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Letter to the Editor
Unilateral eyelid myokymia as a form of presentation of multiple sclerosis
Mioquimias palpebrales unilaterales como forma de presentación de una esclerosis múltiple
A. Palasía,
Corresponding author
toni.palasi@gmail.com

Corresponding author.
, N. Martínez-Sánchezb, L. Bauc, J. Campdelacreuc
a Servicio de Neurología, Hospital Universitario Valle de Hebrón, Universidad Autónoma de Barcelona, Barcelona, Spain
b Área Salut Básica Sant Josep, ICS, L’Hospitalet de Llobregat, Barcelona, Spain
c Servicio de Neurología, IDIBELL Hospital Universitario de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Myokymias are localised involuntary contractions that are wavelike or vermicular and propagate through affected striated muscle&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> They are caused by simultaneous or sequential activations of 1&#44; 2&#44; or more motor units of a muscle&#46; An electromyography reading shows spontaneous muscle activity with different motor units producing brief&#44; repetitive discharges of action potentials in rhythmic or semi-rhythmic bursts&#46; This is followed by a short &#40;0&#46;5 to 3<span class="elsevierStyleHsp" style=""></span>seconds&#41; and frequently irregular interval of electric silence before the following myokymic discharge occurs&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">When myokymia occurs in the face&#44; the most frequently affected muscle is the orbicularis oculi&#46; Myokymia in this muscle results in small&#44; visible contractions of part of the eyelid&#44; typically the lower eyelid&#46; Eyelid myokymias &#40;EM&#41; tend to be transient and self-limiting within a few days of onset&#46; They present in young&#44; healthy subjects with no associated diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6&#44;7</span></a> We describe a patient in whom the presence of continuous EM resulted in a diagnosis of multiple sclerosis &#40;MS&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 34-year-old woman with no relevant medical history or drug use&#46; She was examined for abnormal movements compatible with myokymias in the right lower eyelid which had been occurring for 2 months&#46; The symptoms initially presented sporadically during the day in episodes lasting from a few minutes to an hour&#46; As the weeks passed&#44; their frequency and intensity had increased and muscle twitches had become continuous&#46; The first neurological examination revealed generalised hyperreflexia&#59; all other findings were normal&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the intensity of the myokymias&#44; the patient began treatment with carbamazepine &#40;800<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; but the drug had to be discontinued quickly due to the appearance of a maculopapular rash and elevated transaminases&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The symptoms resolved spontaneously 9 weeks after their onset&#46; A week after EMs had become continuous&#44; doctors performed a brain MRI which showed multiple lesions in supratentorial white matter in both hemispheres&#44; semioval centres&#44; and the juxtaventricular zone&#44; plus a lesion in the posterior right frontal lobe &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; A complete blood study including serology and autoimmune markers yielded normal results&#46; CSF analysis indicated the presence of oligoclonal bands&#44; although they were not found in serum&#46; A second cranial MRI taken at 4 months revealed new lesions&#44; including several with gadolinium uptake &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Based on these findings&#44; the patient was diagnosed with MS&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Facial myokymias that occur continuously and affect all the muscles on one side of the face have often been described in association with different types of lesions of the ipsilateral pontine tegmentum&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;6&#44;9</span></a> especially tumours &#40;gliomas or metastasis&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a> cysticercosis&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and MS&#46; In MS&#44; myokymias may occur either throughout the duration of the disease<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;9&#44;10</span></a> or appear as its first symptom&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Other entities with which EM is less frequently associated are subarachnoid haemorrhage&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> multiple system atrophy&#44; and Guillain-Barr&#233; syndrome&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;5</span></a> In MS&#44; facial myokymias tend to be self-limiting in the course of a few weeks &#40;typically between 2 weeks and 6 months&#41;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;10&#44;12</span></a> and they rarely last as long as a year&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> However&#44; myokymias secondary to malignant tumours typically last several years and resolve with treatment of the neoplasia&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5&#44;10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Unlike facial myokymias&#44; those limited to the eyelid only tend to appear in healthy young subjects&#46; They are associated with stress&#44; fatigue&#44; exercise&#44; and excessive caffeine use&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;7&#44;12</span></a> On rare occasions&#44; they may be associated with underlying disease or extend to other facial muscles&#46; In a typical presentation&#44; they are unilateral and transient&#44; appearing in episodes lasting a few minutes at a time over the course of a few days or weeks&#46; It is very uncommon for EMs to appear continuously during periods spanning months&#44; and they would still be considered benign even in such cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;7</span></a> However&#44; available evidence is scarce&#46; There is only 1 study evaluating persistent long-term EM&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and this study found that only 1 of its study population of 15 developed clinically defined MS&#46; It concluded that associations between long-term EM and other neurological diseases are uncommon&#46; As we were unable to identify any of the trigger factors described for EM in our patient&#44; and the condition persisted&#44; we performed 2 cranial MRI scans and a lumber puncture which resulted in a diagnosis of MS&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Cranial MRI study of our patient was unable to show any lesions specific to the ipsilateral pons&#46; Some cases of hemifacial myokymias are described in which cranial MRI scans did not show typical lesions in the pons&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;6&#44;9</span></a> One possible reason is that the lesion causing facial myokymia in MS tends to resolve when clinical symptoms have stopped appearing&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This was observed in a study that used cranial MRI to re-examine patients in whom typical lesions had previously been detected and whose symptoms had resolved&#46; In 6 of the 8 patients&#44; the lesions had disappeared within periods ranging from 1 week to 44 months&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> A cranial MRI was performed on our patient a week after her referral to our unit&#46; Another possible mechanism could be hyperexcitability of the intra-axial part of facial nerve fibres due to possible functional deafferentation of inhibitory pathways of the facial nerve nucleus caused by demyelinating lesions on the supranuclear level&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;9&#44;13</span></a> As a result&#44; myokymias would not necessarily have to be caused by lesions in the pons&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; we feel that while EM is a benign entity&#44; it may be indicative of an underlying neurological disease&#44; such as MS&#44; if it persists over an extended period of time&#46; We recommend conservative treatment for these patients at first&#44; and elimination of known triggers such as caffeine&#44; tobacco&#44; and alcohol&#46; If the EM continues&#44; imaging studies should be completed in order to rule out any underlying lesions&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Palas&#237; A&#44; et al&#46; Mioquimias palpebrales unilaterales como forma de presentaci&#243;n de una esclerosis m&#250;ltiple&#46; Neurolog&#237;a&#46; 2013&#59;28&#58;187&#8211;9&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Part of this study was presented in poster format at the 15th annual meeting of the Catalan Society of Neurology&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cranial MRI&#46; T2-weighted axial sequences &#40;a&#41; and sagittal FLAIR sequences &#40;b&#41; reveal multiple hyperintense lesions in supratentorial white matter&#46;</p>"
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Article information
ISSN: 21735808
Original language: English
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2023 July 702 9 711
2023 June 740 12 752
2023 May 987 14 1001
2023 April 880 11 891
2023 March 844 9 853
2023 February 577 8 585
2023 January 599 15 614
2022 December 527 24 551
2022 November 655 18 673
2022 October 618 18 636
2022 September 612 21 633
2022 August 615 31 646
2022 July 501 22 523
2022 June 482 28 510
2022 May 470 19 489
2022 April 585 16 601
2022 March 637 26 663
2022 February 617 26 643
2022 January 626 26 652
2021 December 548 22 570
2021 November 549 28 577
2021 October 612 43 655
2021 September 558 31 589
2021 August 649 31 680
2021 July 775 20 795
2021 June 663 21 684
2021 May 770 18 788
2021 April 1674 24 1698
2021 March 1001 21 1022
2021 February 766 34 800
2021 January 672 34 706
2020 December 667 41 708
2020 November 730 35 765
2020 October 529 17 546
2020 September 1082 19 1101
2020 August 894 20 914
2020 July 747 18 765
2020 June 957 17 974
2020 May 1107 31 1138
2020 April 952 14 966
2020 March 943 10 953
2020 February 1074 20 1094
2020 January 1036 19 1055
2019 December 804 14 818
2019 November 872 13 885
2019 October 804 20 824
2019 September 839 13 852
2019 August 709 20 729
2019 July 1034 16 1050
2019 June 726 38 764
2019 May 769 50 819
2019 April 842 15 857
2019 March 496 8 504
2019 February 521 15 536
2019 January 601 14 615
2018 December 410 10 420
2018 November 273 9 282
2018 October 223 14 237
2018 September 262 27 289
2018 August 113 1 114
2018 July 87 4 91
2018 June 84 3 87
2018 May 124 3 127
2018 April 131 2 133
2018 March 180 2 182
2018 February 92 3 95
2018 January 92 3 95
2017 December 89 0 89
2017 November 112 4 116
2017 October 123 2 125
2017 September 101 9 110
2017 August 108 3 111
2017 July 138 1 139
2017 June 153 15 168
2017 May 139 9 148
2017 April 170 12 182
2017 March 117 35 152
2017 February 246 2 248
2017 January 117 5 122
2016 December 121 10 131
2016 November 200 11 211
2016 October 248 7 255
2016 September 263 10 273
2016 August 179 7 186
2016 July 86 2 88
2016 June 127 11 138
2016 May 119 27 146
2016 April 110 31 141
2016 March 124 29 153
2016 February 117 11 128
2016 January 93 7 100
2015 December 90 6 96
2015 November 93 12 105
2015 October 105 7 112
2015 September 87 5 92
2015 August 94 5 99
2015 July 102 10 112
2015 June 69 4 73
2015 May 85 4 89
2015 April 75 6 81
2015 March 72 9 81
2015 February 20 4 24
2015 January 28 9 37
2014 December 37 9 46
2014 November 25 5 30
2014 October 28 6 34
2014 September 26 3 29
2014 August 46 4 50
2014 July 29 3 32
2014 June 30 2 32
2014 May 33 3 36
2014 April 20 3 23
2014 March 20 3 23
2014 February 34 6 40
2014 January 28 4 32
2013 December 27 7 34
2013 November 56 5 61
2013 October 55 2 57
2013 September 50 1 51
2013 August 64 5 69
2013 July 36 6 42
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos