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Letter to the Editor
Postural orthostatic tachycardia syndrome, neurally mediated syncope, and joint hypermobility: a case report
Síndrome de taquicardia postural ortostática, síncopes autonomomediados e hiperlaxitud articular: a propósito de un caso
K. Berganzo
Corresponding author
, B. Tijero, J.J. Zarranz, J.C. Gómez-Esteban
Unidad de Disautonomía y Trastornos del Movimiento, Departamento de Neurociencias, Biocruces Health Research Institute, Universidad del País Vasco, Barakaldo, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present the case of an adolescent girl aged 17 with no relevant medical history who was assessed in our epilepsy unit due to a 2-year history of repeated syncope&#44; preceded by pallor and discomfort&#46; There were no abnormal movements during episodes and the patient recovered in minutes with no subsequent confusion or loss of sphincter control&#46; Episode frequency was variable with a maximum of 2 per week&#46; Some occurred during physical exertion&#46; She sometimes reported palpitations while standing or walking&#46; She had also experienced repeated sprains&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was examined by the cardiology and neurology departments&#59; she had visited the emergency department on 14 previous occasions and been admitted 6 times&#44; including admission to the intensive care unit once due to suspected epilepsy&#46; At that time&#44; a differential diagnosis was performed for psychogenic seizures and epilepsy&#46; The patient was treated with 2<span class="elsevierStyleHsp" style=""></span>g levetiracetam&#47;24<span class="elsevierStyleHsp" style=""></span>hours with no signs of improvement&#46; Test results were normal&#44; except for isolated sinus tachycardia that was detected with an implantable loop recorder&#44; and left-sided hippocampal malrotation detected by brain MRI&#46; It was on this basis that doctors suspected epilepsy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The examination identified venous pooling in the lower limbs while standing&#44; keloid where the implantable loop recorder had been placed&#44; and joint hypermobility with a score of 5&#47;9 on the Beighton scale &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient met Brighton diagnostic criteria for joint hypermobility &#40;1 major and 2 minor criteria&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Doctors opted for a tilt table test and non-invasive haemodynamic monitoring with a Task Force<span class="elsevierStyleSup">&#174;</span> Monitor &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; We observed low blood pressure &#40;BP&#41; at baseline and postural tachycardia with a heart rate above 120<span class="elsevierStyleHsp" style=""></span>bpm and cardioinhibitory syncope associated with vasodepressor response and a drop in peripheral resistance&#44; together with an increase in stroke volume&#46; All findings were compatible with neurally mediated syncope&#46; Doctors began treatment with fludrocortisone dosed at 0&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;day and non-pharmacological therapy&#59; syncope episodes ceased completely&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Postural tachycardia syndrome has an estimated prevalence of 170 per 100<span class="elsevierStyleHsp" style=""></span>000 individuals&#46; It is more common in women &#40;5&#58;1&#41; and at ages between 20 and 40&#59; aetiopathogenesis is heterogeneous&#46; The condition essentially amounts to a variable degree of intolerance to orthostasis with the addition of symptoms secondary to hypoperfusion&#44; such as difficulty concentrating&#44; neck or thoracic pain due to tissue hypoperfusion&#44; and symptoms of sympathetic hyperactivity with palpitations or tremor&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This syndrome is closely linked to repeated episodes of neurally mediated syncope&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Diagnostic criteria are heart rate increase of 30<span class="elsevierStyleHsp" style=""></span>bpm &#40;&#62;40<span class="elsevierStyleHsp" style=""></span>bpm in patients aged 12 to 19 years&#41; when standing or walking or on a tilt table without orthostatic hypotension&#44; or heart rate above 120<span class="elsevierStyleHsp" style=""></span>bpm with no baseline arterial hypotension&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Non-invasive haemodynamic monitoring associated with BP monitoring over 24<span class="elsevierStyleHsp" style=""></span>hours is very useful for evaluating the condition&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Physical examination frequently reveals oedema and venous pooling in the lower limbs resulting from vasoconstriction disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Type 3 Ehlers&#8211;Danlos syndrome &#40;hypermobility syndrome&#41; is related to postural tachycardia syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> It is characterised by presence of joint hypermobility &#40;although this sign may be absent&#41;&#44; skin abnormalities&#44; and other signs&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Diagnosis is clinical&#59; doctors use the Beighton score<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and the Brighton diagnostic criteria<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and rule out other potential entities&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Treatments may be pharmacological or non-pharmacological &#40;increasing fluid and sodium intake&#44; posture therapy&#44; and cognitive behavioural therapy&#41;&#46; Pharmacological treatments include 2 major groups&#46; The first is typically used in cases with low baseline BP &#40;fludrocortisone<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and midodrine<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#41;&#46; The second is for patients with normal BP or arterial hypertension &#40;beta-blockers and pyridostigmine&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Drugs from both of the above groups may be used in combination on a case-by-case basis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">These disorders are prevalent&#44; underdiagnosed&#44; and have a major impact on quality of life&#46; However&#44; patients may benefit from correct diagnostic and therapeutic management provided by specialists&#44; and therefore avoid iatrogenic effects of testing and treatments and periodic visits to doctors and the emergency department&#46; As a screening method&#44; patients or their family members may measure BP and heart rate in the decubitus and standing positions&#46; Proper management of these patients will require additional training for neurologists and the creation of specialised units&#46;</p></span>"
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