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Salazar Alcalá, M. Fernández-Mestre" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "de Mendonça" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Salazar Alcalá" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Fernández-Mestre" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485314002357" "doi" => "10.1016/j.nrl.2014.10.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485314002357?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580816300888?idApp=UINPBA00004N" "url" => "/21735808/0000003100000008/v1_201609280237/S2173580816300888/v1_201609280237/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2173580816300797" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2014.10.004" "estado" => "S300" "fechaPublicacion" => "2016-10-01" "aid" => "699" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2016;31:523-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1322 "formatos" => array:3 [ "EPUB" => 80 "HTML" => 969 "PDF" => 273 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Novel mutation in <span class="elsevierStyleItalic">STXBP1</span> gene in a patient with non-lesional Ohtahara syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "523" "paginaFinal" => "527" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nueva mutación en el gen <span class="elsevierStyleItalic">STXBP1</span> en un paciente con síndrome de Ohtahara no lesional" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1867 "Ancho" => 2666 "Tamanyo" => 207126 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Diagram of the genomic structure of the fragment (exons 11 to 16) of <span class="elsevierStyleItalic">STXBP1</span> containing the mutation c.1249<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>2T<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>C (located at intron 14 and marked with an asterisk). The electropherogram shows the mutation c.1249<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>2T<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>C identified in our patient and the corresponding sequence in each of his parents, which suggests that it is a de novo mutation.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Ortega-Moreno, B.G. Giráldez, A. Verdú, O. García-Campos, G. Sánchez-Martín, J.M. Serratosa, R. Guerrero-López" "autores" => array:7 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Ortega-Moreno" ] 1 => array:2 [ "nombre" => "B.G." "apellidos" => "Giráldez" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Verdú" ] 3 => array:2 [ "nombre" => "O." "apellidos" => "García-Campos" ] 4 => array:2 [ "nombre" => "G." "apellidos" => "Sánchez-Martín" ] 5 => array:2 [ "nombre" => "J.M." "apellidos" => "Serratosa" ] 6 => array:2 [ "nombre" => "R." 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Espinosa Jovel, C.M. Pardo, C.M. Moreno, J. Vergara, D. Hedmont, F.E. Sobrino Mejía" "autores" => array:6 [ 0 => array:4 [ "nombre" => "C.A." "apellidos" => "Espinosa Jovel" "email" => array:1 [ 0 => "camilo_jovel@hotmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C.M." "apellidos" => "Pardo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C.M." "apellidos" => "Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Vergara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "D." "apellidos" => "Hedmont" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "F.E." "apellidos" => "Sobrino Mejía" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Universidad de la Sabana, Facultad de Medicina, Posgrado de Neurología, Bogotá, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Occidente de Kennedy, Centro de excelencia en Epilepsia, Departamento de Neurologia, Bogotá, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Perfil demográfico y social de la epilepsia en una población vulnerable y de bajos recursos económicos en Bogotá, Colombia" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Epilepsy is a chronic disease defined by the International League Against Epilepsy (ILAE) as a brain disorder characterised by a predisposition to generate epileptic seizures which leads to neurobiological, cognitive, psychological and social consequences.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Recently published studies have shown that epilepsy is a prevalent disease with a high social and economic impact, and it is more frequent in countries with low financial resources. The approximate prevalence of active epilepsy (seizures during the last 5 years) in developed countries reaches 5.8 per 1000 population, compared to 15.4 per 1000 population in low-income countries.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a> The most recently published study in Colombia reported an overall prevalence of 11.3 per 1000 individuals. Regional variations are small with the exception of the eastern region, where prevalence is 23 per 1000 population.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a> Hospital Occidente de Kennedy is a public institution in Bogotá (Colombia) which provides care to a mostly low-income population with a high level of social vulnerability. We decided to conduct this study to describe the demographic and social profile of the patients and identify those variables related to social vulnerability and low incomes.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Objective</span><p id="par0010" class="elsevierStylePara elsevierViewall">This study aims to describe the most relevant clinical, demographic, and social characteristics of patients diagnosed with epilepsy who visited the neurology department at Hospital Occidente de Kennedy between January and March 2014.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study population</span><p id="par0015" class="elsevierStylePara elsevierViewall">Our population included patients attending the neurology department at Hospital Occidente de Kennedy in Bogotá, Colombia and diagnosed with epilepsy in the period stated above. Hospital Occidente de Kennedy is a public hospital located in Bogotá. This tertiary care hospital provides care to residents of the locality of Kennedy (Bogotá, Colombia) and its health districts, representing a total approximate population of 2<span class="elsevierStyleHsp" style=""></span>741<span class="elsevierStyleHsp" style=""></span>000 people according to national statistical data. Most residents have a low socioeconomic level; Kennedy has the highest unemployment rate (16.3%) of any locality in Bogotá, therefore also exceeding the overall unemployment rate in Bogotá (13.1%). Of the population of Kennedy, 53% is regarded as below the poverty threshold while 13.3% is indigent. Hospital Occidente de Kennedy is a reference centre for neurological diseases. A total of 2361 patients diagnosed with epilepsy were assessed here in 2013, including patients seen in the emergency department and in external consultations, for a daily average of 6.4 evaluations. All patients included in this study were assessed in the neurology outpatient clinic by a clinical neurologist employed by the hospital.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The study design is observational, descriptive, and cross-sectional. We prospectively recorded data from all patients diagnosed with epilepsy and assessed in our neurology clinic between January and March 2014. The definition of epilepsy used in this study was based on the 2010 ILAE report defining it as a brain disorder characterised by a predisposition to generate epileptic seizures, which leads to neurobiological, cognitive, psychological, and social consequences.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Epilepsy cases were diagnosed and classified using a review of the clinical history, medical interview, electroencephalogram, videotelemetry (when required), brain magnetic resonance, and neuropsychological assessment (when required). During the consultation, the neurologist filled out the data collection form, which included sociodemographic variables (age, sex, marital status, educational level, social health insurance scheme, social category, current employment, and need for a caregiver) and clinical variables (family history of epilepsy, epilepsy risk factors, age at diagnosis, type of seizure, probable aetiology of epilepsy, antiepileptic drugs [AEDs], and trigger factors).</p><p id="par0025" class="elsevierStylePara elsevierViewall">Epilepsy risk factors were defined as the clinical conditions that generate a permanent predisposition to experiencing epileptic seizures and that increase probability of presenting epilepsy. The assessed risk factors were: history of perinatal disease, delayed psychomotor development, head trauma, central nervous system infection, central nervous system neoplasm, cerebrovascular disease, febrile convulsions during childhood, and neurocutaneous syndromes. The probable aetiology of epilepsy was determined based on the ILAE classification of 2010<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> which states that epilepsy can be categorised into 3 types: structural and metabolic (trauma, infection, cerebrovascular diseases, among others); genetic, referring to conditions due to a presumed genetic defect in which seizures are the core symptom of the disease; and ‘unknown cause’, referring to an unknown neutral aetiology whose cause could not be determined at the time of the assessment.</p><p id="par0030" class="elsevierStylePara elsevierViewall">We included all patients older than 15 and diagnosed with epilepsy, excluding those patients not willing to participate, those with a cognitive deficit restricting the quality of the information, patients not accompanied by any family members able to confirm the data, and those who had undergone epilepsy surgery. We excluded patients treated with epilepsy surgery because in our hospital, these patients are assessed in an epilepsy clinic and cannot be treated in general neurology clinics for administrative reasons; instead, they are immediately referred for assessment by the epilepsy surgery team. Treatment adherence was assessed by reviewing the clinical history and the medical interview; this information was confirmed by the patient's family member or companion. We analysed data using descriptive epidemiology tools, including calculations of central tendency and dispersion measurements for quantitative variables, and estimates of absolute and relative frequencies for categorical variables.</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Demographic data</span><p id="par0035" class="elsevierStylePara elsevierViewall">During the period between January and March 2014, we assessed a total of 305 patients diagnosed with epilepsy in our outpatient neurology clinic. Since we excluded a total of 198 patients; the total number of patients analysed was 107. This group comprised 64 men (59.8%) and 43 women (40.1%), with a mean age<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>standard deviation of 42.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>16.7 years and an age range of 16 to 82 years.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Clinical data</span><p id="par0040" class="elsevierStylePara elsevierViewall">Of the 107 patients included in the study, 80 (74.7%) did not have a family history of epilepsy and only 17 (15.8%) mentioned a family history of epilepsy in first- or second-degree relatives. The family history of the remaining 10 patients was unclear. The main epilepsy risk factors found in this population were as follows: delayed psychomotor development (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>24, 22.4%), head trauma (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16, 14.9%), central nervous system infection (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>13, 12.1%), and perinatal disease (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11, 10.2%) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Average age at epilepsy diagnosis was 21.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>20.8 years, with a range of 0 to 82 years. Seizure types were classified using the ILAE's 2010 classification system and only the most frequent type was listed per patient: focal epilepsy evolving to bilateral convulsive (secondarily generalised) seizure in 34.5% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>37), focal seizures with impairment of consciousness (complex focal) in 22.4% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>24), tonic-clonic generalised seizures in 20.5% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>22), and focal seizures with no impairment of consciousness (simple focal) in 13% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>14). Epileptic seizures could not be classified in 10 patients (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The probable aetiology of epilepsy according to the classification system in the 2010 ILAE report was structural and/or metabolic in 47.6% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>51), followed by unknown cause in 45.7% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>49). Genetic aetiology represented 6.5% of the cases (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0050" class="elsevierStylePara elsevierViewall">Regarding current antiepileptic treatment, 57.9% of the patients (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>62) were receiving polytherapy at time of assessment (2 or more AEDs). Of these 62 patients, 46 (67.7%) had been on polytherapy for more than 24 months, and 7 (11.2%) had been polymedicated between 12 and 24 months. The most frequently used antiepileptic drugs were carbamazepine, valproic acid, lamotrigine, phenytoin, clonazepam, levetiracetam, lacosamide, and vigabatrin.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Drug-resistant epilepsy is a clinical condition defined by the ILAE as failure of adequate trials of 2 tolerated and appropriately chosen and used antiepileptic drugs (whether as monotherapies or in combination) to achieve sustained seizure freedom. Seizure freedom is lack of seizures during at least 3 times the longest pretreatment interseizure interval in the preceding year, or 12 months, whichever is longer. Using this framework, we can classify patients with epilepsy into 3 large groups: those who respond well to antiepileptic drugs, those whose epilepsy is resistant to antiepileptic drugs, and unclassified patients (undefined) at the moment of the assessment, who can later be classified as responders and non-responders to drug treatment. According to this definition, of the 107 patients in our population at the beginning, 10 could not be classified; of the remaining 97 patients, 70.1% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>68) of them were responding to antiepileptic drugs (controlled), 15.4% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>15) had drug-resistant (refractory) epilepsy, and 14.4% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>14) were classified as ‘undefined’ at the time of assessment (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0060" class="elsevierStylePara elsevierViewall">Most of the patients included in our study presented good adherence to medical treatment and only a few factors triggering seizures were documented. Nine patients reported irregular use of antiepileptic drugs (8.4%), 5 patients referred exacerbation of seizures during menstruation (4.6%), and 4 patients referred exacerbation of seizures due to frequent consumption of alcohol (3.7%). Of the 9 patients who referred irregular adherence to antiepileptic treatment, 5 (5.55%) reported that discontinuing drugs was due to administrative problems related to delivery.