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Letter to the Editor
Characterization of South-East Asian ovalocytosis using osmotic gradient ektacytometry
Caracterización de la ovalocitosis del sud-este asiático mediante ectacitometría de gradiente osmótico
Marta Canelo-Vilasecaa, Inés Hernández-Rodrígueza,b,
Corresponding author
agnesrh@iconcologia.net

Corresponding author.
, José-Tomás Navarroa,b
a Hematology Department, ICO-Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Badalona, Spain
b Josep Carreras Leukaemia Research Institute, Campus ICO-Germans Trias i Pujol, Badalona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">South-East Asian ovalocytosis &#40;SAO&#41; is an inherited autosomic dominant disorder causing a membranopathy of red blood cells &#40;RBC&#41; which is now widespread in South-East Asia with a prevalence around 30&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> suggesting survival advantage in this geographic area against <span class="elsevierStyleItalic">Plasmodium falciparum</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Despite genetic test being confirmatory of SAO diagnosis&#44; the combination of morphology examination in peripheral blood and ektacytometry test could be very effective for its diagnosis offering a potential tool to be used in clinical practice&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Here-in we present a case of a 24-year-old woman&#44; born in the Philippines&#44; who performed a routine laboratory testing&#46; She was asymptomatic and the physical examination was normal&#46; Macro-ovalocytes were incidentally found on a blood smear examination&#46; Stomatocytes were observed among these ovalocytes&#44; some of them with more than one stoma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1a</a>&#41;&#46; Complete blood test using a hematology analyzer Beckman Coulter DxH 900 &#40;Beckman Coulter&#44; Miami&#44; Florida&#44; USA&#41; showed hemoglobin 15&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;dL &#40;normal range &#91;NR&#93;&#58; 12&#8211;16<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#44; with normal mean corpuscular volume and hemoglobin concentration&#46; No hemolysis signs were observed&#46; Osmotic gradient ektacytometry was performed with new generation ektacytometer LoRRca MaxSis &#40;Mechatronics Instruments&#174;BV&#44; Zwaag&#44; The Netherlands&#41; showing a flat curve reminding hereditary elliptocytosis &#40;HE&#41; profile<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> with marked decrease in the maximal RBC deformability &#40;Elmax&#41;&#44; decrease in osmolality at the Elmax &#40;Omax&#41; and extreme decrease in area under curve&#44; suggesting the presence of non-deformable red blood cells &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1b</a>&#41;&#46; Next generation sequency &#40;NGS&#41; revealed a heterozygous 9-amino-acid deletion <span class="elsevierStyleItalic">in frame</span> &#40;Ala400&#95;Ala408del&#41; in <span class="elsevierStyleItalic">SLC4A1</span> gene codifying for band 3 protein&#46; With this finding&#44; SAO diagnosis was confirmed&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Despite their oval-shaped and rigid RBC&#44; adult carriers in the heterozygous state have no clinical repercussions&#46; Nonetheless&#44; minimal hemolysis with neonatal hyperbilirubinemia and anemia has been observed during childhood&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Genetic lesion consists of a mutation in band 3 of <span class="elsevierStyleItalic">SLC4A1</span> gene causing a misfolding in the transmembrane domain&#46; Band 3 is the dominant glycoprotein of RBC membrane where it carries out anion exchange and confers RBC shape through linkages between the cytoskeleton and the lipid bilayer&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The ektacytometer is a laser diffractometer that measures the deformability potential of RBC over an osmotic gradient&#46; The result of the test is a characteristic graph named Osmoscan&#44; which shows the amount of deformability on the <span class="elsevierStyleItalic">y</span>-axis and osmolality in the <span class="elsevierStyleItalic">x</span>-axis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical considerations</span><p id="par0025" class="elsevierStylePara elsevierViewall">Informed consent was obtained&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">Funds from <span class="elsevierStyleGrantSponsor" id="gs1">Josep Carreras International Foundation</span>&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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Article information
ISSN: 00257753
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos