array:23 [ "pii" => "S1889183708718701" "issn" => "18891837" "doi" => "10.1016/S1889-1837(08)71870-1" "estado" => "S300" "fechaPublicacion" => "2008-07-01" "aid" => "71870" "copyright" => "Sociedad Española de Hipertension-Liga Española para la Lucha de la Hipertensión Arterial (SEH-LELHA)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Hipertens Riesgo Vasc. 2008;25:147-50" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2801 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 2458 "PDF" => 333 ] ] "itemSiguiente" => array:18 [ "pii" => "S1889183708718713" "issn" => "18891837" "doi" => "10.1016/S1889-1837(08)71871-3" "estado" => "S300" "fechaPublicacion" => "2008-07-01" "aid" => "71871" "copyright" => "Sociedad Española de Hipertension-Liga Española para la Lucha de la Hipertensión Arterial (SEH-LELHA)" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Hipertens Riesgo Vasc. 2008;25:151-68" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2309 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1945 "PDF" => 357 ] ] "es" => array:6 [ "idiomaDefecto" => true "titulo" => "Abstracts de la xiv reunión de la sociedad catalana de hipertensión arterial y xx jornadas catalanas sobre hipertensión arterial" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "151" "paginaFinal" => "168" ] ] "contienePdf" => array:1 [ "es" => true ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183708718713?idApp=UINPBA00004N" "url" => "/18891837/0000002500000004/v1_201307261652/S1889183708718713/v1_201307261652/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1889183708718695" "issn" => "18891837" "doi" => "10.1016/S1889-1837(08)71869-5" "estado" => "S300" "fechaPublicacion" => "2008-07-01" "aid" => "71869" "copyright" => "Sociedad Española de Hipertension-Liga Española para la Lucha de la Hipertensión Arterial (SEH-LELHA)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Hipertens Riesgo Vasc. 2008;25:141-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2166 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1868 "PDF" => 291 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Eficacia de una estrategia basada en ARA-II en el tratamiento de pacientes hipertensos con síndrome metabólico" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "141" "paginaFinal" => "146" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy of an ARBs based strategy in the treatment of hypertensive patients with metabolic syndrome" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Rodilla, J.A. Costa, F. Pérez-Lahiguera, S. Mares, C. González, J.M. Pascual" "autores" => array:6 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Rodilla" ] 1 => array:2 [ "nombre" => "J.A." "apellidos" => "Costa" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Pérez-Lahiguera" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Mares" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "González" ] 5 => array:2 [ "nombre" => "J.M." "apellidos" => "Pascual" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183708718695?idApp=UINPBA00004N" "url" => "/18891837/0000002500000004/v1_201307261652/S1889183708718695/v1_201307261652/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Administración temporalizada de fármacos antihipertensivos. Primeros pasos desde una consulta rural de Atención Primaria" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "147" "paginaFinal" => "150" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.L. Lafuente, A. Cabal, F. López" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.L." "apellidos" => "Lafuente" ] 1 => array:4 [ "nombre" => "A." "apellidos" => "Cabal" "email" => array:1 [ 0 => "alberto.cabal@sespa.princast.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "F." "apellidos" => "López" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Centro de Salud de Cabañaquinta. Cabañaquinta. Aller. Asturias. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: A. Cabal García. C./ La Cruz, 38 F. 33191 San Claudio (Oviedo). Asturias. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Temporal administration of antihypertensive drugs. first steps from rural primary care" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-06-25" "fechaAceptado" => "2007-11-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec219109" "palabras" => array:5 [ 0 => "hipertensión" 1 => "monitorización ambulatoria de la presión arterial" 2 => "cronoterapia" 3 => "dipper" 4 => "non dipper" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec219110" "palabras" => array:5 [ 0 => "hypertension" 1 => "ambulatory blood pressure monitoring" 2 => "chronotherapy" 3 => "dipper" 4 => "non-dipper" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El conocimiento del perfil circadiano de la presión arterial en los hipertensos nos permite introducir el concepto «tiempo» en la administración de los medicamentos: la cronoterapia. Analizado el perfil circadiano de nuestros hipertensos introdujimos cambios en la hora de administración de fármacos en los non dipper, sin modificar las dosis ni cambiar los fármacos, para valorar el impacto de esta medida.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional prospectivo. Tras la realización de una primera monitorización ambulatoria de la presión arterial (MAPA) a aquellos hipertensos que presentaron un patrón no reductor de la tensión arterial se les modificó el horario de administración de su medicación (todos ellos la tomaban al desayunar) y se les pasó a la comida, merienda o cena. Tras un período de 3 meses se realizó una nueva MAPA.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Del total de 121 pacientes, 43 presentaron un patrón nocturno de la presión arterial no reductor. A todos estos se les modificó el horario de administración de su tratamiento habitual y, en casos de politerapia, de uno de los fármacos. Pasados 3 meses se iniciaron las reevaluaciones mediante una nueva MAPA. De estos 43 pacientes, el 60% cambió a dipper.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Considerar el horario de ingesta de la medicación puede ser una de las variables en la toma de decisiones del manejo de nuestros pacientes hipertensos no reductores, con lo que podríamos mejorar su pronóstico vital.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Knowing the blood pressure circadian profile in hypertensive patients allows us to introduce the concept of «time» into drugs administration, this being called chronotherapy. After having analyzed the circadian profile of our hypertensive patients, we introduced changes into the time when the drug was administered in the non-dipper subjects, without modifying nor changing the drugs nor their dose, to evaluate the impact of this measurement.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">An observational prospective study was conducted. After having performed the first ambulatory blood pressure monitoring (ABPM), time of administration of the medication (all of them were taking it at breakfast) was modified, changing it to lunch, afternoon snack or dinner. A new ABPM was performed after a 3 month period.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 43 patients (n=121) had non-reduced nocturnal blood pressure (non-dipper). Time of drug administration was modified in all of them. In the case of multiple drug therapy, one drug was modified. At 3 months, reevaluations were initiated by means of a new ABPM. Sixty percent of the 43 patients changed to dipper.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Considering the schedule in the taking of the medication may be one of the variables to be used in the decision making in the management of our hypertensive patients with non-reduced nocturnal pattern. This will help us to improve their life prognosis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Journal Information
Administración temporalizada de fármacos antihipertensivos. Primeros pasos desde una consulta rural de Atención Primaria
Temporal administration of antihypertensive drugs. first steps from rural primary care
M.L. Lafuente, A. Cabal
, F. López
Corresponding author
alberto.cabal@sespa.princast.es
Correspondencia: A. Cabal García. C./ La Cruz, 38 F. 33191 San Claudio (Oviedo). Asturias. España.
Correspondencia: A. Cabal García. C./ La Cruz, 38 F. 33191 San Claudio (Oviedo). Asturias. España.
Centro de Salud de Cabañaquinta. Cabañaquinta. Aller. Asturias. España