Article information
Resumen
Leclercia adecarboxylata es una enterobacteriácea reportada ocasionalmente como un germen oportunista que compromete pacientes con algún tipo de inmunosupresión como neutropenia, cirrosis o cáncer. Se reporta un brote de cinco casos de bacteriemia por L. adecarboxylata en pacientes con diversas condiciones de inmunosupresión, probablemente asociado con el uso de viales de heparina contaminados. Se hace una revisión actualizada de la literatura y una discusión sobre los aspectos particulares del brote y del microorganismo.
Palabras clave:
heparina
Leclercia adecarboxylata
bacteriemia
brote
Abstract
Leclercia adecarboxylata is part of the Enterobacteriaceae family occasionally reported as an opportunist microorganism in patients with any kind of immunosuppression as neutropenia, cirrhosis or cancer. We report an outbreak with five cases of Leclercia adecarboxylata bacteremia in patients with several immune conditions, most likely associated to contaminated heparin vials. We also present an updated literature review and discussion regarding the particular characteristics of the outbreak and the microorganism.
Keywords:
heparin
L. adecarboxylata
bacteremia
outbreak
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Referencias
[1.]
M.O. Pérez-Moreno, J. Anguera, M. Carulla, M. Pérez-Moreno.
Artritis séptica por Leclercia adecarboxylata de origen probablemente yatrogénico.
Enferm Infecc Microbiol Clin, 21 (2003), pp. 167-168
[2.]
P. Davenport, K.J. Land.
Isolation of Leclercia adecarboxylata from the blood culture of an asymptomatic platelet donor.
Transfusion, 47 (2007), pp. 1816-1819
[3.]
M. Dalamaga, M. Pantelaki, K. Karmaniolas, K. Daskalopoulou.
Migdalis I. Isolation of Leclercia adecarboxylata from blood and burn wound after a hydrofluoric acid chemical injury. Burns, 35 (2009), pp. 443-445
[4.]
P.M. Sarma, D. Bhattacharya, S. Krishnan, B. Lal.
Degradation of polycyclic aromatic hydrocarbons by a newly discovered enteric bacterium Leclercia adecarboxylata.
Appl Environ Microbiol, 70 (2004), pp. 3163-3166
[5.]
M. Fernández-Ruiz, F. López-Medrano, L. García-Sánchez, A. García- Reyne, T. Ortuno de Solo, F. Sanz-Sanz, et al.
Successful management of tunneled hemodialysis catheter-related bacteremia by Leclercia adecarboxylata without catheter removal: Report of two cases.
Int J Infect Dis, 13 (2009), pp. e517-e518
[6.]
B. Lee, J.J. Sir, S.W. Park, C.H. Kwak, S.M. Kim, S.B. Kim, et al.
A case of Leclercia adecarboxylata endocarditis in a woman with endometrial cancer.
Am J Med Sci, 337 (2009), pp. 146-147
[7.]
H. Leclerc.
Biochemical study of pigmented Enterobacteriaceae.
Ann Inst Pasteur (Paris), 102 (1962), pp. 726-741
[8.]
K. Tamura, R. Sakazaki, Y. Kosako, E. Yoshizaki.
Leclercia adecarboxylata Gen. Nov., Comb. Nov., formerly known as Escherichia adecarboxylata.
Curr Microbiol, 13 (1986), pp. 179-184
[9.]
R.M. Daza, J. Iborra, N. Alonso, I. Vera, F. Portero, P. Mendaza.
Aislamiento de Leclercia adecarboxylata en paciente cirrotico.
Enferm Infecc Microbiol Clin, 11 (1993), pp. 53-54
[10.]
O. Fattal, J.G. Deville.
Leclercia adecarboxylata peritonitis in a child receiving chronic peritoneal dialysis.
Pediatr Nephrol, 15 (2000), pp. 186-187
[11.]
T. de Baere, G. Wauters, A. Huylenbroeck, G. Claeys, R. Peleman, G. Verschraegen, et al.
Isolations of Leclercia adecarboxylata from a patient with a chronically inflamed gallbladder and from a patient with sepsis without focus.
J Clin Microbiol, 39 (2001), pp. 1674-1675
[12.]
R.F. Chemaly, D.B. Rathod, M.K. Sikka, M.K. Hayden, M. Hutchins, T. Horn, et al.
Serratia marcescens bacteremia because of contaminated prefilled heparin and saline syringes: A multi-state report.
Am J Infect Control, 39 (2011), pp. 521-524
[13.]
D. Liu, L.P. Zhang, S.F. Huang, Z. Wang, P. Chen, H. Wang, et al.
Outbreak of Serratia marcescens infection due to contamination of multiple-dose vial of heparin-saline solution used to flush deep venous catheters or peripheral trocars.
J Hosp Infect, 77 (2011), pp. 175-176
[14.]
D. Blossom, J. Noble-Wang, J. Su, S. Pur, R. Chemaly, A. Shams, et al.
Multistate outbreak of Serratia marcescens bloodstream infections caused by contamination of prefilled heparin and isotonic sodium chloride solution syringes.
Arch Intern Med, 169 (2009), pp. 1705-1711
[15.]
J.R. Su, D.B. Blossom, W. Chung, J.S. Gullion, N. Pascoe, G. Heseltine, et al.
Epidemiologic investigation of a 2007 outbreak of Serratia marcescens bloodstream infection in Texas caused by contamination of syringes prefilled with heparin and saline.
Infect Control Hosp Epidemiol, 30 (2009), pp. 593-595
[16.]
C.J. Yang, T.C. Chen, L.F. Liao, L. Ma, C.S. Wang, P.L. Lu, et al.
Nosocomial outbreak of two strains of Burkholderia cepacia caused by contaminated heparin.
J Hosp Infect, 69 (2008), pp. 398-400
[17.]
M.B. Souza Dias, A.B. Habert, V. Borrasca, V. Stempliuk, A. Ciolli, M.R. Araujo, et al.
Salvage of long-term central venous catheters during an outbreak of Pseudomonas putida and Stenotrophomonas maltophilia infections associated with contaminated heparin catheter-lock solution.
Infect Control Hosp Epidemiol, 29 (2008), pp. 125-130
[18.]
E. Prospero, P. Barbadoro, S. Savini, E. Manso, I. Annino, M.M. D’Errico.
Cluster of Pseudomonas aeruginosa catheter-related bloodstream infections traced to contaminated multidose heparinized saline solutions in a medical ward.
Int J Hyg Environ Health, 209 (2006), pp. 553-556
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