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He reported high fever, cough and severe headache with bilateral temporal arteries thickening. No diagnostic tests could be performed at that time. As a non-severe SARS-CoV-2 infection was suspected, and visual or osteomuscular alterations were not reported, we opted for a late referral to specialized care and remote monitoring of the symptoms.</p><p id="par0015" class="elsevierStylePara elsevierViewall">One month later, the patient presented not any more Covid-19 symptoms but reported persistent headache and temporomandibular joint pain. Clinical examination revealed swelling and inflammation of his right temple, where a filiform pulse was noted. A notable improvement from the previous temporal thickening was observed. At that time, several diagnostic tests were performed. Blood tests yielded normal or negative results, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and autoimmunity profile; Covid-19 IgM/IgG Rapid Test (VivaCheck Biotech (Hangzhou) Co., Ltd.) was positive for both IgG and IgM; and a Doppler ultrasound of the right temporal artery showed a dark halo around lumen with a marked flow impairment, suggesting arterial wall inflammation, while left temporal artery Doppler echography was normal.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Two weeks later, an FDG PET-CT scan was performed, showing a slight increase of metabolic activity in the abdominal aorta, with a maximum standardized uptake value of 2.3<span class="elsevierStyleHsp" style=""></span>g/ml compared to 2.2<span class="elsevierStyleHsp" style=""></span>g/ml in the liver, without current active vasculitis signs.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Follow-up at three weeks revealed spontaneous clinical improvement with no corticosteroid treatment needed and a new temporal artery Doppler ultrasound was performed showing a resolution of arterial wall inflammation and blood flow.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Taking into account the complementary tests and the clinical evolution, we conclude that the most likely diagnosis was a Giant Cell Arteritis (GCA).<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Given the coincidence in time with the surrounding SARS-CoV-2 infection we hypothesize that the virus could have acted as a trigger, because of its affinity for vascular endothelia. Varicella Zoster Virus (VZV),<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a><span class="elsevierStyleItalic">Chlamydia pneumoniae</span>, Parvovirus B19 and Epstein Barr Virus, have been suggested to trigger GCA. Our patient presented atypical clinical features of CGA with spontaneous resolution, which supports a virus-related pathogenesis. In addition, other vasculitis, such as Kawasaki disease in children or neurological complication with CNS vasculitis-like pattern, have been recently linked to Covid-19,<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3,4</span></a> which supports our hypothesis.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Our main limitation is the lack of histological confirmation. However, the absence of any biologic abnormality in blood tests could be explained by the fact that biologic tests were performed after the patient presented with symptoms.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> At the same time, we should take into account that general systemic symptoms, evaluated by telephone triage or similar, might be wrongly attributed to Covid-19, leading to the delayed diagnosis of this rheumatologic condition, which in turn could prompt to an irreversible visual loss, highlighting the severity of indirect morbidity related to Covid-19.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">There is no funding to report for this submission.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Contributors</span><p id="par0045" class="elsevierStylePara elsevierViewall">All authors have made substantial contributions in each of the following aspects: study conception and design, analysis and interpretation of data, draft manuscript, critical review of its intellectual content and definitive approval of the final version.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patient and public involvement</span><p id="par0050" class="elsevierStylePara elsevierViewall">This research was done without patient involvement. Patients were not invited to comment on the study design and were not consulted to develop patient relevant outcomes or interpret the results. Patients were not invited to contribute to the writing or editing of this document for readability or accuracy.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Competing interests</span><p id="par0055" class="elsevierStylePara elsevierViewall">No, there are no competing interests for any author.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Funding" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Contributors" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Patient and public involvement" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Competing interests" ] 6 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Dejaco" 1 => "S. Ramiro" 2 => "C. Duftner" 3 => "F.L. Besson" 4 => "T.A. Bley" 5 => "D. Blockmans" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/annrheumdis-2017-212649" "Revista" => array:7 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2018" "volumen" => "77" "paginaInicial" => "636" "paginaFinal" => "643" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29358285" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673614605250" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Varicella zoster virus in giant cell arteritis: a review of current medical literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.A. Ostrowski" 1 => "S. Metgud" 2 => "R. Tehrani" 3 => "W.M. Jay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/01658107.2019.1604763" "Revista" => array:7 [ "tituloSerie" => "Neuroophthalmology" "fecha" => "2019" "volumen" => "43" "paginaInicial" => "159" "paginaFinal" => "170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31312240" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0302283818304433" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID-19 and Kawasaki disease in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Xu" 1 => "M. Chen" 2 => "J. Weng" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.phrs.2020.104951" "Revista" => array:5 [ "tituloSerie" => "Pharmacol Res" "fecha" => "2020" "volumen" => "159" "paginaInicial" => "104951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32464327" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID-19 neurologic complication with CNS vasculitis-like pattern" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Hanafi" 1 => "P.-A. Roger" 2 => "B. Perin" 3 => "G. Kuchcinski" 4 => "N. Deleval" 5 => "F. Dallery" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3174/ajnr.A6651" "Revista" => array:6 [ "tituloSerie" => "Am J Neuroradiol" "fecha" => "2020" "volumen" => "41" "paginaInicial" => "1" "paginaFinal" => "4" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31924602" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of giant cell arteritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Ponte" 1 => "J. Martins-Martinho" 2 => "R.A. Luqmani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/kez553" "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2020" "volumen" => "59" "paginaInicial" => "iii5" "paginaFinal" => "iii16" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00257753/0000015600000005/v1_202102240836/S0025775320308216/v1_202102240836/en/main.assets" "Apartado" => array:4 [ "identificador" => "66430" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Cartas al Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000015600000005/v1_202102240836/S0025775320308216/v1_202102240836/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320308216?idApp=UINPBA00004N" ]
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