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Review article
Use of commercial video games to improve postural balance in patients with multiple sclerosis:a systematic review and meta-analysis of randomised controlled clinical trials
Efectos de la terapia con videojuegos comerciales sobre el equilibrio postural en pacientes con esclerosis múltiple: revisión sistemática y metaanálisis de ensayos clínicos controlados aleatorizados
M. Parra-Morenoa, J.J. Rodríguez-Juanb, J.D. Ruiz-Cárdenasb,
Corresponding author
jdruiz@ucam.edu

Corresponding author.
a Facultad de Ciencias de la Salud, Universidad Católica de Murcia, Murcia, Spain
b GI. ECOFISTEM, Facultad de Ciencias de la Salud, Universidad Católica de Murcia, Murcia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Multiple sclerosis &#40;MS&#41; is a chronic&#44; inflammatory demyelinating disease of unknown&#44; probably multifactorial origin&#46; The disease is associated with a wide range of symptoms&#44; including depression&#44; fatigue&#44; pain&#44; muscle weakness&#44; and gait and balance alterations&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">1</span></a> Postural imbalance is one of the most disabling symptoms of MS&#44; affecting approximately 80&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Commercial video games constitute a promising tool for improving postural balance in various populations&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">3&#8211;5</span></a> They are inexpensive and widely accessible&#44; and increase patient motivation and satisfaction with treatment&#44; which makes them a useful tool both in clinical practice and in the home environment&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">6</span></a> &#8220;Exergames&#8221; involve such activities as dancing&#44; running&#44; throwing&#44; cycling&#44; boxing&#44; or playing tennis&#59; players use their arms and legs to activate commands in order to accomplish objectives&#46; This stands in contrast with traditional video games&#44; which are usually played in a seated position&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a> Despite increasing evidence on the use of exergames in different populations&#44;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">3&#8211;5</span></a> their benefits for MS are not clear and further research is required&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This systematic review and meta-analysis aims to analyse the available evidence on the effects of exergames on postural balance in patients with MS&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Design</span><p id="par0020" class="elsevierStylePara elsevierViewall">We performed a systematic review of randomised controlled clinical trials using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Search strategy and databases</span><p id="par0025" class="elsevierStylePara elsevierViewall">We performed a literature search on 11 electronic databases&#58; Academic Search Complete&#44; Allied and Complementary Medicine Database &#40;AMED&#41;&#44; Cochrane Central Register of Controlled Trials &#40;CENTRAL&#41;&#44; CINAHL&#44; Web of Science Core Collection&#44; IBECS&#44; LILACS&#44; PubMed&#47;Medline&#44; Scielo&#44; SPORTDiscus&#44; and ScienceDirect&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We used the following search terms&#58; multiple sclerosis&#44; videogames&#44; video games&#44; exergam&#42;&#44; postural balance&#44; posturography&#44; postural control&#44; and balance&#46; These were combined using the Boolean operators AND and OR&#46; We also reviewed the references cited in the studies identified in the literature search&#46; The last search was conducted on 9 October 2017&#46; Additional information on the search strategy used is provided in the Supplementary Material&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Eligibility criteria</span><p id="par0035" class="elsevierStylePara elsevierViewall">We gathered randomised controlled clinical trials evaluating the effects of commercial video games on postural balance in patients with MS and published in full-text format in international&#44; peer-reviewed journals&#46; Studies combining video games with other types of therapy were excluded from our review&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Study selection and data collection process</span><p id="par0040" class="elsevierStylePara elsevierViewall">Studies were selected by 2 independent reviewers&#44; who first read the titles and abstracts of the studies gathered during the electronic search&#44; and then read the full texts of those articles potentially relevant to our review&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">We used the PICO approach<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a> to gather data on participant characteristics &#40;sample size&#44; age&#44; sex&#44; level of disability&#41;&#44; type of intervention &#40;type of exercise&#59; video game used&#59; session intensity&#44; frequency&#44; and duration&#59; duration of the intervention&#41;&#44; characteristics of the control group&#44; and impact on postural balance&#46; We also gathered data on study characteristics &#40;author&#44; year of publication&#41; and the tools used by the authors to evaluate balance&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Risk of bias</span><p id="par0050" class="elsevierStylePara elsevierViewall">We assessed the risk of bias of the studies reviewed using the tool recommended by the Cochrane Handbook for Systematic Reviews of Interventions&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> which evaluates sequence generation&#44; allocation sequence concealment&#44; blinding of participants and personnel&#44; blinding of outcome assessment&#44; incomplete outcome data&#44; selective outcome reporting&#44; and other potential threats to validity&#46; Two independent reviewers evaluated the risk of bias&#59; disagreements were resolved by a third reviewer&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">A meta-analysis was conducted in cases where 2 or more studies measured the same outcome variable&#46; We calculated the difference in means &#40;DM&#41; and the 95&#37; confidence interval &#40;CI&#41; for each relevant outcome from each of the studies selected&#46; The results of the meta-analysis are presented in the form of forest plots&#59; statistical significance was set at <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; The <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span> index was used to assess the heterogeneity of the studies included&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The fixed-effects model was applied when the <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span> index detected no significant heterogeneity &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#59; otherwise&#44; the random-effects model was used&#46; Egger&#39;s regression test was used to assess publication bias&#46; A non-zero intercept indicated publication bias &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Statistical analysis was performed with RevMan 5&#46;3 &#40;Copenhagen&#58; The Nordic Cochrane Centre&#44; The Cochrane Collaboration&#44; 2014&#41; and a Microsoft&#174; Excel 2010 template&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Results</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Study selection</span><p id="par0070" class="elsevierStylePara elsevierViewall">We identified a total of 230 studies in the electronic databases used&#46; We excluded duplicate articles and selected 6 potentially eligible studies&#44; which were read in full text format&#46; One of these was excluded as it combined Wii Fit with balance board exercises&#46; Five studies were included in the qualitative analysis&#44; and 4 were selected for the meta-analysis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Study characteristics and risk of bias</span><p id="par0075" class="elsevierStylePara elsevierViewall">We included randomised controlled clinical trials published between 2013 and 2015&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#8211;14</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In general terms&#44; the articles included show a low risk of bias for all domains&#44; except for blinding of participants and personnel&#44; which had a high risk of bias &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#8211;14</span></a> Eighty percent of studies showed adequate sequence generation and allocation sequence concealment&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#44;11&#44;13&#44;14</span></a> Assessors were blinded in 60&#37; of studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#44;11&#44;13</span></a> The domains &#8220;selective outcome reporting&#8221; and &#8220;incomplete outcome data&#8221; presented a low risk of bias in all studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#8211;14</span></a> Additional information on the risk of bias assessment is provided in the Supplementary Material&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Patient characteristics</span><p id="par0085" class="elsevierStylePara elsevierViewall">A total of 259 patients &#40;176 women&#44; 86 men&#41; with MS and moderate disability &#40;Expanded Disability Status Scale scores 3-6&#41; were included in our systematic review&#46; Patient ages ranged from 35&#46;3 to 53&#46;9 years&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Characteristics of the intervention</span><p id="par0090" class="elsevierStylePara elsevierViewall">Experimental groups used different commercial video game systems&#44; including the Nintendo Wii&#174; for the videogames Wii Fit&#174; and Wii Fit Plus&#174;&#44;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#44;12&#8211;14</span></a> and the Xbox 360&#174; for the videogames Kinect Sports&#174;&#44; Kinect Joy Ride&#174;&#44; and Kinect Adventures&#174;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In some studies&#44; controls received conventional physical therapy with strength&#44; proprioception&#44; and gait exercises&#44; as well as stretching or balance board exercises&#44;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#44;11&#44;14</span></a> whereas in others they received no treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">12&#8211;14</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Exergaming training was performed between 2 and 5 times per week&#44; with sessions lasting 30-60<span class="elsevierStyleHsp" style=""></span>minutes&#59; the duration of the intervention ranged from 4 to 12 weeks&#46; Session intensity was adjusted by progressively increasing the game&#39;s difficulty level&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">11&#8211;14</span></a></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Patient assessment tools</span><p id="par0105" class="elsevierStylePara elsevierViewall">Dynamic balance was assessed with a wide range of functional tests and scales&#58; the Timed Up and Go test&#44; Cognitive Timed-Up-and-Go dual-task test&#44; Timed Chair Stand test&#44; Four Step Square Test &#40;FSST&#41;&#44; Timed 25-Foot Walk &#40;T25-FW&#41;&#44; Dynamic Gait Index &#40;DGI&#41;&#44; Activities-Specific Balance Confidence Scale&#44; Berg Balance Scale &#40;BBS&#41;&#44; and Tinetti Balance and Gait Assessment Scale&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#8211;13</span></a> Some authors used stabilometric parameters to assess static balance with the eyes open and closed&#44; including centre of pressure &#40;CoP&#41; displacement&#44; CoP sway area&#44; CoP velocity&#44; and CoP displacement range in the anteroposterior and mediolateral axes&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#44;13&#44;14</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Effects of exergaming on postural balance</span><p id="par0110" class="elsevierStylePara elsevierViewall">The studies included generally reported improvements in the short term &#40;4 to 12 weeks&#41; in all balance variables analysed in patients receiving exergame therapy as compared to controls receiving no treatment<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a> or performing strength and proprioception exercises<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#44;11&#44;13</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Exergaming improved dynamic balance by 9&#37;-16&#37;&#44; as measured with the BBS &#40;&#43;5 to &#43;7&#46;6 points&#41;&#44; the Tinetti scale &#40;&#43;7&#46;5 points&#41;&#44; the T25-FW &#40;&#8722;0&#46;8<span class="elsevierStyleHsp" style=""></span>s&#41;&#44; and the FSST &#40;&#8722;2&#46;8<span class="elsevierStyleHsp" style=""></span>s&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#44;11&#44;13</span></a> Static balance also improved in terms of CoP displacement &#40;&#8722;88<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; CoP velocity &#40;&#8722;1<span class="elsevierStyleHsp" style=""></span>m&#47;s&#41;&#44; and CoP displacement range in the mediolateral &#40;&#8722;12 to &#8722;18<span class="elsevierStyleHsp" style=""></span>mm&#41; and anteroposterior axes &#40;&#8722;13 to &#8722;14<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">13&#44;14</span></a> Furthermore&#44; CoP sway area decreased by 44&#37; &#40;&#8722;46&#46;3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#41; and 38&#37; &#40;&#8722;97<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#41; during open-eye and closed-eye stabilometry&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Two of the studies included report no differences in any of the variables analysed between the intervention group and controls receiving no treatment<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> or traditional balance training &#40;e&#46;g&#46;&#44; standing with feet together after perturbations&#44; straight line walking&#44; wobble board&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a></p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Meta-analysis</span><p id="par0125" class="elsevierStylePara elsevierViewall">We performed 3 meta-analyses to assess the effects of exergaming on BBS&#44; FSST&#44; and T25-FW scores&#46; We used the fixed-effects model&#44; as the heterogeneity analysis revealed no significant differences between studies for any of the variables analysed &#40;BBS&#58; <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;96&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;33&#44; <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#59; FSST&#58; <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;44&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;51&#44; <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#59; T25-FW&#58; <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;96&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;33&#44; <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Improvements in BBS scores were more marked in patients receiving exergame therapy than in controls performing strength&#44; proprioception&#44; and postural balance exercises &#40;DM&#58; 5&#46;30&#59; 95&#37; CI&#44; 3&#46;39-7&#46;21&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#59; <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#46; However&#44; no significant differences were observed between patients in the intervention group and controls receiving no treatment in FSST &#40;DM&#58; &#8722;0&#46;74&#59; 95&#37; CI&#44; &#8722;2&#46;79 to 1&#46;32&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;48&#59; <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41; or T25-FW scores &#40;DM&#58; &#8722;0&#46;15&#59; 95&#37; CI&#44; &#8722;1&#46;06 to 0&#46;76&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;75&#59; <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>C&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Egger&#39;s regression test showed no significant differences between studies for any of the variables analysed &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>&#46;10&#41;&#44; which points to an absence of publication bias&#59; we should nonetheless bear in mind that our study analysed a small sample of articles&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">Our systematic review and meta-analysis analysed the available evidence on the impact of exergames on postural balance in patients with MS&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In the studies analysed&#44; FSST and T25-FW scores and CoP displacement&#44; velocity&#44; and displacement range improved in patients using exergames as compared to those receiving no treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">13&#44;14</span></a> Exergame therapy also achieved more marked improvements in BBS and Tinetti scale scores and in CoP sway area with open and closed eyes than conventional therapy with proprioceptive&#44; strength&#44; and stretching exercises&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">However&#44; the magnitude of change for FSST and T25-FW scores &#40;&#43;2&#46;8<span class="elsevierStyleHsp" style=""></span>s and &#43;0&#46;9<span class="elsevierStyleHsp" style=""></span>s&#44; respectively&#41; was below the minimal detectable change &#40;MDC&#41; reported in the literature for patients with MS &#40;4&#46;6<span class="elsevierStyleHsp" style=""></span>s and 12&#46;6<span class="elsevierStyleHsp" style=""></span>s&#44; respectively&#41;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">15&#44;16</span></a>&#59; MDC refers to the smallest amount of change required to distinguish a true change after an intervention from a change due to variability or measurement error&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">17</span></a> Furthermore&#44; meta-analysis detected no intergroup differences in any of the variables analysed except for BBS scores&#44; with a magnitude of change of &#43;5&#46;3<span class="elsevierStyleHsp" style=""></span>points in the exergame therapy group&#59; this is below the MDC reported in the literature for this variable in patients with MS &#40;7 points&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> Our results suggest that the magnitude of change for each variable cannot be interpreted as a true change in patients&#8217; clinical status but rather is due to variability in the assessment tool&#46; To our knowledge&#44; the MDC for Tinetti scale scores and static stabilometry variables has not been established for patients with MS&#59; our results for these variables should therefore be interpreted with caution&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Future studies should use assessment tools whose sensitivity to change has been analysed in patients with MS&#44; in order to be able to determine whether changes are attributable to the intervention or to measurement errors&#46;</p><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Limitations</span><p id="par0160" class="elsevierStylePara elsevierViewall">Despite rigorous data collection and analysis&#44; our study is not without limitations&#46; Despite increasing interest in treatment with commercially available exergames for balance training in patients with MS&#44; few studies have analysed the effects of this type of intervention&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#8211;14</span></a> In any case&#44; the studies analysed show a low risk of bias for most domains&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">This review identifies methodological issues that may be accounted for in future research into the effects of exergame therapy on postural balance in patients with MS&#46;</p></span></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Conclusions</span><p id="par0170" class="elsevierStylePara elsevierViewall">Few data are available on the effectiveness of commercial exergames on postural balance in patients with MS&#46; Future studies should use appropriate assessment tools to analyse the effects of this type of intervention on postural balance in MS before it can be recommended in clinical practice&#46;</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Conflicts of interest</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "titulo" => "Results"
