array:22 [ "pii" => "S0025775300713893" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71389-3" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71389" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:641-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1669 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1618 "PDF" => 44 ] ] "itemSiguiente" => array:18 [ "pii" => "S002577530071390X" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71390-X" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71390" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:647-52" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 9723 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 9531 "PDF" => 184 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Validez del cuestionario King’s Health para la evaluación de la calidad de vida en pacientes con incontinencia urinaria" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "647" "paginaFinal" => "652" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Validity of the King’s Health Questionnaire in the assessment of quality of life in patients with urinary incontinence" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Xavier Badia Llach, David Castro Díaz, Joan Conejero Sugrañes" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Xavier" "apellidos" => "Badia Llach" ] 1 => array:2 [ "nombre" => "David" "apellidos" => "Castro Díaz" ] 2 => array:2 [ "nombre" => "Joan" "apellidos" => "Conejero Sugrañes" ] 3 => array:1 [ "colaborador" => "en nombre del Grupo King's" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577530071390X?idApp=UINPBA00004N" "url" => "/00257753/0000011400000017/v1_201307291449/S002577530071390X/v1_201307291449/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Papel de las citocinas y las quimiocinas en la no progresión de la infección por VIH-1 en niños infectados verticalmente" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "641" "paginaFinal" => "646" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Salvador Resino, José María Bellón, José Luis Jiménez, M. Dolores Gurbindo, M. Ángeles Muñoz-Fernández" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Salvador" "apellidos" => "Resino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 1 => array:3 [ "nombre" => "José" "apellidos" => "María Bellón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 2 => array:3 [ "nombre" => "José" "apellidos" => "Luis Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Dolores Gurbindo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 4 => array:4 [ "nombre" => "M." "apellidos" => "Ángeles Muñoz-Fernández" "email" => array:1 [ 0 => "Mmunoz@cbm.uam.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "División de Inmunología" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:3 [ "entidad" => "Departamento de Pediatría. Hospital General Universitario Gregorio Marañón. Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dra. M.A. Muñoz-Fernández. División de Inmunología. Hospital General Universitario Gregorio Marañón. Dr. Esquerdo, 47. 28007 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Role of cytokines and chemokines in the non-progression of the HIV-1 infection in vertically infected children" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-01-10" "fechaAceptado" => "2000-04-04" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221340" "palabras" => array:4 [ 0 => "Infección por VIH" 1 => "Citocinas" 2 => "Quimiocinas" 3 => "Infección vertical" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar la producción de citocinas en niños infectados verticalmente por VIH-1con una duración de la infección mayor de 7 años y diferente velocidad de progresión.</p> <span class="elsevierStyleSectionTitle">Pacientes y metodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudiamos a 32 ninos con VIH-1, divididos en: a) 8 ninos NA (> 7 anos,asintomaticos o con sintomas leves, sin tratamiento antirretroviral y linfocitos TCD4+ > 25%);b) 10 ninos NE2 (> 6 anos, sintomaticos, con tratamiento antirretroviral y linfocitos TCD4+ < 25%); c) 14 ninos NE2-3 (> 6 anos, sintomaticos, con tratamiento antirretroviral y linfocitosTCD4+ < 25%), y d) 16 ninos controles, sin infeccion por el VIH (grupo C). Las celulas mononuclearesde sangre periferica (CMSP) se cultivaron, y se cuantifico la produccion de IL-2, IL-5,IL-10, TNF-α, IFN-γ y RANTES en el sobrenadante.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las CMSP sin estimular de los ninos con infeccion por VIH-1 produjeron mas TNF-α y menos IL-2 que los controles. La produccion de IFN-γ fue menor en los grupos NE1 y NE2-3 que en el control. El grupo NA produjo mas IFN-γ que el NE2-3. En las CMSP estimuladascon fitohemaglutinina (PHA), la produccion de TNF-α fue mayor en los grupo NA y NE1 que enel control. La IL-2 de los grupos NA y NE1 fue similar al control, pero el grupo NE2-3 produjomenos IL-2 que el control y NE1. La produccion de IFN-γ y RANTES fue significativamentemayor en NA que en el control. Los grupos NE1 y NE2-3 produjeron menos IL-5 que el controly NA. El grupo NE2-3 produjo menos IL-10 que el control. El cociente IFN-γ/IL-5 e IFN-γ/IL-10 fue mayor en NA que en el control y NE1.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En niños sin progresión se conserva la funcionalidad inmunológica y la respuestade los linfocitos Th1 se halla incrementada, mientras que en los niños con progresión tratadosse observa una disminución de la producción de citocinas por los linfocitos Th2. Nuestrosdatos indican claramente que la disminución de IL-2 es un marcador temprano de evoluciónde la infección por el VIH y que valores elevados de RANTES no son indicativos de falta deprogresión.