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Inicio Medicina Clínica (English Edition) Monoclonal gammopathy of uncertain significance
Journal Information
Vol. 161. Issue 5.
Pages 217-224 (September 2023)
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Vol. 161. Issue 5.
Pages 217-224 (September 2023)
Review
Monoclonal gammopathy of uncertain significance
Gammapatía monoclonal de significado incierto
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3
Elena Alejo, Borja Puertas, María-Victoria Mateos
Corresponding author
mvmateos@usal.es

Corresponding author.
Hospital Universitario de Salamanca/Instituto de Investigación Biomédica de Salamanca (IBSAL)/Centro Investigación del Cáncer-IBMCC (USAL-CSIC), Salamanca, Spain
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Tables (3)
Table 1. MGUS diagnostic criteria and risk of progression (IMWG 2014).
Table 2. Prognostic indices of MGUS.
Table 3. Recommendations in the follow-up of MGUS.
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Abstract

Monoclonal gammopathy of uncertain significance is a premalignant plasma cell neoplasm with a high prevalence in the population over 50 years of age and an annual risk of progression of 1%. Multiple recent studies have led to advances in understanding both the pathogenesis of these disorders and their risk of progression to other diseases. Patients require lifelong follow-up, and a multidisciplinary and risk-adapted approach is essential. In recent years, an increasing number of entities associated with a paraprotein, known as clinically significant monoclonal gammopathies, have been recognized.

Keywords:
Monoclonal gammopathy of uncertain significance
Screening
Prognosis
Resumen

La gammapatía monoclonal de significado incierto es una neoplasia de células plasmáticas premaligna, con una elevada prevalencia en la población mayor de 50 años y un riesgo anual de progresión del 1%. Numerosos estudios recientes han permitido un avance en la compresión de la patogenia de estos trastornos y su riesgo de progresión a otras enfermedades. Los pacientes requieren un seguimiento de por vida, siendo fundamental un enfoque multidisciplinar y adaptado al riesgo. En los últimos años, cada vez se reconocen más entidades asociadas a la presencia de una paraproteína, conocidas como gammapatías monoclonales de significado clínico.

Palabras clave:
Gammapatía monoclonal de significado incierto
Screening
Pronóstico

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