array:23 [ "pii" => "S1889183701711907" "issn" => "18891837" "doi" => "10.1016/S1889-1837(01)71190-7" "estado" => "S300" "fechaPublicacion" => "2001-11-01" "aid" => "71190" "copyright" => "Sociedad Española de Hipertension-Liga Española para la Lucha de la Hipertensión Arterial (SEH-LELHA)" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Hipertens Riesgo Vasc. 2001;18:389-92" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3708 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 3158 "PDF" => 542 ] ] "itemSiguiente" => array:18 [ "pii" => "S1889183701711919" "issn" => "18891837" "doi" => "10.1016/S1889-1837(01)71191-9" "estado" => "S300" "fechaPublicacion" => "2001-11-01" "aid" => "71191" "copyright" => "Sociedad Española de Hipertension-Liga Española para la Lucha de la Hipertensión Arterial (SEH-LELHA)" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "mis" "cita" => "Hipertens Riesgo Vasc. 2001;18:393" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 9370 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 7559 "PDF" => 1803 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Hipertensión e Internet" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "393" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José M. Alcázar" "autores" => array:1 [ 0 => array:2 [ "nombre" => "José M." "apellidos" => "Alcázar" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183701711919?idApp=UINPBA00004N" "url" => "/18891837/0000001800000008/v1_201307261526/S1889183701711919/v1_201307261526/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1889183701711890" "issn" => "18891837" "doi" => "10.1016/S1889-1837(01)71189-0" "estado" => "S300" "fechaPublicacion" => "2001-11-01" "aid" => "71189" "copyright" => "Sociedad Española de Hipertension-Liga Española para la Lucha de la Hipertensión Arterial (SEH-LELHA)" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Hipertens Riesgo Vasc. 2001;18:383-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2867 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 2269 "PDF" => 589 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Marcadores bioquímicos de fibrosis miocárdica en las enfermedades cardíacas" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "383" "paginaFinal" => "388" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Biochemical markers of myocardial fibrosis in cardiac diseases" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. López Salazar, A. González Miqueo, S. Ravassa Albéniz, J. Beaumont Ezcurra, G. San José Enériz, U. Moreno Zulategui, A. Fortuño Gil, G. Zalba Goñi, M.A. Fortuño Cebamanos, J. Díez Martínez" "autores" => array:10 [ 0 => array:2 [ "nombre" => "B." "apellidos" => "López Salazar" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "González Miqueo" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Ravassa Albéniz" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Beaumont Ezcurra" ] 4 => array:2 [ "nombre" => "G." "apellidos" => "San José Enériz" ] 5 => array:2 [ "nombre" => "U." "apellidos" => "Moreno Zulategui" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "Fortuño Gil" ] 7 => array:2 [ "nombre" => "G." "apellidos" => "Zalba Goñi" ] 8 => array:2 [ "nombre" => "M.A." "apellidos" => "Fortuño Cebamanos" ] 9 => array:2 [ "nombre" => "J." "apellidos" => "Díez Martínez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183701711890?idApp=UINPBA00004N" "url" => "/18891837/0000001800000008/v1_201307261526/S1889183701711890/v1_201307261526/es/main.assets" ] "es" => array:11 [ "idiomaDefecto" => true "titulo" => "Efectos de la trimetazidina en la angina microvascular de origen hipertensivo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "389" "paginaFinal" => "392" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Morillas Blasco, A. Frutos García, V. Bertomeu Martínez, R. Valero Parra, J.A. Rodríguez Ortega" "autores" => array:5 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "Morillas Blasco" "email" => array:1 [ 0 => "pedromorillas@teleline.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Frutos García" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Bertomeu Martínez" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Valero Parra" ] 4 => array:2 [ "nombre" => "J.A." "apellidos" => "Rodríguez Ortega" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Sección de Cardiología. Hospital Universitario San Juan. Alicante" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Sección de Cardiología.Hospital Universitario San Juan.Ctra. Nacional 332 Alicante-Valencia s/n 03550 San Juan de Alicante. Alicante.Correo electrónico:" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave:" "identificador" => "xpalclavsec218621" "palabras" => array:3 [ 0 => "síndrome X" 1 => "trimetazidina" 2 => "hipertensión" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La trimetazidina es un fármaco con propiedades antiisquémicasque protege el miocardio del daño isquémico a través de la preservación del metabolismo oxidativo mitocondrial, sin ejercer ninguna acción hemodinámica. Dicho fármaco ha demostrado disminuir las crisis de angina y mejorar la tolerancia al esfuerzo en pacientes con cardiopatía isquémica. Presentamos el efecto de dicho fármaco sobre la sintomatología anginosa de una paciente hipertensa diagnosticada de angina microvascular</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Trimetazidine is an antiischemic drug protecting the myocardium from ischemic damage through the preservation of mitochondrial oxidative metabolism, without any hemodynamic effects. This drug diminishes angina and improves tolerance of exercise of patients with ischemic heart disease. We report the effects of treatment with trimetazidine in a woman with hypertension and microvascular angina.