Brain disease, connectivity, plasticity and cognitive therapy: A neurological view of mental disorders

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Lubrini, A. Martín-Montes, O. Díez-Ascaso, E. Díez-Tejedor" "autores" => array:4 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Lubrini" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Martín-Montes" ] 2 => array:2 [ "nombre" => "O." "apellidos" => "Díez-Ascaso" ] 3 => array:4 [ "nombre" => "E." "apellidos" => "Díez-Tejedor" "email" => array:1 [ 0 => "exuperio.diez@salud.madrid.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neurología, Centro de Ictus, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Área de Neurociencias, Instituto de Investigación IdiPAZ, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad cerebral, conectividad, plasticidad y terapia cognitiva. Una visión neurológica del trastorno mental" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1212 "Ancho" => 1675 "Tamanyo" => 175509 ] ] "descripcion" => array:1 [ "en" => "The effects of cognitive stimulation on healthy and injured brains." ] ] ] "textoCompleto" => "IntroductionFor many years, mind and brain were regarded as distinct entities. This dualism, most famously defended by René Descartes in the 17th century, has long been a cornerstone of Western culture. Technology and the development of neuroscience as a discipline have since led to the emergence of a new conception of mind as the result of processes occurring in the brain. This new premise requires us to discover how the brain must work to produce such a complex system as the “mind”: as has previously been stated, “there can be brain without mind, but there can be no mind without brain” (E. Díez-Tejedor). Localisationist theories argued that each part of the brain is responsible for a specific function; according to this view, a localised brain lesion would selectively damage certain cognitive processes. However, these brain maps exclude many functions that have classically been attributed to the concept of mind: behaviour, personality, mood, and affect, among others. Although evidence already existed that specific brain injuries could cause behavioural alterations, it was the famous case of Phineas Gage in the mid-19th century that led to investigation into the biological basis of such mental processes as emotion management or decision-making.<a class="elsevierStyleCrossRef" href="#bib0225">1</a> Moving beyond the localisationist approach, the brain was understood to function by means of complex, interconnected circuits involving both the cerebral cortex and the white matter.However, it has long been known that the brain is able to modify itself in response to certain stimuli. Ramón y Cajal's assertion that “any man could, if he were so inclined, be the sculptor of his own brain” was without doubt a reference to brain plasticity. Nonetheless, several decades passed before the discovery would be made that the brain not only has this capability, but is also able to form new nerve cells; Cajal doubted this in his day.This article reviews several aspects of brain disease and how it is related with connectivity and plasticity, as well as the fundamental aspects of cognitive therapy techniques based on these functions.Connectivity and brain diseaseThe human brain is a complex network of structurally and functionally interconnected regions; brain function arises from the networked organisation of the organ as a whole. Brain lesions can therefore cause functional deficits by means of 2 basic mechanisms: local cortical dysfunction in the affected region, and spatially separate dysfunction caused by interruption of the connection between 2 areas.Research into the circuits and networks constituting the highly complex organisation of the brain allows us greater insight into the structuring of the higher cognitive functions and their involvement in various neurological diseases. Indeed, we now know that the deficits associated with such disorders as Alzheimer disease, multiple sclerosis, traumatic brain injury (TBI), schizophrenia, depression, autism, etc., are accompanied by brain connectivity alterations.In Alzheimer disease, we observe reduced density of dendritic spines in cortical pyramidal cells and structural alterations to inhibitory circuits; this leads to a disconnection between different regions of the brain, such as the posterior cingulate and the hippocampus. These changes can be detected in the prodromal stage of the disease, and are correlated with the degree of cognitive impairment in later stages.<a class="elsevierStyleCrossRef" href="#bib0230">2</a> The progression of neurodegeneration is accompanied by reduced connectivity of the default mode network caused by deposition of β-amyloid peptide<a class="elsevierStyleCrossRef" href="#bib0235">3</a>; due to this, reduced connectivity has been found even in patients with mild cognitive impairment, compared to controls.<a class="elsevierStyleCrossRef" href="#bib0240">4</a>Both cognitive deficits and emotional and behavioural alterations have been associated with the interruption of brain networks in patients with multiple sclerosis<a class="elsevierStyleCrossRefs" href="#bib0245">5,6</a>; functional neuroimaging studies have also demonstrated alterations in brain activation and functional connectivity patterns.<a class="elsevierStyleCrossRefs" href="#bib0255">7,8</a> More recently, the introduction of graph theory has revealed structural changes in network topology in these patients, with modifications in the architecture of “small-world” networks<a class="elsevierStyleCrossRef" href="#bib0265">9</a> impairing the efficiency of information transmission, leading to significant reductions in network efficiency.<a class="elsevierStyleCrossRef" href="#bib0270">10</a>Another disease shown to involve a connection disorder is schizophrenia, which features an underlying alteration of the functional connections between different brain regions.<a class="elsevierStyleCrossRefs" href="#bib0275">11,12</a> The disease involves a disruption in the connection between different nodes of the default mode network, specifically the medial frontal cortex and the precuneus, which are key areas of the network,<a class="elsevierStyleCrossRefs" href="#bib0285">13,14</a> and frontoparietal and fronto-striato-temporal circuitry.<a class="elsevierStyleCrossRefs" href="#bib0295">15,16</a>Altered synchronisation has also been described in various brain networks in patients with autism spectrum disorders. In a study including patients with autism, Just et al.<a class="elsevierStyleCrossRef" href="#bib0305">17</a> found reduced functional connectivity between different brain areas (underconnectivity) during a sentence comprehension task. This has been confirmed by several functional magnetic resonance imaging (fMRI) studies.<a class="elsevierStyleCrossRefs" href="#bib0310">18–20</a> However, other studies have also found evidence of this functional connectivity alteration in patients with autism who were at rest.<a class="elsevierStyleCrossRefs" href="#bib0325">21–24</a>Traumatic brain injury also involves the interruption of brain networks, which causes considerable cognitive and behavioural disorders. The diffuse axonal damage caused by such a lesion affects white matter tracts connecting the nodes of widely distributed neural networks.<a class="elsevierStyleCrossRef" href="#bib0345">25</a> The most studied examples are the default mode network and the salience network; abnormal interaction between the 2 has been observed following TBI.<a class="elsevierStyleCrossRefs" href="#bib0350">26,27</a> Specifically, the functioning of the default mode network appears to be predicted by the degree of damage to the salience network which connects the right anterior insula, the presupplementary motor area, and the dorsal anterior cingulate cortex. These findings support the hypothesis that salience network integrity is necessary for the efficient functioning of the default mode network, and that a failure of communication between the networks can lead to disorders of inhibitory control.<a class="elsevierStyleCrossRef" href="#bib0360">28</a>This new connectivity-based approach brings new ways of understanding the mechanisms underlying the deficits that appear following brain injury and the changes to connectivity that occur during recovery.Plasticity and brain repairThe great advantages of the brain's network-based functioning are the resulting plasticity and mutability. Over 50 years ago, Hebb<a class="elsevierStyleCrossRef" href="#bib0365">29</a> proposed that experience may give rise to a reorganisation of neural connections in the cortex; since then, cortical plasticity has been a field of extensive study, both in relation to learning<a class="elsevierStyleCrossRef" href="#bib0370">30</a> and to the brain's response to injury.<a class="elsevierStyleCrossRef" href="#bib0375">31</a> Given the existence of functional networks, reorganising these would enable the functional recovery of the brain; therefore, the phenomenon of neuroplasticity, together with the brain's networked structure and connectivity, enables all the necessary changes to take place for the system to be repaired following injury.<a class="elsevierStyleCrossRef" href="#bib0380">32</a>Plasticity is expressed in varying forms in brain injuries, ranging from functional modifications of existing structures to the growth and proliferation of new structures and neurons.<a class="elsevierStyleCrossRef" href="#bib0385">33</a> In this way, the brain seeks ways of repairing itself, beginning a cascade of regenerative events by creating synapses (synaptogenesis) in perilesional areas and neurons (neurogenesis) in the subgranular zone of the dentate gyrus and the subventricular zone.<a class="elsevierStyleCrossRef" href="#bib0390">34</a> The cells produced in the neurogenic niches are able to migrate towards the damaged tissue, guided by the presence of specific proteins or chemotactic factors.