Correspondence on anti-SARS-CoV-2 antibodies and clinical outcome of hospitalized COVID-19 patients

Dear Editor,

We would like to share ideas on the publication “Role of vaccination and anti-SARS-CoV-2 antibodies in the clinical outcome of hospitalized COVID-19 patients.”¹ Bernal et al. assess the impact of a patient's immunization status, anti-SARS-CoV-2 antibody titer, comorbidities, analytical findings, clinical presentation upon admission, therapies, and need for respiratory support on the patient's outcome.¹ SARS-CoV-2 vaccination, according to Bernal et al., was linked to higher S-protein antibody titers and a decreased risk of radiological progression, the need for immunomodulators, and the need for respiratory support or death. However, vaccination, but not antibody titers, protected against adverse events, suggesting that immune-protective mechanisms in addition to humoral response played a part.¹

We both believe that the COVID-19 vaccination may be advantageous for expectant mothers. As Kontovazainitis et al. pointed out, there is not yet enough information to draw a firm conclusion. In order to completely understand the findings, a variety of things must be taken into account. A markedly unpleasant reaction was one of the potential complicating elements that might have altered how the vaccination behaved. In essence, a pregnant woman may experience concurrent medical issues like diabetes and anemia as a result of her body's reaction to the immunization. It is impossible to draw a connection between asymptomatic COVID-19 and the lack of symptoms without specialist laboratory investigations. There may be a connection between asymptomatic COVID-19 and a lack of clinical symptoms in the absence of specialized laboratory investigations.² A silent COVID-19 must be ruled out if neither the recent clinical symptoms nor the current clinical markers are present. Different people's immune systems appear to react to COVID-19 differently based on inherited genetic variation.²

The findings of the investigation need to be supported by additional clinical research. Any additional research should not include any cases with coexisting medical issues, and if possible, it should also include a review of the patient's genetic background.

Conflict of interest

None declared.