Letter to the Editor
Asymptomatic colpocephaly and partial agenesis of corpus callosum
Colpocefalia y agenesia parcial de cuerpo calloso asintomáticos
a Departamento de Neurología, Hospital Sirio Libanés, Facultad de Medicina de la Universidad de Buenos Aires, Buenos Aires, Argentina
b Departamento de Medicina Interna, Hospital Sirio Libanés, Buenos Aires, Argentina
c Departamento de Medicina Interna, Hospital Sirio Libanés, Buenos Aires, Argentina
d Departamento de Neurología, Hospital Sirio Libanés, Facultad de Medicina de la Universidad de Buenos Aires, Buenos Aires, Argentina
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Se ve la gran diferencia en el tamaño del ventrículo lateral, normal en la prolongación frontal y muy agrandado (a partir de la flecha) en la región occipital. b) Corte axial en T1. Se observa el tercer ventrículo con la flecha señalando la rodilla adelgazada del cuerpo calloso. c) Corte coronal en T1. Se ve el rodete del cuerpo calloso (flecha) cruzando la línea media a nivel de la fosa posterior (flecha punteada sobre la tienda del cerebelo). d) Corte sagital en T2. Se observan los surcos corticales frontales y occipitales que, a diferencia del caso 1, tienen similar ensanchamiento.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E.L. Bartolomé, J.C. Cottura, R. Britos Frescia, R.O. Domínguez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "E.L." "apellidos" => "Bartolomé" ] 1 => array:2 [ "nombre" => "J.C." "apellidos" => "Cottura" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Britos Frescia" ] 3 => array:2 [ "nombre" => "R.O." "apellidos" => "Domínguez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173580815001534" "doi" => "10.1016/j.nrleng.2013.11.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580815001534?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485313002843?idApp=UINPBA00004N" "url" => "/02134853/0000003100000001/v1_201601140049/S0213485313002843/v1_201601140049/es/main.assets" ] ] "itemAnterior" => array:20 [ "pii" => "S2173580815001558" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2013.12.019" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "aid" => "587" "copyright" => "Sociedad Española de Neurología" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "cor" "cita" => "Neurologia. 2016;31:66-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2236 "formatos" => array:3 [ "EPUB" => 61 "HTML" => 1731 "PDF" => 444 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Preganglionic or postganglionic efferent pupillary defect? Clinical versus neuroimaging diagnosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "66" "paginaFinal" => "68" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Defecto pupilar eferente, ¿preganglionar o posganglionar? Diagnóstico clínico vs neuroimagen" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 593 "Ancho" => 1300 "Tamanyo" => 202324 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical examination: light-near dissociation. a) Anisocoria due to mydriatic right eye. b) Intact near-response (tonic response in the RE). c) Response to instillation of 0.125% pilocarpine (RE, mydriasis caused by cholinergic denervation supersensitivity; LE, intact). d) No miosis with RE adduction (aberrant reinnervation of the OMN is ruled out).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C.A. Arciniegas-Perasso, R.A. Díaz-Cespedes, L. Manfreda-Domínguez, D. Toro-Giraldo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C.A." "apellidos" => "Arciniegas-Perasso" ] 1 => array:2 [ "nombre" => "R.A." "apellidos" => "Díaz-Cespedes" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Manfreda-Domínguez" ] 3 => array:2 [ "nombre" => "D." "apellidos" => "Toro-Giraldo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485314000061" "doi" => "10.1016/j.nrl.2013.12.017" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485314000061?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580815001558?idApp=UINPBA00004N" "url" => "/21735808/0000003100000001/v1_201601210907/S2173580815001558/v1_201601210907/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Asymptomatic colpocephaly and partial agenesis of corpus callosum" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "68" "paginaFinal" => "70" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E.L. Bartolomé, J.C. Cottura, R. Britos Frescia, R.O. Domínguez" "autores" => array:4 [ 0 => array:4 [ "nombre" => "E.L." "apellidos" => "Bartolomé" "email" => array:1 [ 0 => "bartolomeeduardol@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "J.C." "apellidos" => "Cottura" "email" => array:1 [ 0 => "juliocottura@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "nombre" => "R." "apellidos" => "Britos Frescia" "email" => array:1 [ 0 => "rodneybritos@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:4 [ "nombre" => "R.O." "apellidos" => "Domínguez" "email" => array:2 [ 0 => "dominguezraulo@yahoo.com.ar" 1 => "neurologiasirio@yahoo.com.ar" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Departamento de Neurología, Hospital Sirio Libanés, Facultad de Medicina de la Universidad de Buenos Aires, Buenos Aires, Argentina" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina Interna, Hospital Sirio Libanés, Buenos Aires, Argentina" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Medicina Interna, Hospital Sirio Libanés, Buenos Aires, Argentina" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Departamento de Neurología, Hospital Sirio Libanés, Facultad de Medicina de la Universidad de Buenos Aires, Buenos Aires, Argentina" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Colpocefalia y agenesia parcial de cuerpo calloso asintomáticos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1066 "Ancho" => 1000 "Tamanyo" => 216019 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Head MRI scan of case 1. a) Axial FLAIR sequence. Frontal ventricles (dotted arrow) are small, and the frontal parenchyma features small hyperintense images (arrow) that could be associated with arterial hypertension. The third ventricle and occipital horns are dilated (CC). b) Axial FLAIR sequence. The third ventricle appears dilated (arrow) and the upper part of the corpus callosum is very thin. c) T1-weighted sagittal slice: the genu and trunk of the corpus callosum (arrow) seem faint. The fourth ventricle is normal-sized. d) T2-weighted axial slice. Frontal sulci are much smaller than cortical sulci on the posterior part of the brain.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Colpocephaly (CC) can be observed in radiological findings from brain computed tomography (BCT) and magnetic resonance imaging (MRI). These images show dilated lateral ventricles, specifically in the occipital and temporal horns, and the third ventricle. Frontal horns retain their normal size. This type of hydrocephalus of the posterior half of the brain is a congenital malformation. It can be associated with myelocele, microgyria, cerebellar atrophy, total or partial absence of the corpus callosum, and other structural anomalies. Neurological manifestations occur mainly in children, and include cognitive and motor developmental delay, and epileptic seizures. Diagnosis in adult patients who have learned to perform activities of daily living normally is very infrequent. Imaging studies will show malformations, and differential diagnosis is required to rule out obstructive and non-obstructive ventriculomegaly.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1–5</span></a> Case 1 is a 67-year-old man who presented sudden loss of consciousness with no seizures or loss of sphincter control. He regained consciousness, cognitive functions, and motor functions after 1 or 2<span class="elsevierStyleHsp" style=""></span>minutes. According to his personal history, his developmental progression was normal and he had been working as administrative clerk until his retirement. Ten years before the event, he was diagnosed with arterial hypertension and had since been treated with enalapril dosed at 5<span class="elsevierStyleHsp" style=""></span>mg twice a day. Clinical, cardiological, and neurological examinations did not show any abnormalities 2<span class="elsevierStyleHsp" style=""></span>hours after the event, and neither did the electrocardiogram and blood test. The BCT performed in the emergency department revealed very pronounced posterior ventricular dilatation. The patient was then admitted for subsequent studies. A head MRI revealed CC and partial agenesis of the corpus callosum. The electroencephalogram did not show any abnormalities, thus ruling out adult onset of epileptic seizures.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> On the following day, cognitive tests and exploration of ideomotor, ideational, and limb-kinetic praxis showed normal results, and no interhemispheric disconnection syndrome could be detected.