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Letter to the Editor
Pulmonary embolism and acro-ischemia in a lung cancer patient with COVID-19
Tromboembolismo pulmonar y acro-isquemia en un paciente con cáncer de pulmón y COVID-19
Elisabet González del Portillo, Luis Alberto Pérez-Romasanta
Corresponding author
Servicio de Oncología Radioterápica, Hospital Universitario de Salamanca, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Several authors have reported the association between COVID-19&#44; acral dermo-vascular findings&#44; pulmonary embolism &#40;PE&#41; and disseminated intravascular coagulation &#40;DIC&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;5</span></a> Herein we report a case of a COVID-19 pneumonia in a lung cancer patient with solitary brain metastases&#44; whose initial clinical findings were secondary acrocyanosis and PE&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 59-year-old man diagnosed with bone metastasis and solitary brain metastasis secondary to lung adenocarcinoma in treatment with osimertinib came into Radiation Oncology Department to receive brain stereotactic radiation therapy&#46; Several comorbidities were identified&#58; atrial fibrillation anticoagulated with LMWH&#44; arterial hypertension and hypercholesterolemia treated with medications&#46; Previous neurologic symptoms were fully abolished with dexamethasone 12<span class="elsevierStyleHsp" style=""></span>mg&#47;d and lumbar pain related with bone metastases was controlled with transdermic fentanyl&#46; No respiratory distress was present upon the first visit&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On the first treatment day &#40;day 0&#41; the patient presented to the hospital with cushingoid face&#44; cough&#44; fatigue&#44; shortness of breath beginning suddenly two days before&#44; lower extremities edemas&#44; and painful&#44; discolored skin area surrounding small shallow ulcer on the right big toe&#46; Vital signs on day 0 were <span class="elsevierStyleItalic">T</span> 37&#46;0<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; HR 110<span class="elsevierStyleHsp" style=""></span>bpm&#44; BP 89&#47;56<span class="elsevierStyleHsp" style=""></span>mm Hg&#44; and SpO<span class="elsevierStyleInf">2</span> 88&#37; on room air&#46; Most prominent physical exam findings were dispersed crackles on lungs auscultation&#44; leg edemas up to the knees&#44; and a painful 5<span class="elsevierStyleHsp" style=""></span>mm in diameter clean shallow ulcer with sharp margins located in the plantar surface of the right big toe&#44; surrounded by patches of violaceous skin extended to the second toe&#46; The violaceus patches faded under pressure&#46; The baseline EKG showed rapid atrial fibrillation&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Cardiac failure secondary to PE was suspected and treatment with digoxin was started&#46; On CT pulmonary angiogram &#40;CTPA&#41; it was documented the presence of filling defects in several lobar arteries diagnostic for PE associated with extensive opacifications involving both lungs interpreted as lung infarctions&#46; Furthermore&#44; tumor progression in the primary site and mediastinum was observed&#46; Based on these findings&#44; the patient was hospitalized&#44; the LMWH dose was increased&#44; oxygen was supplied through nasal cannula&#44; and diuretics plus antibiotics &#40;tazobactam and clindamycin&#41; were started&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Vascular surgeons examined the patient on day 8&#44; verifying popliteal and foot pulse and not recommending vascular radiological exams due to the apparent distal nature of the vascular compromise&#46; On day 9&#44; the violaceus discoloration was more extensive&#44; involving the right aspect of the foot&#46; More severe dyspnea than before prompted to a thorax X-ray showing an extensive and diffuse bilateral lung infiltrate raising the suspicion of COVID-19 pneumonia&#46; The patient was tested with positive result on PCR for SARS-CoV-2&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the most relevant analytical parameters in chronological order&#46; The clotting profile was not impaired &#40;aPTT normal and Prothrombin INR slightly increased above 1&#46;2&#41;&#44; but <span class="elsevierStyleSmallCaps">d</span>-dimer levels were elevated above 0&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;mL &#40;normal level&#44; &#60;0&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#41; and low platelet count reached grade 2 thrombocytopenia&#46; No DIC criteria were fulfilled&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">After 22 days of hospitalization the patient died due to COVID-19 infection&#44; Staph&#46; Aureus bacteremia&#44; bilateral pulmonary embolism&#44; and progressive metastatic lung cancer&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Compared with COVID-19 patients without cancer&#44; COVID-19 patients with cancer had higher risks in death&#44; admission into an intensive care unit&#44; development of severe&#47;critical symptoms&#44; and utilization of invasive mechanical ventilation&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Patients with blood cancers&#44; lung cancers&#44; or with metastatic cancer &#40;stage IV&#41; had the highest frequency of severe events&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Cases of COVID-19 bilateral pneumonia and concomitant acute PE have been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;3</span></a> The incidence of venous thrombo-embolism &#40;VTE&#41; in 81 patients with severe COVID-19 pneumonia is 25&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> The VTE group had older age&#44; lower lymphocytes count&#44; longer APTT&#44; and higher <span class="elsevierStyleSmallCaps">d</span>-dimer&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Among 184 COVID-19 patients in a Dutch ICU&#44; 31&#37; had thrombotic complications&#44; PE being the most frequent thrombotic complication &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>25&#44; 81&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Central thromboembolic events are not the only vascular complications of COVID-19&#46; Zhang et al&#46; have reported 7 patients with critical COVID-19 pneumonia and acro-ischemia&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> All patients had finger&#47;toe cyanosis&#44; skin bulla and dry gangrene&#46; <span class="elsevierStyleSmallCaps">d</span>-Dimer&#44; fibrinogen and fibrinogen degradation product &#40;FDP&#41; were significantly elevated in most patients&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In summary&#44; we now report one COVID-19 case with lung cancer and atrial fibrillation presenting central and peripheral intravascular complications highlighting the importance of hypercoagulation status in the pathogenesis&#44; clinical presentation and prognosis of the disease&#46;</p></span>"
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                  """
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analytical parameters in chronological order&#46;</p>"
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      "titulo" => "References"
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        0 => array:2 [
          "identificador" => "bibs0015"
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            0 => array:3 [
              "identificador" => "bib0030"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Patients with cancer appear more vulnerable to SARS-COV-2&#58; a multicenter study during the COVID-19 Outbreak"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Dai"
                            1 => "D&#46; Liu"
                            2 => "M&#46; Liu"
                            3 => "Y&#46;J&#46; Li"
                            4 => "Y&#46; Yang"
                            5 => "J&#46; Zhao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/2159-8290.CD-20-0422"
                      "Revista" => array:3 [
                        "tituloSerie" => "Cancer Discov"
                        "fecha" => "2020"
                        "paginaInicial" => "10"
                      ]
                    ]
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              "identificador" => "bib0035"
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ISSN: 00257753
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