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Original article
Tendencies in cerebral aneurism treatment: Analysis of a hospital series
Tendencias en el tratamiento de los aneurismas cerebrales: análisis de una serie hospitalaria
A. Lagoa,
Corresponding author
aida.lago@sen.es

Corresponding author.
, R. López-Cuevasa, J.I. Tembla, G. Forteaa, D. Górriza, F. Aparicib, V. Parkhutika
a Servicio de Neurología, Hospital Universitario La Fe, Valencia, Spain
b Sevicio de Radiología, Hospital Universitario La Fe, Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Non-traumatic subarachnoid haemorrhage &#40;SAH&#41; accounts for 5&#37; of all cases of stroke&#46; Compared to other types of stroke&#44; this severe condition affects younger patients&#44; and it is associated with high mortality&#44; severe disability&#44; and a substantial economic and social burden&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Treatment for SAH has evolved over the past few decades&#44; mainly due to the introduction of endovascular treatment&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a> but also thanks to the development of neurosurgical techniques<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a> and recent advances in neurocritical care&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Hospital Universitario y Polit&#233;cnico de La Fe&#44; in Valencia&#44; is a reference centre for the treatment of SAH&#46; Our patients with SAH are managed according to the following protocol&#58; after SAH diagnosis&#44; patients are admitted to the intensive care unit &#40;ICU&#41; and undergo cerebral angiography as soon as possible&#46; When aneurysms are detected&#44; patients undergo embolisation immediately following diagnosis if the procedure is viable&#59; when this is not the case&#44; patients either undergo embolisation at a later time or receive surgical treatment&#44; according to the neuroradiologist&#39;s and neurosurgeon&#39;s joint assessment&#46; As a general rule&#44; after discharge&#44; patients receiving endovascular treatment are monitored by the neurology department whereas those undergoing surgery are monitored by the neurosurgery department&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Treatment for cerebral aneurysms has undergone a paradigm shift&#58; at present&#44; endovascular treatment is the first-line option&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> The growing interest in improving SAH management shown by neurologists&#44; neurosurgeons&#44; and neuroradiologists alike has led to developing protocols for treating SAH and its associated complications&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We were able to analyse SAH treatment outcomes longitudinally in our setting given that we had access to data on SAH spanning over a decade&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Objective</span><p id="par0025" class="elsevierStylePara elsevierViewall">Our purpose was to analyse any changes in SAH management over time in our setting&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 571 patients with SAH treated at our hospital were included in our study&#46; We compared 2 databases of consecutive patients &#40;both created by our team&#41; and covering 2 different periods&#46; The first one is a retrospective database &#40;SAH-OLD&#41; including 462 patients with SAH receiving medical attention at our hospital between April 1997 and March 2005&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> The second is a prospective database &#40;SAH-NEW&#41; comprising 109 consecutive patients attended between March 2007 and April 2010&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">All patients had been admitted to the ICU according to our hospital&#39;s action protocol for SAH management and received treatment to prevent vasospasm in line with established practices in each period&#46; Demographic characteristics &#40;age&#44; sex&#41;&#44; risk factors&#44; clinical status at admission &#40;Hunt and Hess scale and Glasgow Coma Scale&#41;&#44; time to angiography&#44; diagnosis of aneurysm&#44; surgical&#47;endovascular treatment&#44; and time to treatment were compared between the 2 groups&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Likewise&#44; we studied frequencies of the following neurological complications in both periods&#58; epileptic seizures&#44; rebleeding&#44; hydrocephalus&#44; and clinical vasospasm &#40;defined as delayed neurological impairment associated with signs of vasospasm in a vascular study and&#47;or signs of ischaemia in imaging studies&#41;&#46; We also gathered data on presence of infections and compared mean hospitalisation times&#44; in-hospital mortality&#44; and modified Rankin Scale &#40;mRS&#41; scores at discharge&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Statistical analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">Qualitative variables are expressed as relative frequencies and quantitative variables as means<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#46; Qualitative variables were compared using the chi-square test&#59; quantitative variables were compared using either the <span class="elsevierStyleItalic">t</span> test for independent samples or the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test for quantitative variables lacking a normal distribution &#40;hospitalisation time&#41;&#46; Values of <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05 were considered statistically significant&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">The retrospective database included 462 cases of spontaneous SAH&#59; 55&#46;8&#37; were women and mean age was 56&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;8 years &#40;range&#44; 14-96&#41;&#46; The prospective database included 109 cases of SAH&#59; 62&#46;4&#37; were women and mean age was 55&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;61 years &#40;range&#44; 16-85&#41;&#46; Mean hospitalisation time was 20&#46;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;83 days &#40;range&#44; 1-199&#41; in SAH-OLD patients and 23&#46;89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;43 days &#40;range&#44; 1-245&#41; in SAH-NEW patients &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;15&#41;&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Demographic characteristics and risk factors</span><p id="par0055" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows demographic characteristics and risk factors of patients with SAH in both study periods&#46; The only significant differences were in presence of diabetes mellitus&#44; which was more prevalent among SAH-NEW patients &#40;21&#46;1&#37; vs 10&#46;6&#37;&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;005&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Diagnosis</span><p id="par0060" class="elsevierStylePara elsevierViewall">During the first period&#44; 369 patients underwent a diagnostic cerebral angiography &#40;80&#37;&#41; vs 97 patients &#40;89&#37;&#41; in the second period &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;02&#41;&#46; Aneurysms were detected in 245 SAH-OLD patients &#40;66&#46;4&#37;&#41; and 67 SAH-NEW patients &#40;69&#37;&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;62&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Of the 369 SAH-OLD patients undergoing cerebral angiography&#44; 57&#46;2&#37; displayed only one aneurysm&#44; 9&#46;2&#37; had multiple aneurysms&#44; and 2&#46;7&#37; displayed arteriovenous malformations&#46; Studies yielded normal results in 30&#46;9&#37;&#46; Cerebral angiography was not performed in this period in 20&#37; of the patients&#44; 80&#37; of whom died prematurely&#46; During the second period&#44; 97 patients underwent cerebral angiography&#59; 64&#37; had only one aneurysm&#44; 5&#46;2&#37; multiple aneurysms&#44; and 3&#37; had arteriovenous malformations&#46; Results were normal in 24&#46;8&#37; of these patients&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In this subgroup&#44; 11&#37; did not undergo cerebral angiography and most of these patients &#40;83&#37;&#41; died prematurely&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Mean time to angiography in the first period was 2&#46;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;5 days &#40;median&#44; 1&#59; mode&#44; 1&#41; and 2&#46;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;23 days in the second &#40;median&#44; 2&#59; mode&#44; 1&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;49&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Outcomes</span><p id="par0080" class="elsevierStylePara elsevierViewall">Regarding outcomes&#44; 139 patients &#40;30&#46;1&#37;&#41; died during the first period and 20 &#40;18&#46;3&#37;&#41; during the second period &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46; Among survivors&#44; 13&#46;3&#37; of SAH-OLD patients scored over 3 on the mRS at discharge vs 21&#46;3&#37; of SAH-NEW patients &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;06&#41;&#46;</p><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Severity at admission</span><p id="par0085" class="elsevierStylePara elsevierViewall">Severity at admission was similar in both subgroups according to Hunt and Hess scale scores &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and Glasgow Coma Scale scores &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Complications</span><p id="par0090" class="elsevierStylePara elsevierViewall">Complications in the 2 groups are summarised in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; Although there were more cases of hydrocephalus among SAH-NEW patients&#44; the difference was not statistically significant&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Treatment</span><p id="par0095" class="elsevierStylePara elsevierViewall">Of the 245 SAH-OLD patients with cerebral aneurysms&#44; 208 &#40;45&#37; of the patient total&#41; received treatment&#46; In the second period&#44; 65 patients of the 109 with aneurysms &#40;60&#37; of the patient total&#41; were treated &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;007&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> summarises times to treatment&#44; which were significantly shorter in the second period&#44; for both embolisation and surgery&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">Management of SAH has improved in our hospital&#58; during the second period&#44; the mortality rate was lower&#44; a greater number of patients received treatment &#40;increases were more marked for endovascular treatment&#41;&#44; and times to treatment were shorter &#40;for both embolisation and surgery&#41;&#46; However&#44; time to angiography has remained stable&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Both databases present comparable demographical data except for presence of diabetes &#40;there were significantly more cases in the second period&#41; and severity at SAH onset&#46; Severity is an essential measure when comparing progression over time as it has the most bearing on prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Guidelines for the management of SAH recommend early treatment of aneurysms to avoid rebleeding&#44; the most severe complication of SAH&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">10&#44;11</span></a> Emergency cerebral angiography is therefore essential to determine the most appropriate treatment &#40;embolisation or surgery&#41; as quickly as possible&#46; Time to angiography is similar in both study periods&#44; which suggests that the status of SAH as a medical emergency has not changed&#46; Since January 2014&#44; our hospital has had an on-call vascular surgeon who performs emergency angiography studies in cases of SAH&#44; especially during the weekends&#46; This measure will presumably reduce time to angiography in the future&#46; In any case&#44; time to treatment&#44; whether embolisation or surgery&#44; has also decreased significantly&#44; which probably reflects good adherence to treatment protocols and guidelines for SAH management&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Endovascular treatment for cerebral aneurysm is on the rise&#44; although surgeries are still performed&#46; The publication of the International Subarachnoid Aneurysm Trial<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a> has resulted in a change in medical practice&#58; at present&#44; aneurysms are more frequently managed with endovascular treatment than with surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">6&#44;12</span></a> This pattern holds in our hospital&#58; treatment for aneurysms increased significantly during both study periods&#44; mainly due to expanded use of endovascular treatment&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">While mortality rates in SAH are high compared to those of other types of stroke&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a> they have decreased in the past few decades &#40;17&#37; between 1973 and 2002&#44; according to a meta-analysis by Nieuwkamp et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a>&#41;&#46; In our hospital&#44; mortality decreased significantly during the study periods&#44; and severity at SAH onset was similar in both periods&#46; This decrease has been attributed to improvements in SAH management and increased use of endovascular treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a> Fewer patients in our series died during the acute phase&#44; although disability was greater among SAH-NEW patients &#40;differences approach statistical significance&#41;&#46; If this is confirmed&#44; we may be witnessing a change with a major healthcare&#44; economic&#44; and social impact&#46; According to Lovelock et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a>&#44; if fewer patients with SAH die during the acute phase and the survivors are left more severely disabled&#44; the rehabilitation and hospitalisation burden will increase considerably&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In addition to such factors as age and severity at SAH onset&#44; mortality is also believed to depend on complications&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Both databases provide the number of complications per patient&#46; No differences in the presence of complications were detected between the 2 periods except for hydrocephalus&#44; which was more frequent among SAH-NEW patients &#40;the difference was not significant&#41;&#46; We therefore cannot attribute the decrease in mortality to a lower number of complications&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Another change observed during this time was the introduction of a protocol for multidisciplinary management of SAH patients&#46; Treatment guidelines recommend admitting patients to the stroke unit or ICU<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">11&#44;16</span></a> in the most severe cases&#46; Management of SAH in neurocritical care units&#44; such as the one in our hospital&#44; is widely accepted&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a> Prognosis in patients attended in these units has improved in recent years<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">18&#44;19</span></a>&#59; our study provides a clear example&#46; Management protocols are essential in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">One of the limitations of our study is that it is hospital-based rather than population-based&#46; Furthermore&#44; although the second database is prospective&#44; the first is retrospective&#44; which may affect data quality&#46; In contrast&#44; one of the strengths of our study is that it compares data from 2 different periods in the same population affected by a specific condition&#44; SAH&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusions</span><p id="par0145" class="elsevierStylePara elsevierViewall">At our hospital&#44; management of SAH has improved in the analysed period and time to angiography has remained stable over time&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction and objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To discover if there have been changes in the treatment time for SAH in our hospital environment&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Comparative analysis of 571 patients treated at Hospital Universitari la Fe during 2 different time periods&#46; The SAH-OLD group consisted of 462 patients attended consecutively between April 1997 and March 2005&#44; while SAH-NEW comprised 109 patients attended consecutively between March 2007 and April 2010&#46; We analysed demographic factors&#44; risk factors&#44; severity at time of admission&#44; time to arteriography&#44; diagnosis of aneurysm&#44; use of surgical or endovascular treatment and time to treatment&#44; frequency of neurological complications&#44; in-hospital deaths&#44; and modified Rankin Scale &#40;mRS&#41; at discharge&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Mean time to arteriography was 2&#46;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;5 days for the SAH-OLD group and 2&#46;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;23 days&#44; for the SAH-NEW group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;49&#41;&#46; Mortality rates for SAH-OLD patients were calculated at 30&#37;&#44; compared to 18&#46;3&#37; in SAH-NEW patients &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Among patients surviving the hospital stay in the SAH-OLD group&#44; 13&#46;3&#37; had an mRS<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>3&#44; compared to 21&#46;3&#37; of survivors in the SAH-NEW group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;06&#41;&#46; Two hundred forty-five patients in the SAH-OLD group had cerebral aneurysms and 208 were treated &#40;45&#37; of the patient total&#41;&#46; Sixty-five of the SAH-NEW patients received treatment &#40;60&#37; of the patient total&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;007&#41;&#46; In the SAH-OLD group&#44; 62&#46;9&#37; of the patients underwent embolisation vs 74&#46;6&#37; in the SAH-NEW group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;08&#41;&#46; Time to embolisation was 4&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;2 days for SAH-OLD patients and 2&#46;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;2 days for SAH-NEW patients &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46; Twenty-two percent of SAH-OLD patients underwent surgery&#44; compared to 25&#46;4&#37; in the SAH-NEW