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treating ischemic heart disease by pharmacologically improving cardiac energy metabolim" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.D. Lopaschuk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1998" "volumen" => "82" "paginaInicial" => "14K" "paginaFinal" => "17K" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9737481" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angina de pecho microvascular. Síndrome X" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Sarnago" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cardiopatía isquémica" "paginaInicial" => "509" "paginaFinal" => "556" "serieFecha" => "1999" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angina de pecho con angiografía coronaria normal. Síndrome X cardíaco" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.C. Kaski" 1 => "F. Atienza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cardiopatía hipertensiva" "paginaInicial" => "179" "paginaFinal" => "186" "serieFecha" => "1997" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of angiotensin- converting enzyme inhibition on exercise-induced angina and ST segment depression in patients with microvascular angina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.C. Kasky" 1 => "G. Rosano" 2 => "S. Gavrielides" 3 => "L. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "1994" "volumen" => "23" "paginaInicial" => "652" "paginaFinal" => "657" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8113548" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Kantor" 1 => "A. Lucien" 2 => "R. Kozak" 3 => "G. Lopaschuk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Circulation Research" "fecha" => "2000" "volumen" => "86" "paginaInicial" => "580" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10720420" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of trimetazidine with nifedipine in effort angina: a double-blind, crossover stugy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Dalla-Volta" 1 => "G. Maraglino" 2 => "P. Della-Valentina" 3 => "P. Viena" 4 => "A. Desideri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cardiovasc Drugs Ther" "fecha" => "1990" "volumen" => "4" "paginaInicial" => "853" "paginaFinal" => "860" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2093381" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trimetazidine: a new concept in the treatment of angina. Comparison with propanolol in patients with stable angina. TEMS study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.M. Detry" 1 => "P. Sellier" 2 => "S. Pennaforte" 3 => "D. Cokkinos" 4 => "H. Dargie" 5 => "P. Mathes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol" "fecha" => "1994" "volumen" => "37" "paginaInicial" => "279" "paginaFinal" => "288" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8198938" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of rimetazidine on clinical symptoms and tolerance of exercise of patients with syndrome X: a preliminary study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Rogacka" 1 => "P. Guzik" 2 => "A. Wykretowicz" 3 => "J. Rzezniczak" 4 => "M. Dziarmaga" 5 => "H. Wysocky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Coron Artery Dis" "fecha" => "2000" "volumen" => "11" "numero" => "2" "paginaInicial" => "171" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10758819" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of trimetazidine with atenolol in patients with syndrome X: effects on diastolic function and exercise tolerance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "L. Leonardo" 1 => "G. Fragasso" 2 => "E. Rosetti" 3 => "P. Dabrowski" 4 => "P. Pagnotta" 5 => "G.M. Rosano" 6 => "S.L. Chierchia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cardiología" "fecha" => "1999" "volumen" => "44" "numero" => "12" "paginaInicial" => "1.065" "paginaFinal" => "1.069" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12497950" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/18891837/0000001800000008/v1_201307261526/S1889183701711907/v1_201307261526/es/main.assets" "Apartado" => array:4 [ "identificador" => "9113" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Caso clínico" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/18891837/0000001800000008/v1_201307261526/S1889183701711907/v1_201307261526/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183701711907?idApp=UINPBA00004N" ]
Journal Information
Efectos de la trimetazidina en la angina microvascular de origen hipertensivo
P. Morillas Blasco1
, A. Frutos García, V. Bertomeu Martínez, R. Valero Parra, J.A. Rodríguez Ortega
Corresponding author
pedromorillas@teleline.es
Correspondencia: Sección de Cardiología.Hospital Universitario San Juan.Ctra. Nacional 332 Alicante-Valencia s/n 03550 San Juan de Alicante. Alicante.Correo electrónico:
Correspondencia: Sección de Cardiología.Hospital Universitario San Juan.Ctra. Nacional 332 Alicante-Valencia s/n 03550 San Juan de Alicante. Alicante.Correo electrónico:
Sección de Cardiología. Hospital Universitario San Juan. Alicante