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Original article
Demographic and social profile of epilepsy in a vulnerable low-income population in Bogotá, Colombia
Perfil demográfico y social de la epilepsia en una población vulnerable y de bajos recursos económicos en Bogotá, Colombia
C.A. Espinosa Jovela,b,
Corresponding author
camilo_jovel@hotmail.com

Corresponding author.
, C.M. Pardob, C.M. Morenob, J. Vergarab, D. Hedmontb, F.E. Sobrino Mejíaa,b
a Universidad de la Sabana, Facultad de Medicina, Posgrado de Neurología, Bogotá, Colombia
b Hospital Occidente de Kennedy, Centro de excelencia en Epilepsia, Departamento de Neurologia, Bogotá, Colombia
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Epilepsy is a chronic disease defined by the International League Against Epilepsy &#40;ILAE&#41; as a brain disorder characterised by a predisposition to generate epileptic seizures which leads to neurobiological&#44; cognitive&#44; psychological and social consequences&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Recently published studies have shown that epilepsy is a prevalent disease with a high social and economic impact&#44; and it is more frequent in countries with low financial resources&#46; The approximate prevalence of active epilepsy &#40;seizures during the last 5 years&#41; in developed countries reaches 5&#46;8 per 1000 population&#44; compared to 15&#46;4 per 1000 population in low-income countries&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a> The most recently published study in Colombia reported an overall prevalence of 11&#46;3 per 1000 individuals&#46; Regional variations are small with the exception of the eastern region&#44; where prevalence is 23 per 1000 population&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a> Hospital Occidente de Kennedy is a public institution in Bogot&#225; &#40;Colombia&#41; which provides care to a mostly low-income population with a high level of social vulnerability&#46; We decided to conduct this study to describe the demographic and social profile of the patients and identify those variables related to social vulnerability and low incomes&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Objective</span><p id="par0010" class="elsevierStylePara elsevierViewall">This study aims to describe the most relevant clinical&#44; demographic&#44; and social characteristics of patients diagnosed with epilepsy who visited the neurology department at Hospital Occidente de Kennedy between January and March 2014&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study population</span><p id="par0015" class="elsevierStylePara elsevierViewall">Our population included patients attending the neurology department at Hospital Occidente de Kennedy in Bogot&#225;&#44; Colombia and diagnosed with epilepsy in the period stated above&#46; Hospital Occidente de Kennedy is a public hospital located in Bogot&#225;&#46; This tertiary care hospital provides care to residents of the locality of Kennedy &#40;Bogot&#225;&#44; Colombia&#41; and its health districts&#44; representing a total approximate population of 2<span class="elsevierStyleHsp" style=""></span>741<span class="elsevierStyleHsp" style=""></span>000 people according to national statistical data&#46; Most residents have a low socioeconomic level&#59; Kennedy has the highest unemployment rate &#40;16&#46;3&#37;&#41; of any locality in Bogot&#225;&#44; therefore also exceeding the overall unemployment rate in Bogot&#225; &#40;13&#46;1&#37;&#41;&#46; Of the population of Kennedy&#44; 53&#37; is regarded as below the poverty threshold while 13&#46;3&#37; is indigent&#46; Hospital Occidente de Kennedy is a reference centre for neurological diseases&#46; A total of 2361 patients diagnosed with epilepsy were assessed here in 2013&#44; including patients seen in the emergency department and in external consultations&#44; for a daily average of 6&#46;4 evaluations&#46; All patients included in this study were assessed in the neurology outpatient clinic by a clinical neurologist employed by the hospital&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The study design is observational&#44; descriptive&#44; and cross-sectional&#46; We prospectively recorded data from all patients diagnosed with epilepsy and assessed in our neurology clinic between January and March 2014&#46; The definition of epilepsy used in this study was based on the 2010 ILAE report defining it as a brain disorder characterised by a predisposition to generate epileptic seizures&#44; which leads to neurobiological&#44; cognitive&#44; psychological&#44; and social consequences&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Epilepsy cases were diagnosed and classified using a review of the clinical history&#44; medical interview&#44; electroencephalogram&#44; videotelemetry &#40;when required&#41;&#44; brain magnetic resonance&#44; and neuropsychological assessment &#40;when required&#41;&#46; During the consultation&#44; the neurologist filled out the data collection form&#44; which included sociodemographic variables &#40;age&#44; sex&#44; marital status&#44; educational level&#44; social health insurance scheme&#44; social category&#44; current employment&#44; and need for a caregiver&#41; and clinical variables &#40;family