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Social data</span><p id="par0065" class="elsevierStylePara elsevierViewall">Regarding educational level, 26 patients (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>26, 24.2%) were illiterate, understood here as the inability to read and write due to lack of education. The Colombian school system is divided into a basic primary level (grades 1 through 5) and a basic secondary level (grades 6 through 11). Higher education includes technical schools and universities. According to this system, 24 of our patients (22.4%) had finished basic secondary education, 17 patients (15.8%) had not finished basic primary education, and only 11 patients (10.2%) had completed higher studies consisting of technical or university education (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Socioeconomic levels in Colombia are defined according to the classification of residential buildings eligible for public services. Socioeconomic levels used to classify dwellings and properties are ranked from 1 to 6, with 1 being the lowest stratum and 6 the highest. With this in mind, 71 of the 107 patients (66.3%) belonged to socioeconomic level 2; 22 patients (20.5%) belonged to level 1; 12 patients (11.2%) belonged to level 3; and only 2 patients (1.86%) were classified in level 5.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Regarding marital status, 79 patients (73.8%) were single, 13 patients (12.1%) were married, and 8 patients (7.4%) were divorced (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><p id="par0080" class="elsevierStylePara elsevierViewall">Regarding employment at the time of assessment, 76 patients (71%) were unemployed and only 31 patients (28.9%) were actively working. Of the 76 unemployed patients, 34 (44.7%) reported that unemployment was secondary to the disease; the remaining 42 did not associate unemployment with the underlying disease (epilepsy) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). Approximately 34.5% of the included patients (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>37) required a permanent caregiver; only 3 of them (8.1%) reported that their caregiver was drawing a salary for that role.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Several social, labour-related, demographic, and clinical factors have an impact on epilepsy. Sex and race are demographic factors that seem to affect the presentation of epilepsy in populations with low incomes. This was shown by a study conducted by Kaiboriboon et al.,<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a> who reported that epilepsy in low-income populations was more frequent among adult black men with previous comorbidities and/or incapacitating conditions. These data support our own results; 59.8% of our patients were men with a mean age of 42.7 years. However, given the sample size, the sampling strategy, and the study methodology, we cannot state that epilepsy in our sample is more frequent in adult men than in other groups; therefore, further population-based analytical studies will have to be conducted to confirm this hypothesis.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Explanations of why men might present epilepsy more frequently than women vary greatly. The explanation we suggest is based on the risk factors for epilepsy, especially head trauma and cerebrovascular accidents, which are frequent and incapacitating in vulnerable, low-income populations like this one. In Colombia, both of these factors are more frequently found in men than in women.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Educational level is one of the most important variables in the social profile of epileptic patients, and our study reports a low educational level for most of the patients; however, this finding is not exclusive to low-income populations. The REST-1 group showed that in some European countries (Italy, Germany, Spain, the Netherlands, England, Portugal, and Russia), epileptic patients had fewer years of study than the general population, presenting a social profile characterised by low educational level, unemployment, and single marital status.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> The REST-1 group also reported that only 13% of the patients with epilepsy from the above mentioned countries had completed a course of higher education (university); this figure is quite similar to that found in our population (10.2%). The difference in the educational profile resides in the percentage of illiteracy; in our study, we found illiteracy in 24.2% of our patient population. A much lower percentage is reported in European populations, at only 2%.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Although our sample does not reflect the educational profile of all epileptic patients in our setting due to its size and the sampling methodology used, we may still hypothesise that illiteracy in this vulnerable low-income population is more prevalent than in higher-income populations. Low educational level has a significant effect not only on the social profile of epileptic patients, but also on the clinical presentation of epilepsy. It may increase the risk of poor seizure control and the need for polytherapy.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Unemployment is an important factor of the social profile of epileptic patients; in our study, we found a rate of 76.7%, which is high compared to populations with high incomes. A study of 1009 patients conducted in the Netherlands reported an unemployment rate of about 49%<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a> in epileptic patients. Another study conducted in England reported an unemployment rate near 46%.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a> In addition to being relevant to the social profile of epileptic patients, unemployment is also associated with some interesting clinical variables. For example, the study conducted by Marinas et al.,<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a> reported that the main factors associated with unemployment were refractory epilepsy, seizures during the last 12 months, low educational level, and polytherapy. Further analytical studies in low income populations should be conducted to determine whether unemployment rates are higher in epileptic patients than in the general population.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Most of the patients in our population were single (73.8%) while only 12.1% were married; these data are similar to those published by Stavem et al.,<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a> who reported that, compared to the general population, epileptic patients were less likely to be married, employed, or studying. In comparison with populations with high incomes, our population contains a higher percentage of single patients (56% in the REST-1 group vs 73.8% in our sample).<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> The study conducted by the REST-1 group also showed that only 2% of the epileptic patients were divorced,<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> while this percentage was 7.4% in our study.</p><p id="par0115" class="elsevierStylePara elsevierViewall">Based on the above data, we can hypothesise that rates of unemployment, illiteracy, and single status are much higher in low-income populations, which contributes to their social and labour market vulnerability. However, these data will have to be confirmed by studies that are methodologically prepared to investigate this idea.</p><p id="par0120" class="elsevierStylePara elsevierViewall">The clinical profile of the epileptic patients reported by our study is similar to that observed in populations with high incomes. Regarding type of epileptic seizure, most of our patients (77.2%) presented focal-onset seizures, while 22.6% presented generalised seizures. The epidemiology of types of epileptic seizure is quite variable and depends on multiple factors, such as presence of a reliable clinical history, the diagnostic methods used, the age of the patient, and the probable aetiologies of epilepsy. For this reason, there is no specific clinical pattern to help us determine the most frequent epileptic seizures.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> However, a comparison of our data to those from studies conducted in high-income populations reveals no major differences. Forsgren<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a> found that the prevalence of focal onset seizures in a Swedish population reached 60%, and generalised seizures, 13%; Luengo et al.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> identified focal-onset seizures in 63% of a Spanish epileptic population, with generalised seizures in 37%. Some studies conducted in such Latin American countries as Chile have reported similar percentages, with focal-onset seizures in 55% and generalised seizures in 40%.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Regarding epilepsy aetiology, and using the classification proposed by the ILAE in 2010, we observed that seizures in most of our patients have structural or metabolic causes (47.6%), whereas aetiology was unknown in 45.7%, and a genetic cause was only observed in 6.5%. This aetiological profile also presents some similarities to those from studies in high-income populations. In a Spanish population from Barcelona, Torres-Ferrús et al.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">16</span></a> showed that most of their patients presented symptomatic epilepsies (57.2%), followed by cryptogenic epilepsy (19.2%). The cause of epilepsy is unknown in a large percentage of cases due to diagnostic limitations which do not allow doctors to properly determine a structural or genetic cause.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a> This clinical profile is similar in other populations with low incomes, and in such African countries as Ethiopia the percentage of patients with epilepsy of an unknown cause may reach 86%.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a> Regarding the clinical profile of epileptic patients assessed in this study, it is important to highlight that most had no family history of epilepsy. The main risk factors observed were delayed psychomotor development, head trauma, and central nervous system infection. These findings supported the hypothesis that structural or symptomatic aetiology may be more frequent than genetic or idiopathic aetiology.</p><p id="par0130" class="elsevierStylePara elsevierViewall">The pattern of clinical responses to AEDs in our population is similar to that observed in populations with high incomes. Based on the classification of responses to antiepileptic drugs proposed by the ILAE in 2010, we observed that 70.1% of the patients were adequately controlled, 15.4% were classified as having drug-resistant epilepsy, and 14.4% were undefined. These data are similar to those published by Brodie et al.,<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a> in a Scottish population in Glasgow, which reported that some 59% of the patients would remain seizure free and therefore be considered controlled; 25% would never attain seizure freedom; and the remaining 16% would present periods of seizure freedom lasting more than one year between relapses.