was read the article
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Berciano" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Berciano" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173580819300689" "doi" => "10.1016/j.nrleng.2017.07.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580819300689?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485317302578?idApp=UINPBA00004N" "url" => "/02134853/0000003500000001/v1_202003180804/S0213485317302578/v1_202003180804/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2173580819300690" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2017.07.004" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "1108" "copyright" => "Sociedad Española de Neurología" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Neurologia. 2020;35:59-61" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 179 "formatos" => array:3 [ "EPUB" => 28 "HTML" => 102 "PDF" => 49 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "The great imitator: mesial temporal alterations in MRI in an atypical case of neurosyphilis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "59" "paginaFinal" => "61" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La gran imitadora: alteraciones mesiotemporales en RM en una presentación atípica de neurosífilis" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3363 "Ancho" => 2333 "Tamanyo" => 273668 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brain MRI showing cortical hyperintensity on coronal T2-weighted FLAIR (A and B) and axial T2-weighted sequences (C and D), affecting the bilateral hippocampi, amygdalae, temporal lobes, basal and parasagittal regions of the frontal lobes, insulae, globus pallidi, and caudate nuclei. No pathological enhancement was observed after intravenous administration of contrast (E). Lesions do not cause a mass effect or show diffusion restriction on DWI sequences (F).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R.N. Villar-Quiles, N. Gómez-Ruiz, M. Jorquera-Moya, J. Porta-Etessam" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R.N." "apellidos" => "Villar-Quiles" ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Gómez-Ruiz" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Jorquera-Moya" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Porta-Etessam" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S021348531730258X" "doi" => "10.1016/j.nrl.2017.07.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021348531730258X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580819300690?idApp=UINPBA00004N" "url" => "/21735808/0000003500000001/v1_202004040635/S2173580819300690/v1_202004040635/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2173580819300677" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2017.06.004" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "1106" "copyright" => "Sociedad Española de Neurología" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Neurologia. 2020;35:56-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 247 "formatos" => array:3 [ "EPUB" => 68 "HTML" => 93 "PDF" => 86 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Basilar artery thrombosis caused by vertebral dissection secondary to brachial plexus block" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "56" "paginaFinal" => "58" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Trombosis basilar por disección vertebral secundaria a bloqueo del plexo braquial" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 826 "Ancho" => 3167 "Tamanyo" => 228382 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Coronal CT angiography slice showing the origin of the left vertebral artery and its narrowing, which confirms arterial dissection. (B) Angiography with lateral projection confirming thrombosis of the distal third of the basilar artery. (C) Angiography with frontal projection following mechanical thrombectomy, displaying complete recanalisation. (D) Chest radiography with the patient in the supine position, revealing left hemithorax opacification.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Montejo, M. Vicente, A. Sánchez, A. Renú" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Montejo" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Vicente" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Sánchez" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Renú" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485317302566" "doi" => "10.1016/j.nrl.2017.06.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485317302566?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580819300677?idApp=UINPBA00004N" "url" => "/21735808/0000003500000001/v1_202004040635/S2173580819300677/v1_202004040635/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Progressive multifocal leukoencephalopathy in an immunocompetent patient" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor:</span>" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "58" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Berciano" "autores" => array:1 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Berciano" "email" => array:1 [ 0 => "jaberciano@humv.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neurología, Hospital Universitario Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Santander, Cantabria, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Leucoencefalopatía multifocal progresiva en un paciente inmunocompetente" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">I read with great interest the study by Muiño et al.,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> describing the case of a 72-year-old patient who presented progressive multifocal leukoencephalopathy (PML) with no underlying immune disorder. The authors report 7 cases of PML in immunocompetent individuals. I would like to comment on another case reported by myself and colleagues.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> Our patient was a 45-year-old woman presenting weakness and numbness of the right hand, with onset in March 2000. The initial examination, 2 months after symptom onset, revealed postural tremor, rigidity, and hyperreflexia of the right arm. This motor deficit progressed over the following months, with myoclonic jerks developing. In September 2000, she presented right hemiparesis with continuous myoclonic jerks, mainly affecting the flexor and extensor muscles of the right hand. From October 2000, she presented the same symptoms on the left side. In the final stage, the patient developed decorticate posture, although she remained lucid until her death in June 2001. The patient did not respond to antiepileptic drugs. Analytical studies, including an immunological profile, tumour markers, and serology studies, yielded normal or negative results. Consecutive EEG and EMG recordings detected signs characteristic of epilepsia partialis continua (EPC) and progressive slowing of background activity. The baseline brain MRI study (May 2000), especially the FLAIR sequences, showed hyperintensities in the U-shaped fibres of the left precentral cortex. Consecutive follow-up MRI scans showed lesion progression and the appearance of similar contralateral alterations. A stereotactic brain biopsy was not diagnostic. A complete autopsy revealed that the patient died due to bronchopneumonia and massive gastrointestinal bleeding, with no signs of neoplasm. The brain showed microscopic lesions characteristic of PML, with demyelination, predominantly in the motor and parietal areas and corticospinal tracts. The cerebral cortex, basal ganglia, brainstem, and cerebellum were intact. In view of these findings, we suggested that a “motor cortex isolation syndrome” may be the cause of the EPC.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The title of our article was intended to emphasise the semiological aspects, that is, it made no reference to the state of the immune system; furthermore, we did not include “immunocompetence” as keyword. This explains why a literature search on Pubmed, combining the terms “progressive multifocal leukoencephalopathy” and “immunocompetence,” does not return our article. In any case, I do agree with the authors that the presence of PML in an immunocompetent individual is exceptional.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Berciano J. Leucoencefalopatía multifocal progresiva en un paciente inmunocompetente. Neurología. 2020;35:58.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leucoencefalopatía multifocal progresiva en un paciente inmunocompetente" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Muiño" 1 => "M.A. Rubio" 2 => "I. Navalpotro" 3 => "E. Munteis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neurologia" "fecha" => "2017" "volumen" => "52" "paginaInicial" => "337" "paginaFinal" => "339" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epilepsia partialis continua in progressive multifocal leukoencephalopathy: a motor cortex isolation syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Berciano" 1 => "C. Leno" 2 => "J. Figols" 3 => "A. García" 4 => "J.M. Polo" 5 => "M.T. Berciano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mds.10599" "Revista" => array:6 [ "tituloSerie" => "Mov Disord" "fecha" => "2003" "volumen" => "18" "paginaInicial" => "1559" "paginaFinal" => "1564" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14673902" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735808/0000003500000001/v1_202004040635/S2173580819300689/v1_202004040635/en/main.assets" "Apartado" => array:4 [ "identificador" => "9409" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735808/0000003500000001/v1_202004040635/S2173580819300689/v1_202004040635/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580819300689?idApp=UINPBA00004N" ]
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