Original Article
Use of Bevacizumab for neurological complications during initial treatment of malignant gliomas
Utilización de bevacizumab en las complicaciones neurológicas durante el tratamiento inicial de los gliomas malignos
Neurology Department, Neuro-Oncology Division, University of Pennsylvania, Philadelphia, USA
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"apellidos" => "Roda" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580811700165?idApp=UINPBA00004N" "url" => "/21735808/0000002600000002/v1_201305151241/S2173580811700165/v1_201305151241/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Use of Bevacizumab for neurological complications during initial treatment of malignant gliomas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "74" "paginaFinal" => "80" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Arratibel-Echarren, K. Albright, J. Dalmau, M.R. Rosenfeld" "autores" => array:4 [ 0 => array:3 [ "nombre" => "I." "apellidos" => "Arratibel-Echarren" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">&</span>" "identificador" => "fn0005" ] ] ] 1 => array:2 [ "nombre" => "K." "apellidos" => "Albright" ] 2 => array:4 [ "nombre" => "J." "apellidos" => "Dalmau" "email" => array:1 [ 0 => "josep.dalmau@uphs.upenn.edu" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 3 => array:2 [ "nombre" => "M.R." "apellidos" => "Rosenfeld" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Neurology Department, Neuro-Oncology Division, University of Pennsylvania, Philadelphia, USA" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilización de bevacizumab en las complicaciones neurológicas durante el tratamiento inicial de los gliomas malignos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-04-29" "fechaAceptado" => "2010-05-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec157368" "palabras" => array:6 [ 0 => "High grade glioma" 1 => "Radiation necrosis" 2 => "Tumour progression" 3 => "Oedema" 4 => "Corticosteroids" 5 => "Bevacizumab" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec157369" "palabras" => array:6 [ 0 => "Glioma de alto grado" 1 => "Radionecrosis" 2 => "Progresión tumoral" 3 => "Edema" 4 => "Corticoides" 5 => "Bevacizumab" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">High grade gliomas are the most common primary malignant brain tumours. Treatment with chemoradiation and adjuvant chemotherapy with Temozolomide may prolong survival but some patients develop complications during or soon after therapy due to radiation necrosis, oedema or tumour progression.</p> <span class="elsevierStyleSectionTitle">Patients</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We report the use of Bevacizumab in four patients with newly diagnosed high grade gliomas who developed cerebral oedema due to tumour progression or radiation necrosis that did not respond to corticosteroids, and who were not candidates for surgical debulking.</p> <span class="elsevierStyleSectionTitle">Outcomes</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">All four patients had a rapid response to treatment with bevacizumab, tolerating a decrease of the dose of corticosteroids, and were able to continue their standard therapy.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Bevacizumab is effective in controlling some of the neurological complications from oedema, radiation necrosis, or rapid tumour progression during the initial treatment of malignant gliomas.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los gliomas de alto grado son los tumores malignos más frecuentes del sistema nervioso central. El tratamiento con quimiorradioterapia y quimioterapia adyuvante con temozolomida puede prolongar la supervivencia, pero algunos pacientes desarrollan complicaciones durante o poco después de acabar el tratamiento debido a radionecrosis, edema o progresión tumoral.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Presentamos el uso de bevacizumab en 4 pacientes que desarrollaron edema cerebral en relación con radionecrosis o progresión tumoral durante la fase inicial del tratamiento, con respuesta inadecuada a los corticoides y que no eran subsidiarios de tratamiento quirúrgico por la localización de la lesión o la mala situación clínica.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los cuatro pacientes presentaron una rápida respuesta al tratamiento con bevacizumab, lo cual permitió reducir la dosis de corticoides y continuar el tratamiento estándar.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Bevacizumab es efectivo en el control de algunas complicaciones neurológicas debidas a edema, radionecrosis o rápida progresión de tumores no extirpables durante el tratamiento inicial de los gliomas malignos.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "&" "nota" => "<p class="elsevierStyleNotepara">Izaskun Arratibel Echarren is a resident in Neurology at the Hospital Donostia. The present study was carried out during her stay at the Neuro-Oncology Division of the University of Pennsylvania.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Stupp" 1 => "W.P. Mason" 2 => "M.J. Van den Bent" 3 => "M. Weller" 4 => "B. Fisher" 5 => "M.J. 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| 2018 September | 4 | 7 | 11 |
| 2018 August | 0 | 4 | 4 |
| 2018 July | 2 | 2 | 4 |
| 2018 June | 0 | 2 | 2 |
| 2018 May | 1 | 1 | 2 |
| 2018 April | 0 | 1 | 1 |
| 2018 March | 1 | 1 | 2 |
| 2017 December | 0 | 1 | 1 |
| 2017 November | 0 | 2 | 2 |
| 2017 October | 1 | 3 | 4 |
| 2017 September | 1 | 7 | 8 |
| 2017 August | 3 | 9 | 12 |
| 2017 July | 0 | 1 | 1 |
| 2017 June | 2 | 3 | 5 |
| 2017 May | 3 | 1 | 4 |
| 2017 April | 4 | 1 | 5 |
| 2017 March | 8 | 36 | 44 |
| 2017 February | 2 | 0 | 2 |
| 2017 January | 1 | 1 | 2 |
| 2016 December | 10 | 0 | 10 |
| 2016 November | 12 | 1 | 13 |
| 2016 October | 8 | 0 | 8 |
| 2016 September | 7 | 0 | 7 |
| 2016 August | 7 | 1 | 8 |
| 2016 July | 4 | 0 | 4 |
Show all