group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;62&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Care for SAH patients has improved in this hospital&#58; results include fewer mortalities&#44; a higher number of treatments with a smaller proportion of endovascular treatments&#44; and shorter times to treatment&#46; Elapsed time to arteriography remains stable&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction and objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n y objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Conocer&#44; en nuestro medio&#44; si ha habido variaciones en el tiempo en la atenci&#243;n a la HSA&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis de 571 pacientes con HSA tratados en el Hospital Universitario La Fe&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Comparaci&#243;n de 2 periodos&#58; HSA-VIEJA&#58; 462 pacientes consecutivos atendidos entre abril del 1997 y marzo del 2005&#59; HSA-NUEVA&#58; 109 pacientes consecutivos atendidos entre marzo del 2007 y abril del 2010&#46; Se analizaron las caracter&#237;sticas demogr&#225;ficas&#44; los factores de riesgo&#44; la gravedad al ingreso&#44; los tiempos hasta la arteriograf&#237;a&#44; el diagn&#243;stico de aneurisma&#44; el tratamiento quir&#250;rgico o intravascular y sus tiempos&#44; frecuencia de complicaciones neurol&#243;gicas&#44; la mortalidad durante el ingreso y escala de Rankin modificada &#40;mRS&#41; al alta&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Media hasta la realizaci&#243;n de la arteriograf&#237;a&#58; HSA-VIEJA&#58; 2&#44;18 &#177; 2&#44;5 d&#237;as&#44; HSA-NUEVA&#58; 2&#44;37 &#177; 2&#44;23 d&#237;as&#44; p &#61; 0&#44;49&#46; Mortalidad&#58; HSA-VIEJA 30&#37; frente al 18&#44;3&#37; en HSA-NUEVA&#44; p &#61; 0&#44;01&#46; Entre los supervivientes al alta hospitalaria&#44; un 13&#44;3&#37; en HSA-VIEJA ten&#237;a mRS &#62; 3 frente a un 21&#44;3&#37; en HSA-NUEVA&#44; p &#61; 0&#44;06&#46; HSA-VIEJA&#58; 245 pacientes ten&#237;an aneurisma cerebral&#44; se trataron 208 &#40;45&#37; del total de los pacientes&#41;&#59; HSA-NUEVA&#58; reciben tratamiento 65 &#40;60&#37; del total de los pacientes&#41;&#44; p &#61; 0&#44;007&#46; HSA-VIEJA&#58; se embolizaron 62&#44;9&#37;&#44; HSA-NUEVA&#58; 74&#44;6&#37;&#44; p &#61; 0&#44;08&#46; HSA-VIEJA&#58; cirug&#237;a 22&#37;&#44; HSA-NUEVA&#58; 25&#44;4&#37;&#44; p &#61; 0&#44;62&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">En nuestro hospital ha mejorado la atenci&#243;n a la HSA&#58; menor mortalidad&#44; mayor n&#250;mero de tratamientos a expensas del tratamiento intravascular y menor tiempo hasta el tratamiento&#46; El tiempo hasta la arteriograf&#237;a ha permanecido estable&#46;</p></span>"
        "secciones" => array:4 [
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            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n y objetivo"
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            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
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          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
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    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lago A&#44; L&#243;pez-Cuevas R&#44; Tembl JI&#44; Fortea G&#44; G&#243;rriz D&#44; Aparici F&#44; et al&#46; Tendencias en el tratamiento de los aneurismas cerebrales&#58; an&#225;lisis de una serie hospitalaria&#46; Neurolog&#237;a&#46; 2017&#59;32&#58;371&#8211;376&#46;</p>"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Hunt and Hess scale&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SAH-OLD<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>462&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SAH-NEW<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age&#44; years&#58; mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;8 &#40;14-96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;6 &#40;16-85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">258 &#40;55&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68 &#40;62&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AHT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">186 &#40;40&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 &#40;40&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49 &#40;10&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;21&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dyslipidaemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;16&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;21&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ischaemic heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;4&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;3&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tobacco dependency&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">151 &#40;32&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;31&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alcohol dependency&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;6&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;6&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SAH-OLD<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>462&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hydrocephalus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">86 &#40;18&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29 &#40;26&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Epileptic seizures&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43 &#40;9&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;12&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Rebleeding&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36 &#40;7&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;7&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vasospasm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;10&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;9&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Infections&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Treatment for SAH in our sample&#46;</p>"
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