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the cytokine production in vertically HIV-1-infected children with more of7 years of HIV infection and different pattern of progression.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We study 32 HIV-1-infected children: 8 NA children (age > 7 years,asymptomatic or with light symptoms, without antiretroviral treatment and TCD4+ > 25%);10 NE1 children (> 6 years, symptomatic, with antiretroviral treatment and TCD4+ > 25%);14 NE2-3 children (> 6 years, symptomatic, with antiretroviral treatment and TCD4+ < 25%)and 16 (C) controls, children non-VIH+. The peripheral mononuclear cells of HIV-infected children(PBLs) were cultivated and cytokine production was quantified in the supernatant.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The non-stimulated PBMC from HIV-infected children produced more TNF-α and lessIL-2 that C-group. The production of IFN-γ was lower in the groups NE1 and NE2-3 than in Cgroup.The production of IFN-γ was higher in group NA than in NE2-3. In the phytohaemagglutinin(PHA) stimulated PBLs, the production of TNF-α was higher in NA and NE1 than in controls.The production of IL-2 was similar in NA and NE1 than in controls. The production of IL-2was similar in NA and NE1 than in control group, but the groups NE2-3 produced less IL-2 thancontrol and NE1 groups. The production of IFN-γ and RANTES were significantly higher in NAthan in controls. The groups NE1 and NE2-3 produced lower levels of IL-5 than control and NAgroups. The groups NE2-3 produced lower levels of IL-10 than control group. The ratio IFN-γ/IL-5 and IFN-γ/IL-10 were higher in group NA than in control and NE1.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In non-progressors HIV-infected children the immune response is conserved andwe have observed an increased Th1 response, while in progressors HIV-infected children receivingantiretroviral treatment we could observe a diminished Th2 response. Moreover, our dataclearly indicate that the decrease of IL-2 is an early marker of HIV-infection.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:59 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y. Cao" 1 => "L. Qin" 2 => "L. Zhang" 3 => "J. Safrit" 4 => "D.D. Ho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199501263320401" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1995" "volumen" => "332" "paginaInicial" => "201" "paginaFinal" => "208" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7808485" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HIV pathogenesis and long-term survival" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.A. Levy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1993" "volumen" => "7" "paginaInicial" => "1427" "paginaFinal" => "1433" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8280407" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characteristics of long-term asymptomatic infection with human immunodeficiency virus type 1 in men with normal and low CD4+ cell counts" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.P. Keet" 1 => "A. Krol" 2 => "M.R. Klein" 3 => "P. Veugelers" 4 => "J. de Wit" 5 => "M. Roos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1994" "volumen" => "169" "paginaInicial" => "1256" "paginaFinal" => "1264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7910836" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Marcadores predictivos de supervivencia en niños menores de 12 meses de edad infectados verticalmente por el virus de la inmunodeficiencia humana" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Resino" 1 => "J.L. Jiménez" 2 => "D. Gurbindo" 3 => "M.A. Muñoz-Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1999" "volumen" => "113" "paginaInicial" => "561" "paginaFinal" => "566" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurological manifestations of HIV-1 infection in infants: viro-immunologic markers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Gurbindo" 1 => "S. Resino" 2 => "S. Sánchez-Ramón" 3 => "J.A. León" 4 => "M.A. Muñoz-Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2007-973490" "Revista" => array:6 [ "tituloSerie" => "Neuropediatrics" "fecha" => "1999" "volumen" => "30" "paginaInicial" => "197" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10569211" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive markers of clinical outcome in vertically HIV-1 infected infants, a prospective longitudinal study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Resino" 1 => "M.D. Gurbindo" 2 => "J.M. Bellón" 3 => "S. Sánchez-Ramón" 4 => "M.A. Muñoz-Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr Res" "fecha" => "2000" "volumen" => "47" "paginaInicial" => "1" "paginaFinal" => "7" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Natural history of human immunodeficiency virus type 1 infection in children: prognostic value of laboratory tests on the bimodal progression of the disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.M. Duliege" 1 => "A. Messiah" 2 => "S. Blanche" 3 => "M. Tardieu" 4 => "C. Griscelli" 5 => "A. Spira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1992" "volumen" => "11" "paginaInicial" => "630" "paginaFinal" => "635" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1523073" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective study of infants born to women seropositive for human immunodeficiency virus type 1. HIV Infection in Newborns French Collaborative Study Group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Blanche" 1 => "C. Rouzioux" 2 => "M.L. Moscato" 3 => "F. Veber" 4 => "M.J. Mayaux" 5 => "C. Jacomet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198906223202502" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1989" "volumen" => "320" "paginaInicial" => "1643" "paginaFinal" => "1648" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2657430" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "NIH conference. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.S. Fauci" 1 => "S.M. Schnittman" 2 => "G. Poli" 3 => "S. Koenig" 4 => "G. Pantaleo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1991" "volumen" => "114" "paginaInicial" => "678" "paginaFinal" => "693" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1672248" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokine modulation of HIV expression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Poli" 1 => "A.S. Fauci" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/smim.1993.1020" "Revista" => array:6 [ "tituloSerie" => "Semin Immunol" "fecha" => "1993" "volumen" => "5" "paginaInicial" => "165" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7688596" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokine patterns during the progression to AIDS" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.R. Mosmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1994" "volumen" => "265" "paginaInicial" => "193" "paginaFinal" => "194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8023139" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Th1-Th2 hypothesis of HIV infection: new insights" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Clerici" 1 => "G.M. Shearer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0167-5699(94)90220-8" "Revista" => array:6 [ "tituloSerie" => "Immunol Today" "fecha" => "1994" "volumen" => "15" "paginaInicial" => "575" "paginaFinal" => "581" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7848519" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunologic characterization of children vertically infected with human immunodeficiency virus, with slow or rapid disease progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Vigano" 1 => "N. Principi" 2 => "M.L. Villa" 3 => "C. Riva" 4 => "L. Crupi" 5 => "D. Trabattoni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1995" "volumen" => "126" "paginaInicial" => "368" "paginaFinal" => "374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7869194" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A TH1 > TH2 switch is a critical step in the etiology of HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Clerici" 1 => "G.M. Shearer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0167-5699(93)90208-3" "Revista" => array:6 [ "tituloSerie" => "Immunol Today" "fecha" => "1993" "volumen" => "14" "paginaInicial" => "107" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8096699" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Clerici" 1 => "T.A. Wynn" 2 => "J.A. Berzofsky" 3 => "S.P. Blatt" 4 => "C.W. Hendrix" 5 => "A. Sher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI117031" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1994" "volumen" => "93" "paginaInicial" => "768" "paginaFinal" => "775" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8113410" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Clerici" 1 => "F.T. Hakim" 2 => "D.J. Venzon" 3 => "S. Blatt" 4 => "C.W. Hendrix" 5 => "T.A. Wynn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI116294" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1993" "volumen" => "91" "paginaInicial" => "759" "paginaFinal" => "765" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8450057" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W. Barcellini" 1 => "G.P. Rizzardi" 2 => "M.O. Borghi" 3 => "C. Fain" 4 => "A. Lazzarin" 5 => "P.L. Meroni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1994" "volumen" => "8" "paginaInicial" => "757" "paginaFinal" => "762" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8086133" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Graziosi" 1 => "G. Pantaleo" 2 => "K.R. Gantt" 3 => "J.P. Fortin" 4 => "J.F. Demarest" 5 => "O.J. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1994" "volumen" => "265" "paginaInicial" => "248" "paginaFinal" => "252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8023143" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Maggi" 1 => "M. Mazzetti" 2 => "A. Ravina" 3 => "F. Annunziato" 4 => "M. De Carli" 5 => "M.P. Piccinni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1994" "volumen" => "265" "paginaInicial" => "244" "paginaFinal" => "248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8023142" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.A. Muñoz-Fernández" 1 => "J. Navarro" 2 => "A. García" 3 => "C. Punzón" 4 => "E. Fernández-Cruz" 5 => "M. Fresno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1997" "volumen" => "100" "paginaInicial" => "838" "paginaFinal" => "845" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9438495" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumour necrosis factors (alpha, beta) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Vyakarnam" 1 => "J. McKeating" 2 => "A. Meager" 3 => "P.C. Beverley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1990" "volumen" => "4" "paginaInicial" => "21" "paginaFinal" => "27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1969279" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elevated levels of circulating intercellular adhesion molecule 1 and tumor necrosis factor a in the serum of children vertically infected with HIV-1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Obregón" 1 => "C. Börner" 2 => "J. Navarro" 3 => "M.D. Gurbindo" 4 => "E. Fernández-Cruz" 5 => "M.A. Muñoz-Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatric AIDS and HIV Infection: Fetus and adolescent" "fecha" => "1996" "volumen" => "7" "paginaInicial" => "413" "paginaFinal" => "417" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative analysis of constitutive cytokine expression in peripheral blood and lymph nodes of HIV-infected individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Graziosi" 1 => "G. Pantaleo" 2 => "A.S. Fauci" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Res Immunol" "fecha" => "1994" "volumen" => "145" "paginaInicial" => "602" "paginaFinal" => "607" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7754207" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor necrosis factor production in HIV-seropositive subjects. Relationship with lung opportunistic infections and HIV expression in alveolar macrophages" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Israel-Biet" 1 => "J. Cadranel" 2 => "K. Beldjord" 3 => "J.M. Andrieu" 4 => "A. Jeffrey" 5 => "P. Even" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1991" "volumen" => "147" "paginaInicial" => "490" "paginaFinal" => "494" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1906500" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIVsuppressive factors produced by CD8+ T cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Cocchi" 1 => "A.L. DeVico" 2 => "A. Garzino-Demo" 3 => "S.K. Arya" 4 => "R.C. Gallo" 5 => "P. Lusso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1995" "volumen" => "270" "paginaInicial" => "1811" "paginaFinal" => "1815" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8525373" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HIV replication in CD4+ T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous beta-chemokines and the viral inductive effects of other endogenous cytokines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.L. Kinter" 1 => "M. Ostrowski" 2 => "D. Goletti" 3 => "A. Oliva" 4 => "D. Weissman" 5 => "K. Gantt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1996" "volumen" => "93" "paginaInicial" => "14076" "paginaFinal" => "14081" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8943063" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term resistance to HIV infection in vertical HIV infection: cytokine production, HIV isolation, and HIV phenotype define long-term resistant hosts" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Vigano" 1 => "C. Balotta" 2 => "D. Trabattoni" 3 => "D. Bricalli" 4 => "L. Crupi" 5 => "E. Palomba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pathobiology" "fecha" => "1997" "volumen" => "65" "paginaInicial" => "169" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9396039" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Older children and adolescents living with perinatally acquired human immunodeficiency virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Grubman" 1 => "E. Gross" 2 => "N. Lerner-Weiss" 3 => "M. Hernández" 4 => "G.D. McSherry" 5 => "L.G. Hoyt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1995" "volumen" => "95" "paginaInicial" => "657" "paginaFinal" => "663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7724299" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship of virologic, immunologic, and clinical parameters in infants with vertically acquired human immunodeficiency virus type 1 infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Muñoz-Fernández" 1 => "E. Obregón" 2 => "J. Navarro" 3 => "C. Borner" 4 => "M.D. Gurbindo" 5 => "T.H. Sampelayo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1203/00006450-199610000-00014" "Revista" => array:6 [ "tituloSerie" => "Pediatr Res" "fecha" => "1996" "volumen" => "40" "paginaInicial" => "597" "paginaFinal" => "602" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8888289" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantification of low levels of HIV-1 RNA viremia in p24-antigen-negative asymptomatic HIV+ patients by use of the polymerase chain reaction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.A. Muñoz-Fernández" 1 => "J. Navarro" 2 => "M. García Montes" 3 => "J. Cosín" 4 => "J.M. Zabay" 5 => "E. Fernández-Cruz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "1996" "volumen" => "2" "paginaInicial" => "404" "paginaFinal" => "408" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HIV-1 viral load and CD4 cell count in untreated children with vertically acquired asymptomatic or mild disease" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Pediatric European Network for treatment of AIDS (PENTA)" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1998" "volumen" => "12" "paginaInicial" => "F1" "paginaFinal" => "F8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9520161" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High viral load in children long-term non progressor vertically infected with HIV-1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.A. Muñoz-Fernández" 1 => "S. Resino" 2 => "J. Navarro" 3 => "E. Obregón" 4 => "J.L. Jiménez" 5 => "R. Alonso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Immunologyc characterization" "paginaInicial" => "45" "paginaFinal" => "49" "serieFecha" => "1998" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Features of children perinatally infected with HIV-1 surviving longer than 5 years" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Italian Register HIVc" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1994" "volumen" => "343" "paginaInicial" => "191" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7904665" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human retrovirus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Mofenson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Text book of pediatric infectious diseases (4.a ed.)" "paginaInicial" => "2169" "paginaFinal" => "2226" "serieFecha" => "1998" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human immunodeficiency virus HIV and acquired immunodeficiency syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Y. Maldonado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Principle and practice of Pediatric Infectious Disease (4.a ed.)" "paginaInicial" => "2169" "paginaFinal" => "2226" "serieFecha" => "1997" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "SIDA pediátrico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Navarro" 1 => "D. Gurbindo" 2 => "T. Sampelayo" 3 => "M.A. Muñoz-Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Madr)" "fecha" => "1998" "volumen" => "7" "paginaInicial" => "3990" "paginaFinal" => "3998" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunological and virological markers of disease progression in HIV-1 infected children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.A. Muñoz-Fernández" 1 => "J. Navarro" 2 => "E. Obregón" 3 => "R.A. Arias" 4 => "M.D. Gurbindo" 5 => "T.H. Sampelayo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Acta Paediatr Suppl" "fecha" => "1997" "paginaInicial" => "46" "paginaFinal" => "51" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morbidity and mortality in European children vertically infected by HIV-1. The French Pediatric HIV Infection Study Group and European Collaborative Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Blanche" 1 => "M.L. Newell" 2 => "M.J. Mayaux" 3 => "D.T. Dunn" 4 => "J.P. Teglas" 5 => "C. Rouzioux" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Acquir Immune Defic Syndr Hum Retrovirol" "fecha" => "1997" "volumen" => "14" "paginaInicial" => "442" "paginaFinal" => "450" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9170419" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal characteristics in rapidly progressive perinatally acquired HIV-1 disease. The French Pediatric HIV Infection Study Group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Mayaux" 1 => "M. Burgard" 2 => "J.P. Teglas" 3 => "J. Cottalorda" 4 => "A. Krivine" 5 => "F. Simon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1996" "volumen" => "275" "paginaInicial" => "606" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8594241" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The European Collaborative Study" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Age-related standards for T lymphocyte subsets based on uninfected children born to human immunodeficiency virus 1-infected women" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1992" "volumen" => "102" "paginaInicial" => "1899" "paginaFinal" => "1901" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1446516" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival in children with perinatally acquired human immunodeficiency virus type 1 infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.B. Scott" 1 => "C. Hutto" 2 => "R.W. Makuch" 3 => "M.T. Mastrucci" 4 => "T. O'Connor" 5 => "C.D. Mitchell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198912283212604" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1989" "volumen" => "321" "paginaInicial" => "1791" "paginaFinal" => "1796" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2594038" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors and survival in children with perinatal HIV-1 infection. The Italian Register for HIV Infections in Children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.A. Tovo" 1 => "M. De Martino" 2 => "C. Gabiano" 3 => "N. Cappello" 4 => "R. D'Elia" 5 => "A. Loy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1992" "volumen" => "339" "paginaInicial" => "1249" "paginaFinal" => "1253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1349667" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends in survival for children reported with maternally transmitted acquired immunodeficiency syndrome in New York City, 1982 to 1989" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Thomas" 1 => "T. Singh" 2 => "R. Williams" 3 => "S. Blum" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1992" "volumen" => "11" "paginaInicial" => "34" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1549406" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Production of lymphokine mRNA by CD45R+ and CD45Rhelper T cells from human peripheral blood and by human CD4+ T cell clones" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Salmon" 1 => "G.D. Kitas" 2 => "P.A. Bacon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1989" "volumen" => "143" "paginaInicial" => "907" "paginaFinal" => "912" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2526179" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Meyaard" 1 => "S.A. Otto" 2 => "I.P. Keet" 3 => "R.A. Van Lier" 4 => "F. Miedema" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1994" "volumen" => "84" "paginaInicial" => "4262" "paginaFinal" => "4268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7994041" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Clerici" 1 => "D.R. Lucey" 2 => "J.A. Berzofsky" 3 => "L.A. Pinto" 4 => "T.A. Wynn" 5 => "S.P. Blatt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1993" "volumen" => "262" "paginaInicial" => "1721" "paginaFinal" => "1724" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7903123" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Th1 cells specific for HIV-1 gag p24 are less efficient than Th0 cells in supporting HIV replication, and inhibit virus replication in Th0 cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Vyakarnam" 1 => "P.M. Matear" 2 => "S.J. Martin" 3 => "M. Wagstaff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Immunology" "fecha" => "1995" "volumen" => "86" "paginaInicial" => "85" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7590887" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Type 1 and type 2 cytokines in HIV infection – a possible role in apoptosis and disease progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Clerici" 1 => "M.L. Fusi" 2 => "S. Ruzzante" 3 => "S. Piconi" 4 => "M. Biasin" 5 => "D. Arienti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Med" "fecha" => "1997" "volumen" => "29" "paginaInicial" => "185" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9240622" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Type 1 cytokine production and low prevalence of viral isolation correlate with long-term nonprogression in HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Clerici" 1 => "C. Balotta" 2 => "L. Meroni" 3 => "E. Ferrario" 4 => "C. Riva" 5 => "D. Trabattoni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/aid.1996.12.1053" "Revista" => array:6 [ "tituloSerie" => "AIDS Res Hum Retroviruses" "fecha" => "1996" "volumen" => "12" "paginaInicial" => "1053" "paginaFinal" => "1061" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8827221" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokine pattern in relation to disease progression in human immunodeficiency virus-infected children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Than" 1 => "R. Hu" 2 => "N. Oyaizu" 3 => "J. Romano" 4 => "X. Wang" 5 => "S. Sheikh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1997" "volumen" => "175" "paginaInicial" => "47" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8985195" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K.W. Moore" 1 => "P. Vieira" 2 => "D.F. Fiorentino" 3 => "M.L. Trounstine" 4 => "T.A. Khan" 5 => "T.R. Mosmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1990" "volumen" => "248" "paginaInicial" => "1230" "paginaFinal" => "1234" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2161559" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-10" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.W. Moore" 1 => "A. O'Garra" 2 => "R. De Waal Malefyt" 3 => "P. Vieira" 4 => "T.R. Mosmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.iy.11.040193.001121" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Immunol" "fecha" => "1993" "volumen" => "11" "paginaInicial" => "165" "paginaFinal" => "190" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8386517" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Del Prete" 1 => "M. De Carli" 2 => "F. Almerigogna" 3 => "M.G. Giudizi" 4 => "R. Biagiotti" 5 => "S. Romagnani" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1993" "volumen" => "150" "paginaInicial" => "353" "paginaFinal" => "360" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8419468" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum tumor necrosis factor alpha, interleukin 1-beta, p24 antigen concentrations and CD4+ cells at various stages of human immunodeficiency virus 1 infection in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Arditi" 1 => "W. Kabat" 2 => "R. Yogev" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1991" "volumen" => "10" "paginaInicial" => "450" "paginaFinal" => "455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1677177" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors in human immunodeficiency virus type 1 infection – correlations to clinical, immunologic, and virologic parameters" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Aukrust" 1 => "N.B. Liabakk" 2 => "F. Muller" 3 => "E. Lien" 4 => "T. Espevik" 5 => "S.S. Froland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1994" "volumen" => "169" "paginaInicial" => "420" "paginaFinal" => "424" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7906293" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum chemokine levels in patients with non-progressing HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. McKenzie" 1 => "G. Dallalio" 2 => "M. North" 3 => "P. Frame" 4 => "R. Means" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "AIDS" "fecha" => "1996" "volumen" => "10" "paginaInicial" => "29" "paginaFinal" => "33" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum levels of RANTES and MIP-1a in HIV-positive long-term survivors and progressor patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Zanussi" 1 => "M. D'Andrea" 2 => "C. Simonelli" 3 => "U. Tirelli" 4 => "P. DePaoli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1996" "volumen" => "10" "paginaInicial" => "1431" "paginaFinal" => "1432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8902075" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemokine production in HIV-seropositive long-term asymptomatic individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Clerici" 1 => "C. Balotta" 2 => "D. Trabattoni" 3 => "L. Papagno" 4 => "S. Ruzzante" 5 => "S. Rusconi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1996" "volumen" => "10" "paginaInicial" => "1432" "paginaFinal" => "1433" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8902076" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RANTES, MIP, and interleukin-16 in HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V. Blazevic" 1 => "M. Heino" 2 => "A. Ranki" 3 => "T. Jussila" 4 => "K. Krohn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1996" "volumen" => "10" "paginaInicial" => "1435" "paginaFinal" => "1436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8902078" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011400000017/v1_201307291449/S0025775300713893/v1_201307291449/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011400000017/v1_201307291449/S0025775300713893/v1_201307291449/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300713893?idApp=UINPBA00004N" ]
Journal Information
Papel de las citocinas y las quimiocinas en la no progresión de la infección por VIH-1 en niños infectados verticalmente
Role of cytokines and chemokines in the non-progression of the HIV-1 infection in vertically infected children