array:24 [ "pii" => "S2387020621002692" "issn" => "23870206" "doi" => "10.1016/j.medcle.2020.04.050" "estado" => "S300" "fechaPublicacion" => "2021-07-09" "aid" => "5257" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;157:45" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0025775320303845" "issn" => "00257753" "doi" => "10.1016/j.medcli.2020.04.037" "estado" => "S300" "fechaPublicacion" => "2021-07-09" "aid" => "5257" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;157:45" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>" "titulo" => "Manifestaciones clínicas del neuro-Behçet" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "45" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical features of neuro-Behçet" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ricardo Gomez de la Torre, Lilyan Consuelo Charca-Benavente, Luis Caminal-Montero" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Ricardo" "apellidos" => "Gomez de la Torre" ] 1 => array:2 [ "nombre" => "Lilyan" "apellidos" => "Consuelo Charca-Benavente" ] 2 => array:2 [ "nombre" => "Luis" "apellidos" => "Caminal-Montero" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020621002692" "doi" => "10.1016/j.medcle.2020.04.050" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621002692?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320303845?idApp=UINPBA00004N" "url" => "/00257753/0000015700000001/v1_202106240818/S0025775320303845/v1_202106240818/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2387020621002679" "issn" => "23870206" "doi" => "10.1016/j.medcle.2020.04.049" "estado" => "S300" "fechaPublicacion" => "2021-07-09" "aid" => "5252" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;157:45-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Non-immune haemolytic anaemia in a patient with acute hepatitis B" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "45" "paginaFinal" => "46" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Anemia hemolítica no inmune en un paciente con hepatitis B aguda" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio Amo-Lozano, Julia Portilla-Tamarit, Joaquín Portilla" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Antonio" "apellidos" => "Amo-Lozano" ] 1 => array:2 [ "nombre" => "Julia" "apellidos" => "Portilla-Tamarit" ] 2 => array:2 [ "nombre" => "Joaquín" "apellidos" => "Portilla" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775320303705" "doi" => "10.1016/j.medcli.2020.04.033" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320303705?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621002679?idApp=UINPBA00004N" "url" => "/23870206/0000015700000001/v1_202107030650/S2387020621002679/v1_202107030650/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2387020621002709" "issn" => "23870206" "doi" => "10.1016/j.medcle.2020.04.051" "estado" => "S300" "fechaPublicacion" => "2021-07-09" "aid" => "5260" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;157:44" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Dopamine-producing adrenal medulla hyperplasia associated with Conn syndrome. An unusual coexistence of refractory hypertension" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "44" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hiperplasia de médula suprarrenal productora de dopamina asociada a síndrome de Conn. Una inusual coexistencia de hipertensión arterial refractaria" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan José Ruiz-Manzanera, Beatriz Febrero, José M. Rodríguez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Juan José" "apellidos" => "Ruiz-Manzanera" ] 1 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Febrero" ] 2 => array:2 [ "nombre" => "José M." "apellidos" => "Rodríguez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775320303870" "doi" => "10.1016/j.medcli.2020.04.040" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320303870?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621002709?idApp=UINPBA00004N" "url" => "/23870206/0000015700000001/v1_202107030650/S2387020621002709/v1_202107030650/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Clinical features of neuro-Behçet" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "45" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ricardo Gomez de la Torre, Lilyan Consuelo Charca-Benavente, Luis Caminal-Montero" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Ricardo" "apellidos" => "Gomez de la Torre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Lilyan Consuelo" "apellidos" => "Charca-Benavente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "nombre" => "Luis" "apellidos" => "Caminal-Montero" "email" => array:1 [ 0 => "lcaminal@yahoo.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Enfermedades Autoinmunes Sistémicas, Medicina Interna, Hospital Universitario Central de Asturias, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Reumatología, Hospital Universitario Central de Asturias, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Manifestaciones clínicas del neuro-Behçet" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We have reviewed with interest the paper by Toledo-Samaniego et al.,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> on the neurological manifestations of Behçet's disease (BD), also called Neuro-Behçet's disease (NBD). In it, they report their experience and analyse 55 episodes of NBD in 25 patients out of a series of 57 with BD in a tertiary hospital in Madrid over 13 years.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We have similarly and almost simultaneously reported our experience throughout the period 1981–2018<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> from our Autoimmune and Systemic Diseases Unit, also from Internal Medicine.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Our study only reports 10 cases with NBD in 39 patients with BD. We did not observe any differential characteristic or clinical-biological marker characteristic in NBD, although ocular inflammatory involvement was significantly higher in isolated BD, as if this involvement, even when associated with HLA B-51, were a protective factor for not developing NBD.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the interest of complementing the study by Toledo-Samaniego et al.,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> it seems worth mentioning other unique and clinically interesting forms of presentation that were not observed in their series. There is a "pseudotumor" presentation located in the brainstem, which on MRI appears as a mass effect with contrast uptake in the form of annular enhancement. Most of these cases are diagnosed after a biopsy of the lesion. Our only patient with this manifestation<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> began with symptoms of progressive bulbar syndrome; after treatment with corticosteroids, the imaging controls showed a significant decrease in the size of the lesion, but this patient was the only one with a significant motor disability in his progression. Cerebral venous sinus thrombosis (CVST) has also been reported, in up to 5–10% of patients. A thrombophilic state underlies BD and several types of vascular manifestations and CVST and pulmonary artery thrombosis<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a> can coexist in the same individual, as in a patient in our cohort who suffered a CVST, and at 2 years presented with bilateral pulmonary artery thrombosis only attributable to BD. Finally, there are also forms of presentation that are clinically and radiologically similar to multiple sclerosis, with a complex diagnosis, as in another patient studied by us.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The diagnosis of NBD implies the presence of neurological symptoms in BD that cannot be explained by other causes, without the existence of specific clinical-biological markers, making its diagnosis and follow-up complex, with joint work with neurologists and neuroradiologists being essential.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Gomez de la Torre R, Charca-Benavente LC, Caminal-Montero L. Manifestaciones clínicas del neuro-Behçet. Med Clin (Barc). 2021;157:45.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manifestaciones neurológicas en la enfermedad de Behçet: estudio de 57 pacientes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Toledo-Samaniego" 1 => "F. Galeano Valle" 2 => "P. Ascanio Palomares" 3 => "B. González Martínez" 4 => "A. Valencia Kruszyna" 5 => "P. Demelo- Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.med cli.2019.11.004" "Revista" => array:3 [ "tituloSerie" => "Med Clin (Barc)." "fecha" => "2019" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7603093" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedad de neuro- Behçet en el Hospital Universitario Central de Asturias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L.C. Charca-Benavente" 1 => "R. Gómez de la Torre" 2 => "L. Caminal-Montero" 3 => "R. Coto-Hernández" 4 => "D. Colunga-Argüelles" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.reuma.2019. 03.005" "Revista" => array:2 [ "tituloSerie" => "Reumatol Clin." "fecha" => "2019" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuro-Behçet disease: Epidemiology, clinical characteristics and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Al-Araji" 1 => "D.P. Kidd" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1474-4422(09)70015-8" "Revista" => array:6 [ "tituloSerie" => "Lancet Neurol." "fecha" => "2009" "volumen" => "8" "paginaInicial" => "192" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19161910" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The spectrum of nervous system involvement in Behçet’s syndrome and its differential diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Siva" 1 => "S. Saip" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00415-009-0145-6" "Revista" => array:6 [ "tituloSerie" => "J Neurol." "fecha" => "2009" "volumen" => "256" "paginaInicial" => "513" "paginaFinal" => "529" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19444529" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurological complications of Beçhet’s syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.P. Kid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00415-017-8436-9" "Revista" => array:6 [ "tituloSerie" => "J Neurol." "fecha" => "2017" "volumen" => "264" "paginaInicial" => "2178" "paginaFinal" => "2183" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28283819" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015700000001/v1_202107030650/S2387020621002692/v1_202107030650/en/main.assets" "Apartado" => array:4 [ "identificador" => "43309" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015700000001/v1_202107030650/S2387020621002692/v1_202107030650/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621002692?idApp=UINPBA00004N" ]
Journal Information
Vol. 157. Issue 1.
Pages 45 (July 2021)
Share
Download PDF
More article options
Vol. 157. Issue 1.
Pages 45 (July 2021)
Letter to the Editor
Clinical features of neuro-Behçet
Manifestaciones clínicas del neuro-Behçet
Visits
5
This item has received
Article information
These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscribe
Purchase
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail