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A wide complementary study was conducted, including a skin biopsy, which revealed the presence of multiple intravascular hyaline thrombi with absence of inflammation (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Electrophoresis and immunofixation of proteins in blood and urine showed the existence of a stable IgG-lambda monoclonal component in 2<span class="elsevierStyleHsp" style=""></span>g/dl. Hepatotropic virus serology was negative. The study of autoimmunity, thrombophilia, bone and bone marrow series was normal. Cryoglobulin determination in peripheral blood was positive. Given these findings, the patient was diagnosed with Type I cryoglobulinemia. The term cryoglobulinemia describes a set of entities defined by the presence of immunoglobulins which precipitate in the cold. There are 3 types depending on monoclonality or polyclonality, as well as on rheumatoid factor positivity, showing different levels of severity and systemic involvement.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ortiz-Prieto A, Cabrera-Fuentes R, Zulueta Dorado T, Conejo-Mir J. Crioglobulinemia tipo I. 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Journal Information
Vol. 148. Issue 6.
Pages 290 (March 2017)
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Vol. 148. Issue 6.
Pages 290 (March 2017)
Image in medicine
Type I cryoglobulinemia
Crioglobulinemia tipo I
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