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Palacios, C. Clavijo-Prado, A. Ruiz, A. Arias Antun, E. Julián Duran" "autores" => array:5 [ 0 => array:3 [ "nombre" => "E." "apellidos" => "Palacios" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 1 => array:4 [ "nombre" => "C." "apellidos" => "Clavijo-Prado" "email" => array:1 [ 0 => "caclavijo@fucsalud.edu.co" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Ruiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Arias Antun" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "E." "apellidos" => "Julián Duran" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Grupo de Neurología, Fundación Universitaria de Ciencias de la Salud, Hospital de San José, Bogotá, DC, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Programa de Neurología, Hospital de San José, Bogotá, DC, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Mielitis longitudinalmente extensa y virus del Zika, reto diagnóstico: a propósito de un caso en hospital de Colombia 2016" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1900 "Ancho" => 1800 "Tamanyo" => 338087 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">MR image of the thoracic spinal cord. (A-C) Sagittal T2-weighted and FLAIR sequences showing a longitudinally extensive hyperintensity in the anterior part of the spinal cord. (D) Axial plane of the thoracic region at the T2 level, showing a hyperintense lesion.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Zika virus is an arbovirus of the genus <span class="elsevierStyleItalic">Flavivirus</span>, which also includes the Japanese encephalitis, yellow fever, West Nile, and dengue viruses. Zika virus is spread by an arthropod, <span class="elsevierStyleItalic">Aedes aegypti</span>, and was first described in a population of rhesus monkeys in Uganda in 1947. Zika virus infection was described in humans in 1968, in Nigeria, when Zika-neutralising antibodies were isolated in a group of people presenting fever, skin rash, arthralgia, and conjunctivitis. The virus has since reached other parts of Africa and Asia. Since 2007, it has rapidly spread across several islands in the Pacific Ocean and various South American countries, including Brazil, French Guiana, and more recently Colombia. Zika virus infection causes a wide range of neurological complications, including longitudinally extensive transverse myelitis.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a patient with Zika virus infection manifesting as longitudinally extensive transverse myelitis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 23-year-old man presenting with pelvic pain followed by urinary retention; 24 h after onset of the initial symptoms, he developed progressive loss of strength in the lower limbs, resulting in paraplegia, and left-sided paraesthesia and hypoaesthesia below the upper abdomen (T6-T7 dermatomes). The physical examination revealed normal cranial nerve function, no meningeal signs, flaccid paralysis (0/5 strength), hyperactive patellar and Achilles reflexes (3-4), and hypoaesthesia below the T7 sensory level. The patient had experienced non-purulent conjunctival injection, fever, and arthralgia 15 days previously. A cranial and thoracolumbar CT scan, complete blood count, electrolyte study, renal function study, C-reactive protein (CRP) and procalcitonin tests, and blood and urine cultures all yielded normal results. A CSF cytochemical study revealed pleocytosis and low protein levels (200 leukocytes/mm<span class="elsevierStyleSup">3</span>, 90% monocytes, 10% polymorphonuclear; glucose 41<span class="elsevierStyleHsp" style=""></span>mg/dL; proteins 31.4<span class="elsevierStyleHsp" style=""></span>mg/dL; HDL 26<span class="elsevierStyleHsp" style=""></span>mg/dL). Nigrosin, Gram, and KOH staining and serology, HIV test, serum culture, and a blood lead test yielded negative results, and complement C3 and C4 levels were normal. The patient also tested negative for cardiolipin IgG and IgM antibodies, beta-2 glycoprotein 1 antibodies, IgM for dengue and chikungunya, antinuclear antibodies, anti-DNA antibodies, and C- and P-ANCA. ANA titre was 1:80. Protein electrophoresis revealed mild hypoalbuminaemia in alpha-1 and alpha-2 zones, and polyclonal hyperalbuminaemia in the gamma region. A spinal cord MRI scan revealed signal alterations from C1 to the conus medullaris, with hyperintense foci in the anterior part of the spinal cord on T2-weighted and FLAIR sequences (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A-D). Symptoms were compatible with longitudinally extensive transverse myelitis associated with lymphocytic pleocytosis in the context of Zika virus infection 15 days previously; infection was confirmed by the presence of CRP in the serum. The patient started treatment with corticosteroids (methylprednisolone 1<span class="elsevierStyleHsp" style=""></span>g/day for 5 days), with no clinical improvement. He was subsequently treated with 5 sessions of plasmapheresis; at discharge, he was able to walk with a cane and strength had increased to 4/5.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Zika virus is an RNA virus containing 10<span class="elsevierStyleHsp" style=""></span>974 nucleotides coding for 3419 amino acids. The virus is arthropod-borne and replicates rapidly in dendritic cells near the inoculation site. It can be isolated in the blood from day 1 to day 11 after inoculation. Some studies suggest changes in the virus’ biological cycle affect signalling pathways and various organelles; animal studies have shown alterations in the endoplasmic reticulum, which is associated with multiple disorders of the central nervous system.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3,4</span></a> Some case reports have shown positive CSF CRP test results for Zika virus, indicating a certain degree of neurotropism; this was also seen in our patient, whose cytochemical results revealed viral infection. Neurotropic flaviviruses may cause encephalitis, transverse myelitis, or longitudinally extensive transverse myelitis.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1,5,6</span></a> The lumbosacral nerve roots have also been found to be involved.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">7,8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Diagnostic tests for Zika virus infection include serum CRP determination and other tests for detecting specific antibodies against Zika virus in the serum. There is evidence of cross-reactivity in patients with a history of flavivirus infection, which makes IgM testing less reliable. CRP tests can be performed from day 5 to day 11 after infection; a second sample can be taken 2-3 weeks after the first.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In our patient, clinical symptoms compatible with longitudinally extensive transverse myelitis, the clearly visible spinal cord MRI alterations (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A-D), the classic symptoms of Zika virus infection, and positive serum CRP results for the virus enabled correct management, leading to an optimal outcome.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Zika virus infection should be suspected in patients with acute myelitis who come from or live in endemic areas; further studies should aim to determine the spectrum and magnitude of the associated neurological complications.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Palacios E, Clavijo-Prado C, Ruiz A, Arias Antun A, Julián Duran E. Mielitis longitudinalmente extensa y virus del Zika, reto diagnóstico: a propósito de un caso en hospital de Colombia 2016. Neurología. 2019;34:204–206.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1900 "Ancho" => 1800 "Tamanyo" => 338087 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">MR image of the thoracic spinal cord. (A-C) Sagittal T2-weighted and FLAIR sequences showing a longitudinally extensive hyperintensity in the anterior part of the spinal cord. 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Year/Month | Html | Total | |
---|---|---|---|
2024 October | 16 | 4 | 20 |
2024 September | 37 | 3 | 40 |
2024 August | 35 | 8 | 43 |
2024 July | 19 | 4 | 23 |
2024 June | 30 | 5 | 35 |
2024 May | 29 | 5 | 34 |
2024 April | 43 | 10 | 53 |
2024 March | 27 | 6 | 33 |
2024 February | 37 | 6 | 43 |
2024 January | 46 | 7 | 53 |
2023 December | 34 | 3 | 37 |
2023 November | 38 | 7 | 45 |
2023 October | 60 | 9 | 69 |
2023 September | 31 | 2 | 33 |
2023 August | 26 | 5 | 31 |
2023 July | 36 | 4 | 40 |
2023 June | 36 | 3 | 39 |
2023 May | 70 | 3 | 73 |
2023 April | 37 | 2 | 39 |
2023 March | 61 | 3 | 64 |
2023 February | 43 | 1 | 44 |
2023 January | 47 | 4 | 51 |
2022 December | 46 | 9 | 55 |
2022 November | 45 | 9 | 54 |
2022 October | 46 | 13 | 59 |
2022 September | 75 | 13 | 88 |
2022 August | 66 | 16 | 82 |
2022 July | 52 | 8 | 60 |
2022 June | 41 | 14 | 55 |
2022 May | 34 | 9 | 43 |
2022 April | 43 | 9 | 52 |
2022 March | 37 | 8 | 45 |
2022 February | 31 | 12 | 43 |
2022 January | 46 | 12 | 58 |
2021 December | 31 | 11 | 42 |
2021 November | 39 | 11 | 50 |
2021 October | 37 | 11 | 48 |
2021 September | 32 | 16 | 48 |
2021 August | 51 | 8 | 59 |
2021 July | 28 | 5 | 33 |
2021 June | 20 | 7 | 27 |
2021 May | 32 | 11 | 43 |
2021 April | 94 | 20 | 114 |
2021 March | 60 | 10 | 70 |
2021 February | 33 | 8 | 41 |
2021 January | 33 | 10 | 43 |
2020 December | 38 | 13 | 51 |
2020 November | 30 | 10 | 40 |
2020 October | 35 | 2 | 37 |
2020 September | 36 | 10 | 46 |
2020 August | 43 | 8 | 51 |
2020 July | 40 | 9 | 49 |
2020 June | 29 | 9 | 38 |
2020 May | 25 | 16 | 41 |
2020 April | 25 | 4 | 29 |
2020 March | 26 | 3 | 29 |
2020 February | 26 | 5 | 31 |
2020 January | 21 | 4 | 25 |
2019 December | 26 | 9 | 35 |
2019 November | 25 | 16 | 41 |
2019 October | 20 | 2 | 22 |
2019 September | 20 | 2 | 22 |
2019 August | 23 | 3 | 26 |
2019 July | 45 | 8 | 53 |
2019 June | 27 | 11 | 38 |
2019 May | 83 | 30 | 113 |
2019 April | 41 | 30 | 71 |
2019 March | 3 | 4 | 7 |
2019 February | 0 | 5 | 5 |
2019 January | 0 | 5 | 5 |
2018 December | 0 | 2 | 2 |
2018 November | 0 | 1 | 1 |
2018 October | 0 | 5 | 5 |