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Letter to the Editor
Long standing polyneuropathy as a form of presentation of primary systemic amyloidosis
Polineuropatía de larga evolución como forma de inicio de amiloidosis sistémica primaria
P.E. Jiménez Caballero
Sección de Neurología, Hospital San Pedro de Alcántara, Cáceres, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Systemic amyloidosis is a rare disease caused by deposition of a fibrillar protein in immunoglobulin light chains &#40;kappa or lambda&#41; on different tissues&#46; Symptoms depend on the organs affected by the deposits&#44; but may include myocardiopathy&#44; liver disease&#44; kidney failure&#44; lingual hypertrophy&#44; dermatitis&#44; gastro-oesophageal reflux disorder&#44; and polyneuropathy&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 59-year-old male patient was examined due to sensory deficit of the hands and feet associated with very painful paraesthesia which had been developing gradually over the course of a year&#46; Neurological examination showed cortical functions and cranial nerve pairs to be normal&#46; The motor system revealed preserved tone with slight motor weakness in dorsiflexion of the feet and extension of the fingers and intrinsic hand muscles&#46; All other muscle groups were normal&#46; Deep muscle reflexes were hypoactive&#44; except for the Achilles reflex which was absent&#46; There was neither amyotrophy nor fasciculations&#46; Decreased superficial and deep sensitivity in a stocking-and-glove pattern were observed&#46; Autonomic changes in hands and feet were also observed&#46; The coordination was normal&#46; Heel-to-toe gait was somewhat abnormal&#46; The general examination did not reveal relevant changes&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We ran a haemogram and complete biochemical analyses&#59; glucose and antinuclear antibodies&#44; proteinogram&#44; tumour markers&#44; and onconeural antibodies were all within normal ranges&#46; The lumbar puncture revealed no relevant biochemical or cytological changes&#46; Serological tests for Borrelia&#44; Brucella&#44; syphilis&#44; HIV&#44; and neurotropic viruses were negative&#46; The thoracic and abdominal CT showed no alterations&#46; The electromyogram showed decreased amplitude of sensory potentials at the sural and superficial peroneal nerve levels&#44; and to a lesser extent&#44; in median and cubital nerves&#46; Sensory nerve conduction velocities and distal latencies were within normal limits&#46; There was a slight decrease in motor evoked potential amplitude at the level of both common peroneal nerves&#44; with normal motor potentials at the median and cubital levels&#46; Data were compatible with predominantly sensory axonal polyneuropathy&#46; Biopsies of the sural nerve on 2 different occasions showed no vasculitic changes or amyloid deposits&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was treated with different drug groups such as antiepileptic agents &#40;carbamazepine&#44; topiramate&#44; gabapentin&#44; oxcarbazepine&#44; pregabalin&#44; and clonazepam&#41;&#59; antidepressants &#40;amitriptyline&#44; venlafaxine&#41;&#59; morphine derivatives&#44; and a cycle of intravenous gamma globulin without symptoms improving&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">After 4 years of follow-up&#44; a proteinogram with immunoelectrophoresis showed a monoclonal spike of light lambda chains&#46; The patient refused consent for a bone marrow aspiration&#46; The haematology department diagnosed him with probable monoclonal gammopathy of undetermined significance&#44; and the patient stopped attending haematology check-ups&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The course of the patient&#39;s disease from symptom onset was insidious&#44; but progressive&#46; On the clinical level&#44; sensory polyneuropathy worsened&#44; producing more resistant neuropathic pain&#44; with the autonomic disorder progressing at the same time&#46; This deterioration was detected using several electromyograms performed after symptom onset&#46; Repeated complementary studies did not show any other possible causes of polyneuropathy&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">After more than 12 years of follow-up with no extraneurological symptoms&#44; he suffered a major wasting disorder associated with heart failure secondary to atrial fibrillation and hypertrophic myocardiopathy&#44; dyspepsia&#44; detached right retina&#44; and multiple lacunar infarcts that were probably cardioembolic in origin&#46; He died a few days later of septic shock&#46; Complementary analyses performed during this hospitalisation revealed a monoclonal band &#40;M-spike&#41; in the gamma-globulin region&#59; immunofixation showed lambda light chains&#46; A biopsy of the duodenum and of abdominal cutaneous fat showed eosinophilic material in the vascular walls of the submucous membrane with positive Congo red and thioflavin stains&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Polyneuropathy may be caused by a wide variety of processes&#46; In patients with predominantly sensory polyneuropathy&#44; doctors must rule out diabetes mellitus&#44; vitamin B12 deficiency&#44; Sj&#246;gren syndrome&#44; HIV&#44; leprosy&#44; paraneoplastic syndrome&#44; and amyloidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The prevalence of amyloidosis in sural nerve biopsies is approximately 1&#37; in some series&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> An amyloid deposit is an amorphous extracellular eosinophilic deposit that shows apple green birefringence after staining with Congo red&#46; Polyneuropathy in primary systemic amyloidosis follows different patterns&#44; but axonal damage predominates over demyelinating damage&#46; It typically presents with an intractable and progressive course&#59; it is painful&#44; affects sensation&#44; and has a significant autonomic component&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Diagnosis of primary systemic amyloidosis can often take as long as 2 years from the onset of polyneuropathy&#59; the case we present is extreme&#46; We therefore recommend monitoring over 10 years or more in order to detect amyloidosis if there is a clinical suspicion of that entity&#46; Using abdominal fat aspiration to detect amyloid may be more sensitive than using rectal biopsies&#44; and may therefore be carried out in cases in which the latter procedure gives a negative result&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> On the other hand&#44; there may be cases of neuropathy in primary systemic amyloidosis in which an increase in immunoglobulins is not detected in serum or in urine&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The presence of an autonomic disorder supports a suspected diagnosis of polyneuropathy due to amyloid deposition&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Progression of systemic amyloidosis is the cause of death in most of these cases&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p></span>"
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Article information
ISSN: 21735808
Original language: English
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es en pt

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