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Gómez-Angelats, M. Larrouse Morellón, E. Bragulat Baurd" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Gómez-Angelats" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Larrouse Morellón" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Bragulat Baurd" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183701711348?idApp=UINPBA00004N" "url" => "/18891837/0000001800000004/v1_201307261521/S1889183701711348/v1_201307261521/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1889183701711324" "issn" => "18891837" "doi" => "10.1016/S1889-1837(01)71132-4" "estado" => "S300" "fechaPublicacion" => "2001-05-01" "aid" => "71132" "copyright" => "Sociedad Española de Hipertension-Liga Española para la Lucha de la Hipertensión Arterial (SEH-LELHA)" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Hipertens Riesgo Vasc. 2001;18:171-85" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5497 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 4825 "PDF" => 663 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Los nuevos factores de riesgo cardiovascular" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "171" "paginaFinal" => "185" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The new cardiovascular risk factors" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Abellán Alemán, F. Hernández Menárguez, J.A. García-Galbis Marín, J.B. Gómez Castaño, J. Madrid Conesa, A. Martínez Pastor, M. Leal Hernández" "autores" => array:7 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Abellán Alemán" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Hernández Menárguez" ] 2 => array:2 [ "nombre" => "J.A." "apellidos" => "García-Galbis Marín" ] 3 => array:2 [ "nombre" => "J.B." "apellidos" => "Gómez Castaño" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Madrid Conesa" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Martínez Pastor" ] 6 => array:2 [ "nombre" => "M." "apellidos" => "Leal Hernández" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183701711324?idApp=UINPBA00004N" "url" => "/18891837/0000001800000004/v1_201307261521/S1889183701711324/v1_201307261521/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Papel de los antagonistas de los receptores de la angiotensina II en la insuficiencia cardíaca" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "186" "paginaFinal" => "196" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "V. Barrios Alonso, R. Campuzano Ruiz, A. Camino López" "autores" => array:3 [ 0 => array:3 [ "nombre" => "V." "apellidos" => "Barrios Alonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Campuzano Ruiz" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Camino López" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Instituto de Enfermedades del Corazón. Hospital Ramón y Cajal. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: V. Barrios Alonso. Cardiología. Hospital Ramón y Cajal. Ctra. de Colmenar, km. 9,100. 28034 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Role of angiotensin II receptor antagonists in heart failure" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec218576" "palabras" => array:4 [ 0 => "insuficiencia cardíaca" 1 => "sistema reninaangiotensina-aldosterona" 2 => "inhibidores de la enzima de conversión de angiotensina" 3 => "antagonistas de los receptores de angiotensina II" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec218575" "palabras" => array:4 [ 0 => "Heart failure" 1 => "renin-angiotensin-aldosterone system" 2 => "ACE inhibitors" 3 => "angiotensin receptor blockers" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A pesar de que en los últimos años hemos asistido a un importante avance en el tratamiento de la insuficiencia cardíaca, esta enfermedad sigue presentando una alta morbimortalidad y un progresivo aumento en su prevalencia. Por tanto, parece necesario seguir investigando nuevos fármacos para mejorar su pronóstico y si es posible prevenir su aparición. Se ha demostrado que la activación del sistema renina-angiotensina-aldosterona desempeña un papel fundamental en la insuficiencia cardíaca y el bloqueo del sistema es un objetivo primordial en el tratamiento. En la última década ha aparecido un nuevo grupo farmacológico: los antagonistas de los receptores de angiotensina II. Estos fármacos, al actuar específicamente sobre el receptor AT1, podrían ser de gran utilidad en la insuficiencia cardíaca. En este sentido pequeños estudios han demostrado que estos productos, tanto solos como combinados con inhibidores de la enzima de conversión de la angiotensina (IECA), presentan un perfil hemodinámico y clínico muy favorable. Para conocer sus efectos en insuficiencia cardíaca se han puesto en marcha 3 grandes ensayos clínicos multicéntricos de morbimortalidad. Hasta la fecha sólo se han publicado los resultados del ELITE II, que comparó un antagonista (losartán) con captopril y demostró que losartán no fue superior al IECA en mortalidad total, aunque fue mejor tolerado. Recientemente se han presentado los resultados de Val-HeFT (aún no publicados). Este estudio analizó el efecto de añadir valsartán al tratamiento habitual de la insuficiencia cardíaca. Los resultados mostraron que la adición de valsartán redujo significativamente la morbimortalidad (fundamentalmente a expensas de una importante disminución en las hospitalizaciones por insuficiencia cardíaca). Por tanto, ya se puede afirmar que los antagonistas de los receptores de angiotensina son útiles en insuficiencia cardíaca. No obstante, en un futuro próximo dispondremos de nuevos datos que nos permitirán definir mejor cuál es definitivamente su papel en esta enfermedad.</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Despite significant advances have been achieved in the treatment of heart failure in the last years, this disease still exhibits a high morbi-mortality and a progressive increase in the prevalence is being observed. Therefore, research on new drugs aimed to improve the prognosis of this disease and, if possible, to prevent its appearance seems necessary. Renin-angiotensin- aldosterone system plays a key role in heart failure and its blockade appears to be a crucial goal. In the last decade, a new pharmacological group has been launched: the angiotensin receptor blockers. These products act as specific AT1 receptors blockers, what could be extremely useful in the setting of heart failure. These drugs, with and without combination with ACE inhibitors, have shown a good hemodynamic and clinic profile in some small studies. With the aim to investigate the effects of these agents in heart failure, three multicenter clinical trials focused on morbi-mortality in heart failure have raised. To date, only ELITE II results habe been published. This trial compared an angiotensin receptor blocker (losartan) to captopril and showed that losartan was not superior to the ACE inhibitor to reduce all cause-mortality, but it was much better tolerated. Recently, the Val- HeFT results have been communicated (still unpublished). This trial examined the effect to associate valsartan to usual heart failure therapy. The study revealed that the addition of valsartan significantly reduced morbi-mortality (mainly due to a marked reduction in hospitalizations due to heart failure). Thus, it is already adequate to state that angiotensin receptor blockers are useful in heart failure. However, in the very next future, new data will bring very relevant information to better define the role of these drugs in this clinical setting.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:74 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. 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Journal Information
Papel de los antagonistas de los receptores de la angiotensina II en la insuficiencia cardíaca
Role of angiotensin II receptor antagonists in heart failure
Instituto de Enfermedades del Corazón. Hospital Ramón y Cajal. Madrid