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              "identificador" => "sec0050"
              "titulo" => "Study selection"
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            1 => array:2 [
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              "titulo" => "Characteristics of the intervention"
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              "identificador" => "sec0070"
              "titulo" => "Patient assessment tools"
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              "identificador" => "sec0075"
              "titulo" => "Effects of exergaming on postural balance"
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              "identificador" => "sec0080"
              "titulo" => "Meta-analysis"
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            0 => array:2 [
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              "titulo" => "Limitations"
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          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2017-10-10"
    "fechaAceptado" => "2017-12-01"
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          "clase" => "keyword"
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            0 => "Demyelinating diseases"
            1 => "Postural balance"
            2 => "Video games"
            3 => "Multiple sclerosis"
            4 => "Proprioception"
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          "palabras" => array:6 [
            0 => "Enfermedades desmielinizantes"
            1 => "Equilibrio postural"
            2 => "Videojuegos"
            3 => "Esclerosis m&#250;ltiple"
            4 => "Propiocepci&#243;n"
            5 => "Estabilidad"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Commercial video ga<span class="elsevierStyleItalic"><span class="elsevierStyleInf">me</span></span><span class="elsevierStyleItalic"><span class="elsevierStyleInf"><span class="elsevierStyleBold"><span class="elsevierStyleSup">s are considered an effective tool to improve postural balance in different populations&#46; Howe</span></span></span></span><span class="elsevierStyleItalic"><span class="elsevierStyleInf"><span class="elsevierStyleBold">ver&#44; t</span></span></span><span class="elsevierStyleItalic"><span class="elsevierStyleInf">he effectivenes</span></span><span class="elsevierStyleItalic">s o</span>f these video games for patients with multiple sclerosis &#40;MS&#41; is unclear&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To analyse existing evidence on the effects of commercial video games on postural balance in patients with MS&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and method</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We conducted a systematic literature search on 11 databases &#40;Academic-Search Complete&#44; AMED&#44; CENTRAL&#44; CINAHL&#44; WoS&#44; IBECS&#44; LILACS&#44; Pubmed&#47;Medline&#44; Scielo&#44; SPORTDiscus&#44; and Science Direct&#41; using the following terms&#58; &#8220;multiple sclerosis&#8221;&#44; videogames&#44; &#8220;video games&#8221;&#44; exergam&#42;&#44; &#8220;postural balance&#8221;&#44; posturography&#44; &#8220;postural control&#8221;&#44; balance&#46; Risk of bias was analysed by 2 independent reviewers&#46; We conducted 3 fixed effect meta-analyses and calculated the difference of means &#40;DM&#41; and the 95&#37; confidence interval &#40;95&#37; CI&#41; for the Four Step Square Test&#44; Timed 25-Foot Walk&#44; and Berg Balance Scale &#40;BBS&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Five randomised controlled trials were included in the qualitative systematic review and 4 in the meta-analysis&#46; We found no significant differences between the video game therapy group and the control group in Four Step Square Test &#40;DM&#58; &#8722;&#46;74&#59; 95&#37; CI&#44; &#8722;2&#46;79 to 1&#46;32&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;48&#59; <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41; and Timed 25-Foot Walk scores &#40;DM&#58; &#46;15&#59; 95&#37; CI&#44; &#8722;1&#46;06 to &#46;76&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;75&#59; <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41;&#46; We did observe intergroup differences in BBS scores in favour of video game therapy &#40;DM&#58; 5&#46;30&#59; 95&#37; CI&#44; 3&#46;39&#8211;7&#46;21&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#59; <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41;&#44; but these were not greater than the minimum detectable change reported in the literature&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The effectiveness of commercial video game therapy for improving postural balance in patients with MS is limited&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objectives"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material and method"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El uso de videojuegos comerciales ha sido considerado una herramienta eficaz para mejorar el equilibrio postural en diferentes poblaciones&#46; Sin embargo&#44; los beneficios reportados en pacientes con esclerosis m&#250;ltiple &#40;PEM&#41; no est&#225;n claros&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Analizar la evidencia existente sobre los efectos de las terapias con videojuegos comerciales en el equilibrio postural en PEM&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material y m&#233;todo</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una b&#250;squeda en las bases de datos Academic-Search-Complete&#44; AMED&#44; CENTRAL&#44; CINAHL&#44; WoS&#44; IBECS&#44; LILACS&#44; Pubmed&#47;Medline&#44; Scielo&#44; SPORTDiscus&#44; ScienceDirect utilizando los t&#233;rminos <span class="elsevierStyleItalic">multiple sclerosis</span>&#44; <span class="elsevierStyleItalic">videogames</span>&#44; <span class="elsevierStyleItalic">video games</span>&#44; <span class="elsevierStyleItalic">exergam</span>&#42;&#44; <span class="elsevierStyleItalic">postural balance</span>&#44; <span class="elsevierStyleItalic">posturography&#44;</span><span class="elsevierStyleItalic">postural control</span>&#44; <span class="elsevierStyleItalic">balance</span>&#46; El riesgo de sesgo fue analizado por 2 revisores independientes&#46; Se realizaron 3 metaan&#225;lisis modelos de efectos fijos calculando la diferencia de medias &#40;DM&#41; y el intervalo de confianza &#40;IC&#41; del 95&#37; para las variables <span class="elsevierStyleItalic">Four-Step-Square-Test</span>&#44; <span class="elsevierStyleItalic">Timed-25-Foot-Walk</span> y <span class="elsevierStyleItalic">Berg-Balance-Scale</span>&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Cinco ensayos cl&#237;nicos controlados aleatorizados fueron incluidos en la s&#237;ntesis cualitativa&#44; mientras que 4 fueron incluidos en el metaan&#225;lisis&#46; No se observaron diferencias entre las terapias con videojuegos y los grupos controles para la variable <span class="elsevierStyleItalic">Four-Step-Square-Test</span> &#40;DM&#58; &#8211;0&#44;74&#59; IC 95&#37;&#58; &#8211;2&#44;79 a 1&#44;32&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;48&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41; y <span class="elsevierStyleItalic">Timed-25-Foot-Walk</span> &#40;DM&#58; &#8211;0&#44;15&#59; IC 95&#37;&#58; &#8211;1&#44;06 a 0&#44;76&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;75&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41;&#46; Sin embargo&#44; la variable <span class="elsevierStyleItalic">Berg-Balance-Scale</span> mostr&#243; diferencias a favor del grupo de videojuegos &#40;DM&#58; 5&#44;30&#59; IC 95&#37;&#58; 3&#44;39 a 7&#44;21&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41;&#44; aunque estos resultados no fueron superiores al m&#237;nimo cambio detectable reportado en la literatura cient&#237;fica&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La eficacia de las terapias con videojuegos comerciales sobre el equilibrio postural en PEM es escasa&#46;</p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Parra-Moreno M&#44; Rodr&#237;guez-Juan JJ&#44; Ruiz-C&#225;rdenas JD&#46; Efectos de la terapia con videojuegos comerciales sobre el equilibrio postural en pacientes con esclerosis m&#250;ltiple&#58; revisi&#243;n sistem&#225;tica y metaan&#225;lisis de ensayos cl&#237;nicos controlados aleatorizados&#46; Neurolog&#237;a&#46; 2019&#46; <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.nrl.2017.12.001">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;nrl&#46;2017&#46;12&#46;001</span></p>"
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            "apendice" => "<p id="par0190" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0115"
          ]
        ]
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Flow chart illustrating the article selection process&#46;</p>"
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        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Risk of bias of the studies included&#46;</p>"
        ]
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        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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            "imagen" => "gr3.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Forest plots&#58; differences between patients receiving exergame therapy and controls for the Berg Balance Scale &#40;A&#41;&#44; the Four Step Square Test &#40;B&#41;&#44; and the Timed 25-Foot Walk &#40;C&#41;&#46; 95&#37; CI&#58; 95&#37; confidence interval&#59; df&#58; degrees of freedom&#59; IV&#58; inverse variance&#59; SD&#58; standard deviation&#46;</p>"
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            "identificador" => "at1"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Data are expressed as means &#40;SD&#41; or number &#40;&#37;&#41;&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">ABC&#58; Activities-specific Balance Confidence&#59; BBS&#58; Berg Balance Scale&#59; CoP&#58; centre of pressure&#59; DGI&#58; Dynamic Gait Index&#59; EDSS&#58; Expanded Disability Status Scale&#59; FSST&#58; Four Step Square Test&#59; CG&#58; control group&#59; EG&#58; experimental group&#59; MSIS&#58; Multiple Sclerosis Impact Scale&#59; min&#58; minutes&#59; n&#46;d&#46;&#58; no data&#59; TCS&#58; Timed Chair Stands test&#59; T25-FW&#58; Timed 25-Foot Walk test&#59; TUG&#58; Timed Up and Go test&#59; cogTUG&#58; Cognitive Timed-Up-and-Go dual-task test&#46;</p>"
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                  \t\t\t\t" scope="col">Author &#40;year&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intensity&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Frequency&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Nilsag&#229;rd et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> &#40;2013&#41;</td><td class="td" title="\n
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                  \t\t\t\t">EG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>42 &#40;10 men&#44; 32 women&#41;50 &#40;11&#46;5&#41; years oldMSIS&#58; 72 &#40;19&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Nintendo Wii&#174; &#8211; Wii Fit&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Increasing game difficulty level&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 sessions&#47;week &#40;30<span class="elsevierStyleHsp" style=""></span>min&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#8211;7 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; improvements of 0&#46;8<span class="elsevierStyleHsp" style=""></span>s &#40;6&#37;&#41; in TUG&#44; 1&#46;9<span class="elsevierStyleHsp" style=""></span>s &#40;12&#37;&#41; in cogTUG&#44; 1&#46;6<span class="elsevierStyleHsp" style=""></span>s &#40;9&#37;&#41; in FSST&#44; 3&#46;2<span class="elsevierStyleHsp" style=""></span>s &#40;9&#37;&#41; in TCS&#44; 5&#46;0 points &#40;7&#46;6&#37;&#41; in ABC&#44; and 1&#46;8 points &#40;10&#37;&#41; in DGI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>42 &#40;10 men&#44; 32 women&#41;49 &#40;11&#46;1&#41; years oldMSIS&#58; 74 &#40;21&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No intervention</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; improvements of 0&#46;8<span class="elsevierStyleHsp" style=""></span>s &#40;6&#37;&#41; in cogTUG and 2<span class="elsevierStyleHsp" style=""></span>s &#40;11&#46;3&#37;&#41; in FSSTEG vs CG&#58; no difference in any variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brichetto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> &#40;2013&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18 &#40;8 men&#44; 10 women&#41;41 &#40;11&#46;5&#41; years oldEDSS&#58; &#8804;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nintendo Wii&#174; &#8211; Wii Fit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 sessions&#47;week &#40;60<span class="elsevierStyleHsp" style=""></span>min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; improvements of 5 points &#40;10&#37;&#41; in BBS&#44; 36&#46;3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> &#40;38&#37;&#41; in open-eye stabilometry&#44; and 117<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> &#40;42&#46;7&#37;&#41; in closed-eye stabilometry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18 &#40;6 men&#44; 12 women&#41;43 &#40;10&#46;6&#41; years oldEDSS&#58; &#8804;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Single- and double-leg stance exercises with balance board&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 sessions&#47;week &#40;60<span class="elsevierStyleHsp" style=""></span>min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; improvements of 1 point &#40;2&#37;&#41; in BBS and 1&#46;2<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> &#40;1&#46;1&#37;&#41; in open-eye stabilometry&#59; worsening of 2&#46;9<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> &#40;4&#46;4&#37;&#41; in closed-eye stabilometryEG vs CG&#58; improvements of 5 points &#40;9&#46;8&#37;&#41; in BBS&#44; 46&#46;3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> &#40;44&#37;&#41; in open-eye stabilometry&#44; and 97<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> &#40;38&#37;&#41; in closed-eye stabilometry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Guti&#233;rrez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a> &#40;2013&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24 &#40;11 men&#44; 13 women&#41;40 &#40;8&#46;1&#41; years oldEDSS&#58; 3&#46;7 &#40;0&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xbox 360&#174; &#8211; Kinect Sports&#44; Joy Ride&#44; Adventures&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increasing game difficulty level&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 sessions&#47;week &#40;20<span class="elsevierStyleHsp" style=""></span>min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; improvements of 5&#46;8 points &#40;6&#46;9&#37;&#41; in BBS and 7&#46;9 points &#40;10&#46;9&#37;&#41; in Tinetti test&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23 &#40;9 men&#44; 14 women&#41;43 &#40;7&#46;4&#41; years oldEDSS&#58; 3&#46;9 &#40;0&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Strength&#44; proprioception&#44; gait&#44; and stretch exercises&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Low load&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 sessions&#47;week &#40;40<span class="elsevierStyleHsp" style=""></span>min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; improvements of 1 point &#40;1&#46;4&#37;&#41; in BBS and 1&#46;9 points &#40;2&#46;7&#37;&#41; in Tinetti testEG vs CG&#58; improvements of 7&#46;6 points &#40;9&#46;2&#37;&#41; in BBS and 7&#46;5 points &#40;10&#37;&#41; in Tinetti test&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prosperini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> &#40;2013&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18 &#40;5 men&#44; 13 women&#41;35 &#40;8&#46;6&#41; years oldEDSS&#58; &#8804;5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nintendo Wii&#174; &#8211; Wii Fit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increasing game difficulty level&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 sessions&#47;week &#40;30<span class="elsevierStyleHsp" style=""></span>min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; no difference vs baseline results in any of the variables analysed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18 &#40;6 men&#44; 12 women&#41;37 &#40;8&#46;8&#41; years oldEDSS&#58; &#8804;5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No intervention</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; no difference vs baseline results in any of the variables analysedEG vs CG&#58; improvements of 88<span class="elsevierStyleHsp" style=""></span>mm &#40;15&#37;&#41; in CoP displacement&#44; 2&#46;8<span class="elsevierStyleHsp" style=""></span>s &#40;16&#37;&#41; in FSST&#44; and 0&#46;9<span class="elsevierStyleHsp" style=""></span>s &#40;10&#37;&#41; in T25-FW&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Robinson et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a> &#40;2015&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20 &#40;6 men&#44; 14 women&#41;52&#46;6 &#40;6&#46;1&#41; years oldEDSS&#58; 6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nintendo Wii&#174; &#8211; Wii Fit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increasing game difficulty level&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 sessions&#47;week &#40;40&#8211;60<span class="elsevierStyleHsp" style=""></span>min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EG vs CG2&#58; improvements of 13<span class="elsevierStyleHsp" style=""></span>mm in CoP displacement range on the anteroposterior axis&#44; 12<span class="elsevierStyleHsp" style=""></span>mm in CoP displacement range on the mediolateral axis&#44; and 1<span class="elsevierStyleHsp" style=""></span>m&#47;s in CoP velocity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG1&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19 &#40;7 men&#44; 12 women&#41;53&#46;9 &#40;6&#46;5&#41; years oldEDSS&#58; 6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Traditional balance training&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;d&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 sessions&#47;week &#40;40&#8211;60<span class="elsevierStyleHsp" style=""></span>min&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 weeks&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">CG2&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17 &#40;5 men&#44; 12 women&#41;51&#46;9 &#40;4&#46;7&#41; years oldEDSS&#58; &#8804;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">EG vs CG2&#58; improvements of 14<span class="elsevierStyleHsp" style=""></span>mm in CoP displacement range on the anteroposterior axis&#44; 18<span class="elsevierStyleHsp" style=""></span>mm in CoP displacement range on the mediolateral axis&#44; and 1<span class="elsevierStyleHsp" style=""></span>m&#47;s in CoP velocity&nbsp;\t\t\t\t\t\t\n
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              "identificador" => "bib0090"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Understanding falls in multiple sclerosis&#58; association of mobility status&#44; concerns about falling&#44; and accumulated impairments"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;N&#46; Matsuda"
                            1 => "A&#46; Shumway-Cook"
                            2 => "M&#46;A&#46; Ciol"
                            3 => "C&#46;H&#46; Bombardier"
                            4 => "D&#46;A&#46; Kartin"
                          ]
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                    0 => array:2 [
                      "doi" => "10.2522/ptj.20100380"
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                        "tituloSerie" => "Phys Ther"
                        "fecha" => "2012"
                        "volumen" => "92"
                        "paginaInicial" => "407"
                        "paginaFinal" => "415"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22135709"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0095"
              "etiqueta" => "2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sensory impairments in quiet standing in subjects with multiple sclerosis"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Cattaneo"
                            1 => "J&#46; Jonsdottir"
                          ]
                        ]
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1177/1352458508096874"
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                        "tituloSerie" => "Mult Scler"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "paginaInicial" => "59"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18845654"
                            "web" => "Medline"
                          ]
                        ]
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                    0 => array:2 [
                      "titulo" => "The effect of a virtual reality game intervention on balance for patients with stroke&#58; a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "S&#46;-H&#46; Ho"
                            3 => "W&#46;-H&#46; Sung"
                          ]
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                        "tituloSerie" => "Games Health J"
                        "fecha" => "2017"
                        "volumen" => "6"
                        "paginaInicial" => "303"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28771379"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0105"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Individualized exergame training improves postural control in advanced degenerative spinocerebellar ataxia&#58; a rater-blinded&#44; intra-individually controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Schatton"
                            1 => "M&#46; Synofzik"
                            2 => "Z&#46; Fleszar"
                            3 => "M&#46;A&#46; Giese"
                            4 => "L&#46; Sch&#246;ls"
                            5 => "W&#46; Ilg"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.parkreldis.2017.03.016"
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                        "tituloSerie" => "Parkinsonism Relat Disord"
                        "fecha" => "2017"
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                        "paginaInicial" => "80"
                        "paginaFinal" => "84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28365204"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exergames for unsupervised balance training at home&#58; a pilot study in healthy older adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; van Diest"
                            1 => "J&#46; Stegenga"
                            2 => "H&#46;J&#46; W&#246;rtche"
                            3 => "G&#46;J&#46; Verkerke"
                            4 => "K&#46; Postema"
                            5 => "C&#46;J&#46;C&#46; Lamoth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.gaitpost.2015.11.019"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gait Posture"
                        "fecha" => "2016"
                        "volumen" => "44"
                        "paginaInicial" => "161"
                        "paginaFinal" => "167"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27004651"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Optimising engagement for stroke rehabilitation using serious games"
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                        0 => array:2 [
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                          "autores" => array:6 [
                            0 => "J&#46;W&#46; Burke"
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                            3 => "P&#46;J&#46; Morrow"
                            4 => "J&#46;H&#46; Crosbie"
                            5 => "S&#46;M&#46; McDonough"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Vis Comput"
                        "fecha" => "2009"
                        "volumen" => "25"
                        "paginaInicial" => "1085"
                        "paginaFinal" => "1099"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is playing exergames really exercising&#63; A meta-analysis of energy expenditure in active video games"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Peng"
                            1 => "J&#46;H&#46; Lin"
                            2 => "J&#46; Crouse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/cyber.2010.0578"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cyberpsychol Behav Soc Netw"
                        "fecha" => "2011"
                        "volumen" => "14"
                        "paginaInicial" => "681"
