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Inicio Medicina Clínica (English Edition) Microvascular thrombosis and clinical implications
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Vol. 156. Issue 12.
Pages 609-614 (June 2021)
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Vol. 156. Issue 12.
Pages 609-614 (June 2021)
Review
Microvascular thrombosis and clinical implications
Trombosis microvascular y sus implicaciones clínicas
Visits
4
José A. Páramo
Servicio de Hematología, Clínica Universidad de Navarra, IdiSNA, CIBERCV, Pamplona, Navarra, Spain
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Tables (4)
Table 1. Vascular endothelium thromboregulatory mechanisms.
Table 2. Diseases associated with microvascular thrombosis.
Table 3. PLASMIC index for the diagnosis of thrombocytopenic thrombotic purpura.
Table 4. HIT Clinical Probability Index (4 Ts).
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Abstract

Thrombosis is often present in the microcirculation in a variety of significant human diseases, such as disseminated intravascular coagulation, thrombotic microangiopathy, sickle cell disease, and others. Further, microvascular thrombosis has recently been demonstrated in patients with COVID-19, and has been proposed to mediate the pathogenesis of organ injury in the lung and other organs. In many of these conditions, microvascular thrombosis is accompanied by inflammation, an association referred to as thromboinflammation or immunothrombosis. A greater understanding of the links between inflammation and thrombosis in the microcirculation will provide new therapeutic options for human diseases accompanied by microvascular thrombosis.

Keywords:
Microvascular thrombosis
Thrombotic microangiopathies
Disseminated intravascular coagulation
Immunothrombosis
COVID-19
Plasma exchange
Resumen

La trombosis en la microcirculación está presente en numerosas situaciones clínicas, como coagulación intravascular diseminada, microangiopatía trombótica o anemia falciforme, entre otras. Asimismo, se ha demostrado trombosis microvascular en pacientes con COVID-19 como un mecanismo patogénico implicado en la lesión tisular pulmonar y de otros órganos. La trombosis microvascular se acompaña frecuentemente de inflamación, una asociación conocida como tromboinflamación o inmunotrombosis. El conocimiento de las interacciones entre inflamación y trombosis abre nuevas perspectivas en el tratamiento de enfermedades que cursan con trombosis microvascular.

Palabras clave:
Trombosis microvascular
Microangiopatías trombóticas
Coagulación intravascular diseminada
Inmunotrombosis
COVID-19
Recambio plasmático

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