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Letter to the Editor
Parotid abscess by Candida glabrata
Absceso parotídeo por Candida glabrata
Daniel Pampín Ozán, Paolo Cariati
Corresponding author
paolocariati1@gmail.com

Corresponding author.
, Susana Arroyo Rodriguez
Oral and Maxillofacial surgeon. Hospital General Universitario de Albacete, Oral and Maxillofacial Surgery Department, Albacete, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Salivary glands could be affected by acute and chronic infections&#46; In this sense&#44; parotid represents the salivary gland most commonly affected by infectious diseases&#46; These infections could be acute or chronic and are usually caused by viruses or bacteria&#46; Acute suppurative parotitis occurs mainly in elderly people affected by systemic diseases such as diabetes&#44; immunosuppression and previous surgeries&#46; Other predisposing factors include malnutrition&#44; dehydration&#44; oral cavity malignancies&#44; ductal ectasia and medications that suppress salivary flow &#40;antihistamines&#44; diuretics and anticholinergic agents&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> With respect to the etiology&#44; Staphylococcus aureus is the pathogen most frequently associated with acute suppurative parotitis&#46; Other pathogens reported are&#58; streptococcus&#44; gram negative bacilli and anaerobes&#46; Fungal infections rarely affect the parotid gland&#46; In these cases&#44; the most common etiological agents are&#58; Cryptococcus neoformans&#44; Histoplasma capsulatum and Candida albicans&#46; Specifically&#44; parotid gland infections caused by Candida subspecies are extremely uncommon and only 6 cases have been described in the common literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;3</span></a> Thus&#44; due to the rarity of this disease there is no consensus on the management and treatment of these cases&#46; We report the case of a 50-year-old man with no medical history of interest&#46; The patient was referred to our department due to the appearance of a hard and elastic nodule &#40;1&#46;5<span class="elsevierStyleHsp" style=""></span>cm in diameter&#41; in the tail of right parotid of 3 months of evolution&#46; The lesion was painful on palpation&#44; mobile and not adhered to deep planes&#46; Importantly&#44; patient didn&#8217;t show signs of peripheral facial paralysis&#46; Due to the findings observed in the clinical examination&#44; an ultrasound of the parotid gland and a head and neck Ct scan were performed to guide the diagnosis&#46; The ultrasound showed a well-defined nodular lump with posterior acoustic reinforcement&#46; The CT scan evidenced a hypodense nodular lesion of 1&#46;4<span class="elsevierStyleHsp" style=""></span>cm suggestive of parotid abscess&#46; Moreover&#44; an FNA &#40;Fine-needle-aspiration&#41; puncture was also performed&#46; This test showed small intracytoplasmic inclusions and lymphohistiocytic cells&#44; which were identified as spores by PAS staining&#46; The microbiological study demonstrated the existence of yeast cells&#46; Finally&#44; Candida glabrata was isolated in the culture&#46; After analyzing the antibiogram&#44; the pathogen was considered resistant to fluconazole and susceptible to voriconazole&#46; Hence&#44; patient was referred to the department of Infectious Diseases of our hospital and oral treatment with voriconazole &#40;200<span class="elsevierStyleHsp" style=""></span>mg twice per day for 6 weeks&#41; was prescribed&#46; The patient was again evaluated 2 months later&#46; However&#44; no improvements were observed after a careful clinical examination&#46; A new Ct scan and a new culture showed the same result evidenced before starting antifungal treatment&#46; Consequently&#44; a new cycle of treatment with voriconazole &#40;200<span class="elsevierStyleHsp" style=""></span>mg twice per day&#41; was prescribed during three months&#46; Unfortunately&#44; the patient also did not respond to this new treatment cycle&#46; Thus&#44; patient underwent surgical treatment with superficial parotidectomy&#46; Postoperative pathological examination confirmed the fungal infection by Candida glabrata&#46; Interestingly&#44; no signs of recurrence were evidenced 12 months after surgery&#46; Despite its rarity&#44; fungal infection should be considered in the differential diagnosis of localized abscess of salivary gland even in immunocompetent patients&#46; The differential diagnosis includes a large number of neoplastic and non-neoplastic diseases&#46; The growth of fungal subspecies such Cryptococcus neoformans&#44; Histoplasma capsulatum or Candida in microbiological cultures is mandatory to guarantee a proper diagnosis&#46; Because a large number of microorganisms are usually observed&#44; fungal sialadenitis is usually easily distinguished from other pathologies&#46; A potential problem might occur when the lesion presents central necrosis and the organisms are not abundant&#46; Primary and metastatic malignant tumors that could be confused with fungal infections include mucoepidermoid carcinoma&#44; acinar cell carcinoma and squamous cell carcinoma metastasis&#46; The incidence of fungal infection as opportunistic disease has risen parallelly to the increase of immunosuppressive condition secondary to chronic illnesses&#44; malignancies&#44; transplants&#44; immunosuppressive treatments&#44; and HIV infection&#46; The treatment depends on the specific subspecies&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Medical treatments based on antifungal agents such as fluconazole&#44; voriconazole and ravuconazole might be useful and should always be considered as the first-choice treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> However&#44; the high resistance rate observed to these substances in our case forced to choose the surgical treatment as the definitive option&#46; A strict follow-up is recommended to facilitate the early diagnosis of eventual recurrences&#46; Even in case of complete healing and long-term free disease&#44; the possibility of relapses has to be considered&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical standards</span><p id="par0010" class="elsevierStylePara elsevierViewall">Authors declare we that they have taken into account the ethical responsibilities&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0015" class="elsevierStylePara elsevierViewall">All authors participated in the creation of manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financial assistance</span><p id="par0020" class="elsevierStylePara elsevierViewall">Authors not received financial assistance&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflict of interests</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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Article information
ISSN: 00257753
Original language: English
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