<a class="elsevierStyleCrossRef" href="#bib0395">35</a> Certain trophic factors also mediate the processes of cell and fibre regeneration. Examples are brain-derived neurotrophic factor, neuropsin (involved in neural growth), and the Nogo-A and LINGO-1 proteins (which inhibit the growth of nerve fibres).Plasticity as the basis of cognitive and behavioural therapyPlasticity mechanisms are triggered at the moment of brain injury, enabling some amount of spontaneous recovery and repair. This is limited, however: recovery is most evident in the first 3 to 6 months following the injury, and while it does continue for several years after this, it occurs at a “negatively accelerating” rate. The implication of this is that as time progresses, changes become more difficult to observe. Cognitive and behavioural therapy has been proposed as a possible non-pharmacological intervention that may strengthen recovery.Cognitive therapy acts on the alterations that occur following brain injury, with a view to restoring or compensating for the damaged function in order to improve the patient's abilities and promote reincorporation into work and everyday activities (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<a class="elsevierStyleCrossRef" href="#bib0400">36</a><elsevierMultimedia ident="fig0005"></elsevierMultimedia>The effectiveness of this therapy is a complex issue, although sufficient data is available to recommend specific types of cognitive rehabilitation for problems with attention, information processing speed, memory, and language.<a class="elsevierStyleCrossRefs" href="#bib0405">37,38</a>Various fMRI studies have found evidence that the brain reorganises itself during the recovery period following a brain injury; however, they do not describe the cooperation of adjacent or distant brain regions.<a class="elsevierStyleCrossRef" href="#bib0415">39</a> The white matter is also involved in the restructuring associated with recovery.<a class="elsevierStyleCrossRef" href="#bib0420">40</a> It is therefore appropriate to consider the observable changes in the interaction between different brain areas, rather than only local modifications to functional activation patterns.<a class="elsevierStyleCrossRef" href="#bib0425">41</a> In other words, the neural network–based functioning of the brain improves our understanding of the relationship between observable plasticity and recovery mechanisms. Magnetoencephalography studies of patients with TBIs have shown increased connectivity after patients participated in an intensive programme of cognitive therapy.<a class="elsevierStyleCrossRef" href="#bib0430">42</a>An fMRI study into patients with stroke revealed increased connectivity in regions functionally related to the hippocampus after 3 months of computer-assisted cognitive therapy.<a class="elsevierStyleCrossRef" href="#bib0435">43</a>A similar phenomenon occurs in patients with multiple sclerosis; one study found increased resting-state functional connectivity in the anterior cingulate and inferior parietal cortices after 8 weeks of the same treatment.<a class="elsevierStyleCrossRef" href="#bib0440">44</a>ConclusionThe brain functions holistically by means of an extensive network of circuits which are responsible for all sensorimotor, vegetative, and mental processes. Understanding of the brain's connectivity and plasticity offers a new perspective from which to approach brain functioning and disease and the repair and recovery mechanisms that constitute the basis of cognitive and behavioural therapy.Conflicts of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1012479" "titulo" => "Abstract" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Development" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec971650" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1012480" "titulo" => "Resumen" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Desarrollo" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec971649" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Connectivity and brain disease" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Plasticity and brain repair" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Plasticity as the basis of cognitive and behavioural therapy" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conclusion" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 10 => array:2 [ "identificador" => "xack341544" "titulo" => "Acknowledgements" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-09-06" "fechaAceptado" => "2017-02-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec971650" "palabras" => array:5 [ 0 => "Brain plasticity" 1 => "Brain damage" 2 => "Cognitive therapy" 3 => "Behaviour disorders" 4 => "Mental disorders" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec971649" "palabras" => array:5 [ 0 => "Plasticidad cerebral" 1 => "Daño cerebral" 2 => "Terapia cognitiva" 3 => "Alteraciones del comportamiento" 4 => "Trastornos mentales" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionOur conception of the mind-brain relationship has evolved from the traditional idea of dualism to current evidence that mental functions result from brain activity. This paradigm shift, combined with recent advances in neuroimaging, has led to a novel definition of brain functioning in terms of structural and functional connectivity. The purpose of this literature review is to describe the relationship between connectivity, brain lesions, cerebral plasticity, and functional recovery. DevelopmentAssuming that brain function results from the organisation of the entire brain in networks, brain dysfunction would be a consequence of altered brain network connectivity. According to this approach, cognitive and behavioural impairment following brain damage result from disrupted functional organisation of brain networks. However, the dynamic and versatile nature of these circuits makes recovering brain function possible. Cerebral plasticity allows for functional reorganisation leading to recovery, whether spontaneous or resulting from cognitive therapy, after brain disease. ConclusionsCurrent knowledge of brain connectivity and cerebral plasticity provides new insights into normal brain functioning, the mechanisms of brain damage, and functional recovery, which in turn serve as the foundations of cognitive therapy." "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Development" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "IntroducciónLa relación entre mente y cerebro ha evolucionado desde el clásico dualismo hasta los conocimientos actuales que ponen de manifiesto que las funciones mentales son el resultado de la actividad cerebral. Este cambio de paradigma, junto con los recientes avances en diferentes técnicas de neuroimagen, ha dado lugar a una novedosa concepción del funcionamiento cerebral en términos de conectividad estructural y funcional. El objetivo del presente trabajo es describir la relación entre conectividad, lesión cerebral, plasticidad cerebral y recuperación funcional. DesarrolloSi la función cerebral surge de la organización en red del cerebro como un todo, la disfunción cerebral se puede producir por una alteración en la conexión de estas redes. Así, a partir del modelo conectivista, los trastornos cognitivos y del comportamiento que aparecen tras una afección cerebral se describen como consecuencia de una alteración en la organización funcional de las redes cerebrales. Sin embargo, la pérdida de funciones puede ser recuperada gracias a la capacidad de los circuitos de ser dinámicos y versátiles. La plasticidad cerebral permite una reorganización funcional que llevará a una recuperación, espontánea o potenciada con terapia cognitiva, después de algún tipo de enfermedad cerebral. ConclusionesEl conocimiento de la conectividad y la plasticidad cerebrales proporciona una nueva perspectiva desde la que entender el funcionamiento cerebral en condiciones normales, los mecanismos del daño cerebral y los de la recuperación funcional, constituyendo las bases para el desarrollo de la terapia cognitiva." "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Desarrollo" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Lubrini G, Martín-Montes A, Díez-Ascaso O, Díez-Tejedor E. Enfermedad cerebral, conectividad, plasticidad y terapia cognitiva. Una visión neurológica del trastorno mental. Neurología. 2018;33:187–191." ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1212 "Ancho" => 1675 "Tamanyo" => 175509 ] ] "descripcion" => array:1 [ "en" => "The effects of cognitive stimulation on healthy and injured brains." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:44 [ 0 => array:3 [ "identificador" => "bib0225" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El error de Descartes: la emoción, la razón y el cerebro humano" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.R. 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Enfermedad cerebral, conectividad, plasticidad y terapia cognitiva. Una visión neurológica del trastorno mental

G. Lubrini, A. Martín-Montes, O. Díez-Ascaso, E. Díez-Tejedor

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exuperio.diez@salud.madrid.org

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Servicio de Neurología, Centro de Ictus, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Área de Neurociencias, Instituto de Investigación IdiPAZ, Madrid, Spain

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">For many years&#44; mind and brain were regarded as distinct entities&#46; This dualism&#44; most famously defended by Ren&#233; Descartes in the 17th century&#44; has long been a cornerstone of Western culture&#46; Technology and the development of neuroscience as a discipline have since led to the emergence of a new conception of mind as the result of processes occurring in the brain&#46; This new premise requires us to discover how the brain must work to produce such a complex system as the &#8220;mind&#8221;&#58; as has previously been stated&#44; &#8220;there can be brain without mind&#44; but there can be no mind without brain&#8221; &#40;E&#46; D&#237;ez-Tejedor&#41;&#46; Localisationist theories argued that each part of the brain is responsible for a specific function&#59; according to this view&#44; a localised brain lesion would selectively damage certain cognitive processes&#46; However&#44; these brain maps exclude many functions that have classically been attributed to the concept of mind&#58; behaviour&#44; personality&#44; mood&#44; and affect&#44; among others&#46; Although evidence already existed that specific brain injuries could cause behavioural alterations&#44; it was the famous case of Phineas Gage in the mid-19th century that led to investigation into the biological basis of such mental processes as emotion management or decision-making&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">1</span></a> Moving beyond the localisationist approach&#44; the brain was understood to function by means of complex&#44; interconnected circuits involving both the cerebral cortex and the white matter&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">However&#44; it has long been known that the brain is able to modify itself in response to certain stimuli&#46; Ram&#243;n y Cajal&#39;s assertion that &#8220;any man could&#44; if he were so inclined&#44; be the sculptor of his own brain&#8221; was without doubt a reference to brain plasticity&#46; Nonetheless&#44; several decades passed before the discovery would be made that the brain not only has this capability&#44; but is also able to form new nerve cells&#59; Cajal doubted this in his day&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This article reviews several aspects of brain disease and how it is related with connectivity and plasticity&#44; as well as the fundamental aspects of cognitive therapy techniques based on these functions&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Connectivity and brain disease</span><p id="par0020" class="elsevierStylePara elsevierViewall">The human brain is a complex network of structurally and functionally interconnected regions&#59; brain function arises from the networked organisation of the organ as a whole&#46; Brain lesions can therefore cause functional deficits by means of 2 basic mechanisms&#58; local cortical dysfunction in the affected region&#44; and spatially separate dysfunction caused by interruption of the connection between 2 areas&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Research into the circuits and networks constituting the highly complex organisation of the brain allows us greater insight into the structuring of the higher cognitive functions and their involvement in various neurological diseases&#46; Indeed&#44; we now know that the deficits associated with such disorders as Alzheimer disease&#44; multiple sclerosis&#44; traumatic brain injury &#40;TBI&#41;&#44; schizophrenia&#44; depression&#44; autism&#44; etc&#46;&#44; are accompanied by brain connectivity alterations&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In Alzheimer disease&#44; we observe reduced density of dendritic spines in cortical pyramidal cells and structural alterations to inhibitory circuits&#59; this leads to a disconnection between different regions of the brain&#44; such as the posterior cingulate and the hippocampus&#46; These changes can be detected in the prodromal stage of the disease&#44; and are correlated with the degree of cognitive impairment in later stages&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">2</span></a> The progression of neurodegeneration is accompanied by reduced connectivity of the default mode network caused by deposition of &#946;-amyloid peptide<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">3</span></a>&#59; due to this&#44; reduced connectivity has been found even in patients with mild cognitive impairment&#44; compared to controls&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Both cognitive deficits and emotional and behavioural alterations have been associated with the interruption of brain networks in patients with multiple sclerosis<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">5&#44;6</span></a>&#59; functional neuroimaging studies have also demonstrated alterations in brain activation and functional connectivity patterns&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">7&#44;8</span></a> More recently&#44; the introduction of graph theory has revealed structural changes in network topology in these patients&#44; with modifications in the architecture of &#8220;small-world&#8221; networks<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">9</span></a> impairing the efficiency of information transmission&#44; leading to significant reductions in network efficiency&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Another disease shown to involve a connection disorder is schizophrenia&#44; which features an underlying alteration of the functional connections between different brain regions&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">11&#44;12</span></a> The disease involves a disruption in the connection between different nodes of the default mode network&#44; specifically the medial frontal cortex and the precuneus&#44; which are key areas of the network&#44;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">13&#44;14</span></a> and frontoparietal and fronto-striato-temporal circuitry&#46;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">15&#44;16</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Altered synchronisation has also been described in various brain networks in patients with autism spectrum disorders&#46; In a study including patients with autism&#44; Just et al&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">17</span></a> found reduced functional connectivity between different brain areas &#40;underconnectivity&#41; during a sentence comprehension task&#46; This has been confirmed by several functional magnetic resonance imaging &#40;fMRI&#41; studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">18&#8211;20</span></a> However&#44; other studies have also found evidence of this functional connectivity alteration in patients with autism who were at rest&#46;<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">21&#8211;24</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Traumatic brain injury also involves the interruption of brain networks&#44; which causes considerable cognitive and behavioural disorders&#46; The diffuse axonal damage caused by such a lesion affects white matter tracts connecting the nodes of widely distributed neural networks&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">25</span></a> The most studied examples are the default mode network and the salience network&#59; abnormal interaction between the 2 has been observed following TBI&#46;<a class="elsevierStyleCrossRefs" href="#bib0350"><span class="elsevierStyleSup">26&#44;27</span></a> Specifically&#44; the functioning of the default mode network appears to be predicted by the degree of damage to the salience network which connects the right anterior insula&#44; the presupplementary motor area&#44; and the dorsal anterior cingulate cortex&#46; These findings support the hypothesis that salience network integrity is necessary for the efficient functioning of the default mode network&#44; and that a failure of communication between the networks can lead to disorders of inhibitory control&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">28</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">This new connectivity-based approach brings new ways of understanding the mechanisms underlying the deficits that appear following brain injury and the changes to connectivity that occur during recovery&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Plasticity and brain repair</span><p id="par0060" class="elsevierStylePara elsevierViewall">The great advantages of the brain&#39;s network-based functioning are the resulting plasticity and mutability&#46; Over 50 years ago&#44; Hebb<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">29</span></a> proposed that experience may give rise to a reorganisation of neural connections in the cortex&#59; since then&#44; cortical plasticity has been a field of extensive study&#44; both in relation to learning<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">30</span></a> and to the brain&#39;s response to injury&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">31</span></a> Given the existence of functional networks&#44; reorganising these would enable the functional recovery of the brain&#59; therefore&#44; the phenomenon of neuroplasticity&#44; together with the brain&#39;s networked structure and connectivity&#44; enables all the necessary changes to take place for the system to be repaired following injury&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">32</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Plasticity is expressed in varying forms in brain injuries&#44; ranging from functional modifications of existing structures to the growth and proliferation of new structures and neurons&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">33</span></a> In this way&#44; the brain seeks ways of repairing itself&#44; beginning a cascade of regenerative events by creating synapses &#40;synaptogenesis&#41; in perilesional areas and neurons &#40;neurogenesis&#41; in the subgranular zone of the dentate gyrus and the subventricular zone&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">34</span></a> The cells produced in the neurogenic niches are able to migrate towards the damaged tissue&#44; guided by the presence of specific proteins or chemotactic factors&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">35</span></a> Certain trophic factors also mediate the processes of cell and fibre regeneration&#46; Examples are brain-derived neurotrophic factor&#44; neuropsin &#40;involved in neural growth&#41;&#44; and the Nogo-A and LINGO-1 proteins &#40;which inhibit the growth of nerve fibres&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Plasticity as the basis of cognitive and behavioural therapy</span><p id="par0070" class="elsevierStylePara elsevierViewall">Plasticity mechanisms are triggered at the moment of brain injury&#44; enabling some amount of spontaneous recovery and repair&#46; This is limited&#44; however&#58; recovery is most evident in the first 3 to 6 months following the injury&#44; and while it does continue for several years after this&#44; it occurs at a &#8220;negatively accelerating&#8221; rate&#46; The implication of this is that as time progresses&#44; changes become more difficult to observe&#46; Cognitive and behavioural therapy has been proposed as a possible non-pharmacological intervention that may strengthen recovery&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Cognitive therapy acts on the alterations that occur following brain injury&#44; with a view to restoring or compensating for the damaged function in order to improve the patient&#39;s abilities and promote reincorporation into work and everyday activities &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">36</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The effectiveness of this therapy is a complex issue&#44; although sufficient data is available to recommend specific types of cognitive rehabilitation for problems with attention&#44; information processing speed&#44; memory&#44; and language&#46;<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">37&#44;38</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Various fMRI studies have found evidence that the brain reorganises itself during the recovery period following a brain injury&#59; however&#44; they do not describe the cooperation of adjacent or distant brain regions&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">39</span></a> The white matter is also involved in the restructuring associated with recovery&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">40</span></a> It is therefore appropriate to consider the observable changes in the interaction between different brain areas&#44; rather than only local modifications to functional activation patterns&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">41</span></a> In other words&#44; the neural network&#8211;based functioning of the brain improves our understanding of the relationship between observable plasticity and recovery mechanisms&#46; Magnetoencephalography studies of patients with TBIs have shown increased connectivity after patients participated in an intensive programme of cognitive therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">42</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">An fMRI study into patients with stroke revealed increased connectivity in regions functionally related to the hippocampus after 3 months of computer-assisted cognitive therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">43</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">A similar phenomenon occurs in patients with multiple sclerosis&#59; one study found increased resting-state functional connectivity in the anterior cingulate and inferior parietal cortices after 8 weeks of the same treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">44</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conclusion</span><p id="par0100" class="elsevierStylePara elsevierViewall">The brain functions holistically by means of an extensive network of circuits which are responsible for all sensorimotor&#44; vegetative&#44; and mental processes&#46; Understanding of the brain&#39;s connectivity and plasticity offers a new perspective from which to approach brain functioning and disease and the repair and recovery mechanisms that constitute the basis of cognitive and behavioural therapy&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            0 => "Plasticidad cerebral"
            1 => "Da&#241;o cerebral"
            2 => "Terapia cognitiva"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Our conception of the mind-brain relationship has evolved from the traditional idea of dualism to current evidence that mental functions result from brain activity&#46; This paradigm shift&#44; combined with recent advances in neuroimaging&#44; has led to a novel definition of brain functioning in terms of structural and functional connectivity&#46; The purpose of this literature review is to describe the relationship between connectivity&#44; brain lesions&#44; cerebral plasticity&#44; and functional recovery&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Development</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Assuming that brain function results from the organisation of the entire brain in networks&#44; brain dysfunction would be a consequence of altered brain network connectivity&#46; According to this approach&#44; cognitive and behavioural impairment following brain damage result from disrupted functional organisation of brain networks&#46; However&#44; the dynamic and versatile nature of these circuits makes recovering brain function possible&#46; Cerebral plasticity allows for functional reorganisation leading to recovery&#44; whether spontaneous or resulting from cognitive therapy&#44; after brain disease&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusions</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Current knowledge of brain connectivity and cerebral plasticity provides new insights into normal brain functioning&#44; the mechanisms of brain damage&#44; and functional recovery&#44; which in turn serve as the foundations of cognitive therapy&#46;</p></span>"
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        "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introducci&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La relaci&#243;n entre mente y cerebro ha evolucionado desde el cl&#225;sico dualismo hasta los conocimientos actuales que ponen de manifiesto que las funciones mentales son el resultado de la actividad cerebral&#46; Este cambio de paradigma&#44; junto con los recientes avances en diferentes t&#233;cnicas de neuroimagen&#44; ha dado lugar a una novedosa concepci&#243;n del funcionamiento cerebral en t&#233;rminos de conectividad estructural y funcional&#46; El objetivo del presente trabajo es describir la relaci&#243;n entre conectividad&#44; lesi&#243;n cerebral&#44; plasticidad cerebral y recuperaci&#243;n funcional&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Desarrollo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Si la funci&#243;n cerebral surge de la organizaci&#243;n en red del cerebro como un todo&#44; la disfunci&#243;n cerebral se puede producir por una alteraci&#243;n en la conexi&#243;n de estas redes&#46; As&#237;&#44; a partir del modelo conectivista&#44; los trastornos cognitivos y del comportamiento que aparecen tras una afecci&#243;n cerebral se describen como consecuencia de una alteraci&#243;n en la organizaci&#243;n funcional de las redes cerebrales&#46; Sin embargo&#44; la p&#233;rdida de funciones puede ser recuperada gracias a la capacidad de los circuitos de ser din&#225;micos y vers&#225;tiles&#46; La plasticidad cerebral permite una reorganizaci&#243;n funcional que llevar&#225; a una recuperaci&#243;n&#44; espont&#225;nea o potenciada con terapia cognitiva&#44; despu&#233;s de alg&#250;n tipo de enfermedad cerebral&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El conocimiento de la conectividad y la plasticidad cerebrales proporciona una nueva perspectiva desde la que entender el funcionamiento cerebral en condiciones normales&#44; los mecanismos del da&#241;o cerebral y los de la recuperaci&#243;n funcional&#44; constituyendo las bases para el desarrollo de la terapia cognitiva&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lubrini G&#44; Mart&#237;n-Montes A&#44; D&#237;ez-Ascaso O&#44; D&#237;ez-Tejedor E&#46; Enfermedad cerebral&#44; conectividad&#44; plasticidad y terapia cognitiva&#46; Una visi&#243;n neurol&#243;gica del trastorno mental&#46; Neurolog&#237;a&#46; 2018&#59;33&#58;187&#8211;191&#46;</p>"
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Article information

ISSN: 21735808
Original language: English

DOI:10.1016/j.nrleng.2017.02.001

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Year/Month	Html	Pdf	Total

2024 November	12	3	15
2024 October	53	14	67
2024 September	55	13	68
2024 August	62	15	77
2024 July	58	10	68
2024 June	39	11	50
2024 May	39	9	48
2024 April	50	11	61
2024 March	60	5	65
2024 February	76	10	86
2024 January	82	8	90
2023 December	51	14	65
2023 November	75	11	86
2023 October	71	14	85
2023 September	62	8	70
2023 August	67	8	75
2023 July	64	11	75
2023 June	81	14	95
2023 May	106	8	114
2023 April	123	6	129
2023 March	122	8	130
2023 February	95	1	96
2023 January	111	10	121
2022 December	117	9	126
2022 November	159	11	170
2022 October	133	14	147
2022 September	93	18	111
2022 August	136	20	156
2022 July	112	14	126
2022 June	127	15	142
2022 May	107	16	123
2022 April	103	12	115
2022 March	115	16	131
2022 February	113	10	123
2022 January	156	8	164
2021 December	148	20	168
2021 November	131	10	141
2021 October	147	20	167
2021 September	124	18	142
2021 August	116	10	126
2021 July	39	8	47
2021 June	49	13	62
2021 May	71	32	103
2021 April	169	52	221
2021 March	94	7	101
2021 February	87	21	108
2021 January	68	24	92
2020 December	86	11	97
2020 November	57	12	69
2020 October	50	6	56
2020 September	47	11	58
2020 August	79	8	87
2020 July	35	9	44
2020 June	42	22	64
2020 May	68	15	83
2020 April	27	13	40
2020 March	47	12	59
2020 February	45	19	64
2020 January	93	22	115
2019 December	66	5	71
2019 November	31	8	39
2019 October	55	11	66
2019 September	53	15	68
2019 August	30	4	34
2019 July	41	13	54
2019 June	130	14	144
2019 May	234	24	258
2019 April	80	20	100
2019 March	31	15	46
2019 February	30	15	45
2019 January	43	17	60
2018 December	19	13	32
2018 November	20	5	25
2018 October	38	32	70
2018 September	27	4	31
2018 August	11	3	14
2018 July	10	2	12
2018 June	9	3	12
2018 May	18	4	22
2018 April	15	3	18
2018 March	0	2	2
2018 February	0	2	2

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