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Letter to the Editor
Acute pancreatitis in a patient with COVID-19 infection
Pancreatitis aguda en paciente con infección por COVID-19
Ana Gonzalo-Voltasa, Clara Uxia Fernández-Pérez-Torresa, José Miguel Baena-Díeza,b,c,
Corresponding author
josemibaena@gmail.com

Corresponding author.
a Centro de Atención Primaria La Marina, Instituto Catalán de la Salud, Barcelona, Spain
b IDIAP Jordi Gol, Instituto Catalán de la Salud, Barcelona, Spain
c Grupo de Epidemiología Cardiovascular y Genética, Instituto de Investigación Médica IMIM-Hospital del Mar, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Since the first cases of the SARS-CoV-2 coronavirus infection appeared in the city of Wuhan&#44; the disease has taken on pandemic characteristics&#46; In Spain&#44; according to the 14th May 2020 update from the Ministry of Health&#44; there have been 228&#44;540 cases&#44; with a total of 27&#44;321 deaths&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Although the severity of the infection is mainly determined by the development of severe pneumonia and acute respiratory <span class="elsevierStyleItalic">distress</span>&#44; other conditions have been described in different organs and systems&#46; Vomiting&#44; diarrhoea and abdominal pain are common digestive system-related symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Liver involvement is also common&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> We report a case of acute pancreatitis that could be related to COVID-19 infection&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A 76 year-old woman&#44; ex-smoker&#44; with low-risk alcohol consumption &#40;10 g of pure alcohol&#44; one day a week&#41;&#46; Personal history of hypercholesterolemia and gastroesophageal reflux&#46; Chronic omeprazole treatment &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41; for more than 10 years&#44; which took on demand&#46; Twenty-four days before hospital admission&#44; the patient had taken three 500 mg tablets of azithromycin for acute sinusitis&#46; She came to the hospital for an 8 h-history of epigastric pain&#44; radiated to both hypochondriac regions&#44; accompanied by vomiting&#46; Approached as possible acute pancreatitis&#44; it was confirmed by high levels of plasma amylase &#40;3568<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41; and compatible abdominal ultrasound&#44; without cholelithiasis&#46; The rest of the laboratory parameters were normal&#44; except for a slight increase of neutrophils &#40;84&#37;&#41; and C-reactive protein &#40;1&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; An abdominal CT confirmed the diagnosis and classified it as interstitial oedematous pancreatitis&#46; A subsequent CT and magnetic resonance cholangiography showed similar findings and again ruled out biliary pathology&#46; The PCR was positive for COVID-19&#44; with symptoms of fever and diarrhoea&#46; A chest X-ray was normal&#46; Treatment with hydroxychloroquine&#44; azithromycin&#44; and lopinavir plus ritonavir was started&#44; with a good response&#46; Similarly&#44; regarding the pancreatitis&#44; the patient progressed favourably under conservative treatment&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We believe that the absence of at-risk alcohol consumption and calculous disease&#44; the main causes of acute pancreatitis&#44; point to a possible infectious cause of COVID-19&#46; We do not believe that the history of taking azithromycin more than 3 weeks before is related to pancreatitis&#44; which was not made worse by the reintroduction of azithromycin treatment&#46; In this sense&#44; a possible case of azithromycin-induced pancreatitis has been described in our setting&#44; although the authors themselves stated that it was a difficult-to-demonstrate relationship&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Nor do we believe that omeprazole intake is the cause&#44; since although cases<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> have been described&#44; it is unlikely after 10 years of exposure&#46; Both with azithromycin and omeprazole&#44; the attribution of causality is doubtful with the Naranjo algorithm&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">COVID-19-related pancreatic involvement has been described in the form of high amylase and lipase levels&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> This involvement is pathophysiologically consistent&#44; as the pancreas expresses the angiotensin-converting enzyme&#44; whose receptors facilitate the penetration of the virus&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> One case of acute pancreatitis attributable to COVID-19 infection has been described&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> with compatible symptoms and CT scans&#44; although no laboratory tests were available to demonstrate high levels of amylase&#46; The patient had been diagnosed with COVID-19 infection and had received treatment with vancomycin and tetracycline&#44; showing the symptoms compatible with acute pancreatitis 5 days after discharge&#46; The latter antibiotic has also been linked to the development of acute pancreatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p></span>"
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Article information
ISSN: 23870206
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos