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Letter to the Editor
Role of neurophysiological studies in Miller-Fisher syndrome
Papel del estudio neurofisiológico en el síndrome de Miller-Fisher
L. Gabaldón Torres
Corresponding author
laura.gabaldon@marinasalud.es

Corresponding author.
, C. Badía Picazo, J. Salas Felipe
Unidad de Neurología y Neurofisiología, Hospital de Dénia, Alicante, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Miller-Fisher syndrome &#40;MFS&#41; is a clinical variant of Guillain&#8211;Barr&#233; syndrome characterised by the triad of ophthalmoparesis&#44; ataxia&#44; and areflexia&#46; Additionally&#44; it is often associated with other symptoms secondary to cranial nerve weakness &#40;facial paralysis&#44; swallowing disorders&#44; etc&#46;&#41;&#44; and even with sensory symptoms in the distal limbs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">It is usually preceded by an infection&#44; most typically a gastrointestinal infection caused by <span class="elsevierStyleItalic">Campylobacter jejuni</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Other triggers have been described&#44; including vaccination&#44; surgical procedures&#44; etc&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Diagnosis tends not to be difficult when patients have the classic triad of symptoms&#44; albumino-cytological dissociation&#44; and neurophysiological findings&#46; Further clues are provided by certain antibodies associated with these dysimmune neuropathies of the peripheral nervous system&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">At times&#44; the presence of other associated symptoms&#44; the absence of Anti-GQ1b&#44; and lack of anomalous results on complementary tests during the acute phase of the syndrome may delay diagnosis and result in requests for unnecessary diagnostic tests&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We present the case of a 35-year-old man with no relevant personal history except for obesity&#46; He experienced an episode of progressive-onset binocular diplopia and gait instability associated with a headache that had lasted 4 to 5 days&#46; The patient reported having gone scuba diving before the onset of symptoms&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The neurological examination performed at the Emergency Department revealed bilateral eyelid ptosis&#44; eyes remaining immobile in a neutral position&#44; reactive bilateral mydriasis&#44; bilateral but predominantly right-sided peripheral facial paralysis&#44; weakness&#44; bilateral elevation of the soft palate with no muscular atrophy or muscle tone alteration&#44; universal areflexia&#44; preserved sensitivity&#44; and ataxic gait&#46; During the hospital stay&#44; he presented high blood pressure and required treatment with intravenous nitrates&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A complete complementary study was performed&#44; including biochemical&#44; immunology &#40;Anti-GQ1b&#41;&#44; tumour marker&#44; folate&#44; and cyanocobalamin tests&#46; Results were negative or normal&#46; Serology tests were normal&#44; except for the test for <span class="elsevierStyleItalic">C&#46; jejuni</span> antibodies&#44; which delivered positive results&#46; The CSF study showed albumino-cytological dissociation&#46; Neuroimaging studies &#40;including brain MRI&#41;&#44; and intracranial vessel and cerebral blood flow studies all yielded normal results&#46; The neurophysiological study during the acute phase revealed a decrease in M response amplitude in the bilateral facial nerve and abolished blink reflex&#46; An EMG taken 15 days later showed severe demyelinating neuropathy with axonal damage in the facial nerve&#46; While its latency was still high&#44; the previously abolished palpebral reflex &#40;blink reflex&#41; could be observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The patient was diagnosed with Miller-Fisher syndrome associated with <span class="elsevierStyleItalic">C&#46; jejuni</span>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The patient was treated with intravenous immunoglobulins &#40;IGIV&#41; during 5 consecutive days&#46; His facial weakness initially increased to the point of becoming bilateral facial paralysis&#44; but the condition began to subside slowly after a week&#46; Throughout the course of the disease&#44; he presented no swallowing&#47;respiratory disorders or ECG abnormalities&#44; although his diastolic blood pressure was high&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">After 3 months&#44; doctors observed clinical improvement and near-complete resolution of facial weakness&#46; Diplopia and ocular motility resolved partially&#44; and the patient experienced no gait abnormalities and no other associated symptoms&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Regarding the predisposing factors&#44; the infection caused by <span class="elsevierStyleItalic">C&#46; jejuni</span> is widely described in the scientific literature&#46; After a long Medline search&#44; however&#44; we did not find any association between this disease and scuba diving&#44; even if the nervous system is frequently affected by decompression problems and one of the divers&#8217; most common symptom is headache&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Although our case does not enable us to consider diving a predisposing factor&#44; we do think that it could facilitate and probably cause other associated symptoms &#40;headache&#41; that were unclear upon initial diagnosis&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">While non-reactive bilateral mydriasis is not usually present in MFS&#44; neither is it uncommon&#46; The symptom calls for differential diagnosis&#44; especially in cases of botulism&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Clinical data led us to order complementary studies of the central nervous system in order to rule out processes associated with diving&#44; as well as other processes including cerebral venous sinus thrombosis&#46; Another approach was to examine sociodemographic data&#44; such as canned food consumption&#44; in order to rule out the possibility of botulism&#44; which would have been consistent with the marked cranial nerve involvement and the finding of mydriasis&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Despite the atypical symptoms and the negative result for Anti-GQ1b&#44; findings that are present in more than 90&#37; of MFS patients&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> results from the neurophysiological study during the acute phase helped us establish an early diagnosis and rapidly administer immunomodulatory therapy&#46; In severe cases&#44; this treatment is associated with better clinical progression and&#44; consequently&#44; with a better prognosis&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">In general&#44; neurophysiological findings during the acute phase of the disease have not been widely studied&#44; and the subject remains controversial&#46; The study by Calleja et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> assessed 5 patients who were diagnosed with MFS&#46; Their results were similar to those from our patient&#44; with a decrease in M response amplitude and abolished palpebral reflex&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In conclusion&#44; we believe neurophysiological studies are necessary during the acute phase of polyneuropathies such as Miller-Fisher syndrome&#46; Results will serve to support the suspected diagnosis from the beginning and unnecessary complementary studies may therefore be avoided&#46;</p></span>"
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ISSN: 21735808
Original language: English
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