Letter to the Editor
Infection and thrombosis associated with COVID-19: Possible role of the ABO blood group
Infección y trombosis asociada a la COVID-19: posible papel del grupo sanguíneo ABO
a Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu City 610041, China
b Office of Good Clinical Practice, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China
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In the current situation of the health crisis, any step forward is a great step forward. And this is exactly what the study by Saioa Zalba Marcos and colleagues add. However, the result needs to be interpreted with caution.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In their article, the authors have stated that there is lower susceptibility to SARS-CoV-2 infection in group O (although the difference between Group O patients and the global population was not statistically significant). Several very similar articles related to the relationship between the ABO blood group and the COVID-19 susceptibility have been published in the early days of the pandemic.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> With the results indicating a higher rate of infection among type A and lower among type O subjects. These hypotheses are reinforced by a study employing genome-wide association, which identified a region on chromosome 9 corresponding to the ABO locus, with frequency misbalance between severe COVID-19 patients and healthy blood donors from Italy and Spain.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">However, a recent study suggested that the ABO blood group types do not seem to significantly impact the risk of SARS-CoV-2 infection.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> To our knowledge, this is by far the biggest and most complete study about the association between risk of SARS-CoV-2 infection and ABO blood groups that's been done. Furthermore, another US study also failed to reveal a relationship between ABO blood type and susceptibility to SARS-CoV-2 infection.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Both studies point out that ethnicity may have biased previous analysis.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Thus, considering the study led by Dr. Saioa Zalba Marcos and colleagues are small so inferential caution is warranted. Time lag bias may partly have affected the findings of previous studies, and more concerns are warranted. And we fully agree with the authors that further large and sufficiently powered studies including different ethnicities, preferably from several countries are needed.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">We declare no competing interests.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Funding" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infection and thrombosis associated with COVID-19: Possible role of the ABO blood group" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. 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Lu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2020" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomewide association study of severe Covid-19 with respiratory failure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Ellinghaus" 1 => "F. Degenhardt" 2 => "L. Bujanda" 3 => "M. Buti" 4 => "A. Albillos" 5 => "P. Invernizzi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa2020283" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2020" "volumen" => "383" "paginaInicial" => "1522" "paginaFinal" => "1534" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32558485" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of association between ABO blood groups and susceptibility to SARS-CoV-2 infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.E. Levi" 1 => "P.R. Telles" 2 => "H. Scrivani" 3 => "G. 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