                        "paginaFinal" => "688"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21668370"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions&#58; explanation and elaboration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Liberati"
                            1 => "D&#46;G&#46; Altman"
                            2 => "J&#46; Tetzlaff"
                            3 => "C&#46; Mulrow"
                            4 => "P&#46;C&#46; G&#248;tzsche"
                            5 => "J&#46;P&#46;A&#46; Ioannidis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.b2700"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2009"
                        "volumen" => "339"
                        "paginaInicial" => "b2700"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19622552"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Higgins&#46; Cochrane handbook for systematic reviews of interventions&#46; Edici&#243;n&#58; 1&#46; Chichester&#58; Wiley-Blackwell&#59; 2008&#46; p&#46; 672&#46;"
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of Nintendo&#174; Wii&#174; on balance in people with multiple sclerosis&#58; a pilot randomized control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Brichetto"
                            1 => "P&#46; Spallarossa"
                            2 => "M&#46;L&#46;L&#46; de Carvalho"
                            3 => "M&#46;A&#46; Battaglia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1352458512472747"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mult Scler"
                        "fecha" => "2013"
                        "volumen" => "19"
                        "paginaInicial" => "1219"
                        "paginaFinal" => "1221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23322502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A telerehabilitation program by virtual reality-video games improves balance and postural control in multiple sclerosis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "F&#46; Gal&#225;n del R&#237;o"
                            2 => "R&#46; Cano de la Cuerda"
                            3 => "I&#46;M&#46; Alguacil Diego"
                            4 => "R&#46;A&#46; Gonz&#225;lez"
                            5 => "J&#46;C&#46;M&#46; Page"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3233/NRE-130995"
                      "Revista" => array:6 [
                        "tituloSerie" => "NeuroRehabilitation"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "545"
                        "paginaFinal" => "554"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24029009"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Balance exercise for persons with multiple sclerosis using Wii games&#58; a randomised&#44; controlled multi-centre study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46;E&#46; Nilsag&#229;rd"
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                            2 => "L&#46; von Koch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1352458512450088"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mult Scler"
                        "fecha" => "2013"
                        "volumen" => "19"
                        "paginaInicial" => "209"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22674972"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Home-based balance training using the Wii balance board&#58; a randomized&#44; crossover pilot study in multiple sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "D&#46; Fortuna"
                            2 => "C&#46; Giann&#236;"
                            3 => "L&#46; Leonardi"
                            4 => "M&#46;R&#46; Marchetti"
                            5 => "C&#46; Pozzilli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1545968313478484"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurorehabil Neural Repair"
                        "fecha" => "2013"
                        "volumen" => "27"
                        "paginaInicial" => "516"
                        "paginaFinal" => "525"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23478168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effects of exergaming on balance&#44; gait&#44; technology acceptance and flow experience in people with multiple sclerosis&#58; a randomized controlled trial"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            3 => "P&#46; van Schaik"
                            4 => "D&#46; Martin"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "tituloSerie" => "BMC Sports Sci Med Rehabil"
                        "fecha" => "2015"
                        "volumen" => "7"
                        "paginaInicial" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25969739"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reliability and clinical significance of mobility and balance assessments in multiple sclerosis"
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                            2 => "A&#46;K&#46; McFadyen"
                            3 => "P&#46; Mattison"
                            4 => "L&#46; Miller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Rehabil Res Int Z Rehabil Rev Int Rech Readapt"
                        "fecha" => "2012"
                        "volumen" => "35"
                        "paginaInicial" => "69"
                        "paginaFinal" => "74"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0165"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Four Square Step Test in ambulant persons with multiple sclerosis&#58; validity&#44; reliability&#44; and responsiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "R&#46;A&#46; Norris"
                            2 => "L&#46;R&#46; Van Dillen"
                            3 => "F&#46;P&#46; Thomas"
                            4 => "R&#46;T&#46; Naismith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Rehabil Res Int Z Rehabil Rev Int Rech Readapt"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "paginaInicial" => "253"
                        "paginaFinal" => "259"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0170"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interpreting change scores of tests and measures used in physical therapy"
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Article information
ISSN: 21735808
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

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