Article information
Resumen
El desarrollo de las células linfoides a partir de células troncales hematopoyéticas es un proceso organizado en el que se pierden gradualmente múltiples potenciales de diferenciación alternos; y coinciden el compromiso de linaje y la ganancia de funciones especializadas. En los últimos años se han registrado avances notables en la caracterización de los progenitores primitivos que dan inicio al programa linfoide, y en la definición de los patrones de actividad transcripcional que controlan las decisiones del linaje, aunque está poco definida la relación entre las señales ambientales y la estabilidad de la ruta de diferenciación linfoide. Esta revisión bibliográfica pretende proporcionar un panorama claro del conocimiento actual en los eventos tempranos de la linfopoyesis y su interrelación con el microambiente hematopoyético.
Palabras clave:
Progenitores linfoides
Compromiso de linaje linfoide
Médula ósea
Linfopoyesis temprana
Nicho hematopoyético
Abstract
Development of lymphoid cells from hematopoietic stem cells is an ordered process where multiple alternate lineage potentials are gradually lost and lineage commitment is coincident with gain of specialized functions. Over the last few years remarkable advances have been made in characterizing primitive progenitors that initiate the lymphoid program, and patterns of transcriptional activity controlling lineage fate decisions during normal hematopoiesis, but less is known about environmental signals that may influence the differentiation pathway stability. This review discusses the current knowledge with relevance to hierarchy and early events in lymphopoiesis and their relationship to hematopoietic microenvironment.
Key words:
Lymphoid progenitors
Lymphoid lineage commitment
Adult bone marrow
Early lymphopoiesis
Hematopoietic niche
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