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Original article
Code stroke in Asturias
El código ictus de Asturias
L. Benaventea,
Corresponding author
lbf.benfer@gmail.com

Corresponding author.
, M.J. Villanuevab, P. Vegac, I. Casadod, J.A. Vidale, B. Castañof, M. Amoríng, V. de la Vegah, H. Santosi, A. Trigob, M.B. Gómezb, D. Larrosaa, T. Tempranod, M. Gonzáleza, E. Muriasc, S. Callejaa
a Servicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Spain
b Servicio de Asistencia Médica Urgente de Asturias, Spain
c Servicio de Radiología, Hospital Universitario Central de Asturias, Oviedo, Spain
d Sección de Neurología, Hospital de Cabueñes, Gijón, Spain
e Sección de Neurología, Hospital San Agustín, Avilés, Spain
f Sección de Neurología, Hospital Valle del Nalón, Langreo, Spain
g Sección de Neurología, Fundación Hospital de Jove, Gijón, Spain
h Sección de Neurología, Hospital Álvarez Buylla, Mieres, Spain
i Servicio de Medicina Interna, Sección de Neurología, Hospital de Jarrio, Coaña, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Stroke is the most frequent cause of permanent disability in adults and one of the leading causes of death both in Spain and throughout the Western world&#44; resulting in enormous personal suffering and a high cost to society&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> In the case of Spain&#44; the cumulative incidence of cerebrovascular disease per 100 000 people older than 24 years has risen to 218 new cases in men and 127 in women&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Intravenous thrombolysis with tissue plasminogen activator &#40;tPA&#41; is an effective treatment for acute ischaemic stroke if administered within 4&#46;5<span class="elsevierStyleHsp" style=""></span>hours from symptom onset&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a> In the case of proximal large-vessel occlusion&#44; however&#44; mechanical thrombectomy appears to be more effective&#44; although until now no studies have provided conclusive evidence&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#8211;10</span></a> In any case&#44; the sooner these treatments are administered&#44; even within the time window&#44; the greater their effectiveness&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Code stroke is a system of patient identification and follow-up whose objective is to ensure that acute stroke patients have access to a cerebrovascular reference centre in the minimum time possible&#46; This system requires that emergency services&#44; primary care centres&#44; and local hospitals of a specific area work in close coordination with the stroke reference centre&#44; where specialised seamless care is offered to patients&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Occasionally&#44; treatments directed towards rapid and effective arterial recanalisation are based on advanced interventional neuroimaging or neuroradiology techniques&#44; which are only available at tertiary centres&#46; Therefore&#44; code stroke should include several levels of care&#44; or types of healthcare centres&#44; to provide the most suitable treatment for each case&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Code stroke has been proven to be effective&#44; reducing time from symptom onset to diagnosis and specialised treatment&#44; as well as increasing the number of patients attended in stroke units and those treated with fibrinolytics&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">14</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Public healthcare resources in Asturias</span><p id="par0030" class="elsevierStylePara elsevierViewall">Asturias is a single-province autonomous community with a total area of 10<span class="elsevierStyleHsp" style=""></span>603&#46;57<span class="elsevierStyleHsp" style=""></span>km<span class="elsevierStyleSup">2</span> and 1<span class="elsevierStyleHsp" style=""></span>068 165 inhabitants &#40;according to 2014 data from Spain&#39;s National Statistics Institute&#41;&#46; This region has the highest mortality rate in Spain &#40;11&#46;77 deaths per 1000 population&#41; and the lowest birth rate &#40;6&#46;91 births per 1000 population&#41;&#44; which results in a negative growth rate and progressive population ageing&#46; The bulk of this population is concentrated in the central area of Asturias&#44; while the eastern and western areas are depopulating&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The terrain is rugged&#44; which historically has meant difficulties in communication&#46; In recent years&#44; the construction of motorways has to some extent alleviated this problem&#44; but in some rural areas access is still limited&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The health service is organised into 8 administrative areas &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; each of which has one hospital as a base&#44; except for area V&#44; which is divided into 2 districts and has&#44; accordingly&#44; 2 reference hospitals&#46; In total there are 66 health centres in the region&#46; Of the 9 hospitals mentioned&#44; only the Hospital Universitario Central de Asturias &#40;HUCA&#41;&#44; in Oviedo&#44; has a neurology department&#46; Another 5 hospitals &#40;Cabue&#241;es and Jove&#44; in Gij&#243;n&#44; as well as Avil&#233;s&#44; Valle del Nal&#243;n&#44; and Mieres&#41; have neurology sections in the internal medicine departments&#46; In addition&#44; one hospital&#44; Jarrio&#44; has an on-staff neurologist&#46; The remaining 2&#44; in Cangas del Narcea and Arriondas&#44; do not have any neurologists on staff&#46; There are stroke units with 24-hour on-call neurologists at the HUCA and the Hospital de Cabue&#241;es&#44; and on-call neurointerventionists and a neurosurgery department exclusively at the HUCA&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Changes in acute stroke care in Asturias</span><p id="par0045" class="elsevierStylePara elsevierViewall">The first intravenous fibrinolysis took place in the Hospital Universitario Central de Asturias in February 2001 under a compassionate use protocol&#46; At that time there were no stroke units in the region&#44; and patients who had undergone fibrinolysis were subsequently monitored in the intermediate care unit&#44; which pertained to the intensive care unit&#46; That was the first version of code stroke&#44; although at that point it was solely for patients from healthcare district IV&#44; where the HUCA is the reference hospital&#46; In 2005&#44; code stroke was established regionally&#46; It provided healthcare to the whole region and was centralised in Oviedo&#44; since the HUCA continued to be the only hospital which offered fibrinolytic treatment for stroke&#44; as well as the only one with on-call neurologists&#46; A year later&#44; the HUCA conducted the first neurointerventional procedures&#44; which were only available in the mornings&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In 2008&#44; the first stroke unit in Asturias was created in the Hospital de Cabue&#241;es&#44; and in 2009&#44; the HUCA and the Cabue&#241;es both began to offer intravenous fibrinolytic treatment&#46; The Hospital de Cabue&#241;es served as the reference hospital for its health district &#40;<span class="elsevierStyleSmallCaps">V</span>&#41; and the HUCA for the rest of the region&#46; In 2010&#44; the HUCA inaugurated the second stroke unit&#46; That same year neurointerventionists began to use stent-retrievers&#44; although this treatment remained available only in the mornings&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">These progressive steps resulted in an increase in the number of patients who benefited from the new treatments&#46; <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> shows the changes in the number of treated patients between 2002 and 2013&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Code stroke protocol 2013</span><p id="par0060" class="elsevierStylePara elsevierViewall">In June 2012&#44; the HUCA introduced its on-call neurointerventional service&#46; For the first time&#44; mechanical thrombectomy techniques&#44; including the use of extraction devices such as stent-retrievers&#44; were available 24<span class="elsevierStyleHsp" style=""></span>hours a day&#44; 7 days a week&#46; The acute stroke treatment protocol was modified to include this new therapeutic option as shown in the algorithm in <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; following the recommendations agreed upon by the ad hoc SEN&#39;s Cerebrovascular Disease Study Group&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">15</span></a> It should be noted that people up to 80 years of age are eligible for interventional treatment&#46; When our protocol was implemented&#44; these treatments had not yet been well validated&#44; and several studies conducted at that time included patients only from within that age range&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">5&#44;8&#44;10</span></a> However our current protocol should be modified in light of the results of new clinical trials&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;6&#44;7&#44;9</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Until then&#44; the regional code stroke had established that patients from area V should be referred to the Hospital of Cabue&#241;es&#44; as it was the reference hospital for that area&#44; much as patients from the rest of the region used the HUCA&#44; in Oviedo&#44; as their reference hospital&#46; It was quickly noted that the introduction of neurointerventional techniques resulted in inequality of treatment standards&#46; Patients referred to Oviedo could undergo intra-arterial procedures as soon as these were indicated&#44; while patients who were treated in Gij&#243;n had to be transported to Oviedo once the inefficacy of the IV treatment was confirmed&#44; with the ensuing delays &#40;over an hour in the majority of cases&#41;&#46; In addition&#44; Gij&#243;n did not have a multimodal CT scanner in the emergency department so radiological findings could not be used to indicate intra-arterial treatment&#46; Indication was based solely on patients&#8217; clinical assessment and response to treatment&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The most important variable predicting how an acute stroke patient will respond to recanalisation is the time elapsed between symptom onset and initiation of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> However&#44; a second element to consider when assessing acute stroke treatment is the poor effectiveness of fibrinolysis for large-vessel occlusions&#46; Only one in 3 patients treated with IV recombinant tPA within the first 3<span class="elsevierStyleHsp" style=""></span>hours after symptom onset will return to a modified Rankin Scale score of 0 or 1&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">17</span></a> However&#44; if the occlusion is located in the proximal middle cerebral artery only 15&#37; to 20&#37; of cases will recanalise in the 2<span class="elsevierStyleHsp" style=""></span>hours following recombinant tPA infusion&#44; and the numbers are even lower for occlusions in the carotid or basilar arteries&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">18</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">This leads us to the dilemma of prehospital stroke assessment&#58; patients should be treated as quickly as possible&#44; which means moving them to the closest hospital that can administer IV fibrinolysis&#44; but those with more severe strokes will benefit little from that treatment and would be better off going straight to centres with the capacity for more advanced treatment&#46; The problem that arises is how to do the prehospital triage and decide where to transport each patient&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The probability of presenting a large-vessel intracranial occlusion is directly proportional to stroke severity as measured by the National Institutes of Health Stroke Scale &#40;NIHSS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">19</span></a> In the United States&#44; where prehospital care is primarily administered by paramedics&#44; simple stroke assessment scales for use in situ have been designed to improve stroke diagnosis&#46; The Los Angeles motor scale has demonstrated the capacity to predict the presence of large-vessel occlusions &#40;scores<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>4&#41; with a sensitivity of 0&#46;81&#44; a specificity of 0&#46;89&#44; and an overall accuracy of 0&#46;85&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">20</span></a> This scale is being used in a number of prehospital stroke triage programmes in the U&#46;S&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">21</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Prehospital care in Spain is provided by healthcare teams which each consist of a doctor and a nurse&#46; In Asturias&#44; emergency medical service staff members receive instruction in the application of NIHSS and when code stroke is activated in our region&#44; prehospital care teams assess stroke severity using this scale&#46; There is a strong correlation between NIHSS scores reported by emergency medical service doctors and those from the neurologists in our setting&#44; which supports the validity of patient triage by prehospital personnel&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">22</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Various studies have concluded that a threshold of 10 points on this scale reliably discriminates between patients with large-vessel occlusions &#40;eventual intravascular treatment candidates&#41; and those without&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">11&#44;23</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Considering these results&#44; the following territorial structure was established for acute stroke care &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0100" class="elsevierStylePara elsevierViewall">The Hospital de Cabue&#241;es is the primary stroke centre for patients from areas V&#44; VI&#44; and VII&#46; The exclusion criteria are&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">o</span><p id="par0105" class="elsevierStylePara elsevierViewall">NIHSS score<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>10</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">o</span><p id="par0110" class="elsevierStylePara elsevierViewall">Patients taking anticoagulants</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">o</span><p id="par0115" class="elsevierStylePara elsevierViewall">Patients for whom IV fibrinolysis is contraindicated but who could undergo mechanical thrombectomy</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Patients from the rest of the healthcare areas of Asturias and those from areas V&#44; VI&#44; and VII who meet the previously mentioned requirements are taken directly to the Hospital Universitario Central de Asturias&#46;</p></li></ul></p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0125" class="elsevierStylePara elsevierViewall">The latest version of the Asturian code stroke protocol offers recanalisation to acute stroke patients in an equitable manner&#44; minimising geographical limitations and optimising management of the severity-time ratio in order to offer each patient the best possible treatment in the least time&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Additional changes should be made to further the knowledge of the general population and prehospital emergency care and primary care professionals with regards to stroke warning signs and the best way to proceed when the first symptoms occur&#46; Without these additional changes&#44; the percentage of patients receiving treatment will reach a ceiling despite any further therapeutic advances&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "titulo" => "Changes in acute stroke care in Asturias"
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          "titulo" => "Code stroke protocol 2013"
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    "fechaRecibido" => "2015-01-22"
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          "clase" => "keyword"
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            1 => "Health district"
            2 => "Severity-time"
            3 => "Fibrinolysis"
            4 => "Thrombectomy"
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            0 => "C&#243;digo ictus"
            1 => "&#193;reas sanitarias"
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            3 => "Fibrin&#243;lisis"
            4 => "Trombectom&#237;a"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Intravenous thrombolysis with alteplase is an effective treatment for ischaemic stroke when applied during the first 4&#46;5<span class="elsevierStyleHsp" style=""></span>hours&#44; but less than 15&#37; of patients have access to this technique&#46; Mechanical thrombectomy is more frequently able to recanalise proximal occlusions in large vessels&#44; but the infrastructure it requires makes it even less available&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We describe the implementation of code stroke in Asturias&#44; as well as the process of adapting various existing resources for urgent stroke care in the region&#46; By considering these resources&#44; and the demographic and geographic circumstances of our region&#44; we examine ways of reorganising the code stroke protocol that would optimise treatment times and provide the most appropriate treatment for each patient&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We distributed the 8 health districts in Asturias so as to permit referral of candidates for reperfusion therapies to either of the 2 hospitals with 24-hour stroke units and on-call neurologists and providing IV fibrinolysis&#46; Hospitals were assigned according to proximity and stroke severity&#59; the most severe cases were immediately referred to the hospital with on-call interventional neurology care&#46; Patient triage was provided by pre-hospital emergency services according to the NIHSS score&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Modifications to code stroke in Asturias have allowed us to apply reperfusion therapies with good results&#44; while emphasising equitable care and managing the severity-time ratio to offer the best and safest treatment for each patient as soon as possible&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La tromb&#243;lisis intravenosa con alteplasa es un tratamiento efectivo para el ictus isqu&#233;mico si se aplica dentro de las primeras 4&#44;5 horas&#44; pero al que acceden &#60;15&#37; de los pacientes&#46; La trombectom&#237;a mec&#225;nica recanaliza m&#225;s obstrucciones proximales en las grandes arterias&#44; pero necesita una infraestructura que la hace menos disponible&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se detalla la evoluci&#243;n del c&#243;digo ictus en el Principado de Asturias y la adaptaci&#243;n del mismo a los sucesivos recursos para la atenci&#243;n urgente al ictus en la regi&#243;n&#46; Teniendo en cuenta dichos recursos&#44; las circunstancias poblacionales y geogr&#225;ficas de nuestra regi&#243;n&#44; se plantea la reorganizaci&#243;n del c&#243;digo ictus buscando la optimizaci&#243;n del tiempo y la adecuaci&#243;n a cada paciente&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Reparto de las ocho &#225;reas sanitarias de Asturias para derivar los pacientes candidatos a tratamientos de reperfusi&#243;n hacia los dos hospitales donde se dispone de Unidad de Ictus y guardia de Neurolog&#237;a&#44; con posibilidad de aplicar la fibrin&#243;lisis IV&#46; Este reparto se realiz&#243; en funci&#243;n de la proximidad y la gravedad de los mismos&#44; derivando todos los casos m&#225;s graves directamente al hospital que dispone de guardia de Neurorradiolog&#237;a Intervencionista&#46; El cribado del paciente se realiz&#243; por los Servicios de Emergencias Extrahospitalarias seg&#250;n la escala NIHSS&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las modificaciones en el c&#243;digo ictus de Asturias permiten ofrecer tratamientos recanalizadores con buenos resultados&#44; buscando la equidad y optimizando el manejo del binomio gravedad-tiempo para ofrecer a cada paciente el tratamiento &#243;ptimo en el menor plazo de tiempo posible y en condiciones de seguridad&#46;</p></span>"
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