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Methodological limitations</span><p id="par0135" class="elsevierStylePara elsevierViewall">Our study presents the limitations inherent to descriptive studies. This study is based on health centre records rather than a population register, so its sample size and sampling strategy (based on consecutive visits) do not allow us to extrapolate data to the entire population. Nor did we calculate a sample enabling us to create a statistically significant model of the study population (locality of Kennedy in Bogotá, Colombia). For this reason, this study does not enable us to estimate the real value of variables measured in this population. A selection bias is also present since 198 patients of the 305 initially assessed were excluded. Reasons for exclusion were as follows: 85 patients (42.9%) were unwilling to participate or complete the data collection form, 56 patients (28.2%) came to our clinic alone so no family members or companions could corroborate the data they provided, 41 patients (20.7%) were excluded because they exhibited significant cognitive impairment which limited the quality of their information, and 16 patients (8.1%) were excluded due to a history of epilepsy surgery.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusion</span><p id="par0140" class="elsevierStylePara elsevierViewall">The demographic and clinical profile of the patients included in this study resembles profiles described in high income populations; any differences seem to reside in the aetiological classification and risk factors. The social profile of the patients included in our study is characterised by unemployment, illiteracy, and being single. These features seem to be more frequent and prevalent in our patients than they are in high income populations. Further population-based analytical studies should be conducted to confirm these observations in low-income epileptic patients so as to promote comprehensive care strategies adapted to the clinical and demographic profile of this population.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">This study was financed by the authors’ personal resources.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">There are no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres735092" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec738828" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres735091" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec738829" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Study population" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Methods" ] ] ] 6 => array:3 [ "identificador" => "sec0030" "titulo" => "Results" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Demographic data" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Clinical data" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Social data" ] ] ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Methodological limitations" ] 9 => array:2 [ "identificador" => "sec0060" "titulo" => "Conclusion" ] 10 => array:2 [ "identificador" => "sec0065" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "sec0070" "titulo" => "Conflicts of interest" ] 12 => array:2 [ "identificador" => "xack244399" "titulo" => "Acknowledgements" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-07-22" "fechaAceptado" => "2014-10-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec738828" "palabras" => array:3 [ 0 => "Epilepsy" 1 => "Low-income countries" 2 => "Social vulnerability" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec738829" "palabras" => array:3 [ 0 => "Epilepsia" 1 => "Bajos recursos económicos" 2 => "Vulnerabilidad social" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Very few studies describe the demographic and social profile of epilepsy in vulnerable low-income populations.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Observational, descriptive, cross-sectional study prospectively recording data from all patients diagnosed with epilepsy who attended a specialist neurology consultation between January and March 2014. Data were analysed using descriptive epidemiology tools.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 107 patients were evaluated, of whom 24.2% were illiterate and only 10.2% had completed a higher education programme. Most of the patients (86.8%) had a low socioeconomic status; 73.8% were single and 76.7% were unemployed. The main risk factors for epilepsy in this population were recorded as follows: delayed psychomotor development (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>24, 22.4%), head trauma (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16, 14.9%), and central nervous system infection (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>13, 12.1%). Most patients (70.1%) responded to antiepileptic drugs (controlled cases) and 15.4% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>15) had drug-resistant epilepsy (refractory cases).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The demographic and clinical profiles of the patients included in this study resemble those published for high-income populations; differences are mostly limited to aetiological classification and risk factors. The social profile of the patients evaluated in this study shows high rates of unemployment, illiteracy, and single marital status. These findings seem to be more frequent and prevalent in this group than in high income populations.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Existen pocos estudios que demuestren el perfil demográfico y social de la epilepsia en poblaciones vulnerables y de bajos recursos económicos.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional, descriptivo, de corte transversal, en donde se registraron prospectivamente los datos de todos los pacientes con diagnóstico de epilepsia que asistieron a la consulta especializada de neurología durante el periodo comprendido entre enero y marzo del 2014. Se analizaron los datos utilizando herramientas de la epidemiología descriptiva.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se valoraron un total de 107 pacientes, de los cuales el 24,2% son analfabetas, y solamente el 10,2% completó estudios de educación superior. El 86,8% de los pacientes viven en un estrato socioeconómico bajo y cerca del 73,8% son solteros. El 76,7% se encuentra desempleado. Los principales factores de riesgo para epilepsia documentados en esta población fueron: retraso en el desarrollo psicomotor (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>24, 22,4%), trauma craneoencefálico (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16, 14,9%) e infección del sistema nervioso central (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>13, 12,1%). La mayoría de los pacientes (70,1%) son respondedores a los fármacos anticonvulsivos (controlados) y el 15,4% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>15) son resistentes (refractarios).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El perfil demográfico y clínico de los pacientes incluidos en este estudio es similar a los datos publicados en poblaciones de altos recursos económicos, la diferencia parece fundamentarse en la clasificación etiológica y los factores de riesgo. El perfil social de los pacientes evaluados en este estudio se caracteriza por desempleo, analfabetismo y soltería. Estos datos, en comparación con poblaciones de altos recursos económicos, parecen ser más frecuentes y prevalentes.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Espinosa Jovel CA, Pardo CM, Moreno CM, Vergara J, Hedmont D, Sobrino Mejía FE. Perfil demográfico y social de la epilepsia en una población vulnerable y de bajos recursos económicos en Bogotá, Colombia. Neurología. 2016;31:528–534.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Most relevant clinical characteristics</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Structural and/or metabolic <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Genetic <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Unknown cause <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aetiology of epilepsy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">51 (47.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7 (6.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">49 (45.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Epilepsy risk factors</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Number</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Percentage</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Delayed psychomotor development \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">22.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Head trauma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CNS infection \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Perinatal disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Type of epileptic seizure (ILAE 2010)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Number</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Percentage</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal seizure evolving to bilateral convulsive seizure \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">34.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal seizure with impairment of consciousness \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">22.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tonic–clonic generalised seizure \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">20.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal seizure with no impairment of consciousness \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Classification according to response to antiepileptic drugs</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Number</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Percentage</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Respondents (controlled) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">70.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">With drug-resistant epilepsy (refractory) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Undetermined \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1213256.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Most relevant social characteristics</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Educational level (in order of frequency) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Number \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Percentage \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Illiterate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Finished basic secondary education \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">22.