history of epilepsy&#44; epilepsy risk factors&#44; age at diagnosis&#44; type of seizure&#44; probable aetiology of epilepsy&#44; antiepileptic drugs &#91;AEDs&#93;&#44; and trigger factors&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Epilepsy risk factors were defined as the clinical conditions that generate a permanent predisposition to experiencing epileptic seizures and that increase probability of presenting epilepsy&#46; The assessed risk factors were&#58; history of perinatal disease&#44; delayed psychomotor development&#44; head trauma&#44; central nervous system infection&#44; central nervous system neoplasm&#44; cerebrovascular disease&#44; febrile convulsions during childhood&#44; and neurocutaneous syndromes&#46; The probable aetiology of epilepsy was determined based on the ILAE classification of 2010<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> which states that epilepsy can be categorised into 3 types&#58; structural and metabolic &#40;trauma&#44; infection&#44; cerebrovascular diseases&#44; among others&#41;&#59; genetic&#44; referring to conditions due to a presumed genetic defect in which seizures are the core symptom of the disease&#59; and &#8216;unknown cause&#8217;&#44; referring to an unknown neutral aetiology whose cause could not be determined at the time of the assessment&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We included all patients older than 15 and diagnosed with epilepsy&#44; excluding those patients not willing to participate&#44; those with a cognitive deficit restricting the quality of the information&#44; patients not accompanied by any family members able to confirm the data&#44; and those who had undergone epilepsy surgery&#46; We excluded patients treated with epilepsy surgery because in our hospital&#44; these patients are assessed in an epilepsy clinic and cannot be treated in general neurology clinics for administrative reasons&#59; instead&#44; they are immediately referred for assessment by the epilepsy surgery team&#46; Treatment adherence was assessed by reviewing the clinical history and the medical interview&#59; this information was confirmed by the patient&#39;s family member or companion&#46; We analysed data using descriptive epidemiology tools&#44; including calculations of central tendency and dispersion measurements for quantitative variables&#44; and estimates of absolute and relative frequencies for categorical variables&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Demographic data</span><p id="par0035" class="elsevierStylePara elsevierViewall">During the period between January and March 2014&#44; we assessed a total of 305 patients diagnosed with epilepsy in our outpatient neurology clinic&#46; Since we excluded a total of 198 patients&#59; the total number of patients analysed was 107&#46; This group comprised 64 men &#40;59&#46;8&#37;&#41; and 43 women &#40;40&#46;1&#37;&#41;&#44; with a mean age<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation of 42&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;7 years and an age range of 16 to 82 years&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Clinical data</span><p id="par0040" class="elsevierStylePara elsevierViewall">Of the 107 patients included in the study&#44; 80 &#40;74&#46;7&#37;&#41; did not have a family history of epilepsy and only 17 &#40;15&#46;8&#37;&#41; mentioned a family history of epilepsy in first- or second-degree relatives&#46; The family history of the remaining 10 patients was unclear&#46; The main epilepsy risk factors found in this population were as follows&#58; delayed psychomotor development &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#44; 22&#46;4&#37;&#41;&#44; head trauma &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#44; 14&#46;9&#37;&#41;&#44; central nervous system infection &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44; 12&#46;1&#37;&#41;&#44; and perinatal disease &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44; 10&#46;2&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Average age at epilepsy diagnosis was 21&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;8 years&#44; with a range of 0 to 82 years&#46; Seizure types were classified using the ILAE&#39;s 2010 classification system and only the most frequent type was listed per patient&#58; focal epilepsy evolving to bilateral convulsive &#40;secondarily generalised&#41; seizure in 34&#46;5&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>37&#41;&#44; focal seizures with impairment of consciousness &#40;complex focal&#41; in 22&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#41;&#44; tonic-clonic generalised seizures in 20&#46;5&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&#41;&#44; and focal seizures with no impairment of consciousness &#40;simple focal&#41; in 13&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#41;&#46; Epileptic seizures could not be classified in 10 patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The probable aetiology of epilepsy according to the classification system in the 2010 ILAE report was structural and&#47;or metabolic in 47&#46;6&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>51&#41;&#44; followed by unknown cause in 45&#46;7&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>49&#41;&#46; Genetic aetiology represented 6&#46;5&#37; of the cases &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Regarding current antiepileptic treatment&#44; 57&#46;9&#37; of the patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>62&#41; were receiving polytherapy at time of assessment &#40;2 or more AEDs&#41;&#46; Of these 62 patients&#44; 46 &#40;67&#46;7&#37;&#41; had been on polytherapy for more than 24 months&#44; and 7 &#40;11&#46;2&#37;&#41; had been polymedicated between 12 and 24 months&#46; The most frequently used antiepileptic drugs were carbamazepine&#44; valproic acid&#44; lamotrigine&#44; phenytoin&#44; clonazepam&#44; levetiracetam&#44; lacosamide&#44; and vigabatrin&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Drug-resistant epilepsy is a clinical condition defined by the ILAE as failure of adequate trials of 2 tolerated and appropriately chosen and used antiepileptic drugs &#40;whether as monotherapies or in combination&#41; to achieve sustained seizure freedom&#46; Seizure freedom is lack of seizures during at least 3 times the longest pretreatment interseizure interval in the preceding year&#44; or 12 months&#44; whichever is longer&#46; Using this framework&#44; we can classify patients with epilepsy into 3 large groups&#58; those who respond well to antiepileptic drugs&#44; those whose epilepsy is resistant to antiepileptic drugs&#44; and unclassified patients &#40;undefined&#41; at the moment of the assessment&#44; who can later be classified as responders and non-responders to drug treatment&#46; According to this definition&#44; of the 107 patients in our population at the beginning&#44; 10 could not be classified&#59; of the remaining 97 patients&#44; 70&#46;1&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>68&#41; of them were responding to antiepileptic drugs &#40;controlled&#41;&#44; 15&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#41; had drug-resistant &#40;refractory&#41; epilepsy&#44; and 14&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#41; were classified as &#8216;undefined&#8217; at the time of assessment &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Most of the patients included in our study presented good adherence to medical treatment and only a few factors triggering seizures were documented&#46; Nine patients reported irregular use of antiepileptic drugs &#40;8&#46;4&#37;&#41;&#44; 5 patients referred exacerbation of seizures during menstruation &#40;4&#46;6&#37;&#41;&#44; and 4 patients referred exacerbation of seizures due to frequent consumption of alcohol &#40;3&#46;7&#37;&#41;&#46; Of the 9 patients who referred irregular adherence to antiepileptic treatment&#44; 5 &#40;5&#46;55&#37;&#41; reported that discontinuing drugs was due to administrative problems related to delivery&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Social data</span><p id="par0065" class="elsevierStylePara elsevierViewall">Regarding educational level&#44; 26 patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>26&#44; 24&#46;2&#37;&#41; were illiterate&#44; understood here as the inability to read and write due to lack of education&#46; The Colombian school system is divided into a basic primary level &#40;grades 1 through 5&#41; and a basic secondary level &#40;grades 6 through 11&#41;&#46; Higher education includes technical schools and universities&#46; According to this system&#44; 24 of our patients &#40;22&#46;4&#37;&#41; had finished basic secondary education&#44; 17 patients &#40;15&#46;8&#37;&#41; had not finished basic primary education&#44; and only 11 patients &#40;10&#46;2&#37;&#41; had completed higher studies consisting of technical or university education &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Socioeconomic levels in Colombia are defined according to the classification of residential buildings eligible for public services&#46; Socioeconomic levels used to classify dwellings and properties are ranked from 1 to 6&#44; with 1 being the lowest stratum and 6 the highest&#46; With this in mind&#44; 71 of the 107 patients &#40;66&#46;3&#37;&#41; belonged to socioeconomic level 2&#59; 22 patients &#40;20&#46;5&#37;&#41; belonged to level 1&#59; 12 patients &#40;11&#46;2&#37;&#41; belonged to level 3&#59; and only 2 patients &#40;1&#46;86&#37;&#41; were classified in level 5&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Regarding marital status&#44; 79 patients &#40;73&#46;8&#37;&#41; were single&#44; 13 patients &#40;12&#46;1&#37;&#41; were married&#44; and 8 patients &#40;7&#46;4&#37;&#41; were divorced &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Regarding employment at the time of assessment&#44; 76 patients &#40;71&#37;&#41; were unemployed and only 31 patients &#40;28&#46;9&#37;&#41; were actively working&#46; Of the 76 unemployed patients&#44; 34 &#40;44&#46;7&#37;&#41; reported that unemployment was secondary to the disease&#59; the remaining 42 did not associate unemployment with the underlying disease &#40;epilepsy&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Approximately 34&#46;5&#37; of the included patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>37&#41; required a permanent caregiver&#59; only 3 of them &#40;8&#46;1&#37;&#41; reported