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Inicio Hipertensión y Riesgo Vascular Implicaciones de la arginina-vasopresina y de la copeptina en la gestación norm...
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Vol. 41. Issue 1.
Pages 35-39 (January - March 2024)
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Vol. 41. Issue 1.
Pages 35-39 (January - March 2024)
Artículo especial
Implicaciones de la arginina-vasopresina y de la copeptina en la gestación normal y en la preeclampsia
Implications of arginine-vasopressin and copeptin in normal gestation and in pre-eclampsia
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M. Heras Benito
Corresponding author
mherasb@saludcastillayleon.es

Autor para correspondencia.
Servicio de Nefrología, Hospital Universitario de Salamanca, Salamanca, España
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Tabla 1. Principales estudios efectuados con copeptina en preeclampsia
Resumen

La preeclampsia representa una complicación específica de hipertensión del embarazo, que aparece de novo después de la 20 semana de gestación, acompañada de proteinuria y/o disfunción orgánica materna o útero-placentaria. A pesar de una etiopatogenia incierta, la alteración en el remodelado vascular de la arteria espiral e isquemia placentaria es la hipótesis más generalizada. El hallazgo de niveles elevados de copeptina, en mujeres con preeclampsia respecto a gestantes normales, ha puesto en valor la implicación de la arginina-vasopresina en la etiopatogenia de esta complicación. En este trabajo se considera su utilidad como marcador de preeclampsia a través de la revisión de los principales estudios efectuados con esta molécula.

Palabras clave:
Gestación
Preeclampsia
Arginina-vasopresina
Copeptina
Abstract

Preeclampsia represents a specific complication of pregnancy hypertension, which appears de novo after the 20th week of gestation, accompanied by proteinuria and/or maternal or utero-placental organ dysfunction. Despite an uncertain etiopathogenesis, impaired vascular remodeling of the spiral artery and placental ischemia is the most widespread hypothesis. The finding of elevated levels of copeptin in women with preeclampsia compared to normal pregnant women has valued the involvement of arginine vasopressin in the etiopathogenesis of this complication. In this paper, its usefulness as a marker of preeclampsia is considered through the review of the main studies carried out with this molecule.

Keywords:
Gestation
Preeclampsia
Arginine-vasopressin
Copeptin

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