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Letter to the Editor
Reply to the letter to the editor by Lucena Romero et al. on the article “Epileptic seizure and lipoma of corpus callosum: Cause or incidental finding”
Respuesta a la carta al editor de Lucena Romero et al en relación con el artículo «Crisis epiléptica y lipoma del cuerpo calloso: causa o hallazgo»
E.H. Martínez-Lapiscinaa,
Corresponding author
elena_yosoy@hotmail.com

Corresponding author.
, M.P. Moreno Garcíab, M. Bujanda Alegríaa
a Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
b Servicio de Neurología, Hospital de Txagorritxu, Vitoria, Álava, Spain
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        "titulo" => "Respuesta a la carta al editor de Lucena Romero et al en relaci&#243;n con el art&#237;culo &#171;Crisis epil&#233;ptica y lipoma del cuerpo calloso&#58; causa o hallazgo&#187;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We wish to thank Dr&#46; Lucena et al&#46; for their interest in the review &#8220;Epileptic seizures and lipoma of the corpus callosum&#58; Cause or finding&#8221;&#44; in which they have contributed their experience with intracranial lipomas&#46; We would also like to clarify some of the comments made&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The incidence reported by the authors &#40;0&#46;03&#37;&#41; is similar to that reported by other authors in autopsy cases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The authors describe two clinical cases with discovery of lipoma of the corpus callosum in the midline&#46; The first case<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> describes a patient who died due to bronchoaspiration after an episode of generalised tonic-clonic epileptic seizure&#46; The clinical history mentioned that the patient had suffered two previous episodes of epileptic seizures&#44; which led to an aetiological study being conducted&#46; This pointed to the existence of an intracranial lipoma &#40;&#8220;brain fat&#8221;&#41;&#44; which was confirmed during the autopsy by the finding of two lipomas located in the genu of the corpus callosum&#46; Intracranial lipomas can be the cause of epileptic seizures&#46; The prevalence of lipomas in the epileptic population is higher than that among the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> For this reason&#44; the finding of an intracranial lipoma in epileptic patients does not necessarily indicate a causal association&#44; but it should invite us to consider other possible aetiologies&#46; In addition&#44; we should conduct a study to assess whether there is adequate correlation between the location of the mass and the clinical-EEG characteristics of the epileptic seizures&#44; thus allowing us to consider a causal association&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> According to the authors&#44; it was not possible to access the test results &#40;especially the EEG&#41; and no information was provided on the semiology of the epileptic seizures &#40;primarily generalised or focal with secondary generalisation&#63;&#41;&#59; consequently&#44; the association between lipomas and epileptic seizures should be taken with particular caution in this case&#44; as it is not possible to ensure that lipomas are a causal factor&#46; The second patient did not have a history of epileptic seizures&#44; although she did suffer headache and psychomotor retardation&#44; as well as the phenotypic traits characteristic of a congenital malformation&#46; As we mentioned before&#44; headache is the symptom most frequently reported in association with lipomas of the corpus callosum in adults<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#59; whereas it is psychomotor retardation in children&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> We agree with the authors that&#44; in the second case&#44; the presence of lipoma of the corpus callosum might be in the context of a congenital malformation of the midline&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion&#44; intracranial lipomas can be regarded as the cause for epileptic seizures as long as there is adequate correlation between the location of the mass and the clinical-EEG characteristics of the epileptic seizures&#44; and if other alternative aetiologies have been excluded&#46;</p></span>"
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Article information
ISSN: 21735808
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos