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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:201-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1856 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 1806 "PDF" => 45 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Efecto de la erradicación de <span class="elsevierStyleItalic">Helicobacter pylori</span> sobre la recurrencia de la úlcera gástrica a lo largo de 12 meses" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "204" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effect of <span class="elsevierStyleItalic">Helicobacter pylori</span> eradication on gastric ulcer recurrence. 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"apellidos" => "Javier Gisbert" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300715090?idApp=UINPBA00004N" "url" => "/00257753/0000011500000006/v1_201307291645/S0025775300715090/v1_201307291645/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "La concentración de ácido hialurónico citosólico define ciertas propiedades clinicobiológicas del carcinoma ductal infiltrante de mama CD44v5 positivo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "205" "paginaFinal" => "207" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Álvaro Ruibal, José Ignacio Arias, M. Carmen del Río, Juan Manuel San Román, Gregoria Lapeña, José Schneider, Armando Tejerina" "autores" => array:7 [ 0 => array:3 [ "nombre" => "Álvaro" "apellidos" => "Ruibal" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "José" "apellidos" => "Ignacio Arias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Carmen del Río" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 3 => array:3 [ "nombre" => "Juan" "apellidos" => "Manuel San Román" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 4 => array:3 [ "nombre" => "Gregoria" "apellidos" => "Lapeña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "José" "apellidos" => "Schneider" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 6 => array:3 [ "nombre" => "Armando" "apellidos" => "Tejerina" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Nuclear Fundación Jiménez Díaz. Madrid." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Nuclear. Fundación Tejerina." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Cirugía General. Hospital Monte del Naranco. Oviedo." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Bioquímica. Hospital de Barbanza. Ribeira. La Coruña." "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Cirugía. Fundación Jiménez Díaz. Madrid." "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Centro de Patología de la Mama. Madrid." "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. A. Ruibal.Servicio de Medicina Nuclear. Fundación Jiménez Díaz.Avda. Reyes Católicos, 2. 28040 Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The cytosolic hyaluronic acid level defines some clinical-biological properties of CD44v5-positive infiltrating ductal carcinomas of the breast" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-01-17" "fechaAceptado" => "2000-06-08" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave: Carcinoma ductal" "identificador" => "xpalclavsec222495" "palabras" => array:3 [ 0 => "Ácido hialurónico" 1 => "Parámetros clinicobiológicos" 2 => "Citosol" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El ácido hialurónico es uno de los ligandos de la molécula de adhesión CD44. En este estudio hemos querido analizar si su concentración citosólica podía modular ciertos pará-metros clinicobiológicos en el carcinoma ductal infiltrante (CDI) de mama CD44v5+.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hemos determinado, mediante un método de radioligando, las concentra-ciones citosólicas de ácido hialurónico en 127 casos. Así mismo, dosificamos los valores cito-sólicos de receptor de estrógenos, progesterona, pS2, catepsina D y activador del plasminógeno tipo tisular (t-AP), así como las del receptor del factor de crecimiento epidérmico (EGFR) en las membranas celulares. Se tuvieron presentes también el estado menopáusico, tamaño, invasión ganglionar axilar, grado histológico, ploidía y fase de síntesis celular.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los CDI con ácido hialurónico positivo (> 4.800 ng/mg de proteína) que representa la mediana obtenida en 252 CDI, cursaron con mayores concentraciones de receptores de pro-gesterona (p = 0,035) y t-AP (p = 0,000), mientras que los CDI con ácido hialurónico negativo mostraron con mayor frecuencia un tamaño superior a 2 cm (p = 0,015), aneuploidía (p = 0,002) y una fase S mayor del 14% (p = 0,019), así como un grado histológico 3 que rozó la significación estadística (p = 0,062), indicadores todos ellos de un peor comportamiento y evolución.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los resultados anteriores indican que, como ocurre con el de membrana, la con-centración del ácido hialurónico citosólico parece modular ciertas propiedades clínicobiológicas del CDI/CD44v5+, lo que realza el papel de ambos parámetros y podría ayudar a explicar algunas discordancias descritas en la bibliografía acerca de su interés práctico cuando se consideran aisladamente cada uno de ellos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The hyaluronic acid (HA) is a ligand of CD44 adhesion molecule. In this work, we study if the cytosolic level of this proteoglycan can modulate certain clinical-biological properties at CD44v5-positive infiltrating ductal carcinomas (IDC) of the breast.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have assayed, by a radioligand method, the cytosolic level of hyaluro-nic acid in 127 IDC.Likewise, cytosolic levels of estrogen receptors (ER), progesterone receptors (PR), pS2, cathepsin D and tissu.-type plasminogen activators (t-PA) have been dossified, as well as those of epidermal growth factor receptor (EGFR) at cell surfaces. The menopausal status, tumor size, axillary lymph node involvement, histological grade, ploidy and S-phase have also been taken into account.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">HA positive (> 4800 ng/mg prt., which represents the median value obtained with 252 tumors) carcinomas had higher levels of PR (p = 0.035) and t-PA (p = 0.000), whereas HA negative showed a higher frequency of a tumor size > 2 cm (p = 0.015), aneuploidy (p = 0.015) and S-phase > 14% (p = 0,019), as well as histological grade 3 which reached statistical significance (p = 0.062), all of which were indicators of a worse behaviour and evolution.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our results suggest that, as it also happens with that of the cell surface, cytosolic HA levels seems to modulate certain clinical-biological features of CD44v5-positive infiltrating ductal carcinomas of the breast. Likewise, they can help us to explain the discordant results described at the literature concerning its practical value when each of them are considered separately.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CD44 modulates HS578T human breast cancer cell adhesion, migration and invasiveness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Herrera Gayol" 1 => "S. 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Journal Information
La concentración de ácido hialurónico citosólico define ciertas propiedades clinicobiológicas del carcinoma ductal infiltrante de mama CD44v5 positivo
The cytosolic hyaluronic acid level defines some clinical-biological properties of CD44v5-positive infiltrating ductal carcinomas of the breast
Álvaro Ruibala,b,*, José Ignacio Ariasc, M. Carmen del Ríod, Juan Manuel San Románe, Gregoria Lapeñaa, José Schneiderb,f, Armando Tejerinab,f
a Servicio de Medicina Nuclear Fundación Jiménez Díaz. Madrid.
b Servicio de Medicina Nuclear. Fundación Tejerina.
c Servicio de Cirugía General. Hospital Monte del Naranco. Oviedo.
d Servicio de Bioquímica. Hospital de Barbanza. Ribeira. La Coruña.
e Servicio de Cirugía. Fundación Jiménez Díaz. Madrid.
f Centro de Patología de la Mama. Madrid.