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7,8</span></a> A lumbar puncture did not reveal any inflammatory or infectious processes. Given the normal structure of frontal ventricles, we ruled out normal pressure hydrocephalus (gait, sphincter control, and cognition were unaltered). The transient nature of the clinical manifestation led us to consider syncope as the probable diagnosis, regardless of any brain malformations. <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> shows findings of CC and agenesis of the corpus callosum. Case 2 is a 60-year-old man admitted to our hospital due to respiratory tract infection. He presented confusional syndrome during a hyperthermic episode. Throughout the patient's personal history, he had been independent for activities of daily living and was able to work satisfactorily as keeper and doorman in a condominium. A neurological examination of motor function and cranial nerves yielded no anomalous results. Cardiological examination and blood count results were also within normal limits. No inflammatory activity was detected in CSF extracted by lumbar puncture. A head MRI revealed CC and partial agenesis of the corpus callosum (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Once hyperthermia and the confusional syndrome had resolved, cognitive and praxis assessments yielded normal results, as in case 1. The patient was discharged after one week of hospitalisation. He displayed normal gait and sphincter control, which ruled out normal pressure hydrocephalus. As in the other case, our clinical assessment did not link cerebral malformation to the confusional syndrome. In both cases, the posterior to anterior ratio described by Noorani et al.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> was higher than 3 (CC), indicating a larger diameter of occipital ventricles than of frontal ventricles. In case 1, frontal sulci were found to be strikingly smaller than those in the posterior half of the brain, but no frontal microgyria could be diagnosed. An examination of these cases admitted in 2013 found no other similar cases in the hospital's records in the preceding 30 years. Whipple disease was considered in both cases since it can cause symmetric or asymmetric hydrocephalus. However, no history of this disease was reported for either patient, and CSF analysis showed normal results.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> A recently published study reported the case of an 88-year-old patient diagnosed with agenesis of the corpus callosum and CC. The patient had been asymptomatic until that moment, and the absence of clinical symptoms related to his malformations was thought to be due to neuroplasticity.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> CC is a congenital malformation which causes enlargement of the posterior half of the brain ventricles; it is frequently associated with total or partial agenesis of the corpus callosum. Manifestations are heterogeneous during childhood, but CC can also manifest incidentally in asymptomatic adults. Differential diagnosis to rule out normal pressure hydrocephalus should be performed before proceeding to surgical treatment, since the marked difference in diameter between the occipital and frontal ventricles will help identify the congenital malformation.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0010" class="elsevierStylePara elsevierViewall">This study has not received funding from any sources. All authors are aware of the manuscript content and have approved it for publication.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Bartolomé EL, Cottura JC, Britos Frescia R, Domínguez RO. Colpocefalia y agenesia parcial de cuerpo calloso asintomáticos. Neurología. 2016;31:68–70.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1066 "Ancho" => 1000 "Tamanyo" => 216019 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Head MRI scan of case 1. a) Axial FLAIR sequence. Frontal ventricles (dotted arrow) are small, and the frontal parenchyma features small hyperintense images (arrow) that could be associated with arterial hypertension. The third ventricle and occipital horns are dilated (CC). b) Axial FLAIR sequence. The third ventricle appears dilated (arrow) and the upper part of the corpus callosum is very thin. c) T1-weighted sagittal slice: the genu and trunk of the corpus callosum (arrow) seem faint. The fourth ventricle is normal-sized. d) T2-weighted axial slice. Frontal sulci are much smaller than cortical sulci on the posterior part of the brain.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 878 "Ancho" => 1000 "Tamanyo" => 155767 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Head MRI scan of case 2. a) T2-weighted sagittal sequence. We can observe a great difference in size between the normal anterior horn of the lateral ventricle and the very enlarged portion (from the arrow onwards) in the occipital region. b) T1-weighted axial slice. View of the third ventricle with an arrow indicating the thin genu of the corpus callosum. c) T1-weighted coronal slice. The splenium of the corpus callosum (arrow) is shown crossing the midline at the posterior fossa level (dotted arrow over the cerebellar tentorium). d) T2-weighted sagittal slice: Frontal and occipital cortical sulci show similar degrees of dilatation, unlike in case 1.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Colpocephaly an error of morphogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 18 | 2 | 20 |
| 2024 October | 131 | 20 | 151 |
| 2024 September | 165 | 22 | 187 |
| 2024 August | 130 | 21 | 151 |
| 2024 July | 174 | 20 | 194 |
| 2024 June | 118 | 12 | 130 |
| 2024 May | 172 | 12 | 184 |
| 2024 April | 158 | 10 | 168 |
| 2024 March | 203 | 14 | 217 |
| 2024 February | 287 | 9 | 296 |
| 2024 January | 478 | 15 | 493 |
| 2023 December | 368 | 29 | 397 |
| 2023 November | 412 | 31 | 443 |
| 2023 October | 449 | 24 | 473 |
| 2023 September | 248 | 11 | 259 |
| 2023 August | 281 | 9 | 290 |
| 2023 July | 345 | 13 | 358 |
| 2023 June | 309 | 8 | 317 |
| 2023 May | 383 | 12 | 395 |
| 2023 April | 297 | 4 | 301 |
| 2023 March | 264 | 14 | 278 |
| 2023 February | 223 | 7 | 230 |
| 2023 January | 258 | 14 | 272 |
| 2022 December | 145 | 8 | 153 |
| 2022 November | 235 | 22 | 257 |
| 2022 October | 212 | 20 | 232 |
| 2022 September | 219 | 6 | 225 |
| 2022 August | 250 | 19 | 269 |
| 2022 July | 198 | 18 | 216 |
| 2022 June | 179 | 16 | 195 |
| 2022 May | 176 | 19 | 195 |
| 2022 April | 147 | 21 | 168 |
| 2022 March | 193 | 7 | 200 |
| 2022 February | 198 | 6 | 204 |
| 2022 January | 268 | 17 | 285 |
| 2021 December | 157 | 21 | 178 |
| 2021 November | 197 | 20 | 217 |
| 2021 October | 219 | 16 | 235 |
| 2021 September | 238 | 23 | 261 |
| 2021 August | 287 | 10 | 297 |
| 2021 July | 269 | 20 | 289 |
| 2021 June | 231 | 22 | 253 |
| 2021 May | 250 | 16 | 266 |
| 2021 April | 456 | 45 | 501 |
| 2021 March | 354 | 13 | 367 |
| 2021 February | 322 | 10 | 332 |
| 2021 January | 239 | 20 | 259 |
| 2020 December | 229 | 13 | 242 |
| 2020 November | 251 | 7 | 258 |
| 2020 October | 151 | 10 | 161 |
| 2020 September | 205 | 17 | 222 |
| 2020 August | 249 | 15 | 264 |
| 2020 July | 180 | 13 | 193 |
| 2020 June | 201 | 13 | 214 |
| 2020 May | 211 | 16 | 227 |
| 2020 April | 180 | 15 | 195 |
| 2020 March | 226 | 14 | 240 |
| 2020 February | 212 | 10 | 222 |
| 2020 January | 198 | 8 | 206 |
| 2019 December | 178 | 22 | 200 |
| 2019 November | 155 | 22 | 177 |
| 2019 October | 165 | 16 | 181 |
| 2019 September | 189 | 21 | 210 |
| 2019 August | 149 | 14 | 163 |
| 2019 July | 201 | 20 | 221 |
| 2019 June | 179 | 19 | 198 |
| 2019 May | 167 | 20 | 187 |
| 2019 April | 243 | 53 | 296 |
| 2019 March | 89 | 7 | 96 |
| 2019 February | 72 | 23 | 95 |
| 2019 January | 86 | 27 | 113 |
| 2018 December | 46 | 17 | 63 |
| 2018 November | 88 | 2 | 90 |
| 2018 October | 94 | 17 | 111 |
| 2018 September | 68 | 9 | 77 |
| 2018 August | 48 | 8 | 56 |
| 2018 July | 39 | 19 | 58 |
| 2018 June | 52 | 10 | 62 |
| 2018 May | 42 | 8 | 50 |
| 2018 April | 37 | 6 | 43 |
| 2018 March | 56 | 9 | 65 |
| 2018 February | 19 | 10 | 29 |
| 2018 January | 26 | 7 | 33 |
| 2017 December | 26 | 4 | 30 |
| 2017 November | 40 | 15 | 55 |
| 2017 October | 40 | 7 | 47 |
| 2017 September | 37 | 23 | 60 |
| 2017 August | 28 | 17 | 45 |
| 2017 July | 30 | 13 | 43 |
| 2017 June | 74 | 19 | 93 |
| 2017 May | 44 | 16 | 60 |
| 2017 April | 51 | 5 | 56 |
| 2017 March | 30 | 14 | 44 |
| 2017 February | 29 | 11 | 40 |
| 2017 January | 45 | 7 | 52 |
| 2016 December | 40 | 10 | 50 |
| 2016 November | 46 | 18 | 64 |
| 2016 October | 49 | 11 | 60 |
| 2016 September | 79 | 28 | 107 |
| 2016 August | 52 | 13 | 65 |
| 2016 July | 23 | 7 | 30 |
| 2016 June | 40 | 20 | 60 |
| 2016 May | 46 | 23 | 69 |
| 2016 April | 49 | 25 | 74 |
| 2016 March | 103 | 50 | 153 |
| 2016 February | 88 | 49 | 137 |
| 2016 January | 23 | 12 | 35 |
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