through the following <span class="elsevierStyleItalic">checklist</span> is recommended for all patients&#44; although it is mandatory before the start of any biologic or immunosuppressive treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a><ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">&#8226;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Screening for viral infections at IBD diagnosis&#58; hepatitis A virus&#44; hepatitis B virus &#40;HBV&#41;&#44; hepatitis <span class="elsevierStyleSmallCaps">C</span> virus &#40;HCV&#41;&#44; human immunodeficiency virus &#40;HIV&#41;&#44; Epstein-Barr virus&#44; cytomegalovirus&#44; herpes simplex virus&#44; varicella zoster virus &#40;VZV&#41;&#44; mumps&#44; rubella and measles &#40;<a class="elsevierStyleCrossRef" href="#sec0130">Annex 2</a>&#41;&#46;</p></li></ul></p><p id="par0125" class="elsevierStylePara elsevierViewall">At diagnosis&#44; it is important to be aware of the serological situation regarding different infections such as HBV&#44; HCV&#44; HIV&#44; mumps&#44; rubella&#44; measles&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Epstein-Barr virus&#44; VZV &#40;a history of varicella does not necessarily mean there is no need for serological determination&#41; and cytomegalovirus &#40;not essential&#44; it indicates whether or not infection has passed in view of the risk of cytomegalovirus reactivation in immunosuppressed patients&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The study and vaccination of hepatitis A virus is not always mandatory and will depend on the patient&#39;s individual risk factors &#40;profession&#44; underlying liver disease&#44; coagulation disorder&#44; administration of hepatotoxic drugs or indication for solid organ transplantation&#44; community where the patient lives and if they travel to endemic areas&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">HBV serology should be performed because of the risk of reactivation with immunosuppressive therapy&#46; More importantly&#44; when positive serology is present&#44; the possibility of occult HBV infection should be considered&#46; It is also important to determine HCV serology&#44; as patients with HCV infection on immunosuppressive therapy may present worsened liver disease&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Administration of immunosuppressants may also increase the risk of serious infections in patients with poorly controlled HIV infection&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a><ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">&#8226;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Human papillomavirus &#40;HPV&#41; screening&#46;</p></li></ul></p><p id="par0145" class="elsevierStylePara elsevierViewall">HPV cytology is recommended at the time of IBD diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Immunosuppressed patients should have an annual cytology&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a><ul class="elsevierStyleList" id="lis0035"><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">&#8226;</span><p id="par0150" class="elsevierStylePara elsevierViewall">SARS-CoV-2 screening&#46;</p></li></ul></p><p id="par0155" class="elsevierStylePara elsevierViewall">Current studies show that IBD patients &#40;including immunosuppressed patients&#41; are not at greater risk of infection or more serious infection than the general population&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#8211;29</span></a><ul class="elsevierStyleList" id="lis0040"><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">&#8226;</span><p id="par0160" class="elsevierStylePara elsevierViewall">Immune response to vaccines</p></li></ul></p><p id="par0165" class="elsevierStylePara elsevierViewall">The immune response to different vaccines may vary depending on the type of vaccine administered and the treatment the patient is receiving&#46; The recommended vaccine dosage is listed in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Live attenuated vaccines</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Herpes zoster virus</span><p id="par0170" class="elsevierStylePara elsevierViewall">The infection may occur in the form of VZV or herpes zoster&#46; There is an approximately 50&#37; higher risk of herpes zoster in IBD patients compared to the general population&#46; The risk is higher in patients receiving combined TNF inhibitors and thiopurines&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> Tofacitinib may be associated with a higher risk of herpes zoster infection than TNF inhibitors&#44; with the risk being greater with higher doses of tofacitinib&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> Vedolizumab and ustekinumab have not been associated with an increased risk of herpes infection&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Zostavax&#174; is a live attenuated virus vaccine&#44; administered subcutaneously&#44; with an efficacy of 50&#37;&#8211;60&#37;&#46; It is indicated in patients older than 50 years and contraindicated in immunosuppressed patients&#44; except those on low doses of immunosuppressants&#46; In this case&#44; it could be administered by assessing the risk on an individual basis&#46; Short- and long-term studies have found that vaccine efficacy tends to decline over time &#40;up to 21&#37; at 11 years post-administration&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Recently&#44; the Shingrix vaccine has become available in Spain&#174;&#46; This is an inactivated recombinant vaccine&#44; administered intramuscularly&#44; with an effectiveness of more than 95&#37;&#44; sustained over the first four years&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">33&#44;34</span></a> Two doses are administered two months apart&#44; if possible&#44; before starting immunosuppressive therapy&#46; It is currently only approved for patients&#8239;&#8805;&#8239;18 years of age who are starting JAK inhibitors or are on active therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">MMR vaccine</span><p id="par0185" class="elsevierStylePara elsevierViewall">Although most patients have already received the MMR vaccination &#40;and some children have received the VZV vaccination&#41;&#44; the absence of antibodies against these infections or against vaccination in a screening analysis renders its administration advisable before the start of immunosuppressive treatment&#44; ideally at the diagnosis of IBD&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">In Spain&#44; since 1995&#44; two doses separated by at least four weeks have been recommended&#46; Available data from 2018 indicate that 97&#37; of Spanish children are vaccinated with the first dose&#44; which guarantees good immunity&#44; although only 94&#37; of Spanish children are vaccinated with the second dose&#46; In September 2018&#44; in view of the increase in the number of measles cases&#44; mainly outside Spain&#44; the Ministerio de Sanidad&#44; Consumo y Bienestar &#91;Ministry of Health&#44; Consumption and Welfare&#93; recommended MMR vaccination &#40;against mumps&#44; measles and rubella&#44; since there is no exclusive vaccine for measles&#41; for all those born in 1970 or later who had not received both doses of the vaccine or had not had the disease&#46; It is accepted that those born before 1970 had measles or were in contact with the wild virus and are therefore excluded from these general recommendations&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Inactivated vaccines</span><p id="par0195" class="elsevierStylePara elsevierViewall">Routine vaccination against influenza&#44; pneumococcus&#44; and HBV &#40;regardless of age and immunosuppression status&#41; is recommended for IBD patients&#46;</p><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Flu &#40;influenza&#41; and pneumococcus &#40;Streptococcus pneumoniae&#41;</span><p id="par0200" class="elsevierStylePara elsevierViewall">A retrospective cohort study compared the risk of influenza infection among 140&#44;480 patients with IBD and controls without IBD&#46; The IBD patients had a higher risk of infection and hospitalisation than the controls&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">36&#44;37</span></a> Seroconversion after vaccination against influenza and pneumococcus has been seen to be lower in patients on immunosuppressive treatment&#44; especially in those with combined treatment &#40;TNF inhibitors and immunosuppressive drugs&#41;&#46; For this reason&#44; the withdrawal of methotrexate for two weeks after vaccination and the administration of high doses of influenza vaccine in patients receiving TNF inhibitors are recommended to optimise vaccination outcomes&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">38&#44;39</span></a></p><p id="par0205" class="elsevierStylePara elsevierViewall">Among the risk groups likely to receive influenza and pneumococcal vaccinations&#44; subjects on immunosuppressant therapy and patients with IBD &#40;regardless of whether or not they are immunosuppressed&#41; have been considered&#46; With regard to the new biologic treatments&#44; a recent study reports adequate immunogenicity following influenza vaccination in CD patients treated with ustekinumab&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> In addition&#44; ustekinumab does not appear to influence the response to the HBV or pneumococcal vaccine &#40;although published studies do not include IBD patients&#41;&#46; Similarly&#44; treatment with vedolizumab does not appear to decrease the effectiveness of the influenza and pneumococcal vaccines&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> In patients treated with tofacitinib&#44; it has been observed that the effectiveness of the pneumococcal vaccine PPSV23 may be diminished&#44; but not the influenza vaccine&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Sequential vaccination with both vaccines&#44; conjugate &#40;PCV13 or Prevenar&#174; or 13-valent conjugate&#41; and polysaccharide &#40;PPSV23 or 23-valent polysaccharide&#41;&#44; is recommended&#44; respecting the minimum intervals between doses and type of vaccine&#46; The vaccination schedule depends on the person&#39;s age and on whether they have been vaccinated before&#46; After age six years&#44; the sequential regimen &#40;PCV13&#8239;&#43;&#8239;PPSV23&#41; is administered with a recommended interval of at least eight weeks&#46; In all situations&#44; a dose of PPSV23 is administered and should be repeated every five years&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Human papilloma virus</span><p id="par0215" class="elsevierStylePara elsevierViewall">The HPV vaccine is recommended for women under 26 years&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In addition&#44; national guidelines are considering including boys of school age&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">The HPV vaccine is inactivated and highly effective in preventing HPV infection&#44; precursor lesions of cervical&#44; vaginal&#44; and vulvar cancer&#44; and genital warts caused by serotypes 6&#44; 11&#44; 16 or 18 in women who have not been infected with these serotypes&#46; It is administered in three doses &#40;at zero&#44; two and six months&#41;&#46; In 2017 Gardasil9&#174;&#44; a novel vaccine that includes nine serotypes&#58; 6&#44; 11&#44; 16&#44; 18&#44; 31&#44; 33&#44; 45&#44; 52 and 58&#44; was marketed&#46; It is funded by the Spanish National Health System &#40;according to the systematic schedule&#41; for school-age girls&#44; for HIV-infected men and women &#60;26 years&#44; and for women diagnosed with advanced-grade cervical intraepithelial neoplasia &#40;CIN II or III&#41; or endocervical adenocarcinoma <span class="elsevierStyleItalic">in situ</span>&#46; For other patients this should be consulted&#44; since&#44; although recommended&#44; the vaccine is not funded in most autonomous communities in immunosuppressed patients&#46; There are exceptions&#44; such as in the Autonomous Community of the Canary Islands&#44; where funding for 18&#8722;65-year-old women with a history of IBD is approved&#46; For the screening and diagnosis of HPV infection&#44; an annual cytology is recommended in women with IBD&#44; especially if they are on immunosuppressive therapy&#46; A history of old infection or an active HPV infection does not contraindicate immunosuppressive treatment&#44; since most infections are transient and disappear within two years&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;42&#44;43</span></a></p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Hepatitis B virus</span><p id="par0225" class="elsevierStylePara elsevierViewall">Patients with IBD are not at increased risk of HBV infection&#46; Conversely&#44; HBV reactivation has been observed in 7&#46;5&#37; of patients with a history of HBV infection treated with infliximab&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> All reactivations in IBD patients have occurred in those who were on immunosuppressive or biologic treatment&#44; with the use of two or more immunosuppressants entailing a higher risk&#46; HBV vaccine efficacy is 95&#37; in the general population&#46; However&#44; immunosuppressed IBD patients may have a low response rate &#40;about 50&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p><p id="par0230" class="elsevierStylePara elsevierViewall">Vaccination is recommended due to the potentially fatal consequences of infection&#46; In patients on immunosuppressive treatment&#44; the rapid&#44; double-dose regimen results in increased immunisation and seroconversion&#46; When there are anti-HBs antibody &#40;Ab&#41; levels&#8239;&#62;&#8239;100&#8239;IU&#44; higher response percentages are also obtained&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">45&#44;46</span></a> However&#44; although the recommendation is to achieve anti-HBs levels&#8239;&#62;&#8239;100&#8239;IU in IBD patients&#44; in some autonomous communities it is not funded if anti-HBs levels are higher than 10&#8239;IU&#46; In patients who are already vaccinated&#44; anti-HBs Ab levels should be determined every one to two years to assess whether they have &#60;100&#8239;IU&#47;l&#46; In such a case&#44; a <span class="elsevierStyleItalic">booster</span> dose could be considered and new anti-HBs Ab level determinations at two to three months to check efficacy&#46; If the titres are low&#44; a new vaccination regimen will be necessary&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Attention should be paid to the recommended guidelines for each vaccine available &#40;antigen quantity or number of doses&#41;&#46; For example&#44; vaccine overdose errors have been reported with the Engerix&#174; 20&#8239;&#181;g vaccine due to it being presumed equal to Fendrix&#174; 20&#8239;&#181;g&#46; The Fendrix&#174; vaccine contains 20&#8239;&#181;g but it is adjuvanted&#44; so it is considered an immunity-enhanced vaccine and the antigenic response is much greater&#46; A study was recently published that randomised 173 IBD patients to receive a double dose of Engerix&#174;-B &#40;53&#37;&#41; or a single dose of Fendrix&#174; at months zero&#44; one&#44; two and six &#40;46&#37;&#41;&#46; Forty-five percent of patients responded &#40;anti-HBs&#8239;&#8805;&#8239;100&#8239;IU&#47;l&#41; after three doses and 71&#37; after the fourth dose&#46; The response rate after the fourth dose&#44; was 75&#37; with Fendrix&#174; compared to 68&#37; with Engerix&#174;-B&#46; Advanced age and treatment with steroids&#44; immunosuppressants or TNF inhibitors were associated with a lower likelihood of response&#46; However&#44; Fendrix&#174; was not superior to Engerix&#174;&#44; so either one may be recommended&#46; This study highlights the importance of the fourth dose &#40;more effective than the three-dose regimen&#41; and the importance of taking into account the &#62;100&#8239;IU&#47;l anti-HBs Ab threshold&#44; because the rate of antibody loss during the first year is very rapid &#40;20&#37;&#47;patient-year&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> In contrast&#44; a recent study in patients treated with vedolizumab obtained a response similar to that observed in the vaccination of non-immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a></p><p id="par0240" class="elsevierStylePara elsevierViewall">The following scenarios are considered&#58;<ul class="elsevierStyleList" id="lis0045"><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">-</span><p id="par0245" class="elsevierStylePara elsevierViewall">Immunocompetent patient&#58; standard dose and normal regimen&#58; HBVaxPro&#174; 10&#8239;&#181;g or Engerix&#174; 20&#8239;&#181;g 0-1-6 months&#46;</p></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">-</span><p id="par0250" class="elsevierStylePara elsevierViewall">Patient with immunosuppression or not responding to a first vaccination regimen&#58; double dose intensified with fourth dose&#58; HBVaxPro&#174; 40&#8239;&#181; or Fendrix&#174; 20&#8239;&#181;g 0-1-2-6&#47;12&#8239;months&#46; Subsequent annual or six-monthly anti-HBs Abs monitoring&#46; In the case of low Abs &#40;in previously responsive patients&#41;&#44; administer a <span class="elsevierStyleItalic">booster</span> dose &#40;Fendrix&#174; 20&#8239;&#181;g or HBVaxPro&#174; 40&#8239;&#181;g&#41; and serological control 1&#8722;3 months&#46; If there is no response&#44; start a re-vaccination regimen &#40;maximum two rounds of re-vaccination&#41;&#46;</p></li></ul></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Recommendations for vaccination against SARS-CoV-2 infection</span><p id="par0255" class="elsevierStylePara elsevierViewall">The approval and availability of Pfizer-BioNTech and Moderna vaccines&#44; messenger RNA &#40;mRNA&#41; vaccines&#44; and AstraZeneca and Janssen &#40;modified adenovirus&#41; vaccines&#44; with information provided by the Agencia Espa&#241;ola de Medicamentos y Productos Sanitarios &#91;Spanish Agency for Medicines and Medical Devices&#93; confirms that the vaccines are safe and effective&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#44;49</span></a></p><p id="par0260" class="elsevierStylePara elsevierViewall">Recent articles recommend vaccination against SARS-CoV-2 in IBD patients with any available vaccine&#44; regardless of the underlying immunosuppressive treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">50&#44;51</span></a> Vaccination against SARS-CoV-2 should not be delayed if the patient is on immunosuppressive treatment&#44; although it may decrease the immune response to the vaccine&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> In the vaccine trials&#44; no patient had a worsening of a pre-existing autoimmune disease&#46; As in the general population&#44; vaccinated IBD patients may present the infection&#44; although it is less likely and with a milder course&#46; Patients who have had the infection should also be vaccinated&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Serological responses following SARS-CoV-2 vaccination may be weaker in immunosuppressed individuals&#46; Recently&#44; a study of 6935 IBD patients with symptomatic SARS-CoV-2 infection was published showing that patients treated with infliximab have a lower seroprevalence&#44; seroconversion&#44; and anti-SARS-CoV-2 antibody reactivity magnitude compared to patients treated with vedolizumab&#46; In addition&#44; only one third of patients receiving concomitant immunosuppressive treatment &#40;thiopurines or methotrexate&#41; with infliximab had post-infection anti-SARS-CoV-2 antibodies&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> Another recent systematic review of 46 studies evaluating seroconversion rates after full vaccination against SARS-CoV-2 in patients with IBD found that with the mRNA vaccines seroconversion rates are similar in patients with IBD and controls &#40;healthy population&#41;&#46; Although seroconversion rates are lower in patients treated with corticosteroids and the combination of TNF inhibitors and immunosuppressants&#44; seroconversion &#62;90&#37; is observed after full vaccination&#46; Treatment with TNF inhibitors&#44; vedolizumab&#44; ustekinumab&#44; and JAK inhibitors were all associated with good seroconversion rates with the complete vaccination regimen&#46; The lifespan of antibody response after full vaccination against SARS-CoV-2 is a matter of ongoing evaluation&#46; Many studies point to a decrease in antibody titres from the fourth week post-vaccination&#44; it being greater in patients who are on treatment with TNF inhibitors alone or in combination with immunosuppressants&#46; This systematic review shows that there is a decrease in antibody responses after vaccination against SARS-CoV-2 in patients with IBD&#44; more rapid in patients treated with TNF inhibitors&#44; immunosuppressants or a combination thereof&#44; meaning that additional doses could be considered in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a></p><p id="par0270" class="elsevierStylePara elsevierViewall">Interactions with other inactivated vaccines have not been demonstrated&#46; It is therefore recommended that patients with IBD follow the same vaccination regimen established by the competent bodies as the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Are there vaccines specifically recommended for IBD patients&#63; For cohabitants as well&#63;</span><p id="par0275" class="elsevierStylePara elsevierViewall">Routine mandatory vaccinations are part of the Spanish Public Health programme&#44; whether or not a person has an IBD&#46; Specific mandatory vaccines are those that are not given to the general population on a regular basis&#44; but are mandatory in patients with IBD&#46; Optional vaccines are indicated according to the individual patient&#39;s risk &#40;comorbidities&#44; risky contacts&#44; etc&#46;&#41;&#46; Recommendations for routine and IBD-specific mandatory vaccines are defined in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Cohabitants of patients with diseases who are at risk of infection should have received all the vaccines recommended for their age&#44; including live attenuated vaccines&#46; Vaccination will prevent the disease in contacts and prevent potential transmission to the immunocompromised patient&#46; No vaccine marketed in Spain is contraindicated in cohabitants of at-risk patients&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a> Annual influenza vaccination is recommended for cohabitants&#46; The MMR vaccine should be administered according to the usual recommendations and without requiring any special precautions&#44; since the transmission of any of the viruses contained in the vaccine has not been described&#46; Although precautions should be taken&#44; the administration of VZV&#44; MMR&#44; Zostavax&#174; and rotavirus vaccinations to cohabitants of immunosuppressed people has been shown to be safe and effective&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a></p><p id="par0285" class="elsevierStylePara elsevierViewall">The patient should be informed of the risk of live attenuated vaccines &#40;oral typhoid&#44; VZV&#44; yellow fever&#44; rotavirus&#44; BCG&#41;&#46;</p></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Vaccines abroad</span><p id="par0290" class="elsevierStylePara elsevierViewall">Before going on a trip&#44; an individualised vaccination schedule assessment is recommended&#44; taking into account personal characteristics and the destination&#44; at least four to eight weeks before departure&#44; as there are vaccines that cannot be administered together&#44; or multiple doses or a latency time are required until they are effective&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a> Travellers with IBD should go to their referral centre and consult their IBD specialist and travel prevention specialist&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Travellers with IBD are advised to be aware of the guidelines to follow in the event of an outbreak and to request a medical report specifying their disease&#44; treatment &#40;generic name of drug&#41; and dose&#46; They can submit queries or enquiries to the IBDPassport<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> website&#44; which has a Spanish version&#44; or the World Health Organization and the U&#46;S&#46; Centers for Disease Control and Prevention prevention guidelines&#44;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> which provide country-specific risk information&#46; If patients are not immunosuppressed&#44; the recommendations are the same as those for the general population&#46; If they are immunosuppressed&#44; live attenuated viral vaccines should be avoided&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Three types of vaccinations can be administered &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#58;<ul class="elsevierStyleList" id="lis0050"><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">-</span><p id="par0300" class="elsevierStylePara elsevierViewall">Mandatory vaccinations&#58; vaccinations that are not part of the Spanish vaccination schedule but may be required by the health authorities of the destination country&#46; This type of vaccination may vary depending on the country visited&#44; the type of trip and the age of the traveller&#46; Yellow fever&#44; meningococcal disease and poliomyelitis vaccinations are included&#46;</p></li><li class="elsevierStyleListItem" id="lsti0095"><span class="elsevierStyleLabel">-</span><p id="par0305" class="elsevierStylePara elsevierViewall">Recommended vaccinations&#58; vaccinations that are not mandatory or part of the Spanish public health programme&#44; but are recommended in case of an individual or environmental risk of contracting the disease&#46; These include typhoid&#44; hepatitis&#44; cholera&#44; rabies&#44; Japanese encephalitis&#44; central European borne encephalitis&#44; influenza and rabies&#44; but also poliomyelitis and meningococcal meningitis &#40;already discussed&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0100"><span class="elsevierStyleLabel">-</span><p id="par0310" class="elsevierStylePara elsevierViewall">Routine or universal vaccination&#58; vaccinations recommended for the entire population to protect susceptible people from the disease but also the general population&#46; This type of vaccination includes tetanus&#44; diphtheria&#44; hepatitis B&#44; measles&#44; mumps&#44; rubella and VZV&#46;</p></li></ul></p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0315" class="elsevierStylePara elsevierViewall">The simultaneous administration of vaccines is safe and effective&#44; with certain