metricas
covid
Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Amyloidosis complicating spondyloarthropathies: Study of 15 cases
Journal Information
Vol. 145. Issue 8.
Pages 327-331 (October 2015)
Share
Share
Download PDF
More article options
Visits
4
Vol. 145. Issue 8.
Pages 327-331 (October 2015)
Original article
Amyloidosis complicating spondyloarthropathies: Study of 15 cases
Amiloidosis secundaria a espondiloartritis: estudio de 15 casos
Visits
4
Samantha Rodríguez-Muguruzaa,
Corresponding author
Sam63100@hotmail.com

Corresponding author.
, Melania Martínez-Morilloa, Susana Holgadoa, Xavier Saenz-Sardab, Lourdes Mateoa, Xavier Tenaa, Alejandro Olivéa
a Servicio de Reumatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (3)
Table 1. Clinical and analytical characteristics of 15 patients with spondyloarthropathy and secondary amyloidosis.
Table 2. Case selection algorithm.
Table 3. Relevant cases of spondyloarthritis and secondary amyloidosis described in literature.
Show moreShow less
Abstract
Background and objective

Secondary amyloidosis (AA) is a rare complication of rheumatic diseases.

Objective

The aim of this study was to determine the frequency of symptomatic amyloidosis AA in patients with spondyloarthropathy.

Patients and method

Retrospective study (1984–2013). We reviewed the medical records of patients with spondyloarthropathy who had a histological diagnosis of amyloidosis AA (15 patients).

Results

We identified 1.125 patients with spondyloarthropathies. Fifteen (1.3%) patients with amyloidosis AA were recruited. It was suspected in 14 patients (93.3%) because of nephrotic syndrome in most of them: 14 were symptomatic (93.3%): 5 (33.3%) ankylosing spondylitis (AS), 5 (33.3%) spondylitis associated with inflammatory bowel diseases (IBD), 4 (26.7%) psoriatic arthritis, and one (6.7%) reactive arthritis. The mean disease duration was 23.9 years. Mortality after one and 5 years of follow-up was 30 and 50% respectively.

Conclusions

The frequency of clinical amyloidosis AA in our patients was 1.3%. There was a marked male predominance, with AS or IBD. Clinical amyloidosis was diagnosed at a relatively late stage in spondyloarthropathy.

Keywords:
Secondary amyloidosis
Spondyloarthropathy
Renal failure
Resumen
Fundamento y objetivo

La amiloidosis secundaria (AA) es una complicación de enfermedades inflamatorias crónicas tales como las enfermedades reumáticas. El objetivo de este estudio fue evaluar la prevalencia de amiloidosis AA en una serie retrospectiva de pacientes con espondiloartritis.

Pacientes y método

Estudio retrospectivo entre 1984-2013. Se revisaron las historias clínicas de los pacientes con diagnóstico de espondiloartritis y amiloidosis AA.

Resultados

Se identificaron 1.125 pacientes con espondiloartritis. Quince (1,3%) presentaban amiloidosis AA: 14 (93,3%) fueron sintomáticos, en la mayoría de ellos se presentó como síndrome nefrótico. Cinco (33,3%) estaban diagnosticados de espondilitis anquilosante (EA), 5 (33,3%) de espondiloartritis asociada a enfermedad inflamatoria intestinal (EII), 4 (26,7%) de artritis psoriásica y uno (6,7%) de artritis reactiva. La media de edad de evolución desde el diagnóstico de espondiloartritis hasta el diagnóstico de amiloidosis AA fue de 23,9 años. La mortalidad al año y a los 5 años fue del 30 y 50%, respectivamente.

Conclusiones

En este estudio retrospectivo de pacientes con espondiloartritis, la prevalencia de amiloidosis AA sintomática fue del 1,24%. La mayoría fueron varones con una EA o espondiloartritis asociada a EII de larga evolución. El motivo más frecuente de sospecha del desarrollo de amiloidosis AA fue el síndrome nefrótico.

Palabras clave:
Amiloidosis secundaria
Espondiloartritis
Insuficiencia renal

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Clínica (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.medcle.2020.01.010
No mostrar más