that their caregiver was drawing a salary for that role&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Several social&#44; labour-related&#44; demographic&#44; and clinical factors have an impact on epilepsy&#46; Sex and race are demographic factors that seem to affect the presentation of epilepsy in populations with low incomes&#46; This was shown by a study conducted by Kaiboriboon et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a> who reported that epilepsy in low-income populations was more frequent among adult black men with previous comorbidities and&#47;or incapacitating conditions&#46; These data support our own results&#59; 59&#46;8&#37; of our patients were men with a mean age of 42&#46;7 years&#46; However&#44; given the sample size&#44; the sampling strategy&#44; and the study methodology&#44; we cannot state that epilepsy in our sample is more frequent in adult men than in other groups&#59; therefore&#44; further population-based analytical studies will have to be conducted to confirm this hypothesis&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Explanations of why men might present epilepsy more frequently than women vary greatly&#46; The explanation we suggest is based on the risk factors for epilepsy&#44; especially head trauma and cerebrovascular accidents&#44; which are frequent and incapacitating in vulnerable&#44; low-income populations like this one&#46; In Colombia&#44; both of these factors are more frequently found in men than in women&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Educational level is one of the most important variables in the social profile of epileptic patients&#44; and our study reports a low educational level for most of the patients&#59; however&#44; this finding is not exclusive to low-income populations&#46; The REST-1 group showed that in some European countries &#40;Italy&#44; Germany&#44; Spain&#44; the Netherlands&#44; England&#44; Portugal&#44; and Russia&#41;&#44; epileptic patients had fewer years of study than the general population&#44; presenting a social profile characterised by low educational level&#44; unemployment&#44; and single marital status&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> The REST-1 group also reported that only 13&#37; of the patients with epilepsy from the above mentioned countries had completed a course of higher education &#40;university&#41;&#59; this figure is quite similar to that found in our population &#40;10&#46;2&#37;&#41;&#46; The difference in the educational profile resides in the percentage of illiteracy&#59; in our study&#44; we found illiteracy in 24&#46;2&#37; of our patient population&#46; A much lower percentage is reported in European populations&#44; at only 2&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Although our sample does not reflect the educational profile of all epileptic patients in our setting due to its size and the sampling methodology used&#44; we may still hypothesise that illiteracy in this vulnerable low-income population is more prevalent than in higher-income populations&#46; Low educational level has a significant effect not only on the social profile of epileptic patients&#44; but also on the clinical presentation of epilepsy&#46; It may increase the risk of poor seizure control and the need for polytherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Unemployment is an important factor of the social profile of epileptic patients&#59; in our study&#44; we found a rate of 76&#46;7&#37;&#44; which is high compared to populations with high incomes&#46; A study of 1009 patients conducted in the Netherlands reported an unemployment rate of about 49&#37;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a> in epileptic patients&#46; Another study conducted in England reported an unemployment rate near 46&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a> In addition to being relevant to the social profile of epileptic patients&#44; unemployment is also associated with some interesting clinical variables&#46; For example&#44; the study conducted by Marinas et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a> reported that the main factors associated with unemployment were refractory epilepsy&#44; seizures during the last 12 months&#44; low educational level&#44; and polytherapy&#46; Further analytical studies in low income populations should be conducted to determine whether unemployment rates are higher in epileptic patients than in the general population&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Most of the patients in our population were single &#40;73&#46;8&#37;&#41; while only 12&#46;1&#37; were married&#59; these data are similar to those published by Stavem et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a> who reported that&#44; compared to the general population&#44; epileptic patients were less likely to be married&#44; employed&#44; or studying&#46; In comparison with populations with high incomes&#44; our population contains a higher percentage of single patients &#40;56&#37; in the REST-1 group vs 73&#46;8&#37; in our sample&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> The study conducted by the REST-1 group also showed that only 2&#37; of the epileptic patients were divorced&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> while this percentage was 7&#46;4&#37; in our study&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Based on the above data&#44; we can hypothesise that rates of unemployment&#44; illiteracy&#44; and single status are much higher in low-income populations&#44; which contributes to their social and labour market vulnerability&#46; However&#44; these data will have to be confirmed by studies that are methodologically prepared to investigate this idea&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The clinical profile of the epileptic patients reported by our study is similar to that observed in populations with high incomes&#46; Regarding type of epileptic seizure&#44; most of our patients &#40;77&#46;2&#37;&#41; presented focal-onset seizures&#44; while 22&#46;6&#37; presented generalised seizures&#46; The epidemiology of types of epileptic seizure is quite variable and depends on multiple factors&#44; such as presence of a reliable clinical history&#44; the diagnostic methods used&#44; the age of the patient&#44; and the probable aetiologies of epilepsy&#46; For this reason&#44; there is no specific clinical pattern to help us determine the most frequent epileptic seizures&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> However&#44; a comparison of our data to those from studies conducted in high-income populations reveals no major differences&#46; Forsgren<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a> found that the prevalence of focal onset seizures in a Swedish population reached 60&#37;&#44; and generalised seizures&#44; 13&#37;&#59; Luengo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> identified focal-onset seizures in 63&#37; of a Spanish epileptic population&#44; with generalised seizures in 37&#37;&#46; Some studies conducted in such Latin American countries as Chile have reported similar percentages&#44; with focal-onset seizures in 55&#37; and generalised seizures in 40&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Regarding epilepsy aetiology&#44; and using the classification proposed by the ILAE in 2010&#44; we observed that seizures in most of our patients have structural or metabolic causes &#40;47&#46;6&#37;&#41;&#44; whereas aetiology was unknown in 45&#46;7&#37;&#44; and a genetic cause was only observed in 6&#46;5&#37;&#46; This aetiological profile also presents some similarities to those from studies in high-income populations&#46; In a Spanish population from Barcelona&#44; Torres-Ferr&#250;s et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">16</span></a> showed that most of their patients presented symptomatic epilepsies &#40;57&#46;2&#37;&#41;&#44; followed by cryptogenic epilepsy &#40;19&#46;2&#37;&#41;&#46; The cause of epilepsy is unknown in a large percentage of cases due to diagnostic limitations which do not allow doctors to properly determine a structural or genetic cause&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a> This clinical profile is similar in other populations with low incomes&#44; and in such African countries as Ethiopia the percentage of patients with epilepsy of an unknown cause may reach 86&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a> Regarding the clinical profile of epileptic patients assessed in this study&#44; it is important to highlight that most had no family history of epilepsy&#46; The main risk factors observed were delayed psychomotor development&#44; head trauma&#44; and central nervous system infection&#46; These findings supported the hypothesis that structural or symptomatic aetiology may be more frequent than genetic or idiopathic aetiology&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The pattern of clinical responses to AEDs in our population is similar to that observed in populations with high incomes&#46; Based on the classification of responses to antiepileptic drugs proposed by the ILAE in 2010&#44; we observed that 70&#46;1&#37; of the patients were adequately controlled&#44; 15&#46;4&#37; were classified as having drug-resistant epilepsy&#44; and 14&#46;4&#37; were undefined&#46; These data are similar to those published by Brodie et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a> in a Scottish population in Glasgow&#44; which reported that some 59&#37; of the patients would remain seizure free and therefore be considered controlled&#59; 25&#37; would never attain seizure freedom&#59; and the remaining 16&#37; would present periods of seizure freedom lasting more than one year between relapses&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Methodological limitations</span><p id="par0135" class="elsevierStylePara elsevierViewall">Our study presents the limitations inherent to descriptive studies&#46; This study is based on health centre records rather than a population register&#44; so its sample size and sampling strategy &#40;based on consecutive visits&#41; do not allow us to extrapolate data to the entire population&#46; Nor did we calculate a sample enabling us to create a statistically significant model of the study population &#40;locality of Kennedy in Bogot&#225;&#44; Colombia&#41;&#46; For this reason&#44; this study does not enable us to estimate the real value of variables measured in this population&#46; A selection bias is also present since 198 patients of the 305 initially assessed were excluded&#46; Reasons for exclusion were as follows&#58; 85 patients &#40;42&#46;9&#37;&#41; were unwilling to participate or complete the data collection form&#44; 56 patients &#40;28&#46;2&#37;&#41; came to our clinic alone so no family members or companions could corroborate the data they provided&#44; 41 patients &#40;20&#46;7&#37;&#41; were excluded because they exhibited significant cognitive impairment which limited the quality of their information&#44; and 16 patients &#40;8&#46;1&#37;&#41; were excluded due to a history of epilepsy surgery&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusion</span><p id="par0140" class="elsevierStylePara elsevierViewall">The demographic and clinical profile of the patients included in this study resembles profiles described in high income populations&#59; any differences seem to reside in the aetiological classification and risk factors&#46; The social profile of the patients included in our study is characterised by unemployment&#44; illiteracy&#44; and being single&#46; These features seem to be more frequent and prevalent in our patients than they are in high income populations&#46; Further population-based analytical studies should be conducted to confirm these observations in low-income epileptic patients so as to promote comprehensive care strategies adapted to the clinical and demographic profile of this population&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">This study was financed by the authors&#8217; personal resources&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">There are no conflicts of interest to declare&#46;</p></span></span>"
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          "identificador" => "xres735092"
          "titulo" => "Abstract"
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            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
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            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
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            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
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    "fechaRecibido" => "2014-07-22"
    "fechaAceptado" => "2014-10-16"
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            0 => "Epilepsy"
            1 => "Low-income countries"
            2 => "Social vulnerability"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Very few studies describe the demographic and social profile of epilepsy in vulnerable low-income populations&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Observational&#44; descriptive&#44; cross-sectional study prospectively recording data from all patients diagnosed with epilepsy who attended a specialist neurology consultation between January and March 2014&#46; Data were analysed using descriptive epidemiology tools&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 107 patients were evaluated&#44; of whom 24&#46;2&#37; were illiterate and only 10&#46;2&#37; had completed a higher education programme&#46; Most of the patients &#40;86&#46;8&#37;&#41; had a low socioeconomic status&#59; 73&#46;8&#37; were single and 76&#46;7&#37; were unemployed&#46; The main risk factors for epilepsy in this population were recorded as follows&#58; delayed psychomotor development &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#44; 22&#46;4&#37;&#41;&#44; head trauma &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#44; 14&#46;9&#37;&#41;&#44; and central nervous system infection &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44; 12&#46;1&#37;&#41;&#46; Most patients &#40;70&#46;1&#37;&#41; responded to antiepileptic drugs &#40;controlled cases&#41; and 15&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#41; had drug-resistant epilepsy &#40;refractory cases&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The demographic and clinical profiles of the patients included in this study resemble those published for high-income populations&#59; differences are mostly limited to aetiological classification and risk factors&#46; The social profile of the patients evaluated in this study shows high rates of unemployment&#44; illiteracy&#44; and single marital status&#46; These findings seem to be more frequent and prevalent in this group than in high income populations&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Existen pocos estudios que demuestren el perfil demogr&#225;fico y social de la epilepsia en poblaciones vulnerables y de bajos recursos econ&#243;micos&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional&#44; descriptivo&#44; de corte transversal&#44; en donde se registraron prospectivamente los datos de todos los pacientes con diagn&#243;stico de epilepsia que asistieron a la consulta especializada de neurolog&#237;a durante el periodo comprendido entre enero y marzo del 2014&#46; Se analizaron los datos utilizando herramientas de la epidemiolog&#237;a descriptiva&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se valoraron un total de 107 pacientes&#44; de los cuales el 24&#44;2&#37; son analfabetas&#44; y solamente el 10&#44;2&#37; complet&#243; estudios de educaci&#243;n superior&#46; El 86&#44;8&#37; de los pacientes viven en un estrato socioecon&#243;mico bajo y cerca del 73&#44;8&#37; son solteros&#46; El 76&#44;7&#37; se encuentra desempleado&#46; Los principales factores de riesgo para epilepsia documentados en esta poblaci&#243;n fueron&#58; retraso en el desarrollo psicomotor &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#44; 22&#44;4&#37;&#41;&#44; trauma craneoencef&#225;lico &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#44; 14&#44;9&#37;&#41; e infecci&#243;n del sistema nervioso central &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44; 12&#44;1&#37;&#41;&#46; La mayor&#237;a de los pacientes &#40;70&#44;1&#37;&#41; son respondedores a los f&#225;rmacos anticonvulsivos &#40;controlados&#41; y el 15&#44;4&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#41; son resistentes &#40;refractarios&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El perfil demogr&#225;fico y cl&#237;nico de los pacientes incluidos en este estudio es similar a los datos publicados en poblaciones de altos recursos econ&#243;micos&#44; la diferencia parece fundamentarse en la clasificaci&#243;n etiol&#243;gica y los factores de riesgo&#46; El perfil social de los pacientes evaluados en este estudio se caracteriza por desempleo&#44; analfabetismo y solter&#237;a&#46; Estos datos&#44; en comparaci&#243;n con poblaciones de altos recursos econ&#243;micos&#44; parecen ser m&#225;s frecuentes y prevalentes&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Espinosa Jovel CA&#44; Pardo CM&#44; Moreno CM&#44; Vergara J&#44; Hedmont D&#44; Sobrino Mej&#237;a FE&#46; Perfil demogr&#225;fico y social de la epilepsia en una poblaci&#243;n vulnerable y de bajos recursos econ&#243;micos en Bogot&#225;&#44; Colombia&#46; Neurolog&#237;a&#46; 2016&#59;31&#58;528&#8211;534&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Most relevant clinical characteristics</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Structural and&#47;or metabolic <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Genetic <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Unknown cause <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aetiology of epilepsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51 &#40;47&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;6&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49 &#40;45&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Epilepsy risk factors</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Number</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Percentage</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Delayed psychomotor development&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Head trauma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CNS infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Perinatal disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Type of epileptic seizure &#40;ILAE 2010&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Number</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Percentage</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal seizure evolving to bilateral convulsive seizure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal seizure with impairment of consciousness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tonic&#8211;clonic generalised seizure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal seizure with no impairment of consciousness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Classification according to response to antiepileptic drugs</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Number</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Percentage</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Respondents &#40;controlled&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">With drug-resistant epilepsy &#40;refractory&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Undetermined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Marital status&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cohabiting&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                          "etal" => false
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        "texto" => "<p id="par0155" class="elsevierStylePara elsevierViewall">To the members of the neurology department and the postgraduate programme in neurology at the Universidad de la Sabana&#59; Dr Roberto Baquero&#44; Dr Erik S&#225;nchez&#44; Dr Javier Vicini&#44; Dr Gustavo Barrios&#44; Dr Mar&#237;a Claudia Angulo&#44; Dr Andr&#233;s Betancourt&#44; Dr Marta Ramos&#44; Dr Alejandra Guerrero&#44; Dr Luisa Echavarria&#44; Dr Adriana Casallas&#44; Dr Jorge Ruiz&#46; To the Medical School at Universidad de la Sabana&#59; Dr Camilo Osorio&#44; Dr&#46; Fernando R&#237;os&#44; Dr Mar&#237;a Jos&#233; Maldonado&#46; To the patients of the neurology department at Hospital Occidente de Kennedy&#46; To the directors of Hospital Occidente de Kennedy&#44; Dr Juan Ernesto Oviedo&#44; Dr Wilson Dar&#237;o Bustos&#46; To the nursing and medical staff in training at Hospital Occidente de Kennedy&#46;</p>"
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ISSN: 21735808
Original language: English
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