array:23 [ "pii" => "S2387020624003607" "issn" => "23870206" "doi" => "10.1016/j.medcle.2023.12.028" "estado" => "S300" "fechaPublicacion" => "2024-09-13" "aid" => "6552" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2024" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2024;163:e66" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0025775324000617" "issn" => "00257753" "doi" => "10.1016/j.medcli.2023.12.019" "estado" => "S300" "fechaPublicacion" => "2024-09-13" "aid" => "6552" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2024;163:e66" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imagen médica</span>" "titulo" => "Plasmocitoma del seno maxilar en paciente con mieloma múltiple refractario" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e66" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Plasmacytoma of the maxillary sinus in a patient with refractory multiple myeloma" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 295 "Ancho" => 833 "Tamanyo" => 56396 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Miguel Antonio Lasheras-Pérez, Ignacio Torres-Navarro, Javier López-Davia" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Miguel" "apellidos" => "Antonio Lasheras-Pérez" ] 1 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Torres-Navarro" ] 2 => array:2 [ "nombre" => "Javier" "apellidos" => "López-Davia" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020624003607" "doi" => "10.1016/j.medcle.2023.12.028" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020624003607?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775324000617?idApp=UINPBA00004N" "url" => "/00257753/0000016300000005/v1_202408300438/S0025775324000617/v1_202408300438/es/main.assets" ] ] "itemAnterior" => array:19 [ "pii" => "S2387020624003590" "issn" => "23870206" "doi" => "10.1016/j.medcle.2023.12.027" "estado" => "S300" "fechaPublicacion" => "2024-09-13" "aid" => "6551" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2024;163:e65" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in medicine</span>" "titulo" => "Bisalbuminemia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e65" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Bisalbuminemia" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 579 "Ancho" => 600 "Tamanyo" => 12849 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio Rosales-Castillo" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Antonio" "apellidos" => "Rosales-Castillo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775324000605" "doi" => "10.1016/j.medcli.2023.12.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775324000605?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020624003590?idApp=UINPBA00004N" "url" => "/23870206/0000016300000005/v1_202409110904/S2387020624003590/v1_202409110904/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in medicine</span>" "titulo" => "Plasmacytoma of the maxillary sinus in a patient with refractory multiple myeloma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e66" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Miguel Antonio Lasheras-Pérez, Ignacio Torres-Navarro, Javier López-Davia" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Miguel Antonio" "apellidos" => "Lasheras-Pérez" ] 1 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Torres-Navarro" ] 2 => array:4 [ "nombre" => "Javier" "apellidos" => "López-Davia" "email" => array:1 [ 0 => "jaloda81@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología y Venereología, Hospital Universitario y Politécnico la Fe, Valencia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Plasmocitoma del seno maxilar en paciente con mieloma múltiple refractario" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 404 "Ancho" => 1007 "Tamanyo" => 151958 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 57-year-old man with progressive multiple myeloma after the administration of 8 regimens, including bortezomib-thalidomide-dexamethasone, daratumumab-pomalidomide-dexamethasone, hyper-CVAD (cyclophosphamide-vincristine-adriamycin-dexamethasone) and selinexor-dexamethasone. One month earlier he presented with an increase in the volume of his right cheek (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A) with a stony mass painful on palpation. The CT scan showed a mass, overlying the right maxillary sinus (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B, asterisks), with thinning of its wall. A skin biopsy was performed, in which the skin was normal and a brownish tissue composed of plasmacytoid-like cells with chromatin arranged in a cartwheel pattern was identified in the sample bed (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A, arrows). Immunohistochemistry was strongly positive for CD138 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B, arrows), and negative for CD3 and CD20, allowing for the diagnosis of plasmacytoma.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Extramedullary plasmacytomas arise when tumour cells extend beyond the bone cortex. First-line treatments include alkylating agents, anti-CD38, immunomodulators and proteasome inhibitors. In this case, an external radiotherapy and melflufen/dexamethasone course was decided with a good response (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). Melflufen is a peptide-conjugated alkylating drug that has demonstrated efficacy in patients refractory to multiple lines of therapy.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical considerations</span><p id="par0015" class="elsevierStylePara elsevierViewall">Written consent was obtained from the patient for the dissemination of the images.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">No funding has been received for this work.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Ethical considerations" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Funding" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 295 "Ancho" => 833 "Tamanyo" => 56396 ] ] ] 1 => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 404 "Ancho" => 1007 "Tamanyo" => 151958 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000016300000005/v1_202409110904/S2387020624003607/v1_202409110904/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000016300000005/v1_202409110904/S2387020624003607/v1_202409110904/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020624003607?idApp=UINPBA00004N" ]
Journal Information
Vol. 163. Issue 5.
Pages e66 (September 2024)
Share
Download PDF
More article options
Vol. 163. Issue 5.
Pages e66 (September 2024)
Image in medicine
Plasmacytoma of the maxillary sinus in a patient with refractory multiple myeloma
Plasmocitoma del seno maxilar en paciente con mieloma múltiple refractario
Miguel Antonio Lasheras-Pérez, Ignacio Torres-Navarro, Javier López-Davia
Corresponding author
Servicio de Dermatología y Venereología, Hospital Universitario y Politécnico la Fe, Valencia, Spain
Article information
These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscribe
Purchase
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail