was read the article
array:25 [ "pii" => "S2173580818301159" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2016.07.005" "estado" => "S300" "fechaPublicacion" => "2018-11-01" "aid" => "964" "copyright" => "Sociedad Española de Neurología" "copyrightAnyo" => "2016" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2018;33:583-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 832 "formatos" => array:3 [ "EPUB" => 36 "HTML" => 515 "PDF" => 281 ] ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S0213485316301748" "issn" => "02134853" "doi" => "10.1016/j.nrl.2016.07.009" "estado" => "S300" "fechaPublicacion" => "2018-11-01" "aid" => "964" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2018;33:583-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2356 "formatos" => array:3 [ "EPUB" => 73 "HTML" => 1283 "PDF" => 1000 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Polineuropatía amiloidótica familiar <span class="elsevierStyleSmallCaps">I</span> por mutación Val50Met (Val30Met) en el gen de la transtiretina" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "583" "paginaFinal" => "589" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Familial amyloidosis with polyneuropathy type 1 caused by transthyretin mutation Val50Met (Val30Met): 4 cases in a non-endemic area" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1524 "Ancho" => 1600 "Tamanyo" => 531017 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Biopsia del nervio sural. Tinción hematoxilina-eosina (a y b) y tinción rojo Congo (c y d). Se objetivan depósitos amorfos hialinos eosinófilos en el endoneuro que se tiñen con rojo Congo.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "N. Andrés, J.J. Poza, J.F. Martí Massó" "autores" => array:3 [ 0 => array:2 [ "nombre" => "N." "apellidos" => "Andrés" ] 1 => array:2 [ "nombre" => "J.J." "apellidos" => "Poza" ] 2 => array:2 [ "nombre" => "J.F." "apellidos" => "Martí Massó" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173580818301159" "doi" => "10.1016/j.nrleng.2016.07.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580818301159?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485316301748?idApp=UINPBA00004N" "url" => "/02134853/0000003300000009/v1_201811060625/S0213485316301748/v1_201811060625/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S217358081830107X" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2016.05.015" "estado" => "S300" "fechaPublicacion" => "2018-11-01" "aid" => "939" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "ssu" "cita" => "Neurologia. 2018;33:590-601" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2590 "formatos" => array:3 [ "EPUB" => 56 "HTML" => 1995 "PDF" => 539 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Conservative treatment in patients with mild to moderate carpal tunnel syndrome: A systematic review" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "590" "paginaFinal" => "601" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento conservador en pacientes con síndrome del túnel carpiano con intensidad leve o moderada. Revisión sistemática" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2360 "Ancho" => 2500 "Tamanyo" => 325380 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Oxford levels of evidence scale.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Jiménez del Barrio, E. Bueno Gracia, C. Hidalgo García, E. Estébanez de Miguel, J.M. Tricás Moreno, S. Rodríguez Marco, L. Ceballos Laita" "autores" => array:7 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Jiménez del Barrio" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Bueno Gracia" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Hidalgo García" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Estébanez de Miguel" ] 4 => array:2 [ "nombre" => "J.M." "apellidos" => "Tricás Moreno" ] 5 => array:2 [ "nombre" => "S." "apellidos" => "Rodríguez Marco" ] 6 => array:2 [ "nombre" => "L." "apellidos" => "Ceballos Laita" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485316300949" "doi" => "10.1016/j.nrl.2016.05.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485316300949?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217358081830107X?idApp=UINPBA00004N" "url" => "/21735808/0000003300000009/v1_201811160606/S217358081830107X/v1_201811160606/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2173580818301160" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2016.07.006" "estado" => "S300" "fechaPublicacion" => "2018-11-01" "aid" => "965" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2018;33:577-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 560 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 403 "PDF" => 114 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Time course of the effect of <span class="elsevierStyleItalic">status epilepticus</span> induced in the developing rat on γ-amino butyric acid and glutamate cerebellar concentration" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "577" "paginaFinal" => "582" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación temporal del efecto del <span class="elsevierStyleItalic">status epilepticus</span> inducido en la rata en desarrollo en la concentración cerebelar de ácido γ-aminobutírico y glutamato" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1585 "Ancho" => 2884 "Tamanyo" => 218231 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Glutamate concentration in the cerebellar hemispheres and vermis after status epilepticus (SE). The graphs on the left show the time course of glutamate concentration after SE. The graphs in the centre show the effect of treatment (induced SE or sham manipulation) on glutamate concentration regardless of time. The graphs on the right show glutamate concentration at different time points, regardless of treatment. Bars indicate mean (±SEM) glutamate concentration (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6 rats per group). *<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>.05.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Hernández-Martínez, L. Rocha, J. Martínez-Quiroz, C. Morgado-Valle, J. Manzo, M.L. López-Meraz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Hernández-Martínez" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Rocha" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Martínez-Quiroz" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Morgado-Valle" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Manzo" ] 5 => array:2 [ "nombre" => "M.L." "apellidos" => "López-Meraz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S021348531630175X" "doi" => "10.1016/j.nrl.2016.07.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021348531630175X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580818301160?idApp=UINPBA00004N" "url" => "/21735808/0000003300000009/v1_201811160606/S2173580818301160/v1_201811160606/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Familial amyloidosis with polyneuropathy type 1 caused by transthyretin mutation Val50Met (Val30Met): 4 cases in a non-endemic area" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "583" "paginaFinal" => "589" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "N. Andrés, J.J. Poza, J.F. Martí Massó" "autores" => array:3 [ 0 => array:4 [ "nombre" => "N." "apellidos" => "Andrés" "email" => array:1 [ 0 => "naiara.andresmarin@osakidetza.eus" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.J." "apellidos" => "Poza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J.F." "apellidos" => "Martí Massó" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neurología, Hospital Universitario Donostia, San Sebastián, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Área de Neurociencias, Universidad del País Vasco, San Sebastián, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Polineuropatía amiloidótica familiar <span class="elsevierStyleSmallCaps">I</span> por mutación Val50Met (Val30Met) en el gen de la transtiretina" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1524 "Ancho" => 1600 "Tamanyo" => 532120 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Sural nerve biopsy. Haematoxylin and eosin (A and B) and Congo red (C and D) staining. The endoneurium shows amorphous, eosinophilic hyaline deposits that are positive for Congo red.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a genetic, multisystem disease caused by mutation of the <span class="elsevierStyleItalic">TTR</span> gene.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1–7</span></a> Corinho Andrade first described the condition in 1952 in northern Portugal,<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,3,8</span></a> where it is colloquially referred to as <span class="elsevierStyleItalic">mal dos pezinhos</span>.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The disease is most frequent in 3 endemic foci, in Portugal, Sweden, and Japan.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,4,5,8,9</span></a> The most significant foci in Spain are located on the island of Mallorca<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7–9</span></a> and in Valverde del Camino (province of Huelva).<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> The Basque Country is a non-endemic area. Prevalence of TTR-FAP is estimated at 1/10<span class="elsevierStyleHsp" style=""></span>000 population globally<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">1</span></a> and 1/100<span class="elsevierStyleHsp" style=""></span>000 population in Europe.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7,8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">TTR</span> is a short gene, containing only 4 exons, located on the short arm of chromosome 18 (18q12.1).<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> Over 100 mutations have been described in association with the gene. The most frequent mutation is a valine-to-methionine substitution at position 30 (Val30Met or V30M, now denominated Val50Met due to an update to the reference sequence entailing a change in the order of amino acids) of the 127 amino acid sequence.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1–8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Transmission mainly follows an autosomal dominant pattern of inheritance,<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7,8</span></a> although sporadic and de novo cases have also been reported.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> Penetrance is highly variable, and differs according to the mutation and endemic focus.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5–8</span></a> Early symptom onset and increased penetrance have been associated with maternal transmission of the mutation.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5,8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">TTR is an amyloid precursor protein which transports thyroxine and vitamin A.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,5–8</span></a> It is mainly synthesised in the liver (95%), but is also expressed in the retina and choroid plexuses. The protein circulates as a tetramer in the blood and the cerebrospinal fluid. <span class="elsevierStyleItalic">TTR</span> mutations destabilise the tetramer, giving rise to abnormally folded monomers which are distributed patchily in various tissues, especially in the peripheral nervous system and the heart.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,5–7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The variability in the age of symptom onset and the clinical presentation of TTR-FAP, especially in non-endemic areas, makes diagnosing the condition a complex, lengthy process.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients, methods, and results</span><p id="par0035" class="elsevierStylePara elsevierViewall">We describe the clinical variability of TTR-FAP as observed in 4 identified patients consulting at the Hospital Universitario Donostia neurology department between 2005 and 2016.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patient 1</span><p id="par0040" class="elsevierStylePara elsevierViewall">Patient 1 was a 58-year-old man from Navarre who attended the neurology department in December 2013 due to a 1-year history of fatigue and a “strange” sensation in the feet. In recent months, he had experienced a similar sensation in the hands, hindering certain fine movements, such as opening a clothes peg. He displayed no signs of dysautonomia.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The patient had no relevant history except left-sided amblyopia since infancy and surgery for retinal detachment and cataracts. The neurological examination identified no abnormalities, except mild weakness in dorsiflexion of the ankles and a mild sensory alteration in a “stocking” pattern.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The complete blood count and urine sediment test (including microalbumin determination) yielded normal results. An electromyography study of the short thumb abductor and the left tibialis anterior muscle showed no alterations. Electroneurography findings were compatible with axonal sensorimotor polyneuropathy with predominance of sensory alterations. A sural nerve biopsy revealed a severe axonal neuropathy with no amyloid deposition and no sign of vasculitis.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Both motor and sensory symptoms worsened progressively. In August 2015, the patient's uncle was diagnosed with an amyloid neuropathy after a sural nerve biopsy. This led us to order sequencing of the <span class="elsevierStyleItalic">TTR</span> gene, which revealed the c.148G>A (p.Val50Met) mutation in heterozygosis. An echocardiogram revealed amyloid deposition on the interventricular septum and mild diastolic dysfunction. An ophthalmological examination detected no amyloid deposition. Treatment was started with triflusal and bisoprolol.</p><p id="par0060" class="elsevierStylePara elsevierViewall">We performed a genetic study of the family to identify potential carriers of the mutation. The patient's aunt and brother, aged 87 and 68, respectively, carried the Val50Met mutation, but presented no symptoms or alterations.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patient 2</span><p id="par0065" class="elsevierStylePara elsevierViewall">Patient 2 was a 77-year-old man from Gipuzkoa who attended the department complaining of a 2-year history of fatigue, pain, and a tingling sensation in the feet, interfering with his ability to walk; he also reported a tingling sensation in the fingers. He displayed no signs of dysautonomia.</p><p id="par0070" class="elsevierStylePara elsevierViewall">He had a history of arterial hypertension (treated with indapamide) and constipation (treated with isphagula husk). His parents had died at the ages of 96 and 92, with no neurological diseases. He had 4 older siblings (aged 87, 84, 82, and 81), with no relevant family history of neurological problems.</p><p id="par0075" class="elsevierStylePara elsevierViewall">The neurological examination revealed paralysis of the distal muscles of the legs; amyotrophy of the thenar eminence and the interosseous muscles of the hands; reduced touch, pain, and vibration sensation in a “stocking” distribution and in the fingers; universal areflexia; and mildly ataxic gait with bilateral steppage.</p><p id="par0080" class="elsevierStylePara elsevierViewall">The complete blood count and urine sediment test yielded normal results. Electroneurography findings were compatible with severe axonal sensorimotor polyneuropathy with predominance of sensory alterations. A sural nerve biopsy detected amyloid deposits destroying the nerve fibres; the deposits were positive for Congo red staining (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">TTR</span> gene sequencing was ordered, revealing the Val50Met mutation in heterozygosis.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Patient 3</span><p id="par0090" class="elsevierStylePara elsevierViewall">The patient was a 32-year-old woman from Portugal; her deceased father had been diagnosed with TTR-FAP due to the Val50Met mutation. Her father's 4 siblings (2 men and 2 women) and both paternal grandparents displayed the same disease. She attended our department in 2006 for a genetic study. The physical and neurological examinations and laboratory and neurophysiological studies performed at the time yielded normal results. The genetic study detected the same mutation in heterozygosis. The patient received genetic counselling and preimplantation genetic diagnosis, as she intended to have children. In July 2015, she attended a consultation at our department due to intense low back pain radiating to both lower limbs, together with burning and tingling sensations, allodynia, and oedema in the feet. A month earlier, she experienced alternating diarrhoea and constipation and marked abdominal distension. The patient reported instability and dizziness upon walking. She had no other associated symptoms, and presented no signs or symptoms of orthostatic hypotension. She was receiving treatment with venlafaxine, alprazolam, and mirtazapine due to reactive anxiety in response to the presymptomatic diagnosis of the disease. The neurological examination found normal touch, pain, and vibration sensation; deep tendon reflexes; and muscular balance. The echocardiogram revealed left atrial enlargement, with no additional alterations. A Holter ECG study detected infrequent ventricular extrasystoles. A bone scan revealed no abnormalities. Suspecting initial TTR-FAP symptom manifestation, we started treatment with tafamidis, plus duloxetine for pain control. As duloxetine was unsuccessful, we later prescribed eslicarbazepine; this was also ineffective, and substituted with tapentadol and diazepam. In February 2016, the patient displayed thermal hypoaesthesia in the feet and distal third of the legs; no other abnormalities were found. Given the persistence of intense, refractory neuropathic pain, a liver transplant was ordered in February 2016; the operation was performed 2 weeks ago.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Patient 4</span><p id="par0095" class="elsevierStylePara elsevierViewall">The patient was a 64-year-old former smoker from Gipuzkoa, with no relevant personal history. He attended the neurology department in March 2005 due to cramps and allodynia in the soles of the feet and difficulty climbing stairs, which had started 3 years earlier. His younger brother and deceased sister had both experienced similar symptoms and been diagnosed with TTR-FAP. Both siblings underwent liver transplantation. The neurological examination was normal except for reduced touch and vibration sensation in a “stocking” distribution, absent Achilles reflex, and patellar tendon hyporeflexia. A complete blood count detected no abnormalities. A neurophysiological study revealed axonal sensorimotor polyneuropathy. A genetic study identified the Val50Met mutation in heterozygosis. Holter ECG monitoring showed frequent supraventricular extrasystoles with multiple salvos of supraventricular tachycardia. No alterations were detected in the tilt-table test. We attempted to control neuropathic pain with pregabalin and amitriptyline. Symptoms continued to progress, with the patient developing motor deficits in the lower limbs, affecting gait. Despite a liver transplant performed in 2007, neuropathic pain continued to increase in intensity; duloxetine was added to the patient's treatment schedule. The patient developed constipation and oedema of the feet. The neurological symptoms remained largely stable, with distal weakness in the hands and feet and neuropathic pain; the patient was able to walk with a cane. Cardiac involvement progressed, and the patient died of heart failure 9 years after diagnosis.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">The most common manifestation of TTR-FAP, described by Andrade in the Portuguese variant caused by the Val50Met mutation, is a sensorimotor polyneuropathy presenting with autonomic dysfunction, with onset occurring between the ages of 30 and 40 years.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2–8,10</span></a> The condition initially affects the small myelinated (Aδ) and non-myelinated fibres responsible for transmitting pain and temperature signals.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,3,5</span></a> The greater the length of an axon, the greater its exposure to amyloid deposition and the resulting functional alteration.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,5</span></a> This explains the way the disease progresses, initially involving distal segments and eventually affecting more proximal areas.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,3,5,7</span></a> The natural history of the disease leads to death at 10-15 years after symptom onset.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7,9,10</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The 4 cases presented above demonstrate that TTR-FAP progression does not always follow this pattern. Symptom onset may occur late (in patients older than 50), and the disease may develop as purely motor or sensory polyneuropathy, with no autonomic dysfunction.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2–5,10</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">This is the most frequent form of presentation in non-endemic areas. Another form is mononeuropathy progressing to mononeuritis multiplex and eventually a pattern of polyneuropathy.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2–4,8,10</span></a> Neuropathic pain, which may appear at onset or later in disease progression, is a burning pain associated with allodynia, and exhibits a circadian rhythm, worsening in the evening.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,8,10</span></a> In some cases, such as the first patient's aunt, the mutation is non-penetrant.</p><p id="par0115" class="elsevierStylePara elsevierViewall">TTR-FAP is a genetic but not necessarily a familial disease. Given the autosomal dominant inheritance pattern, family history of the condition assists in diagnosis; this was the case in 3 of the 4 patients presented.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2–5,7</span></a> Family history of the disease is present in the majority of cases with onset at around the age of 30 years, whereas late-onset cases tend to be sporadic.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> The incomplete penetrance and the possibility of very late onset (with some individuals with the mutation dying before presentation of the disease) can give rise to the detection of apparently sporadic cases.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2–5</span></a> There may also be cases where patients are unaware of their family history of the condition and do not report it.</p><p id="par0120" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">TTR</span> variants have been detected worldwide, especially in European countries, and display great genotypic heterogeneity. The genotype–phenotype correlation and the factors influencing phenotypic variability and age of onset are not fully understood.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,5</span></a> Amino acid substitution is not sufficient to explain the condition's variability in terms of penetrance, pathogenesis, and clinical progression.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> In order to better understand the genetic variability of TTR-FAP, haplotype characterisation should be performed for 6 single-nucleotide polymorphisms. In Portugal and Sweden, only haplotype I has been associated with the mutation. Haplotype III, the second most frequent variant, has been observed in individuals from Britain, France, Italy, and Japan.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> Soares et al.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> identified 10 new polymorphisms: 8 caused by single-base substitutions and 2 caused by insertions or deletions in dinucleotide repeat sequences. These authors hypothesise that age of onset may be modulated by a nearby locus linked to the interval defined by the microsatellites D18S457 and D18S456, associated with the 3-2 haplotype on the accompanying chromosome.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">A genetic anticipation phenomenon has been detected in some Portuguese, Swedish, and Japanese families with early-onset variants. This effect is more marked in cases where the mutation is transmitted by the mother.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> The literature includes reports of less severe phenotypes in cases with later onset and longer duration, in patients with such compound heterozygous mutations as Agr104His/Val50Met or Thr119Met/Val50Met.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5,13</span></a> These additional mutations are believed to have a “protective effect” as they have been demonstrated to increase the stability of TTR tetramers.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5,13</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Diagnosis may be complex due to the disease's variability in terms of phenotype and age of onset. Conventional electrophysiological studies detect axonal neuropathy.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3,5,7</span></a> Moderately reduced nerve conduction velocity is often misinterpreted as a form of chronic inflammatory demyelinating polyneuropathy, perhaps due to a desire to provide treatments for these patients. In the classic variants, electroneurography studies in early phases may display normal results, as the disease initially only affects small myelinated and non-myelinated fibres.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,5–7</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Once polyneuropathy is confirmed, aetiology may be difficult to identify if we do not consider late-onset variants. The objective of tissue biopsy is to detect amyloid deposition. TTR amyloid deposits present greenish-yellow birefringence under polarised light following Congo red staining<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,3,5,8</span></a>; this is a pathognomonic feature of TTR-FAP. However, basing aetiological diagnosis on tissue biopsy has several limitations. Firstly, it is not clear which tissue should be examined, as we must select that which combines the best diagnostic yield with the lowest risk of undesired consequences.<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">4,6–8</span></a> Given the relative aggressiveness of nerve biopsy, such other tissues as subcutaneous fat and salivary gland tissue have been proposed.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,4–8</span></a> Secondly, amyloid deposition is patchy; therefore, absence of amyloid deposition in the tissue sample tested does not rule out the condition.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5,8</span></a> Finally, TTR amyloid deposition cannot be confirmed by the detection of amyloid deposits alone.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">6,8</span></a> Indeed, even if an immunohistochemical study determines that deposits are composed of TTR amyloid, it is not possible to differentiate between wild-type and mutant TTR.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3,5,6,8</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">We therefore consider full <span class="elsevierStyleItalic">TTR</span> gene sequencing to be the diagnostic technique of choice<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,3,5–8</span></a>; due to the gene's short length and recent advances in genetic testing, this is an inexpensive, simple, quick technique with high sensitivity and specificity. Given that TTR-FAP can present with late onset and in the absence of known family history of the disease, especially in non-endemic areas, we believe that <span class="elsevierStyleItalic">TTR</span> sequencing should be included in diagnostic protocols for all polyneuropathies. If the disease is confirmed, family members at risk should also be tested, and the appropriate genetic counselling should be given.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,2,7,10</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Comprehensive testing is also important, as this is a multisystem disease.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7,8</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">Numerous treatments have been developed since 1990, with some still in the trial phase.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">14,15</span></a> The only treatments currently accepted are liver transplantation and tafamidis.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Liver transplantation is intended to prevent the formation of additional amyloid deposits (95% of mutant TTR is synthesised in the liver).<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,8</span></a> The technique is intended to stabilise symptoms, but does not correct existing lesions. According to data from the Familial Amyloidotic Polyneuropathy World Transplant Registry, the survival rate following liver transplantation is 85% at 5 years, 67% at 10 years, and 55% at 20 years.<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">8,16,17</span></a> The early-onset form of the Portuguese Val50Met variant responds best to treatment, with a 10-year survival rate of 74%.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,15</span></a> However, other mutations are associated with poorer outcomes,<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a> as are late-onset forms caused by the Val50Met mutation, which have a 10-year survival rate of 44%.<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">10,13,16,18</span></a> Deposition of wild-type TTR may continue after liver transplantation, and can cause both neuropathy<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2,8,18</span></a> and cardiomyopathy.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,2</span></a> Cardiac amyloidosis progression appears to cease after liver transplantation in patients with early-onset TTR-FAP caused by the Val50Met mutation.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,19,20</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Tafamidis stabilises TTR by inhibiting tetramer dissociation, slowing the progression of the disease.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,2,21,22</span></a> The drug performed better than placebo at 18 months in a double-blind randomised controlled trial including a sample of patients with early-stage TTR-FAP caused by the Val50Met mutation.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,2,8,23</span></a> Based on these results, the drug was approved by the Spanish Agency for Medicines and Medical Devices for the treatment of early-stage symptomatic TTR-FAP caused by the Val50Met mutation.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1,8</span></a> It has also been studied in an open-label trial including 21 patients with other mutations; tetramers were observed to have stabilised after 6 weeks of treatment.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a> There is no evidence of the drug's efficacy at later stages of the disease.</p><p id="par0165" class="elsevierStylePara elsevierViewall">Besides these treatments, it is essential to manage multisystem complications.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conclusion</span><p id="par0170" class="elsevierStylePara elsevierViewall">TTR-FAP is a complex, multisystem disease that is highly variable in terms of presentation and age of onset. Given its high sensitivity and specificity, full sequencing of the <span class="elsevierStyleItalic">TTR</span> gene should be included in diagnostic protocols for all patients with progressive polyneuropathies. Some treatments are known to be efficacious in treating the Portuguese variant of the disease, but their usefulness for other phenotypes is not known; future research should address this matter.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Funding</span><p id="par0175" class="elsevierStylePara elsevierViewall">This study has received no funding of any kind.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1107687" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Patients and results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1046910" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1107686" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Objetivos y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Pacientes y resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1046909" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Patients, methods, and results" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patient 1" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Patient 2" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Patient 3" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Patient 4" ] ] ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Conclusion" ] 8 => array:2 [ "identificador" => "sec0045" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-05-12" "fechaAceptado" => "2016-07-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1046910" "palabras" => array:4 [ 0 => "Transthyretin" 1 => "Hereditary amyloid polyneuropathy" 2 => "Val50Met (Val30Met)" 3 => "Amyloid" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1046909" "palabras" => array:4 [ 0 => "Transtiretina" 1 => "Polineuropatía amiloidótica hereditaria" 2 => "Val50Met (Val30Met)" 3 => "Amiloide" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Transthyretin-related familial amyloid polyneuropathy (TTR-FAP) typically arises as an autonomic neuropathy primarily affecting small fibres and it occurs in adult patients in their second or third decades of life. It progresses rapidly and can lead to death in approximately 10 years. Other phenotypes have been described in non-endemic areas.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We described 4 cases from the Spanish province of Guipuzcoa, a non-endemic area, to highlight the clinical variability of this disease.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Patients and results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Three patients presented a late-onset form manifesting after the age of 50, featuring a predominantly motor polyneuropathy initially causing distal impairment of the lower limbs followed by the upper limbs. One patient suffered severe neuropathic pain. None showed signs of autonomic involvement. The fourth patient, of Portuguese descent, presented a typical form with onset in her thirties, neuropathic pain and dysautonomia. All patients carry the Val50Met mutation in the TTR gene.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">FAP is a pleomorphic disease even in patients carrying the same mutation. In non-endemic areas, its main form of presentation may resemble a predominantly motor polyneuropathy developing in the sixth decade of life with no signs of dysautonomia. Given this non-specific presentation and the widely available technical means of studying the TTR gene, we believe that the protocol for the aetiological diagnosis of any polyneuropathy should include genetic sequencing of TTR.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Patients and results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La polineuropatía amiloidótica familiar por transtiretina (PAF por TTR) cursa inicialmente con una afectación preferente de fibra fina e importante afectación autonómica, con un inicio en la segunda-tercera década de la vida y una evolución rápidamente progresiva que puede llevar a la muerte del paciente en unos 10 años. Sin embargo, en zonas no endémicas, se han descrito otros fenotipos.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Objetivos y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Describimos 4 casos procedentes de una zona no endémica, la provincia de Guipúzcoa, con el objetivo de mostrar la variabilidad clínica de esta enfermedad.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Pacientes y resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Tres pacientes presentaron una forma de inicio tardío, por encima de los 50 años, que cursó como una polineuropatía de predominio motor con afectación distal inicial en miembros inferiores y posteriormente en los superiores. Uno sufrió dolor neuropático intenso. Ninguno tuvo signos de afectación autonómica. La cuarta paciente, de origen portugués, presentó una forma típica de inicio en la treintena, con dolor neuropático y disautonomía. Los 4 pacientes presentan la mutación Val50Met en el gen TTR.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La PAF es una enfermedad pleomórfica incluso en pacientes con la misma mutación. En zonas no endémicas, su presentación predominante puede ser como una polineuropatía de inicio por encima de la sexta década, de predominio motor y sin signos disautonómicos. Dado lo inespecífico de esta forma de presentación y la facilidad técnica con la que se puede estudiar actualmente el gen TTR, creemos que en el protocolo de diagnóstico etiológico de cualquier polineuropatía se debe incluir la secuenciación de este gen.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Objetivos y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Pacientes y resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Andrés N, Poza JJ, Massó JFM. Polineuropatía amiloidótica familiar <span class="elsevierStyleSmallCaps">I</span> por mutación Val50Met (Val30Met) en el gen de la transtiretina. Neurología. 2018;33:583–589.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">This study was awarded the prize for Best Oral Presentation at the 37th Meeting of the Neurology Society of the Basque Country, held at Hotel Monte Igueldo in San Sebastián on 26 and 27 February 2016.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1524 "Ancho" => 1600 "Tamanyo" => 532120 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Sural nerve biopsy. Haematoxylin and eosin (A and B) and Congo red (C and D) staining. The endoneurium shows amorphous, eosinophilic hyaline deposits that are positive for Congo red.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0125" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolving landscape in the management of transthyretin amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.N. Hawkins" 1 => "Y. Ando" 2 => "A. Dispenzeri" 3 => "A. Gonzalez-Duarte" 4 => "D. Adams" 5 => "O.B. Suhr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/07853890.2015.1068949" "Revista" => array:6 [ "tituloSerie" => "Ann Med" "fecha" => "2015" "volumen" => "47" "paginaInicial" => "625" "paginaFinal" => "638" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26611723" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0130" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial amyloid polyneuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Planté-Bordeneuve" 1 => "G. Said" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1474-4422(11)70246-0" "Revista" => array:6 [ "tituloSerie" => "Lancet Neurol" "fecha" => "2011" "volumen" => "10" "paginaInicial" => "1086" "paginaFinal" => "1097" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22094129" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0135" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Update in the diagnosis and management of transthyretin familial amyloid polyneuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. Planté-Bordeneuve" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00415-014-7373-0" "Revista" => array:6 [ "tituloSerie" => "J Neurol" "fecha" => "2014" "volumen" => "261" "paginaInicial" => "1227" "paginaFinal" => "1233" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24888313" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0140" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "FAP neuropathy and emerging treatments" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Adams" 1 => "M. Théaudin" 2 => "C. Cauquil" 3 => "V. Algalarrondo" 4 => "M. Slama" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11910-013-0435-3" "Revista" => array:5 [ "tituloSerie" => "Curr Neurol Neurosci Rep" "fecha" => "2014" "volumen" => "14" "paginaInicial" => "435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24482069" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0145" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transthyretin familial amyloid polyneuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Planté-Bordeneuve" 1 => "P. Kerschen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/B978-0-444-52902-2.00038-2" "Revista" => array:6 [ "tituloSerie" => "Handb Clin Neurol" "fecha" => "2013" "volumen" => "115" "paginaInicial" => "643" "paginaFinal" => "658" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23931808" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0150" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The molecular biology and clinical features of amyloid neuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.D. Benson" 1 => "J.C. Kincaid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mus.20821" "Revista" => array:6 [ "tituloSerie" => "Muscle Nerve" "fecha" => "2007" "volumen" => "36" "paginaInicial" => "411" "paginaFinal" => "423" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17554795" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0155" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations regarding diagnosis and treatment of transthyretin familial amyloid polyneuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. García-Pavía" 1 => "F. Muñoz-Beamud" 2 => "C. Casasnovas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2015" "volumen" => "145" "paginaInicial" => "211" "paginaFinal" => "217" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0160" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guideline of transthyretin-related hereditary amyloidosis for clinicians" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Ando" 1 => "T. Coelho" 2 => "J.L. Berk" 3 => "M.W. Cruz" 4 => "B.G. Ericzon" 5 => "S. Ikeda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1750-1172-8-31" "Revista" => array:5 [ "tituloSerie" => "Orphanet J Rare Dis" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23425518" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0165" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations for presymptomatic genetic testing and management of individuals at risk for hereditary transthyretin amyloidosis" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "European Network for TTR-FAP (ATTReuNET)" "etal" => true "autores" => array:6 [ 0 => "L. Obici" 1 => "J.B. Kuks" 2 => "J. Buades" 3 => "D. Adams" 4 => "O.B. Suhr" 5 => "T. Coelho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/WCO.0000000000000290" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Neurol" "fecha" => "2016" "volumen" => "29" "numero" => "Suppl. 1" "paginaInicial" => "S27" "paginaFinal" => "S35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26734953" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0170" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transthyretin related familial amyloid polyneuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Planté-Bordeneuve" 1 => "G. Said" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Neurol" "fecha" => "2000" "volumen" => "13" "paginaInicial" => "569" "paginaFinal" => "573" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11073365" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0175" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial amyloidotic polyneuropathies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.M. Vallat" 1 => "B. Funalot" 2 => "F. Faugeras" 3 => "L. Magy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bull Acad Natl Med" "fecha" => "2012" "volumen" => "196" "paginaInicial" => "1321" "paginaFinal" => "1329" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23815017" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0180" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Haplotypes and DNA sequence variation within and surrounding the transthyretin gene: genotype–phenotype correlations in familial amyloid polyneuropathy (V30M) in Portugal and Sweden" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.L. Soares" 1 => "T. Coelho" 2 => "A. Sousa" 3 => "G. Holmgren" 4 => "M.J. Saraiva" 5 => "D.L. Kastner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ejhg.5201095" "Revista" => array:6 [ "tituloSerie" => "Eur J Hum Genet" "fecha" => "2004" "volumen" => "12" "paginaInicial" => "225" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14673473" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0185" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.R. Almeida" 1 => "I.L. Alves" 2 => "H. Terazaki" 3 => "Y. Ando" 4 => "M.J. Saraiva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/bbrc.2000.2554" "Revista" => array:6 [ "tituloSerie" => "Biochem Biophys Res Commun" "fecha" => "2000" "volumen" => "270" "paginaInicial" => "1024" "paginaFinal" => "1028" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10772944" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0190" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimizing the management of transthyretin familial amyloid polyneuropathy in Europe: early diagnosis and effective care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Adams" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/WCO.0000000000000294" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Neurol" "fecha" => "2016" "volumen" => "29" "numero" => "Suppl. 1" "paginaInicial" => "S1" "paginaFinal" => "S2" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26794616" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0195" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver transplantation for hereditary transthyretin amyloidosis: after 20 years still the best therapeutic alternative?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.G. Ericzon" 1 => "H.E. Wilczek" 2 => "M. Larsson" 3 => "P. Wijayatunga" 4 => "A. Stangou" 5 => "J.R. Pena" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/TP.0000000000000574" "Revista" => array:6 [ "tituloSerie" => "Transplantation" "fecha" => "2015" "volumen" => "99" "paginaInicial" => "1847" "paginaFinal" => "1854" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26308415" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0200" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term data from the Familial Amyloidotic Polyneuropathy World Transplant Registry (FAPWTR)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.E. Wilczek" 1 => "M. Larsson" 2 => "B.G. Ericzon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/13506129.2011.574354072" "Revista" => array:7 [ "tituloSerie" => "Amyloid" "fecha" => "2011" "volumen" => "18" "numero" => "Suppl. 1" "paginaInicial" => "193" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21838484" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0205" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver transplantation in transthyretin-related familial amyloid polyneuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.J. Stangou" 1 => "P.N. Hawkins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Neurol" "fecha" => "2004" "volumen" => "17" "paginaInicial" => "615" "paginaFinal" => "620" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15367866" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0210" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progression of transthyretin amyloid neuropathy after liver transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.J. Liepnieks" 1 => "L.Q. Zhang" 2 => "M.D. Benson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1212/WNL.0b013e3181ea15d4" "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "2010" "volumen" => "75" "paginaInicial" => "324" "paginaFinal" => "327" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20660862" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0215" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver transplantation in transthyretin amyloidosis: issues and challenges" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Carvalho" 1 => "A. Rocha" 2 => "L. Lobato" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lt.24058" "Revista" => array:6 [ "tituloSerie" => "Liver Transpl" "fecha" => "2015" "volumen" => "21" "paginaInicial" => "282" "paginaFinal" => "292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25482846" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0220" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progression of cardiomyopathy after liver transplantation in patients with familial amyloidotic polyneuropathy, Portuguese type" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.O. Olofsson" 1 => "C. Backman" 2 => "K. Karp" 3 => "O.B. Suhr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Transplantation" "fecha" => "2002" "volumen" => "73" "paginaInicial" => "745" "paginaFinal" => "751" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11907421" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0225" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent advances in transthyretin amyloidosis therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Ueda" 1 => "Y. Ando" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/2047-9158-3-19" "Revista" => array:5 [ "tituloSerie" => "Transl Neurodegener" "fecha" => "2014" "volumen" => "3" "paginaInicial" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25228988" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0230" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Coelho" 1 => "L.F. Maia" 2 => "A.M. da Silva" 3 => "M.W. Cruz" 4 => "V. Planté-Bordeneuve" 5 => "O.B. Suhr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00415-013-7051-7" "Revista" => array:6 [ "tituloSerie" => "J Neurol" "fecha" => "2013" "volumen" => "260" "paginaInicial" => "2802" "paginaFinal" => "2814" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23974642" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0235" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Coelho" 1 => "L.F. Maia" 2 => "A. Martins da Silva" 3 => "M. Waddington Cruz" 4 => "V. Planté-Bordeneuve" 5 => "P. Lozeron" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1212/WNL.0b013e3182661eb1" "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "2012" "volumen" => "79" "paginaInicial" => "785" "paginaFinal" => "792" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22843282" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0240" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of tafamidis on transthyretin stabilization and clinical outcomes in patients with non-Val30Met transthyretin amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Merlini" 1 => "V. Planté-Bordeneuve" 2 => "D.P. Judge" 3 => "H. Schmidt" 4 => "L. Obici" 5 => "S. Perlini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s12265-013-9512-x" "Revista" => array:6 [ "tituloSerie" => "J Cardiovasc Transl Res" "fecha" => "2013" "volumen" => "6" "paginaInicial" => "1011" "paginaFinal" => "1020" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24101373" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735808/0000003300000009/v1_201811160606/S2173580818301159/v1_201811160606/en/main.assets" "Apartado" => array:4 [ "identificador" => "9491" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735808/0000003300000009/v1_201811160606/S2173580818301159/v1_201811160606/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580818301159?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 October | 24 | 1 | 25 |
2024 September | 50 | 5 | 55 |
2024 August | 61 | 6 | 67 |
2024 July | 36 | 2 | 38 |
2024 June | 40 | 4 | 44 |
2024 May | 36 | 2 | 38 |
2024 April | 45 | 3 | 48 |
2024 March | 72 | 14 | 86 |
2024 February | 60 | 6 | 66 |
2024 January | 52 | 2 | 54 |
2023 December | 55 | 4 | 59 |
2023 November | 58 | 10 | 68 |
2023 October | 72 | 12 | 84 |
2023 September | 58 | 7 | 65 |
2023 August | 50 | 7 | 57 |
2023 July | 70 | 11 | 81 |
2023 June | 69 | 4 | 73 |
2023 May | 91 | 12 | 103 |
2023 April | 69 | 3 | 72 |
2023 March | 75 | 6 | 81 |
2023 February | 50 | 1 | 51 |
2023 January | 70 | 4 | 74 |
2022 December | 62 | 7 | 69 |
2022 November | 71 | 7 | 78 |
2022 October | 46 | 13 | 59 |
2022 September | 49 | 14 | 63 |
2022 August | 47 | 11 | 58 |
2022 July | 36 | 9 | 45 |
2022 June | 32 | 8 | 40 |
2022 May | 35 | 20 | 55 |
2022 April | 50 | 7 | 57 |
2022 March | 60 | 12 | 72 |
2022 February | 46 | 6 | 52 |
2022 January | 44 | 6 | 50 |
2021 December | 59 | 14 | 73 |
2021 November | 40 | 10 | 50 |
2021 October | 35 | 17 | 52 |
2021 September | 51 | 8 | 59 |
2021 August | 61 | 11 | 72 |
2021 July | 31 | 9 | 40 |
2021 June | 29 | 10 | 39 |
2021 May | 33 | 9 | 42 |
2021 April | 93 | 28 | 121 |
2021 March | 78 | 10 | 88 |
2021 February | 40 | 14 | 54 |
2021 January | 28 | 16 | 44 |
2020 December | 27 | 20 | 47 |
2020 November | 25 | 18 | 43 |
2020 October | 24 | 18 | 42 |
2020 September | 21 | 14 | 35 |
2020 August | 23 | 17 | 40 |
2020 July | 18 | 17 | 35 |
2020 June | 18 | 16 | 34 |
2020 May | 18 | 21 | 39 |
2020 April | 17 | 9 | 26 |
2020 March | 12 | 10 | 22 |
2020 February | 18 | 18 | 36 |
2020 January | 23 | 13 | 36 |
2019 December | 32 | 24 | 56 |
2019 November | 20 | 18 | 38 |
2019 October | 18 | 7 | 25 |
2019 September | 15 | 17 | 32 |
2019 August | 17 | 6 | 23 |
2019 July | 14 | 22 | 36 |
2019 June | 60 | 28 | 88 |
2019 May | 147 | 70 | 217 |
2019 April | 74 | 6 | 80 |
2019 March | 13 | 6 | 19 |
2019 February | 15 | 6 | 21 |
2019 January | 21 | 9 | 30 |
2018 December | 15 | 5 | 20 |
2018 November | 7 | 13 | 20 |
2018 October | 3 | 11 | 14 |
2018 September | 7 | 7 | 14 |
2018 August | 1 | 3 | 4 |