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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:85-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4933 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 4838 "PDF" => 90 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Evolución del número de personas infectadas por el virus de la inmunodeficiencia humana y de los casos de sida en España: 1980–1998" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "85" "paginaFinal" => "89" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Trends in the number of HIV infected persons and AIDS cases in Spain: 1980–1998" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jesús Castilla, Luis de la Fuente" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Jesús" "apellidos" => "Castilla" ] 1 => array:2 [ "nombre" => "Luis" "apellidos" => "de la Fuente" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300714734?idApp=UINPBA00004N" "url" => "/00257753/0000011500000003/v1_201307291643/S0025775300714734/v1_201307291643/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Disminución de la actividad de la 11-β-hidroxiesteroide deshidrogenasa en pacientes con síndrome de Cushing" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "90" "paginaFinal" => "92" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Pablo Stiefel, Luis Jiménez, José Salvador García-Morillo, Alfonso Leal, José Villar, Joaquín Carneado" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Pablo" "apellidos" => "Stiefel" "email" => array:1 [ 0 => "stiefel@cica.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Luis" "apellidos" => "Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "José" "apellidos" => "Salvador García-Morillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Alfonso" "apellidos" => "Leal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "José" "apellidos" => "Villar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Joaquín" "apellidos" => "Carneado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Interna. Hospitales Universitarios Virgen del Rocío. Sevilla." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Bioquímica Clínica. Hospitales Universitarios Virgen del Rocío. Sevilla." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Endocrinología. Hospitales Universitarios Virgen del Rocío. Sevilla." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. P. Stiefel García-Junco. Servicio de Medicina Interna. HG (planta baja). Hospitales universitarios Virgen del Rocío. 41013 Sevilla." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Decreased activity of 11 β-hydroxysteroid dehydrogenase in patients with Cushing's syndrome" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-02-21" "fechaAceptado" => "2000-05-30" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222482" "palabras" => array:4 [ 0 => "11-b-hidroxiesteroide deshidrogenasa" 1 => "Síndrome de Cushing" 2 => "Cortisol" 3 => "Cortisona" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Análisis de la actividad de la 11-β-hidroxiesteroide deshidrogenasa en el síndrome de Cushing.</p> <span class="elsevierStyleSectionTitle">Pacientes método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Determinación de la eli-minación en orina de 24 h de cortisol, corti-sona sus tetrahidroderivados en 15 pacientes con síndrome de Cushing 24 controles sanos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Existía una relación lineal significativa entre cortisol cortisona (r = 0,70; p < 0,0001) entre sus tetrahidroderivados (r = 0,75; p < 0,0001) en los controles, pero no en los pacientes.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con síndrome de Cushing presentan un déficit de la actividad de la 11-β-hidroxiesteroide deshidro-genasa.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study 11 β-hydroxysteroid dehydrogenase activity in Cushing's syndro-me.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Measurements of free cortisol, cortisone, tetrahydrocortisol and tetrahydrocortisone in 24 h urine samples of patients with Cushing's syndrome and controls.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The cortisol to cortisone and tetrahy-drocortisol to tetrahydrocortisone relationship was significant (in controls, r = 0.70; p < 0.0001, and r = 0.75; p < 0.0001) respectively, but it was not in patients with Cushing's syndrome.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">11 β-hydroxysteroid dehydro-genase activity is decreased in patients with Cushing's syndrome</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Journal Information
Disminución de la actividad de la 11-β-hidroxiesteroide deshidrogenasa en pacientes con síndrome de Cushing
Decreased activity of 11 β-hydroxysteroid dehydrogenase in patients with Cushing's syndrome