Letter to the Editor
Comments on the published Letter to the Editor by Martínez-Lapiscina et al.: “Epileptic seizure and lipoma of the corpus callosum: Cause or finding”
Comentarios a la carta del editor publicada por Martínez-Lapiscina et al: «Crisis epiléptica y lipoma del cuerpo calloso: causa o hallazgo»
J.S. Lucena Romero
, M. Santos Rodríguez, A. Rico García, R. Marín Andrés, M.R. Blanco Rodríguez
Corresponding author
Servicio de Patología Forense, Instituto de Medicina Legal, Sevilla, Spain
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Lucena Romero, M. Santos Rodríguez, A. Rico García, R. Marín Andrés, M.R. Blanco Rodríguez" "autores" => array:5 [ 0 => array:4 [ "nombre" => "J.S." "apellidos" => "Lucena Romero" "email" => array:1 [ 0 => "joaquin.lucena@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Santos Rodríguez" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Rico García" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Marín Andrés" ] 4 => array:2 [ "nombre" => "M.R." "apellidos" => "Blanco Rodríguez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Patología Forense, Instituto de Medicina Legal, Sevilla, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Comentarios a la carta del editor publicada por Martínez-Lapiscina et al: «Crisis epiléptica y lipoma del cuerpo calloso: causa o hallazgo»" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 746 "Ancho" => 998 "Tamanyo" => 150636 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Fresh coronal section of the brain at the level of the basal ganglia. It is possible to observe an interhemispheric lipoma located in the anterior part of the corpus callosum.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with great interest the recent article by Martinez-Lapiscina et al., “Epileptic seizures and lipoma of the corpus callosum: cause or finding”.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> As the authors demonstrate, “intracranial lipomas can cause epileptic seizures and their correct diagnosis has prognostic and therapeutic implications”.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Some years ago we published a case of lipoma of the corpus callosum in a 42-year-old male who died suddenly due to food aspiration as a result of an epileptic seizure while he was dining. A neuropathological study revealed two curvilinear lipomas located at the top of the genu of the corpus callosum (2.5<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>0.7<span class="elsevierStyleHsp" style=""></span>cm and 1.5<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>0.5<span class="elsevierStyleHsp" style=""></span>cm, respectively). These consisted of mature adipose tissue and were very well vascularised. They were not associated with developmental abnormalities of the corpus callosum.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">It is noteworthy that our patient had presented two previous seizures at 28 and 40 years of age, so he had undergone EEG, CT and MRI scans; these showed “brain fat”, as reported by the family (we did not have access to medical records). The patient was not following anticonvulsant therapy, since no clinical indication was considered. This fact was confirmed by a negative result in the chemical–toxicological analysis performed.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Recently, we had another case of lipoma of the corpus callosum as an incidental finding during the autopsy of a 41-year-old woman who died suddenly due to digestive pathology. It was a tubulonodular lipoma measuring 2<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>cm, of interhemispheric location, situated in the anterior corpus callosum. It was not associated to any dysgenesis or other neuronal migration abnormalities (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Although the patient had not presented epileptic seizures, she had a history of headache and mild psychomotor retardation. The facies was somewhat coarse, with frontal prominence and low-set ears, suggesting a defect in the development of the midline, as other authors have mentioned.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a> Intracranial lipomas are rare congenital malformations, representing only 0.03–0.08% of all intracranial masses.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> In the past 6–1/2 years, we have performed a total of 6011 legal autopsies at our department and found only 2 exposed cases of lipomas of the corpus callosum (an incidence of 0.03%).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">We completely agree with the view expressed by the authors when they mention that intracranial lipomas can cause epileptic seizures, so a higher prevalence of lipomas should be considered in the epileptic population. On the other hand, anticonvulsant therapy may be necessary in these cases, especially in symptomatic patients.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally, we consider that, in addition to diagnosing the cause of death, a forensic pathologist is required to explain the pathophysiological mechanisms of the disease, as well as any possible aetiologies and risk factors involved. This is the philosophy that we attempt to apply during our daily work.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Lucena Romero JS, et al. Comentarios a la carta del editor publicada por Martínez-Lapiscina et al: «Crisis epiléptica y lipoma del cuerpo calloso: causa o hallazgo». Neurología. 2011;27:57–8.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 746 "Ancho" => 998 "Tamanyo" => 150636 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Fresh coronal section of the brain at the level of the basal ganglia. It is possible to observe an interhemispheric lipoma located in the anterior part of the corpus callosum.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Crisis epiléptica y lipoma del cuerpo calloso: causa o hallazgo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.H. Martinez-Lapiscina" 1 => "M.P. Moreno García" 2 => "M. 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| 2022 December | 36 | 3 | 39 |
| 2022 November | 38 | 15 | 53 |
| 2022 October | 26 | 20 | 46 |
| 2022 September | 38 | 18 | 56 |
| 2022 August | 31 | 6 | 37 |
| 2022 July | 17 | 6 | 23 |
| 2022 June | 11 | 7 | 18 |
| 2022 May | 16 | 11 | 27 |
| 2022 April | 15 | 8 | 23 |
| 2022 March | 20 | 9 | 29 |
| 2022 February | 11 | 8 | 19 |
| 2022 January | 12 | 3 | 15 |
| 2021 December | 12 | 8 | 20 |
| 2021 November | 15 | 6 | 21 |
| 2021 October | 18 | 16 | 34 |
| 2021 September | 13 | 12 | 25 |
| 2021 August | 7 | 10 | 17 |
| 2021 July | 9 | 7 | 16 |
| 2021 June | 16 | 12 | 28 |
| 2021 May | 17 | 7 | 24 |
| 2021 April | 12 | 17 | 29 |
| 2021 March | 14 | 10 | 24 |
| 2021 February | 8 | 8 | 16 |
| 2021 January | 16 | 9 | 25 |
| 2020 December | 14 | 9 | 23 |
| 2020 November | 13 | 12 | 25 |
| 2020 October | 8 | 3 | 11 |
| 2020 September | 9 | 6 | 15 |
| 2020 August | 8 | 7 | 15 |
| 2020 July | 12 | 11 | 23 |
| 2020 June | 9 | 2 | 11 |
| 2020 May | 12 | 8 | 20 |
| 2020 April | 10 | 5 | 15 |
| 2020 March | 8 | 1 | 9 |
| 2020 February | 13 | 5 | 18 |
| 2020 January | 11 | 5 | 16 |
| 2019 December | 11 | 10 | 21 |
| 2019 November | 6 | 4 | 10 |
| 2019 October | 11 | 2 | 13 |
| 2019 September | 7 | 5 | 12 |
| 2019 August | 4 | 8 | 12 |
| 2019 July | 9 | 4 | 13 |
| 2019 June | 4 | 10 | 14 |
| 2019 May | 64 | 7 | 71 |
| 2019 April | 23 | 26 | 49 |
| 2019 March | 6 | 4 | 10 |
| 2019 February | 3 | 9 | 12 |
| 2019 January | 5 | 6 | 11 |
| 2018 December | 7 | 12 | 19 |
| 2018 November | 2 | 3 | 5 |
| 2018 October | 10 | 11 | 21 |
| 2018 September | 7 | 5 | 12 |
| 2018 August | 7 | 7 | 14 |
| 2018 July | 4 | 5 | 9 |
| 2018 June | 2 | 1 | 3 |
| 2018 May | 6 | 11 | 17 |
| 2018 April | 18 | 1 | 19 |
| 2018 March | 3 | 2 | 5 |
| 2018 February | 0 | 3 | 3 |
| 2018 January | 4 | 3 | 7 |
| 2017 December | 4 | 4 | 8 |
| 2017 November | 6 | 5 | 11 |
| 2017 October | 10 | 7 | 17 |
| 2017 September | 10 | 8 | 18 |
| 2017 August | 8 | 5 | 13 |
| 2017 July | 16 | 1 | 17 |
| 2017 June | 24 | 3 | 27 |
| 2017 May | 12 | 9 | 21 |
| 2017 April | 13 | 3 | 16 |
| 2017 March | 9 | 16 | 25 |
| 2017 February | 9 | 2 | 11 |
| 2017 January | 7 | 3 | 10 |
| 2016 December | 6 | 5 | 11 |
| 2016 November | 6 | 1 | 7 |
| 2016 October | 12 | 10 | 22 |
| 2016 September | 29 | 5 | 34 |
| 2016 August | 22 | 2 | 24 |
| 2016 July | 13 | 1 | 14 |
| 2016 June | 19 | 7 | 26 |
| 2016 May | 15 | 10 | 25 |
| 2016 April | 15 | 9 | 24 |
| 2016 March | 21 | 13 | 34 |
| 2016 February | 16 | 12 | 28 |
| 2016 January | 14 | 8 | 22 |
| 2015 December | 15 | 10 | 25 |
| 2015 November | 9 | 3 | 12 |
| 2015 October | 13 | 6 | 19 |
| 2015 September | 16 | 6 | 22 |
| 2015 August | 9 | 4 | 13 |
| 2015 July | 8 | 8 | 16 |
| 2015 June | 0 | 2 | 2 |
| 2015 May | 15 | 14 | 29 |
| 2015 April | 12 | 7 | 19 |
| 2015 March | 10 | 2 | 12 |
| 2015 February | 22 | 5 | 27 |
| 2015 January | 27 | 5 | 32 |
| 2014 December | 35 | 8 | 43 |
| 2014 November | 9 | 1 | 10 |
| 2014 October | 18 | 2 | 20 |
| 2014 September | 36 | 1 | 37 |
| 2014 August | 26 | 2 | 28 |
| 2014 July | 33 | 5 | 38 |
| 2014 June | 18 | 1 | 19 |
| 2014 May | 13 | 2 | 15 |
| 2014 April | 13 | 1 | 14 |
| 2014 March | 19 | 4 | 23 |
| 2014 February | 20 | 2 | 22 |
| 2014 January | 6 | 4 | 10 |
| 2013 December | 18 | 5 | 23 |
| 2013 November | 25 | 3 | 28 |
| 2013 October | 35 | 9 | 44 |
| 2013 September | 17 | 8 | 25 |
| 2013 August | 20 | 3 | 23 |
| 2013 July | 23 | 1 | 24 |
Show all