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Did not finish basic primary education \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">University/technical training \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Current employment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Number \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Percentage \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Employed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">28.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Unemployed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">71 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Marital status \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Number \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Percentage \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Single \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">73.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Married \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Separated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cohabiting \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1213257.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Social characteristics.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0100" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.T. Berg" 1 => "S.F. Berkovic" 2 => "M.J. Brodie" 3 => "J. Buchhalter" 4 => "J.H. Cross" 5 => "W. van Emde Boas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1528-1167.2010.02522.x" "Revista" => array:6 [ "tituloSerie" => "Epilepsia" "fecha" => "2010" "volumen" => "51" "paginaInicial" => "676" "paginaFinal" => "685" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20196795" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0105" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimation of the burden of active and life-time epilepsy: a meta-analytic approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.K. Ngugi" 1 => "C. Bottomley" 2 => "I. Kleinschmidt" 3 => "J.W. Sander" 4 => "C.R. 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To the patients of the neurology department at Hospital Occidente de Kennedy. To the directors of Hospital Occidente de Kennedy, Dr Juan Ernesto Oviedo, Dr Wilson Darío Bustos. To the nursing and medical staff in training at Hospital Occidente de Kennedy.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21735808/0000003100000008/v1_201609280237/S2173580816300785/v1_201609280237/en/main.assets" "Apartado" => array:4 [ "identificador" => "9491" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735808/0000003100000008/v1_201609280237/S2173580816300785/v1_201609280237/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580816300785?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
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2024 November | 9 | 1 | 10 |
2024 October | 38 | 2 | 40 |
2024 September | 36 | 9 | 45 |
2024 August | 31 | 12 | 43 |
2024 July | 34 | 7 | 41 |
2024 June | 46 | 3 | 49 |
2024 May | 33 | 4 | 37 |
2024 April | 38 | 8 | 46 |
2024 March | 34 | 4 | 38 |
2024 February | 27 | 4 | 31 |
2024 January | 36 | 2 | 38 |
2023 December | 43 | 11 | 54 |
2023 November | 19 | 5 | 24 |
2023 October | 20 | 4 | 24 |
2023 September | 9 | 4 | 13 |
2023 August | 18 | 6 | 24 |
2023 July | 20 | 7 | 27 |
2023 June | 28 | 7 | 35 |
2023 May | 50 | 6 | 56 |
2023 April | 44 | 2 | 46 |
2023 March | 19 | 8 | 27 |
2023 February | 33 | 0 | 33 |
2023 January | 25 | 1 | 26 |
2022 December | 23 | 6 | 29 |
2022 November | 33 | 17 | 50 |
2022 October | 22 | 11 | 33 |
2022 September | 40 | 9 | 49 |
2022 August | 21 | 12 | 33 |
2022 July | 24 | 11 | 35 |
2022 June | 27 | 7 | 34 |
2022 May | 36 | 4 | 40 |
2022 April | 50 | 8 | 58 |
2022 March | 99 | 11 | 110 |
2022 February | 93 | 5 | 98 |
2022 January | 51 | 11 | 62 |
2021 December | 35 | 15 | 50 |
2021 November | 40 | 6 | 46 |
2021 October | 15 | 10 | 25 |
2021 September | 12 | 10 | 22 |
2021 August | 14 | 12 | 26 |
2021 July | 13 | 8 | 21 |
2021 June | 11 | 7 | 18 |
2021 May | 15 | 10 | 25 |
2021 April | 62 | 13 | 75 |
2021 March | 21 | 6 | 27 |
2021 February | 14 | 14 | 28 |
2021 January | 21 | 11 | 32 |
2020 December | 18 | 14 | 32 |
2020 November | 12 | 9 | 21 |
2020 October | 15 | 6 | 21 |
2020 September | 12 | 7 | 19 |
2020 August | 17 | 9 | 26 |
2020 July | 13 | 9 | 22 |
2020 June | 16 | 9 | 25 |
2020 May | 10 | 12 | 22 |
2020 April | 11 | 1 | 12 |
2020 March | 13 | 4 | 17 |
2020 February | 14 | 2 | 16 |
2020 January | 9 | 4 | 13 |
2019 December | 24 | 8 | 32 |
2019 November | 13 | 5 | 18 |
2019 October | 12 | 4 | 16 |
2019 September | 25 | 3 | 28 |
2019 August | 16 | 7 | 23 |
2019 July | 18 | 11 | 29 |
2019 June | 30 | 34 | 64 |
2019 May | 74 | 53 | 127 |
2019 April | 42 | 21 | 63 |
2019 March | 10 | 4 | 14 |
2019 February | 18 | 4 | 22 |
2019 January | 8 | 4 | 12 |
2018 December | 18 | 6 | 24 |
2018 November | 19 | 8 | 27 |
2018 October | 24 | 16 | 40 |
2018 September | 2 | 0 | 2 |
2018 August | 6 | 4 | 10 |
2018 July | 3 | 2 | 5 |
2018 June | 4 | 1 | 5 |
2018 May | 6 | 1 | 7 |
2018 April | 4 | 1 | 5 |
2018 March | 5 | 2 | 7 |
2018 February | 5 | 6 | 11 |
2018 January | 10 | 1 | 11 |
2017 December | 5 | 0 | 5 |
2017 November | 6 | 2 | 8 |
2017 October | 11 | 5 | 16 |
2017 September | 4 | 1 | 5 |
2017 August | 15 | 0 | 15 |
2017 July | 16 | 2 | 18 |
2017 June | 18 | 8 | 26 |
2017 May | 12 | 4 | 16 |
2017 April | 10 | 3 | 13 |
2017 March | 10 | 32 | 42 |
2017 February | 9 | 5 | 14 |
2017 January | 10 | 2 | 12 |
2016 December | 27 | 4 | 31 |
2016 November | 36 | 10 | 46 |
2016 October | 54 | 8 | 62 |
2016 September | 7 | 2 | 9 |
2016 August | 3 | 3 | 6 |