array:22 [ "pii" => "S0025775302735732" "issn" => "00257753" "doi" => "10.1016/S0025-7753(02)73573-2" "estado" => "S300" "fechaPublicacion" => "2002-01-01" "aid" => "73573" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2002" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2002;119:761-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3480 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 3210 "PDF" => 263 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775302735744" "issn" => "00257753" "doi" => "10.1016/S0025-7753(02)73574-4" "estado" => "S300" "fechaPublicacion" => "2002-01-01" "aid" => "73574" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2002;119:765-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2076 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1810 "PDF" => 260 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Micronutrientes en la infección por el virus de la inmunodeficiencia humana y su relación con la respuesta inflamatoria" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "765" "paginaFinal" => "769" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Micronutrients in HIV-infection and the relationship with the inflammatory response" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Jesúes Jiménez-Expósito, Mònica Bulló Bonet, Carlos Alonso-Villaverde, Pilar Serrano, Pilar García-Lorda, Pedro Pablo García-Luna, Lluís Masana, Jordi Salas-Salvadó" "autores" => array:8 [ 0 => array:2 [ "nombre" => "María" "apellidos" => "Jesúes Jiménez-Expósito" ] 1 => array:2 [ "nombre" => "Mònica" "apellidos" => "Bulló Bonet" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "Alonso-Villaverde" ] 3 => array:2 [ "nombre" => "Pilar" "apellidos" => "Serrano" ] 4 => array:2 [ "nombre" => "Pilar" "apellidos" => "García-Lorda" ] 5 => array:2 [ "nombre" => "Pedro Pablo" "apellidos" => "García-Luna" ] 6 => array:2 [ "nombre" => "Lluís" "apellidos" => "Masana" ] 7 => array:2 [ "nombre" => "Jordi" "apellidos" => "Salas-Salvadó" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775302735744?idApp=UINPBA00004N" "url" => "/00257753/0000011900000020/v1_201307291542/S0025775302735744/v1_201307291542/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Carcinoma ductal infiltrante de mama. Diferencias clinicobiológicas entre mujeres mayores de 70 años y aquéllas de entre 60 y 70 años" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "761" "paginaFinal" => "764" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Álvaro Ruibal, José I. Arias, Belén Aldecoa" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Álvaro" "apellidos" => "Ruibal" "email" => array:1 [ 0 => "ARuibal@fjd.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "José I." "apellidos" => "Arias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Belén" "apellidos" => "Aldecoa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Laboratorio de Biología Tumoral FJD. Departamento de Medicina Nuclear. Fundación Jiménez Díaz. Fundación Tejerina. Madrid</span>" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Servicio de Cirugía General. Hospital Monte del Naranco. Oviedo. Asturias</span>" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Servicio de Ginecología. Hospital de Jarrio. Coaña. Asturias. España</span>" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. A.Ruibal. Departamento de Medicina Nuclear. Fundación Jiménez-Díaz. Avda. Reyes Católicos, 2. 28040 Madrid. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical and biological differences between infiltrating ductal carcinomas of the breast in women over 70 years-old and those aged 60-70" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-03-14" "fechaAceptado" => "2002-09-16" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221870" "palabras" => array:3 [ 0 => "Cáncer de mama" 1 => "Edad" 2 => "70 años" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec221871" "palabras" => array:4 [ 0 => "Breast cancer" 1 => "Age" 2 => "Elderly" 3 => "70 years" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En la bibliografía hay discrepancias acerca del comportamiento del cáncer de mama enmujeres de edad avanzada. Por ello hemos querido estudiar las diferencias clinicobiológicas que pudierahaber entre el grupo de mujeres con carcinoma ductal infiltrante de mama mayores de 70 añosy el grupo de 60-70 años.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hemos incluido a 181 mujeres afectadas de carcinoma ductal infiltrante demama, procedentes de campañas de cribado y de una consulta de mama; 67 tenían edades superioresa 70 años y 114 tenían entre 60 y 70 años. Se han determinado las concentraciones citosólicasde receptores de estrógenos (RE), de progesterona (RP), pS2 y catepsina D, así como las del receptordel factor de crecimiento epidérmico (EGFR) en las membranas celulares. Se consideró, además, eltamaño, la afección ganglionar axilar, las metástasis a distancia, el grado histológico, la ploidía y lafase de síntesis celular (FS).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los carcinomas ductales infiltrantes de mama en las mujeres mayores de 70 años cursaroncon mayores tamaño (p < 0,001), fase de síntesis global (p = 0,009) y número de ganglios axilaresafectados (p = 0,002). Asimismo, presentaron más frecuentemente metástasis a distancia (p < 0,001) y valores de FS > 14%, que rozaron la significación estadística (p = 0,093). Sin embargo, alconsiderar sólo a las mujeres procedentes de la campaña de cribado, no pudimos constatar diferenciasen los diferentes parámetros analizados entre las mujeres mayores de 70 años y las del grupo de60-70 años. Cuando analizamos a las pacientes que acudían a la consulta de mama, pudimos ver quelas de edad superior a 70 años mostraban mayor número de ganglios axilares afectados (p = 0,027).Las mujeres mayores de 70 años procedentes de la consulta de mama mostraron mayor tamaño (p =0,054) y tuvieron tendencia a cursar más frecuentemente con metástasis a distancia (p = 0,075) quelas de la de la campaña de cribado. También las pacientes de consultorio de mama con edades entre60 y 70 años mostraron tumores de mayor tamaño (p < 0,001), afección ganglionar (p = 0,022), númerode ganglios afectados (p = 0,022) y metástasis a distancia (p = 0,048) que las pacientes delmismo intervalo etario provenientes de la campaña de cribado.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los carcinomas ductales infiltrantes de mama en mujeres mayores de 70 años tienencaracterísticas clinicobiológicas que indican peores comportamiento y evolución. Sin embargo, ello seconstata sólo en aquellas mujeres que acuden a la consulta de mama, pero no en las que proceden delas campañas de cribado. Por ello, la procedencia de las pacientes parece ser significativa en las diferenciasclinicobiológicas respecto a los carcinomas mamarios en mujeres de edad avanzada.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">There is discrepancy in the literature regarding the behavior of breast cancer in elderlywomen. For this reason we decided to study the possible clinical and biological differences of infiltrativeductal breast carcinoma between women over 70 years and those aged between 60 and 70 years.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The study group included 181 women with infiltrative ductal carcinomas (IDCs) whowere referred from a breast clinic (BC) and a breast cancer screening campaign (BCS). 67 of them wereolder than 70 and 114 were between 60 and 70 years old. Estrogen receptors (ER), progesterone receptors(PR), pS2 and cathepsin D cytosolic levels were determined, as well as levels of epidermal growthfactor receptor (EGFR) in cell surfaces. Likewise, size, axillary lymph node involvement, distant metastasis,histological grade, ploidy and cellular S-phase fraction were also considered as variables of the study.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">IDCs in women older than 70 had greater size (p < 0.001), global S-phase (p = 0.009) andnumber of axillary lymph nodes involved (p = 0.002). Likewise, these tumors showed more frequentlydistant metastasis (p = 0.001) and S-phase values > 14% (p = 0.093). However, when we consideredonly women referred from BCS, no differences in the parameters studied between women older than70 and those aged between 60 and 70 years were observed. When only patients coming from BC wereconsidered, women older than 70 had a greater number of axillary lymph nodes involved (p= 0.027).Patients older than 70 years from BC showed greater size (p= 0.054) and more common distant metastasis(p= 0.075) than those from BCS. Also, patients between 60 and 70 referred from BC had tumorswith greater size (p < 0.001), nodal involvement (p= 0.022), number of lymph nodes involved(p= 0.022) and distant metastasis (p= 0.048) than those from BCS with the same age.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our results suggest that IDCs in women older than 70 years show clinical and biologicalfeatures associated with a worse behaviour. However, this is only observed in women referred from BCbut not in those coming from BCS. For this reason, the patient's referral site seems to be essential forthe observed clinical and biological differences of breast carcinomas in the elderly.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Uptake of breast cancer screening in older women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Edwards" 1 => "D. 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Journal Information
Carcinoma ductal infiltrante de mama. Diferencias clinicobiológicas entre mujeres mayores de 70 años y aquéllas de entre 60 y 70 años
Clinical and biological differences between infiltrating ductal carcinomas of the breast in women over 70 years-old and those aged 60-70
Álvaro Ruibala,
, José I. Ariasb, Belén Aldecoac
Corresponding author
ARuibal@fjd.es
Correspondencia: Dr. A.Ruibal. Departamento de Medicina Nuclear. Fundación Jiménez-Díaz. Avda. Reyes Católicos, 2. 28040 Madrid. España.
Correspondencia: Dr. A.Ruibal. Departamento de Medicina Nuclear. Fundación Jiménez-Díaz. Avda. Reyes Católicos, 2. 28040 Madrid. España.