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Primeros pasos desde una consulta rural de Atención Primaria" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "147" "paginaFinal" => "150" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Temporal administration of antihypertensive drugs. first steps from rural primary care" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.L. Lafuente, A. Cabal, F. López" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.L." "apellidos" => "Lafuente" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Cabal" ] 2 => array:2 [ "nombre" => "F." 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"apellidos" => "de la Sierra" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183708718683?idApp=UINPBA00004N" "url" => "/18891837/0000002500000004/v1_201307261652/S1889183708718683/v1_201307261652/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Eficacia de una estrategia basada en ARA-II en el tratamiento de pacientes hipertensos con síndrome metabólico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "141" "paginaFinal" => "146" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. Rodilla, J.A. Costa, F. Pérez-Lahiguera, S. Mares, C. González, J.M. Pascual" "autores" => array:6 [ 0 => array:3 [ "nombre" => "E." "apellidos" => "Rodilla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "J.A." "apellidos" => "Costa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "F." "apellidos" => "Pérez-Lahiguera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "S." "apellidos" => "Mares" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:4 [ "nombre" => "J.M." "apellidos" => "Pascual" "email" => array:1 [ 0 => "pascual_jma@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Hipertensión Arterial y Riesgo Vascular. Servicio de Medicina Interna" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Preventiva y Unidad de Investigación. Hospital de Sagunto. Valencia. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: J. M. Pascual. Unidad de Hipertensión Arterial y Riesgo Vascular. Servicio de Medicina Interna. Hospital de Sagunto. C/ Ramón y Cajal, 46 46520 Valencia. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy of an ARBs based strategy in the treatment of hypertensive patients with metabolic syndrome" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-05-25" "fechaAceptado" => "2007-07-18" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec219108" "palabras" => array:3 [ 0 => "ARA-II" 1 => "objetivos terapéuticos" 2 => "síndrome metabólico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec219107" "palabras" => array:3 [ 0 => "ARBs" 1 => "therapeutic goals" 2 => "metabolic syndrome" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar el cumplimiento de objetivos terapéuticos con un tratamiento basado en antagonistas de los receptores de angiotensina II (ARA-II) en pacientes hipertensos con síndrome metabólico</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio longitudinal observacional retrospectivo de cohortes de pacientes hipertensos, no diabéticos, con síndrome metabólico (51 mujeres y 83 varones) de 53,1 (13,3) años y con índice de masa corporal de 30,8 (4,7) (kg/m2) que nunca habían recibido tratamiento farmacológico. Se compararon los que habían recibido tratamiento con una estrategia a base de ARA-II respecto a los que fueron tratados con otros grupos farmacológicos (calcioantagonistas y/o betabloqueantes) como controles. El diagnóstico de síndrome metabólico se estableció a partir de los criterios del NCEP-ATP III. Se consideraron objetivos del tratamiento hipolipemiante los del ATP-III, según su grupo de riesgo, y de presión arterial < 140/90 mmHg.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Un total de 77 pacientes fueron tratados con ARA-II y 57 con otras combinaciones. Tanto los pacientes del grupo control como los del grupo ARA-II tuvieron una clara disminución de la presión arterial sistólica, 18,4 (19,5) frente a 18,9 (20,0) mmHg (p=0,86) y de la presión arterial diastólica 9,2 (12) frente a 10,1 (12,0) mmHg (p=0,46), sin que se encontraran diferencias significativas en el descenso de la presión arterial en ambos grupos. No hubo diferencias significativas entre ambos grupos en las variaciones de los parámetros lipídicos ni en los valores de proteína C reactiva. Tampoco se encontraron diferencias significativas entre ambos grupos en la variación de los valores de glucemia, ni insulina, ni del índice de HOMA, ni en la consecución de los objetivos terapéuticos metabólicos, ni de presión arterial. Al finalizar el estudio los pacientes asignados al grupo ARA-II recibían menos fármacos antihipertensivos que el grupo control: 1,81(0,54) frente a 2,02 (0,42) (p=0,001).</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En pacientes hipertensos con síndrome metabólico una estrategia terapéutica con el uso de ARA-II consigue un control de la presión arterial similar a una estrategia con betabloqueantes o calcioantagonistas, pero con el uso de menor número de fármacos antihipertensivos</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to evaluate achievements of therapeutic goals with an angiotensin receptor blockers (ARBs) based therapy in hypertensive subjects with metabolic syndrome.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A longitudinal, observational and retrospective follow-up study was conduced in 134 non-diabetic, non-previously treated hypertensive patients with metabolic syndrome (51 women and 83 men) of 53.1 (13.3) years and bpdy measurement index of 30.8 (4.5) (kg/m2) who have never received drug treatment. These patients who had received treatment with a strategy based on ARBs-II were compared to patients treated with other drug groups (calcium antagonists and/or beta blockers) who were used as controls. Metabolic syndrome was established according to NCEP-ATP-III criteria. Goals of the lipid lower treatment were considered to be those of the ATP-III, according to the risk group and blood pressure (<140/90 mmHg).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 77 patients were treated with ARB-II and 55 with other combinations. Reduction of blood pressure was similar in both groups 18.4 (19.5) vs. 18.9 (20.0) mmHg (p = 0.86) for systolic blood pressure and 9.2 (12) vs. 10.1 (12.0) mmHg (p=0.46) for diastolic blood pressure. No significant differences in blood pressure decrease were observed in both groups. There were also no significant differences between both groups in the variation of lipid parameters or in the CRP values. In addition, no significant differences were found between groups in the variation of glucose values, insulin and HOMA index, nor in the achievement of the metabolic treatment or blood pressure goals. At the end of follow-up patients treated with ARBs strategy required fewer antihypertensive drugs 1.81 (0.54) vs. 2.02 (0.42) (p = 0.001) than patients treated with the other strategy.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In hypertensive patients with metabolic syndrome an ARB based strategy achieves the same therapeutic blood pressure and lipid and metabolic goals, but requires fewer antihypertensive drugs.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Journal Information
Eficacia de una estrategia basada en ARA-II en el tratamiento de pacientes hipertensos con síndrome metabólico
Efficacy of an ARBs based strategy in the treatment of hypertensive patients with metabolic syndrome
E. Rodillaa, J.A. Costaa, F. Pérez-Lahigueraa, S. Maresa, C. Gonzálezb, J.M. Pascuala,
Corresponding author
pascual_jma@gva.es
Correspondencia: J. M. Pascual. Unidad de Hipertensión Arterial y Riesgo Vascular. Servicio de Medicina Interna. Hospital de Sagunto. C/ Ramón y Cajal, 46 46520 Valencia. España.
Correspondencia: J. M. Pascual. Unidad de Hipertensión Arterial y Riesgo Vascular. Servicio de Medicina Interna. Hospital de Sagunto. C/ Ramón y Cajal, 46 46520 Valencia. España.