array:22 [ "pii" => "S0025775303738251" "issn" => "00257753" "doi" => "10.1016/S0025-7753(03)73825-1" "estado" => "S300" "fechaPublicacion" => "2003-01-01" "aid" => "73825" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2003" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2003;120:721-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2136 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1832 "PDF" => 298 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775303738263" "issn" => "00257753" "doi" => "10.1016/S0025-7753(03)73826-3" "estado" => "S300" "fechaPublicacion" => "2003-01-01" "aid" => "73826" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2003;120:725-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 475 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 281 "PDF" => 187 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Prevalence of infections by hepatitis A, B, C and E viruses in two different socioeconomic groups of children from Santa Cruz, Bolivia" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "725" "paginaFinal" => "727" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prevalencia de las infecciones de los virus A, B, C y E de la hepatitis en dos grupos de niños de nivel socioeconómico distinto de Santa Cruz, Bolivia" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Giuseppe M. Gandolfo, Giovanni M. Ferri, Laura Conti, Anna Antenucci, Rosalia Marrone, Anna M. Frasca, Gaetano Vitelli" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Giuseppe M." "apellidos" => "Gandolfo" ] 1 => array:2 [ "nombre" => "Giovanni M." "apellidos" => "Ferri" ] 2 => array:2 [ "nombre" => "Laura" "apellidos" => "Conti" ] 3 => array:2 [ "nombre" => "Anna" "apellidos" => "Antenucci" ] 4 => array:2 [ "nombre" => "Rosalia" "apellidos" => "Marrone" ] 5 => array:2 [ "nombre" => "Anna M." "apellidos" => "Frasca" ] 6 => array:2 [ "nombre" => "Gaetano" "apellidos" => "Vitelli" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775303738263?idApp=UINPBA00004N" "url" => "/00257753/0000012000000019/v1_201307291713/S0025775303738263/v1_201307291713/en/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Aumento de la rentabilidad diagnóstica en la enfermedad meningocócica mediante la técnica de reacción en cadena de la polimerasa" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "721" "paginaFinal" => "724" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carmen Muñoz-Almagro, Antonio Palomeque, Joan Roca, Amadeo Gené, Edgar Palacín, Cristina Latorre" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Carmen" "apellidos" => "Muñoz-Almagro" "email" => array:1 [ 0 => "cma@hsjdbcn.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Antonio" "apellidos" => "Palomeque" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Joan" "apellidos" => "Roca" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Amadeo" "apellidos" => "Gené" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Edgar" "apellidos" => "Palacín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Cristina" "apellidos" => "Latorre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Microbiología. Hospital Universitario Sant Joan de Déu. Esplugues. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Pediatría. Hospital Universitario Sant Joan de Déu. Esplugues. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Servicio de Microbiología. Hospital Sant Joan de Déu. P.° Sant Joan de Déu, 2. 08950 Esplugues. Barcelona. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Diagnosis of meningococcal disease by polymerase chain reaction" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-10-17" "fechaAceptado" => "2003-02-11" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222773" "palabras" => array:4 [ 0 => "PCR" 1 => "Enfermedad meningocócica" 2 => "Pediatría" 3 => "Diagnóstico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec222772" "palabras" => array:4 [ 0 => "PCR" 1 => "Meningococcal disease" 2 => "Pediatrics" 3 => "Diagnosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento Y Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo del presente estudio fue evaluar la utilidad de una técnica de reacción en cadena de la polimerasa (PCR) rápida y sencilla para el diagnóstico de la enfermedad meningocócica.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Desde enero de 1999 hasta junio de 2002 se realizó un estudio retrospectivo en 110 muestras de líquido cefalorraquídeo o plasma de 110 pacientes pediátricos atendidos en el Hospital Sant Joan de Déu de Barcelona. Para la inclusión de estos pacientes en el estudio se revisó el diagnóstico de alta hospitalaria y se seleccionó a 43 pacientes con diagnóstico de enfermedad meningocócica (13 meningitis, 12 sepsis y 18 sepsis con meningitis) y 67 pacientes con otros diagnósticos que descartaban clínicamente la etiología meningocócica. Las muestras se procesaron por estudio microbiológico convencional (tinción de Gram, hemocultivo y cultivo de líquido cefalorraquídeo) y por técnica de PCR amplificando un fragmento de ADN de la secuencia de inserción IS1106 específica de <span class="elsevierStyleItalic">Neisseria meningitidis</span>.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La sensibilidad de la PCR en el grupo de pacientes diagnosticados clínicamente de enfermedad meningocócica fue del 93%, mientras que la sensibilidad del cultivo fue del 55,8%. En 19 pacientes las muestras se procesaron una vez instaurado el tratamiento con antibióticos betalactámicos (intervalo: 8-144 h) siendo positiva la PCR en 17 de ellos (sensibilidad del 89,4%) y el cultivo en dos (sensibilidad del 10,5%). Se detectó un falso positivo de la PCR en el grupo de pacientes en los que se descartó clínicamente la enfermedad (especificidad del 98,5%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La PCR ensayada es una técnica rápida (duración aproximada de 5 h), sensible y específica que incrementa la confirmación microbiológica de la enfermedad meningocócica, en especial en los pacientes que han recibido tratamiento antibiótico previo.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The objective of the present study was to evaluate the application of a rapid and simple PCR technique to diagnose meningococcal disease.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A retrospective study was undertaken from January 1999 to June 2002, comprising 110 samples of cerebrospinal fluid (CSF) or plasma from 110 different pediatric patients attending the Hospital Sant Joan de Deu of Barcelona. The selection of patients was based on their diagnosis at discharge: Forty three patients had a discharge diagnose of meningococcal disease (13 meningitis, 12 sepsis and 18 sepsis with meningitis) while 67 had clinical conditions other than meningococcal disease. The samples were processed following standard bacteriological methods (Gram smear and culture) and a PCR technique designed to amplify a segment of the meningococcal insertion sequence IS1106 was performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Sensitivity of PCR in the group of patients with a clinical diagnosis of meningococcal disease was 93% while sensitivity of the culture was 55.8%. Samples from 19 patients were processed once treatment with β-lactam antibiotics had begun (range 8-144 hours), and positive PCR results were seen in 17 cases (sensitivity: 89.4%); a positive culture was observed in two cases of pre-treated patients (sensitivity 10.5%). A false positive result was detected in the group of patients with non-meningococcal disease (specificity 98.5%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The application of this PCR permits a rapid (roughly 5 hours), specific and sensitive method that increases the microbiologic confirmation of meningococcal disease, mainly in patients who have received previous antibiotic treatment.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Biblografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performance characteristics of the polymerase chain reaction assay to confirm clinical meningococcal disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.E. Carrol" 1 => "A.P.J. Thomson" 2 => "P. Shears" 3 => "S.J. Gray" 4 => "E.B. Kaczmarski" 5 => "C.A. Hart" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dis Child" "fecha" => "2000" "volumen" => "83" "paginaInicial" => "271" "paginaFinal" => "273" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10952654" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000012000000019/v1_201307291713/S0025775303738251/v1_201307291713/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000012000000019/v1_201307291713/S0025775303738251/v1_201307291713/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775303738251?idApp=UINPBA00004N" ]
Journal Information
Aumento de la rentabilidad diagnóstica en la enfermedad meningocócica mediante la técnica de reacción en cadena de la polimerasa
Diagnosis of meningococcal disease by polymerase chain reaction