Article information
Resumen
Las infecciones por levaduras del género Candida sp. son cada vez más prevalentes en pacientes hospitalizados, especialmente en grupos de mayor riesgo como pueden ser pacientes con neoplasia hematológica bajo tratamiento de quimioterapia y en cuidados intensivos. La resistencia de Candida sp. representa un reto terapéutico que deja un menor número de posibilidades para el tratamiento de estas infecciones que se caracterizan, a su vez, por una alta morbimortalidad. Esta revisión describe los mecanismos de resistencia de Candida sp. a fluconazol y los factores de riesgo para la adquisición de éstos.
Palabras claves:
fluconazol
Candida
Candida albicans
Resistencia a medicamentos
Farmacorresistencia microbiana
Resistencia a múltiples medicamentos
Farmacorresistencia micótica
Abstract
Yeast infections of the genus Candida sp are becoming more prevalent in hospitalized patients, especially in high risk groups such as patients with hematologic malignancy undergoing chemotherapy and in intensive care units. Candida sp's resistance represents a therapeutic challenge that leaves fewer opportunities for the treatment of these infections which are characterized by high morbidity and mortality. This review describes Candida sp's resistance mechanisms to fluconazole and the risk factors for their acquisition.
Key words:
Fluconazole
Candida
Candida albicans
therapeutic use
Drug Resistance
Microbial Drug Resistance
Multiple Drug Resistance
Fungal Drug Resistance
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