metricas
covid
Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Nodular regenerative hyperplasia associated with common variable immunodeficienc...
Journal Information
Vol. 146. Issue 6.
Pages 263-266 (March 2016)
Share
Share
Download PDF
More article options
Visits
2
Vol. 146. Issue 6.
Pages 263-266 (March 2016)
Clinical note
Nodular regenerative hyperplasia associated with common variable immunodeficiency and other comorbidities
Hiperplasia nodular regenerativa hepática asociada a inmunodeficiencia común variable y a otras comorbilidades
Visits
2
Rafael Leóna,
Corresponding author
leonr86@hotmail.com

Corresponding author.
, Rosario Sánchez-Martíneza, José M. Palazónb,c, Artemio Payád, José M. Ramosa,c, Héctor Pinargotea
a Servicio de Medicina Interna, Hospital General Universitario de Alicante, Alicante, Spain
b Servicio de Medicina Digestiva, Hospital General Universitario de Alicante, Alicante, Spain
c Departamento de Medicina Clínica, Universidad Miguel Hernández, Elche, Alicante, Spain
d Servicio de Anatomía Patológica, Hospital General Universitario de Alicante, Alicante, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Tables (2)
Table 1. Characteristics of patients with regenerative nodular hyperplasia.
Table 2. Characteristics of patients with common variable immunodeficiency compared to those with other comorbidities.
Show moreShow less
Abstract
Background and objective

Currently, there are not many data on the evolution of nodular regenerative hyperplasia (NRH) associated or not with underlying diseases and in particular that associated with common variable inmunodeficiency (CVID). Twenty cases of NRH are presented, and the differences between the cases associated with CVID and those related to other diseases are analysed.

Methods

Retrospective and descriptive study over a period of 14 years.

Results

Twelve out of the 20 patients were men; the median age was 51 years. CVID was the main illness associated with NRH. In patients with CVID and NRH, gastrointestinal haemorrhage was more common, all the patients had high gamma glutamyl transferase and alkaline phosphatase and none had altered albumin and bilirubin levels compared to the patients without CVID. On follow-up, 50% of patients with CVID (2/4) had died compared to 33.3% (5/15) without CVID.

Conclusions

NRH in patients with CVID seems to have more biochemical data of anicteric cholestasis and portal hypertension and could be associated with lower survival.

Keywords:
Nodular regenerative hyperplasia
Common variable immunodeficiency
Portal hypertension
Resumen
Fundamento y objetivo

Actualmente no se dispone de muchos datos sobre la evolución de la hiperplasia nodular regenerativa (HNR) asociada o no a enfermedades de base, y en concreto de la asociada a inmunodeficiencia común variable (IDCV). Se presentan 20 casos de HNR y se analizan las diferencias entre los casos asociados a IDCV y los relacionados con otras enfermedades.

Métodos

Estudio retrospectivo y descriptivo durante un período de 14 años.

Resultados

De los 20 pacientes, 12 eran hombres; la mediana de edad fue de 51 años. La IDCV fue la principal enfermedad asociada con HNR. En los pacientes con IDCV y HNR la hemorragia gastrointestinal fue más común, todos tenían elevación de FA y GGT y ninguno tenía valores de albúmina y bilirrubina alterados comparados con los pacientes sin IDCV. De los pacientes con HNR en seguimiento han fallecido el 50% de los asociados a IDCV (2/4) frente al 33,3% (5/15) sin IDCV.

Conclusiones

La HNR en los pacientes con IDCV parece manifestarse más con datos bioquímicos de colestasis anictérica e hipertensión portal y podría asociar una supervivencia menor.

Palabras clave:
Hiperplasia nodular regenerativa
Inmunodeficiencia común variable
Hipertensión portal

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Clínica (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.medcle.2023.11.022
No mostrar más