exceptions<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a>&#58;<ul class="elsevierStyleList" id="lis0055"><li class="elsevierStyleListItem" id="lsti0105"><span class="elsevierStyleLabel">&#8226;</span><p id="par0320" class="elsevierStylePara elsevierViewall">Different vaccine formulations against the same disease should not be administered simultaneously&#44; such as meningococcal or pneumococcal conjugate vaccines&#46;</p></li><li class="elsevierStyleListItem" id="lsti0110"><span class="elsevierStyleLabel">&#8226;</span><p id="par0325" class="elsevierStylePara elsevierViewall">If the oral cholera vaccine is administered and others are to be administered&#44; an least an interval of one hour should be allowed to elapse between them&#46;</p></li><li class="elsevierStyleListItem" id="lsti0115"><span class="elsevierStyleLabel">&#8226;</span><p id="par0330" class="elsevierStylePara elsevierViewall">The oral poliomyelitis vaccine may reduce the response to the rotavirus vaccine&#44; so it is advisable to administer them separately&#46;</p></li><li class="elsevierStyleListItem" id="lsti0120"><span class="elsevierStyleLabel">&#8226;</span><p id="par0335" class="elsevierStylePara elsevierViewall">The simultaneous administration of the MMR and yellow fever vaccines conditions a reduction in humoral response to yellow fever&#44; rubella and mumps and it is therefore advisable to separate them by a minimum of four weeks&#46;</p></li></ul></p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Vaccinations in IBD patients during pregnancy and breast-feeding&#46; Which vaccinations&#44; and when can they be given to children of mothers who have received biologic treatment during pregnancy&#63;</span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Pregnancy and breast-feeding in IBD patients</span><p id="par0340" class="elsevierStylePara elsevierViewall">The indications for vaccination in pregnancy are summarised in <a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0345" class="elsevierStylePara elsevierViewall">Vaccination during breast-feeding has two main objectives&#58; to protect the mother from vaccine-preventable diseases and to protect the infant by protecting the mother &#40;cocooning&#41; and transferring antibodies through breast milk &#40;&#62;90&#37; IgA secretory&#41;&#46; Breastfeeding does not adversely affect vaccination the success or safety&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">61&#44;62</span></a></p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Vaccination of the newborn of a mother with IBD</span><p id="par0350" class="elsevierStylePara elsevierViewall">The vaccination of a newborn of a mother with IBD should follow the same recommendations as for other newborns and should be performed according to the schedule established in the common vaccination schedule &#40;see the peculiarities of each autonomous community&#41;&#46; However&#44; if the mother is exposed to biologic therapy&#44; it is recommended that live attenuated vaccines be avoided for the first 12 months of life &#40;or newborn drug levels for mothers treated with TNF inhibitors be obtained&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">63&#44;64</span></a> Biologics are actively transported through the placenta&#44; especially in the second half of pregnancy&#46; Drug levels are detected in the newborn and&#44; in the case of TNF inhibitors&#44; can remain detectable for up to six to 12 months&#46; The detection of these immunosuppressive drugs in the plasma of the newborn with a possible involvement of the immune system prompts the recommendation not to administer live attenuated vaccines during the first year of life&#46;</p><p id="par0355" class="elsevierStylePara elsevierViewall">Live attenuated vaccines should be avoided during the first 6&#8211;12 months of life in children who have been exposed to biologic treatment in the uterus during the third trimester&#44; including&#58; MMR&#44; VZV&#44; BCG&#44; intranasal influenza&#44; oral polio &#40;not used in Spain&#44; replaced by intramuscular inactivated&#41;&#44; yellow fever and typhoid fever&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a></p><p id="par0360" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">The Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes</span> &#40;PIANO&#41; is a US data registry of children of mothers with IBD from 2007 to 2016 that compares the response to vaccination of children exposed during pregnancy to treatment with&#58; 5-aminosalicylates&#44; steroids&#44; azathioprine&#44; mercaptopurine&#44; infliximab&#44; adalimumab&#44; golimumab&#44; certolizumab&#44; natalizumab&#44; vedolizumab&#44; or ustekinumab&#44; and it concludes that there are no differences in immune response to the vaccinations received and that neither is there a greater number of adverse reactions&#46; However&#44; overall response was slightly lower than the figure reported in the general population&#46; Data from this registry showed that rotavirus vaccine administration is safe&#44; albeit with a sample of only 43 newborns from mothers on biologic treatment &#40;19 infliximab&#44; 12 certolizumab&#44; 7 adalimumab&#44; 1 infliximab and certolizumab&#44; 1 ustekinumab&#41;&#44; with the appearance of mild adverse effects&#58; 26&#37; fever and 5&#37; diarrhoea &#40;vs&#46; 42&#37; and 19&#37;&#44; respectively&#44; in the general population&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a></p><p id="par0365" class="elsevierStylePara elsevierViewall">Orally-administered rotavirus vaccine is the only live attenuated vaccine administered before six months of age&#46; The rotavirus vaccine Summaries of Product Characteristics warn of the need to assess the potential benefits and risks of vaccine administration in children who have been exposed to immunosuppressive and&#47;or biologic treatment in the uterus&#46; A French retrospective abstract study evaluated the administration of live attenuated vaccines&#8239;&#60;&#8239;12 months &#40;BCG&#44; rotavirus&#44; and MMR&#41; in 143 mothers with IBD who received TNF inhibitors treatment during pregnancy&#44; without observing any complications&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a></p></span></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Vaccines in paediatric IBD</span><p id="par0370" class="elsevierStylePara elsevierViewall">Increased diagnosis of paediatric IBD<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">68&#44;69</span></a> is accompanied by an increased use of drugs with immunomodulatory capacity in these patients&#46; Specific guidelines for the treatment of paediatric CD and ulcerative colitis recommend the early use of immunosuppressive drugs and biologic treatments&#46;<a class="elsevierStyleCrossRefs" href="#bib0350"><span class="elsevierStyleSup">70&#8211;72</span></a></p><p id="par0375" class="elsevierStylePara elsevierViewall">The Vaccines Committee of the Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a &#91;Spanish Association of Paediatrics&#93; defines and periodically reviews the vaccination schedule&#44; regarded as being of universal compliance for children to stay healthy in the initial years of life&#46; This vaccination schedule undergoes modifications in the different autonomous communities&#46; Immunisation with live attenuated virus vaccines should be completed by the age of four years&#46; Diagnosing the classical forms of IBD at this stage of life is quite rare&#46; Therefore&#44; most patients diagnosed with IBD in paediatric age should have already received all the live attenuated virus vaccines listed in the vaccine schedule&#46; For cases in which vaccination has not been carried out at the established ages&#44; the Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a also establishes recommendations through the so-called rescue or accelerated guidelines&#46; Two models have been established for these recommendations&#58; one for children up to 6 years of age and one for children and adolescents between 7 and 18 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a></p><p id="par0380" class="elsevierStylePara elsevierViewall">In this regard&#44; and as reflected in a document from the IBD Working Group of the <span class="elsevierStyleItalic">European Society for Paediatric Gastroenterology Hepatology and Nutrition</span> &#8210;ESPGHAN&#8210;&#44; published in 2012&#44; children with IBD should have live attenuated virus vaccinations at least three to four weeks before starting treatment with immunosuppressants or TNF inhibitors&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">74</span></a> The nutritional treatment phase at the onset of paediatric CD or initial salicylate treatment in mild-to-moderate ulcerative colitis are the most appropriate periods for initiating these rescue strategies in incorrectly vaccinated patients or those with inadequate immunisation&#46; If&#44; due to