Systemic infection by Campylobacter in a patient with agammaglobulinemia

García Tellado, Álex; Herreras, Rosa; Riancho, José A.

doi:10.1016/j.medcle.2024.01.015

array:23 ["pii" => "S2387020624002547" "issn" => "23870206" "doi" => "10.1016/j.medcle.2024.01.015" "estado" => "S300" "fechaPublicacion" => "2024-07-12" "aid" => "6590" "copyrightAnyo" => "2024" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2024;163:49-50" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:18 [ "pii" => "S0025775324001428" "issn" => "00257753" "doi" => "10.1016/j.medcli.2024.01.020" "estado" => "S300" "fechaPublicacion" => "2024-07-12" "aid" => "6590" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2024;163:49-50" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "Carta al Editor" "titulo" => "Infección sistémica por Campylobacter en un paciente con agammaglobulinemia" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "49" "paginaFinal" => "50" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Systemic infection by Campylobacter in a patient with agammaglobulinemia" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Álex García Tellado, Rosa Herreras, José A. Riancho" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Álex" "apellidos" => "García Tellado" ] 1 => array:2 [ "nombre" => "Rosa" "apellidos" => "Herreras" ] 2 => array:2 [ "nombre" => "José A." "apellidos" => "Riancho" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020624002547" "doi" => "10.1016/j.medcle.2024.01.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020624002547?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775324001428?idApp=UINPBA00004N" "url" => "/00257753/0000016300000001/v1_202407010442/S0025775324001428/v1_202407010442/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2387020624002523" "issn" => "23870206" "doi" => "10.1016/j.medcle.2024.01.014" "estado" => "S300" "fechaPublicacion" => "2024-07-12" "aid" => "6589" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2024;163:50-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Letter to the Editor" "titulo" => "Adrenocortical oncocytoma: 3 case reports" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "50" "paginaFinal" => "51" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Oncocitoma suprarrenal: presentación de 3 casos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 988 "Ancho" => 2675 "Tamanyo" => 270339 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Left: abdominal CT scan performed in the emergency department, showing the adrenal mass (arrow). Right: macroscopic aspect of the adrenal mass showing the rupture of the tumour capsule (arrow)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Meritxell Viñes Raczkowski, Elena Mena Ribas, Guillermo Serra Soler" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Meritxell" "apellidos" => "Viñes Raczkowski" ] 1 => array:2 [ "nombre" => "Elena" "apellidos" => "Mena Ribas" ] 2 => array:2 [ "nombre" => "Guillermo" "apellidos" => "Serra Soler" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775324001416" "doi" => "10.1016/j.medcli.2024.01.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775324001416?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020624002523?idApp=UINPBA00004N" "url" => "/23870206/0000016300000001/v2_202407071325/S2387020624002523/v2_202407071325/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2387020624002511" "issn" => "23870206" "doi" => "10.1016/j.medcle.2024.01.013" "estado" => "S300" "fechaPublicacion" => "2024-07-12" "aid" => "6573" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2024;163:48-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "Letter to the Editor" "titulo" => "Spontaneous sigma perforation in patient with vascular Ehlers-Danlos syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "48" "paginaFinal" => "49" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Perforación espontánea de sigma en paciente con Ehlers-Danlos vascular" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marta González Bocanegra, Alba Manuel-Vázquez, José Luis Ramos Rodríguez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Marta" "apellidos" => "González Bocanegra" ] 1 => array:2 [ "nombre" => "Alba" "apellidos" => "Manuel-Vázquez" ] 2 => array:2 [ "nombre" => "José Luis" "apellidos" => "Ramos Rodríguez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775324000915" "doi" => "10.1016/j.medcli.2024.01.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775324000915?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020624002511?idApp=UINPBA00004N" "url" => "/23870206/0000016300000001/v2_202407071325/S2387020624002511/v2_202407071325/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Letter to the Editor" "titulo" => "Systemic infection by Campylobacter in a patient with agammaglobulinemia" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "49" "paginaFinal" => "50" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Álex García Tellado, Rosa Herreras, José A. Riancho" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Álex" "apellidos" => "García Tellado" "email" => array:1 [ 0 => "agt1695@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Rosa" "apellidos" => "Herreras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "José A." "apellidos" => "Riancho" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Marqués de Valdecilla, Santander, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto de Investigación Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, Santander, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Santander, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Infección sistémica por Campylobacter en un paciente con agammaglobulinemia" ] ] "textoCompleto" => "X-linked agammaglobulinaemia or Bruton’s disease is caused by the presence of a pathogenic variant in the Bruton’s Tyrosine Kinase (BTK) gene, which interferes with B-cell maturation and prevents the normal production of antibodies.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> As a result, patients often have infections and, paradoxically, an increased incidence of autoimmune phenomena. Bruton’s disease is an ultra-rare disease with a prevalence of about one case per million population. It manifests in males, with a hemizygous mutation. Heterozygous female carriers are usually asymptomatic. Standard treatment is periodic infusions of immunoglobulins; allotransplantation is reserved for selected cases.<a class="elsevierStyleCrossRef" href="#bib0005">1</a>We report the case of a 26-year-old male diagnosed with X-linked agammaglobulinaemia, due to a hemizygous mutation of the BTK gene, under treatment with periodic infusions of intravenous immunoglobulins. In the last 8 weeks he reported persistent fever with peaks of up to 38.5 °C, sweating and weight loss, with no other accompanying symptoms or relevant signs on examination.Laboratory tests showed a moderate elevation of acute phase reactants, with a C-reactive protein of 12 mg/dl (NR: <0.4 mg/dl) and ESR of 120 mm/h (NR: 0–22 mm/h). Likewise, discrete elevation of alkaline phosphatase of 278 UI/l (NR: 44–147 UI/l), normochromic microcytic anaemia without associated nutritional deficit (haemoglobin: 9.3 g/dl; NR: 13.2–16.6 g/dl) and lymphopenia. Initial microbiological screening, which included several blood culture determinations, as well as serology for hepatotropic viruses (HCV, HBV, EBV, CMV) and HIV were negative. Respiratory virus smears (SARS-CoV-2, influenza A and B) and sputum culture were also negative. A thoracoabdominal CT scan revealed hepatosplenomegaly as the only notable finding, and a PET/CT scan showed faint activity in the subdiaphragmatic lymph nodes and bone marrow. For all these reasons, and with the suspicion of a lymphoproliferative or hemophagocytic syndrome type complication, a bone marrow biopsy was performed, which ruled out these processes. However, Campylobacter jejuni grew in the bone marrow culture. Intravenous treatment with imipenem was started, followed by oral doxycycline for a total of 30 days. The clinical course was favourable, with resolution of fever and other manifestations.In addition to the rarity of the underlying disease, this case is exceptional for several reasons. Firstly, it is a systemic infection by a microorganism, Campylobacter, which is a relatively common cause of digestive tract infections, usually in the form of gastroenteritis or colitis, with or without rectal bleeding, but without systemic manifestations. In fact, only a few isolated cases of systemic Campylobacter infection in patients with agammaglobulinaemia have previously been reported.<a class="elsevierStyleCrossRefs" href="#bib0010">2–4</a> On the other hand, it is remarkable that the micro-organism was isolated from the bone marrow, while other samples, including blood cultures, were negative.In short, the case highlights the need to be alert to the possibility that patients with immunodeficiencies, despite receiving replacement therapy, may develop serious infections with atypical manifestations, either in unusual sites or disseminated by microorganisms that typically cause benign processes.Ethical considerationsInformed consent was obtained from the patient for publication of the case.FundingNo funding has been received.Conflict of interestThe authors declare that they have no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Ethical considerations" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Funding" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflict of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An international survey of allogeneic hematopoietic cell transplantation for X-linked agammaglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Nishimura" 1 => "R. Uppuluri" 2 => "R. Raj" 3 => "V.V. Swaminathan" 4 => "Y. Cheng" 5 => "R.F. Abu-Arja" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10875-023-01551-2" "Revista" => array:6 [ "tituloSerie" => "J Clin Immunol" "fecha" => "2023" "volumen" => "43" "paginaInicial" => "1827" "paginaFinal" => "1839" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/37454339" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrent Campylobacter jejuni bacteremia in a patient with hypogammaglobulinemia: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Kim" 1 => "J.A. Shin" 2 => "S.B. Han" 3 => "B. Cho" 4 => "D.C. Jeong" 5 => "J.H. Kang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MD.0000000000007238" "Revista" => array:6 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "2017" "volumen" => "96" "paginaInicial" => "e7238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28640123" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510720341857" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relapsing Campylobacter jejuni systemic infections in a child with X-linked agammaglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Ariganello" 1 => "G. Angelino" 2 => "A. Scarselli" 3 => "I. Salfa" 4 => "M. della Corte" 5 => "A. de Matteis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2013/735108" "Revista" => array:6 [ "tituloSerie" => "Case Rep Pediatr" "fecha" => "2013" "volumen" => "2013" "paginaInicial" => "735108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23862092" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510719316657" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "X-linked agammaglobulinemia: infection frequency and infection-related mortality in the USIDNET Registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. O’Toole" 1 => "D. Groth" 2 => "H. Wright" 3 => "F.A. Bonilla" 4 => "R.L. Fuleihan" 5 => "C. Cunningham-Rundles" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10875-022-01237-1" "Revista" => array:6 [ "tituloSerie" => "J Clin Immunol" "fecha" => "2022" "volumen" => "42" "paginaInicial" => "827" "paginaFinal" => "836" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35288819" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000016300000001/v2_202407071325/S2387020624002547/v2_202407071325/en/main.assets" "Apartado" => array:4 [ "identificador" => "43309" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000016300000001/v2_202407071325/S2387020624002547/v2_202407071325/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020624002547?idApp=UINPBA00004N"]

ISSN: 2387-0206

Launched in 1943, Medicina Clínica is a fortnightly journal aimed at the promotion of clinical research and practice among internal medicine and other specialists. The key characteristics of Medicina Clínica are the scientific and methodological rigor of its manuscripts, the topicality of its contents, and, especially, its practical focus with highly useful information for clinical practice. Medicina Clínica is predominantly interested in publishing original research manuscripts, which are rigorously selected according to their quality, originality, and interest, and also in continued medical education-oriented manuscripts, which are commissioned by the journal to relevant authors (Editorials, Reviews, and Diagnosis and Treatment). These manuscripts contain updated topics with a major clinical or conceptual relevance in modern medicine. The journal adheres to the standards of academic research publications in all aspects including peer-review and ethical principles. Medicina Clínica is included in the General and Internal Medicine category of Thomson Reuters.

See more Open Access Option

Indexed in:

Current Contents/Clinical Medicine, Journal Citation Reports, SCI-Expanded, Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME, MEDES, PASCAL, SCOPUS, SciVerse ScienceDirect

Subscribe:

Impact factor

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.

© Clarivate Analytics, Journal Citation Reports 2022

Impact factor 2023

2.6

Citescore

CiteScore measures average citations received per document published.

Citescore 2023

3.1

SJR

SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.

SJR 2023

0.371

SNIP

SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.

SNIP 2023

0.511

View more metrics

Journal Information

Previous article | Next article

Vol. 163. Issue 1.

Pages 49-50 (July 2024)

Lee este artículo en Español

Export reference

Download PDF

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)

Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”

Subscribe to

Medicina Clínica (English Edition)

More information

Purchase

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now

Contact

Phone for subscriptions and reporting of errors

From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.

Calls from Spain

932 415 960

Calls from outside Spain

+34 932 415 960

E-mail

atencionalcliente@elsevier.com

Publish in

Medicina Clínica

Tools

Free access articles

Associations of physical activity, sedentary time,...

Med Clin. 2024;163:327-35

Burden of COVID-19 variant omicron in immunocompromised...

Med Clin. 2024;163:347-59

Raynaud phenomenon in a baseball...

Med Clin. 2024;163:e79

Medicina Clínica (English Edition) follows the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals

Indexed in:

Follow us:

Subscribe:

Article

Subscribe to our newsletter