the specific needs of these patients&#44; such a plan cannot be carried out&#44; the administration of these vaccines should be postponed at least until three months after cessation&#44; which will not always be feasible&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">75</span></a></p><p id="par0385" class="elsevierStylePara elsevierViewall">As in the adult population&#44; it is recommended that the vaccination history of patients be assessed at the time of diagnosis and the most appropriate strategy for correct immunisation be established&#46; However&#44; the data currently available indicate that follow-up to these recommendations in the paediatric community is frankly suboptimal&#46; A retrospective survey published in 2020 by the ESPGHAN analysed immunisation rates in paediatric patients with IBD&#44; showing vaccination rates of 89&#37; for MMR&#44; 82&#37; for <span class="elsevierStyleItalic">Haemophilus influenzae</span> Type B&#44; 23&#37; for meningococcal C&#44; 18&#37; for VZV&#44; 19&#37; for pneumococcus&#44; 5&#46;9&#37; for HPV and 1&#46;9&#37; for rotavirus&#46; The rate of patients with full immunisation was only 8&#46;8&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">76</span></a> With regard to vaccine safety&#44; the rate of adverse effects in IBD patients did not differ from that of healthy controls&#44; regardless of the base treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">77</span></a></p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">How can adherence to vaccination programmes by patients and healthcare workers be improved&#63;</span><p id="par0390" class="elsevierStylePara elsevierViewall">Adherence is defined by the World Health Organization &#8220;the degree to which the person&#39;s behaviour corresponds with the agreed recommendations from a health care provider&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">78</span></a> Lack of adherence to vaccination is common in patients with IBD&#44; mainly due to fear of side effects and as it is not seen as necessary despite medical recommendations&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a> It is important to individualise the intervention so that the IBD patient feels heard&#44; welcomed and understood with a view to building a trust-based relationship&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">80</span></a> Health education about vaccines&#44; demystifying and explaining their side effects&#44; and informing about the importance of having the vaccine schedule up to date&#44; especially in immunosuppressed patients&#44; is an important task of the IBD unit team&#46; Harmonising criteria in vaccination guidelines is important in providing the same coverage to patients&#46; This also reduces administration errors in different vaccination regimens&#46;</p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">GETECCU recommendations on the importance of screening and vaccination in IBD patients</span><p id="par0395" class="elsevierStylePara elsevierViewall">Based on the review in this document&#44; the following GETECCU recommendations on the importance&#44; screening and vaccination of IBD patients &#40;adult and paediatric populations&#41; are summarised below&#58; <ul class="elsevierStyleList" id="lis0060"><li class="elsevierStyleListItem" id="lsti0125"><span class="elsevierStyleLabel">1</span><p id="par0400" class="elsevierStylePara elsevierViewall">Patients with IBD are at higher risk of infection than the general population&#46;</p></li><li class="elsevierStyleListItem" id="lsti0130"><span class="elsevierStyleLabel">2</span><p id="par0405" class="elsevierStylePara elsevierViewall">A vaccination programme is part of the initial standardised <span class="elsevierStyleItalic">checklist</span> to be performed with IBD patients&#46; Possible risk factors for infection&#44; demographic and epidemiological variables&#44; disease history and comorbidities should be considered before initiating immunosuppressive therapy&#46;</p></li><li class="elsevierStyleListItem" id="lsti0135"><span class="elsevierStyleLabel">3</span><p id="par0410" class="elsevierStylePara elsevierViewall">The best time to vaccinate patients&#44; both adult and paediatric&#44; is <span class="elsevierStyleItalic">before the start of immunosuppressive therapy&#44; if possible when IBD is diagnosed</span>&#46; Otherwise&#44; the risk-benefit ratio of vaccination during treatment should be assessed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0140"><span class="elsevierStyleLabel">4</span><p id="par0415" class="elsevierStylePara elsevierViewall">At the time of diagnosis of IBD&#44; hepatitis B&#44; influenza&#44; pneumococcus&#44; VZV&#44; HPV&#44; diphtheria-tetanus-pertussis&#44; poliomyelitis and MMR vaccinations are recommended&#46;</p></li><li class="elsevierStyleListItem" id="lsti0145"><span class="elsevierStyleLabel">5</span><p id="par0420" class="elsevierStylePara elsevierViewall">Live attenuated vaccines in both the paediatric and adult populations should be administered at least four weeks before starting treatment with immunosuppressants&#44; JAK &#40;tofacitinib&#41; inhibitors or biologics&#46; If this is not possible&#44; it is recommended that the administration of these vaccines be postponed at least until three months after cessation of immunosuppressive therapy and one month after termination of steroids&#46;</p></li><li class="elsevierStyleListItem" id="lsti0150"><span class="elsevierStyleLabel">6</span><p id="par0425" class="elsevierStylePara elsevierViewall">In patients on low-dose immunosuppression or selective immunosuppressants&#44; live attenuated vaccines can be considered on an individual basis by assessing the risk-benefit ratio&#46;</p></li><li class="elsevierStyleListItem" id="lsti0155"><span class="elsevierStyleLabel">7</span><p id="par0430" class="elsevierStylePara elsevierViewall">The live attenuated vaccines that are contraindicated in immunosuppressed patients are&#58; yellow fever&#44; VZV&#44; BCG&#44; MMR&#44; rotavirus&#44; oral polio&#44; nasal influenza and oral typhoid fever&#46;</p></li><li class="elsevierStyleListItem" id="lsti0160"><span class="elsevierStyleLabel">8</span><p id="par0435" class="elsevierStylePara elsevierViewall">Influenza vaccination is recommended annually and pneumococcal vaccination is recommended sequentially with a PPSV23 booster at five years&#46;</p></li><li class="elsevierStyleListItem" id="lsti0165"><span class="elsevierStyleLabel">9</span><p id="par0440" class="elsevierStylePara elsevierViewall">The baseline serological study and vaccination against the hepatitis A virus is not always mandatory and depends on the risk factors and the community in which the patient resides&#46;</p></li><li class="elsevierStyleListItem" id="lsti0170"><span class="elsevierStyleLabel">10</span><p id="par0445" class="elsevierStylePara elsevierViewall">All HBV seronegative patients should be vaccinated&#46; In immunocompetent patients&#44; the standard hepatitis B vaccination regimen may be used&#46; In immunosuppressed patients with titres &#60;100&#8239;IU&#47;mL&#44; a double&#44; rapid-dose regimen should be recommended&#46; Four-dose regimens are more effective than 3-dose regimens&#46;</p></li><li class="elsevierStyleListItem" id="lsti0175"><span class="elsevierStyleLabel">11</span><p id="par0450" class="elsevierStylePara elsevierViewall">In patients vaccinated against hepatitis B&#44; anti-HBs Ab levels should be determined every one to two years&#46; If the anti-HBs Ab levels are &#60;100&#8239;IU&#47;l a <span class="elsevierStyleItalic">booster</span> dose should be considered and new level determinations performed at two to three months to check efficacy&#46; If the titres are low&#44; a new vaccination regimen will be necessary&#46;</p></li><li class="elsevierStyleListItem" id="lsti0180"><span class="elsevierStyleLabel">12</span><p id="par0455" class="elsevierStylePara elsevierViewall">HPV vaccination does not exclude cytology and gynaecological screening for cervical cancer&#46; Vaccination is always recommended in patients who have had a history of HPV infection&#44; CIN II-III&#44; or cervical cancer&#46; Having been infected with one HPV type does not protect against infection with another serotype&#44; and vaccination would continue to be recommended&#46; Administration in men is recommended&#44; although it is not funded in Spain&#46;</p></li><li class="elsevierStyleListItem" id="lsti0185"><span class="elsevierStyleLabel">13</span><p id="par0460" class="elsevierStylePara elsevierViewall">The vaccine &#40;Zostavax&#174;&#41; against herpes zoster is recombinant with live attenuated viruses and should be recommended in patients &#62;50 years&#46; It is contraindicated in immunosuppressed patients&#44; except those on low-dose immunosuppressants&#46; The inactivated virus vaccine &#40;Shingrix&#174;&#41; is now authorised in Spain for patients&#8239;&#8805;&#8239;18 years who are going to start or are already on treatment with JAK inhibitors&#46;</p></li><li class="elsevierStyleListItem" id="lsti0190"><span class="elsevierStyleLabel">14</span><p id="par0465" class="elsevierStylePara elsevierViewall">There is no evidence of an increased risk of SARS-CoV-2 vaccine in IBD patients&#44; so it is recommended that all IBD patients be vaccinated against SARS-CoV-2 regardless of their baseline treatment&#46; Full vaccination against SARS-CoV-2 is associated with seroconversion in most IBD patients&#46; The decrease in antibody titres over time requires the consideration of additional doses&#44; particularly in patients on certain therapies &#40;TNF inhibitors&#44; immunosuppressants or a combination thereof&#41;&#46; As understanding of the management of this pandemic is increasing rapidly&#44; recommendations could change&#46;</p></li><li class="elsevierStyleListItem" id="lsti0195"><span class="elsevierStyleLabel">15</span><p id="par0470" class="elsevierStylePara elsevierViewall">The patient should be informed if they are to travel to areas of endemic diseases&#44; especially those on immunosuppressive treatment&#46; IBD patients going on a trip should consult one to two months before the trip&#46;</p></li><li class="elsevierStyleListItem" id="lsti0200"><span class="elsevierStyleLabel">16</span><p id="par0475" class="elsevierStylePara elsevierViewall">As a rule&#44; live attenuated virus vaccines in the children of mothers who have received biologic treatment during pregnancy should be avoided within the first 6&#8211;12 months or be assessed&#44; according to drug levels in the blood&#44; prior to vaccination&#46;</p></li><li class="elsevierStyleListItem" id="lsti0205"><span class="elsevierStyleLabel">17</span><p id="par0480" class="elsevierStylePara elsevierViewall">Low immunisation rates in IBD could be explained by scant awareness in the medical profession&#44; lack of protocolisation of vaccination circuits and concern about possible adverse effects and vaccine safety in immunocompromised patients&#46;</p></li></ul></p></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflicts of interest</span><p id="par0485" class="elsevierStylePara elsevierViewall">Roc&#237;o Ferreiro-Iglesias has been a speaker for or received research funding from Takeda&#44; MSD&#44; AbbVie&#44; Janssen&#44; Pfizer&#44; Palex&#44; Shire Pharmaceuticals&#44; Tillotts Pharma and Casen Recordati&#46;</p><p id="par0490" class="elsevierStylePara elsevierViewall">Marta Piqueras has been a speaker for or received research funding from Takeda&#44; AbbVie and Janssen&#46;</p><p id="par0495" class="elsevierStylePara elsevierViewall">Elena Ricart has been a speaker for or has received research funding from MSD&#44; AbbVie&#44; Janssen&#44; Takeda&#44; Ferring&#44; Pfizer&#44; Amgen and Fresenius Kabi&#46;</p><p id="par0500" class="elsevierStylePara elsevierViewall">Laura Sampere has been a speaker for or received research funding from Pfizer and Janssen&#46;</p><p id="par0505" class="elsevierStylePara elsevierViewall">Mariona Roca has been a speaker for or received research funding from Pfizer&#44; MSD&#44; GSK&#44; Fresenius Kabi&#44; Braun&#44; Nutricia&#44; Abbott and Nestl&#233;&#46;</p><p id="par0510" class="elsevierStylePara elsevierViewall">Javier Mart&#237;n de Carpi has been a speaker for or received research funding from MSD&#44; AbbVie&#44; Janssen&#44; Fresenius Kabi&#44; Adacyte&#44; Nestl&#233;&#44; Abbott&#44; Lactalis&#44; Ferrer&#44; Kern and Celltrion&#46;</p><p id="par0515" class="elsevierStylePara elsevierViewall">Olga Ben&#237;tez has been a speaker for or received research funding from Janssen&#44; Biogen and MSD&#46;</p><p id="par0520" class="elsevierStylePara elsevierViewall">Yamile Zabana has been a speaker for or has received research funding from AbbVie&#44; MSD&#44; Ferring&#44; Amgen&#44; Janssen&#44; Pfizer&#44; Dr&#46; Falk&#44; Tillotts&#44; Galapagos and Takeda&#46;</p><p id="par0525" class="elsevierStylePara elsevierViewall">Miriam Ma&#241;osa has been a speaker for or has received research funding from AbbVie&#44; MSD&#44; Takeda&#44; Ferring&#44; Janssen&#44; Pfizer&#44; Tillotts&#44; Faes Farma&#44; Gilead&#44; Fresenius&#44; Dr&#46; Falk&#44; Kern and Adacyte&#46;</p><p id="par0530" class="elsevierStylePara elsevierViewall">Francisco Rodr&#237;guez-Moranta has been a speaker for or has received research funding from AbbVie&#44; MSD&#44; Takeda&#44; Ferring&#44; Janssen&#44; Pfizer and Dr&#46; Falk&#46;</p><p id="par0535" class="elsevierStylePara elsevierViewall">Manuel Barreiro-de Acosta has been a speaker for or has received research funding from Pfizer&#44; MSD&#44; Takeda&#44; AbbVie&#44; Kern&#44; Janssen&#44; Fresenius Kabi&#44; Biogen&#44; Sandoz&#44; Ferring&#44; Faes Farma&#44; Shire Pharmaceuticals&#44; Dr&#46; Falk&#44; Chiesi&#44; Gebro Pharma&#44; Adacyte and Tillotts&#46;</p><p id="par0540" class="elsevierStylePara elsevierViewall">None of these activities by the authors were related to this study&#46;</p></span></span>"
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          "titulo" => "Epidemiology&#58; the risk of infection and immunisation rates in IBD patients"
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          "titulo" => "Degree of immunosuppression and risk factors&#46; Vaccine safety"
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              "titulo" => "Are vaccines safe during immunosuppression&#63;"
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          "titulo" => "Screening and protocol prior to vaccination in patients on immunosuppressive and&#47;or biologic treatment&#46; When and how to vaccinate&#63;"
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              "identificador" => "sec0035"
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              "titulo" => "Inactivated vaccines"
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              "titulo" => "Recommendations for vaccination against SARS-CoV-2 infection"
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              "identificador" => "sec0075"
              "titulo" => "Are there vaccines specifically recommended for IBD patients&#63; For cohabitants as well&#63;"
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          "identificador" => "sec0080"
          "titulo" => "Vaccines abroad"
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          "identificador" => "sec0085"
          "titulo" => "Vaccinations in IBD patients during pregnancy and breast-feeding&#46; Which vaccinations&#44; and when can they be given to children of mothers who have received biologic treatment during pregnancy&#63;"
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            0 => array:2 [
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              "titulo" => "Vaccination of the newborn of a mother with IBD"
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          "titulo" => "Vaccines in paediatric IBD"
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          "titulo" => "How can adherence to vaccination programmes by patients and healthcare workers be improved&#63;"
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          "titulo" => "GETECCU recommendations on the importance of screening and vaccination in IBD patients"
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          "titulo" => "Conflicts of interest"
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            1 => "Inflammatory bowel disease"
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            3 => "Prevention"
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          "clase" => "keyword"
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          "palabras" => array:5 [
            0 => "Vacuna"
            1 => "Enfermedad inflamatoria intestinal"
            2 => "Cribado"
            3 => "Prevenci&#243;n"
            4 => "Infecci&#243;n"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Patients with inflammatory bowel disease &#40;IBD&#41; may require different immunosuppressive treatments throughout their illness&#46; It is essential to assess the immunization status of patients at diagnosis or&#44; if this is not possible&#44; at least before the beginning of immunosuppressive therapy and&#44; subsequently&#44; administering the appropriate vaccines&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Therefore&#44; the aim of this work is to establish clear and concise recommendations on vaccination in patients with IBD in the different settings of our clinical practice including vaccination in children&#44; during pregnancy&#44; breastfeeding or on trips&#46; This consensus document emphasizes the differences between inactivated and attenuated vaccines and the different degrees of immunosuppression and correlates them with the administration of both mandatory and optional vaccines recommended to our patients with IBD&#46; Finally&#44; as a summary&#44; 17 recommendations are established based on the available scientific evidence and expert opinion&#46; A multidisciplinary team with extensive experience in IBD and vaccination&#44; made up of specialists in gastroenterology&#44; paediatrics&#44; nursing and pharmacy&#44; has participated in the preparation of these recommendations of the Spanish Working Group on Crohn&#39;s Disease and Ulcerative Colitis &#40;GETECCU&#41;&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con enfermedad inflamatoria intestinal &#40;EII&#41; pueden requerir diferentes tratamientos inmunosupresores a lo largo del curso de su enfermedad&#46; Por ello&#44; es fundamental evaluar el estado de inmunizaci&#243;n en el momento del diagn&#243;stico o&#44; si no es posible&#44; siempre antes de iniciar un tratamiento inmunosupresor y administrar las vacunas apropiadas&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El objetivo del presente documento es establecer unas recomendaciones claras y concisas sobre la vacunaci&#243;n en pacientes con EII en diferentes escenarios de pr&#225;ctica cl&#237;nica&#44; incluyendo situaciones especiales como la vacunaci&#243;n en la edad pedi&#225;trica&#44; el embarazo&#44; la lactancia o en viajes al extranjero&#46; Se presentan las diferencias entre vacunas inactivadas y atenuadas&#44; los diferentes grados de inmunosupresi&#243;n y su relaci&#243;n con las pautas de administraci&#243;n de las diferentes vacunas &#40;tanto obligatorias como opcionales&#41; recomendadas a los pacientes con EII&#46; En el documento&#44; se establecen 17 recomendaciones basadas en la evidencia cient&#237;fica disponible y opini&#243;n de expertos&#46; En la elaboraci&#243;n de estas recomendaciones del Grupo Espa&#241;ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa &#40;GETECCU&#41; ha participado un equipo multidisciplinar con amplia experiencia en EII y vacunaci&#243;n formado por especialistas de gastroenterolog&#237;a&#44; pediatr&#237;a&#44; enfermer&#237;a y farmacia&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Marta Piqueras and Roc&#237;o Ferreiro-Iglesias share co-authorship&#46;</p>"
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            "apendice" => "<p id="par0555" class="elsevierStylePara elsevierViewall">The following are Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia><elsevierMultimedia ident="upi0010"></elsevierMultimedia></p>"
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            "titulo" => "Supplementary data"
            "identificador" => "sec0130"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Types of vaccine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Live attenuated&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Inactivated&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mandatory in IBD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MMR &#40;measles&#44; mumps and rubella&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pneumococcus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Varicella&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Influenza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatitis B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Optional in IBD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rotavirus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatitis A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oral polio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Meningococcal group B &#40;Bexsero&#174;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yellow fever&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Meningococcal groups A&#44; C&#44; W&#44; Y<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diphtheria&#44; tetanus&#44; whooping cough&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Menveo&#174; or Nimenrix&#174;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bacillus Calmette&#8211;Gu&#233;rin<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Haemophilus influenzae</span> type B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Herpes zoster<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> &#40;Zostavax&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Human papilloma virus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Herpes zoster &#40;Shingrix&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Currently&#44; the vaccine against TB &#40;Bacillus Calmette-Gu&#233;rin&#41; is not indicated in Spain&#46; It is only indicated in people who will reside in high-prevalence countries for more than three months &#40;especially children&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Zostavax&#174; is less effective than Shingrix&#174;&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Meningococcal B&#44; Menveo&#174; or Nimenrix&#174; &#40;A&#44; C&#44; W&#44; Y&#41; in the case of a risk group &#40;splenic dysfunction&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Classification of vaccines according to the technology used in their manufacture&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Source&#58; Kucharzik et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">From treatment interruption to vaccination &#40;weeks&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">From vaccination to restart of treatment &#40;weeks&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Corticosteroids&#58; &#8805;20&#8239;mg&#47;day prednisone or equivalent&#8239;&#62;&#8239;2 weeks in adults and &#62;1&#8239;mg&#47;kg &#62;2 weeks in the paediatric age group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bolus corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Azathioprine&#47;6-mercaptopurine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Methotrexate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TNF inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ustekinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vedolizumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#8722;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tofacitinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cyclosporine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tacrolimus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Immunosuppressive treatment interruption intervals for administration of live attenuated vaccines based on the half-life of each treatment&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccinations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients who are <span class="elsevierStyleItalic">not</span> on IMS treatment &#40;like the general population&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients who <span class="elsevierStyleItalic">are on</span> IMS treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pneumococcus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">One dose of conjugate vaccine &#40;Prevenar&#174; 13&#41;&#44; followed at 2 months by a dose of PPSV23&#46; After 5 years&#44; 2nd and last dose of PPSV23&#46; If the patient has already received a dose of PPSV23&#44; they must wait a year for PCV13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">One dose of conjugate vaccine &#40;Prevenar&#174; 13&#41;&#44; followed at 2 months by a dose of PPSV23&#46; After 5 years&#44; 2nd and last dose of PPSV23&#46; If the patient has already received a dose of PPSV23&#44; they must wait a year for PCV13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatitis B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not immunised&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses 0-1-6 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">If anti-HBs&#8239;&#60;&#8239;100&#8239;IU&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 double doses &#40;0-1-2 months&#41; with <span class="elsevierStyleItalic">booster</span> between 6&#8722;12&#8239;m&#46; Re-vaccination if anti-HBs&#8239;&#60;&#8239;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Re-vaccination if anti-HBs&#8239;&#60;&#8239;100&#8239;IU&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Influenza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated in the current year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">One annual dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated in the current year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">One annual dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Measles&#44; mumps&#44; rubella&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not immunised&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">One or 2 doses &#40;interval&#8239;&#62;&#8239;28 days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contraindicated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Varicella&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not immunised&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 doses &#40;0&#44; 1&#8722;2 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contraindicated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tetanus-diphtheria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 initial doses &#40;0&#44; 1 and 7 months&#41; &#43; one dose&#47;10 years until completion of 5 doses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 initial doses &#40;0&#44; 1 and 7 months&#41; &#43; one dose&#47;10 years until completion of 5 doses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DTaP &#40;Diphtheria&#44; tetanus&#44; whooping cough&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pregnancy &#40;week 28&#8722;36&#44; preferably 32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">One dose in each pregnancy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pregnancy &#40;week 28&#8722;36&#44; preferably 32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">One dose in each pregnancy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Human papilloma virus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Females &#40;males<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&#41; 11&#8722;14 years old &#40;up to age 26 or having sexual intercourse&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses &#40;0&#44; 2&#44; 6 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Females &#40;males<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&#41; 11&#8722;14 years old &#40;up to age 26 or having sexual intercourse&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses &#40;0&#44; 2&#44; 6 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Women&#8239;&#62;&#8239;26 years with a history of CIN II-III or conisation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Women&#8239;&#62;&#8239;26 years with a history of CIN II-III or conisation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Poliomyelitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses &#40;0&#44; 1&#8722;2&#44; 6&#8722;12 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses &#40;0&#44; 1&#8722;2&#44; 6&#8722;12 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Meningococcal group C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Single dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Meningococcal group B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 doses &#40;0&#44; 2 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Meningococcal ACWY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Single dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Haemophilus influenzae</span> type B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unvaccinated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Single dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Herpes zoster&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients&#8239;&#8805;&#8239;50 years old&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Single dose &#40;Zostavax&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients&#8239;&#8805;&#8239;18 years on JAK inhibitors &#40;funded&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Two doses &#40;0&#44; 2&#8722;6 months&#41; &#40;Shingrix&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Two doses &#40;Shingrix&#174;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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            0 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Not funded in non-immunosuppressed patients&#46;</p>"
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          ]
        ]
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Dosage of mandatory and optional vaccinations in patients with IBD&#46;</p>"
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        "identificador" => "tbl0020"
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        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0020"
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            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccinations in travellers</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Non-immunosuppressed patients</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Immunosuppressed patients</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yellow fever&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas in South America and Africa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Single dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contraindicated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Typhoid fever&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas in India and South Africa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 oral doses &#40;0&#44; 2&#44; 4 days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas in India and South Africa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Single intramuscular dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatitis A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not immunised&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 doses &#40;0&#44; 6&#8722;12 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not immunised&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 doses &#40;0&#44; 6&#8722;12 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cholera&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas with insufficient access to clean water sources&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 doses &#40;0&#44; 1 week&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas with insufficient access to clean water sources&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 doses &#40;0&#44; 1 week&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Japanese encephalitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas of Asia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 doses &#40;0&#44; 1 month&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas of Asia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 doses &#40;0&#44; 1 month&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Central European encephalitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas of central and north-eastern Europe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses &#40;0&#44; 1&#8722;3&#44; 9&#8722;18 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas of central and north-eastern Europe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses &#40;0&#44; 1&#8722;3&#44; 9&#8722;18 months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rabies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses &#40;0&#44; 7&#44; 21&#8722;28 days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Endemic areas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 doses &#40;0&#44; 7&#44; 21&#8722;28 days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Vaccination recommendations abroad&#46;</p>"
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      ]
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        "tipo" => "MULTIMEDIATABLA"
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        "detalles" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Indication&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DTaP &#40;diphtheria&#44; tetanus&#44; whooping cough&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pregnant &#40;week 28&#8722;36&#44; preferably 32<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Influenza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Any trimester&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Other inactivated vaccines&#58; HAV&#44; HBV&#44; meningococcal&#44; pneumococcal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Selective vaccination if there are associated risk factors<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Measles&#44; mumps and rubella &#40;MMR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contraindicated because it is a live attenuated virus vaccine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Varicella&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contraindicated because it is a live attenuated virus vaccine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Herpes zoster&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zostavax&#174; contraindicated because it is a live attenuated virus vaccine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SARS-CoV-2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recommended&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            ]
          ]
        ]
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Type of vaccine and indication in pregnant patients with IBD&#46;</p>"
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Article information

ISSN: 24443824
Original language: English

DOI:10.1016/j.gastre.2022.03.004

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