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Original article
OnabotulinumtoxinA infiltration and nerve blocks in patients with headache and neuralgia: safety recommendations to prevent SARS-CoV-2 infection
Infiltración con onabotulinumtoxinA y bloqueos en el paciente con cefalea y neuralgia: recomendaciones de seguridad frente a la infección por SARS-CoV-2
S. Santos-Lasaosaa, J. Porta-Etessamb,
Corresponding author
a Unidad de Cefaleas, Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Instituto de Investigación Sanitaria Aragón (IIS-Aragón), Zaragoza, Spain
b Unidad de Cefaleas, Servicio de Neurología, Instituto de Investigación Sanitaria San Carlos, Hospital Clínico San Carlos, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The viral pneumonia outbreak that originated in Wuhan &#40;China&#41; in December 2019 has become a global pandemic&#46; The World Health Organization declared the epidemic a public health emergency of international concern on 30 January 2020&#46; In February 2020&#44; the novel virus was officially denominated severe acute respiratory syndrome coronavirus 2 &#40;SARS-CoV-2&#41;&#44; with the associated disease being named COVID-19 &#40;coronavirus disease 2019&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The virus is transmitted through respiratory microdroplets&#44; which are dispersed 1-2<span class="elsevierStyleHsp" style=""></span>m when a person speaks or coughs&#46; The virus is known to survive for an undetermined period of time on smooth surfaces&#44; and as long as 72<span class="elsevierStyleHsp" style=""></span>hours on plastic or stainless steel&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> In Spain&#44; hospitals were forced to modify their healthcare practices with the publication of Royal Decree 463&#47;2020 of 14 March&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> which declared a state of alarm for the management of the COVID-19 healthcare crisis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">According to data from the Spanish migraine action plan &#40;PALM study&#41;&#44; approximately 12&#37; of the general population &#40;one-year prevalence&#41; have migraine &#40;18&#37; of women and 8&#37; of men&#41;&#46; Chronic migraine affects 2&#46;4&#37; of the population&#44; with rates depending on the geographical area and the methods used&#46; This study was used to draft a national migraine map with data for each Autonomous Community&#44; which showed significant geographic variations&#44; ranging from 7&#46;6&#37; in Navarre to 18&#37; in the Canary Islands&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> Today&#44; onabotulinumtoxinA &#40;OnabotA&#41; and anaesthetic nerve blocks are used to reduce the frequency of migraine attacks and number of headache days per month&#44; and ultimately to improve patients&#8217; quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this article&#44; we present a series of recommendations to ensure adequate safety for both staff and patients&#44; which are based on the measures implemented in the Spanish healthcare system to prevent the spread of SARS-CoV-2&#44; adapted to our professional setting&#46; These recommendations may be modified according to each centre&#39;s needs and characteristics&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We differentiate between measures related to patients and physicians&#44; to the technique&#44; to infrastructure &#40;waiting room and consultation&#41;&#44; and to healthcare management &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Measures related to patients and physicians</span><p id="par0030" class="elsevierStylePara elsevierViewall">Given the high transmissibility of SARS-CoV-2&#44; a distance greater than 1&#46;5<span class="elsevierStyleHsp" style=""></span>m must be maintained to reduce the risk of infection&#46; Examination of patients with headache requires a distance of less than 30<span class="elsevierStyleHsp" style=""></span>cm&#44; and even closer for certain procedures &#40;direct ophthalmoscopy&#44; palpation of cranial and cervical structures&#44; etc&#46;&#41;&#46; As a result&#44; these examinations present a risk and must be performed in accordance with the standard safety measures for these situations&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">7&#8211;9</span></a> Another key consideration is that the disease can be spread by healthcare professionals&#59; therefore&#44; prevention measures should be strictly observed&#46;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Given that the virus can be spread prior to symptom onset&#44; and that many patients present few symptoms&#44; all individuals should be considered as potential sources of infection&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0040" class="elsevierStylePara elsevierViewall">It is advisable for patients to be evaluated prior to entering the consultation to screen for possible exposure to the virus through questions about fever&#44; general discomfort&#44; respiratory symptoms &#40;dry cough&#44; dyspnoea&#41;&#44; ageusia&#44; anosmia&#44; diarrhoea&#44; and headache&#44; and whether patients have had close contact or live with any individual recently diagnosed or under quarantine for COVID-19 in the last 14 days&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Wherever possible&#44; patients should attend consultations alone and wear disposable surgical face masks&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Physicians should wear hospital scrubs&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#46;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Gloves should be used in the examination of pericranial muscles&#44; and the patient should be approached from the side&#46; It is also essential to wear a face mask&#59; the most recommended types are FFP2 masks without exhalation valves and FFP3 masks&#46; If only disposable surgical masks are available&#44; 2 should be worn&#46; In high-risk patients&#44; disposable gowns and protective plastic visors are also recommended&#46; A personal protective suit and&#47;or a surgical gown may be used&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6&#46;</span><p id="par0060" class="elsevierStylePara elsevierViewall">It is essential to wash hands and change gloves between patients&#46; Professionals must be careful not to touch any equipment with gloves that have been used for the procedure&#47;examination&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">7&#46;</span><p id="par0065" class="elsevierStylePara elsevierViewall">All examination equipment must be disinfected with alcohol solution&#44; or with soap and water if this is not available&#46;</p></li></ul></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Measures related to the technique</span><p id="par0070" class="elsevierStylePara elsevierViewall">When administering OnabotA or performing anaesthetic nerve blocks or dry needling&#44; professionals should also follow these additional recommendations&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">1&#46;</span><p id="par0075" class="elsevierStylePara elsevierViewall">Plastic or methacrylate protective visors are recommended over goggles&#46; As the virus is able to survive on plastic surfaces&#44; these should be cleaned on both sides with disinfectant &#40;e&#46;g&#46;&#44; alcohol&#41; after each use&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">2&#46;</span><p id="par0080" class="elsevierStylePara elsevierViewall">Patients should be in the supine decubitus position and be approached from behind&#46; If this is not possible&#44; they should remain seated&#46; In the first case&#44; the paper or sheet on the bed should be replaced following the procedure&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">3&#46;</span><p id="par0085" class="elsevierStylePara elsevierViewall">The number of procedures performed in each consultation should be limited as far as possible&#44; and those with the greatest level of evidence should be prioritised&#46;</p></li></ul></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Measures related to infrastructure</span><p id="par0090" class="elsevierStylePara elsevierViewall">These recommendations may be generalised to all consultations and waiting rooms&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">1&#46;</span><p id="par0095" class="elsevierStylePara elsevierViewall">Patients may be accompanied by a maximum of one person&#44; where strictly necessary&#46;</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">2&#46;</span><p id="par0100" class="elsevierStylePara elsevierViewall">Individuals should be separated by a distance of 2<span class="elsevierStyleHsp" style=""></span>m&#46; Overcrowding of waiting rooms should be avoided&#46;</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">3&#46;</span><p id="par0105" class="elsevierStylePara elsevierViewall">All surfaces &#40;doorknobs and handles&#44; reception desks&#44; telephones&#44; computer equipment&#44; pens&#44; etc&#46;&#41; should be disinfected continuously&#46;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">4&#46;</span><p id="par0110" class="elsevierStylePara elsevierViewall">It is important to display information notices about the hygiene measures recommended by the health ministry and workplace health and safety services&#46;</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">5&#46;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Patients must enter the consultation alone and disinfect their hands with hydroalcoholic gel before and after the consultation&#46; Gel dispensers should be placed in the waiting room for this purpose&#46;</p></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Measures related to the management of headache units</span><p id="par0120" class="elsevierStylePara elsevierViewall">There can be no doubt that the pandemic will lead to significant delays in the provision of care for our patients&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> This makes it necessary to design strategies for the management of waiting lists&#44; in accordance with care quality indicators for headache units<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a>&#58;<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">1&#46;</span><p id="par0125" class="elsevierStylePara elsevierViewall">In order to apply the measures described above&#44; these patients should be grouped together in a single schedule&#46;</p></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">2&#46;</span><p id="par0130" class="elsevierStylePara elsevierViewall">Reconstituting OnabotA vials ahead of time&#44; depending on the number of patient appointments&#44; will enable reduction of consultation times&#46;</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">3&#46;</span><p id="par0135" class="elsevierStylePara elsevierViewall">Another highly practical consideration is the provision of information leaflets on the technique and the treatment for patients with de novo migraine to consult at home&#46;</p></li><li class="elsevierStyleListItem" id="lsti0095"><span class="elsevierStyleLabel">4&#46;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Teleconsultation and electronic communication &#40;telephone&#44; e-mail&#41; will become essential tools in everyday practice&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a></p></li><li class="elsevierStyleListItem" id="lsti0100"><span class="elsevierStyleLabel">5&#46;</span><p id="par0145" class="elsevierStylePara elsevierViewall">Specialist nurses with training in the assessment and care of patients with headache unquestionably play a key role in these consultations&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a></p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusions</span><p id="par0150" class="elsevierStylePara elsevierViewall">The rapid spread of SARS-CoV-2 and the context of the pandemic will bring about a series of changes in the management of patients with migraine&#59; fundamentally&#44; this will involve the management of waiting lists and the implementation of new tools enabling integrated care within the framework of the safety regulations in force&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">OnabotulinumtoxinA and anaesthetic nerve blocks constitute the cornerstone of migraine management&#46; Performing these procedures with the utmost care in order to ensure our patients&#8217; safety&#44; in observance of the regulations in force&#44; requires great responsibility on the part of physicians&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflicts of interest</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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    "fechaRecibido" => "2020-04-30"
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          "clase" => "keyword"
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            0 => "COVID-19"
            1 => "Migraine"
            2 => "Nerve block"
            3 => "Infiltration"
            4 => "OnabotulinumtoxinA"
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          "palabras" => array:5 [
            0 => "COVID-19"
            1 => "Migra&#241;a"
            2 => "Bloqueo"
            3 => "Infiltraci&#243;n"
            4 => "Onabotulinumtoxina"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The COVID-19 pandemic has given rise to the need for changes in clinical practice&#44; with new strategies to enable integrated care for patients with headache and neuralgia&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Given the high spreadability of SARS-CoV-2&#44; new safety measures are required in such procedures as onabotulinumtoxinA infiltration and nerve blocks&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We present a series of recommendations based on the measures implemented to prevent infection in our healthcare system&#46; We differentiate between measures related to patients and physicians&#44; to technique&#44; to infrastructure &#40;waiting room and consultation&#41;&#44; and to healthcare management&#46;</p></span>"
        "secciones" => array:3 [
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            "identificador" => "abst0005"
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        "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introducci&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La infecci&#243;n por SARS-CoV-2 y la situaci&#243;n de pandemia hacen necesario un cambio en nuestra pr&#225;ctica cl&#237;nica&#44; en relaci&#243;n con la adopci&#243;n de nuevas estrategias que permitan la asistencia integral de los pacientes con cefalea y neuralgia&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Material y m&#233;todos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Ante la elevada capacidad de transmisi&#243;n del virus&#44; determinados procedimientos&#44; como la infiltraci&#243;n de onabotulinumtoxinA y la realizaci&#243;n de bloqueos anest&#233;sicos&#44; deben realizarse adoptando medidas que garanticen un nivel adecuado de seguridad&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Resultados</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Nuestro objetivo es presentar una serie de recomendaciones basadas en las medidas establecidas por nuestro sistema sanitario para evitar el contagio&#46; Diferenciaremos entre aquellas medidas relacionadas con el paciente y el facultativo&#44; con la t&#233;cnica&#44; con la infraestructura &#40;sala de espera y consulta&#41; y con la gesti&#243;n asistencial&#46;</p></span>"
        "secciones" => array:3 [
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Santos-Lasaosa S&#44; Porta-Etessam J&#46; Infiltraci&#243;n con onabotulinumtoxinA y bloqueos en el paciente con cefalea y neuralgia&#58; recomendaciones de seguridad frente a la infecci&#243;n por SARS-CoV-2&#46; Neurolog&#237;a&#46; 2020&#59;35&#58;291&#8211;294&#46;</p>"
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">OnabotA&#58; onabotulinumtoxinA&#46;</p>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Measures related to patients and physicians</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>All individuals should be considered a potential source of infection&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>All patients should be evaluated prior to consultation&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patients should attend alone and wear disposable face masks&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Staff should wear hospital scrubs&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Staff should wear gloves and FFP2 masks without exhalation valves or FFP3 masks&#46; If only disposable surgical masks are available&#44; 2 should be worn&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Staff should wash hands and change gloves between patients&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Equipment must be disinfected with alcohol solution&#44; or with soap and water if this is not available&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Measures related to the technique</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Plastic or methacrylate protective visors should be used&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patients should be in the supine decubitus position and approached from behind&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>The number of procedures performed in each consultation should be limited&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Measures related to infrastructure</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patients should be accompanied by a maximum of one person&#44; and only if strictly necessary&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A minimum distance of 2<span class="elsevierStyleHsp" style=""></span>m between individuals should be observed&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>All surfaces should be disinfected continuously&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Information notices about the recommended hygiene measures should be displayed&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patients should wash their hands with hydroalcoholic gel before and after the consultation&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Measures related to the management of headache units</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patients should be grouped in the same schedule for performance of these procedures&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>OnabotA vials should be reconstituted in advance&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Information leaflets should be provided&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Teleconsultation and communication by e-mail should be implemented&#46;&nbsp;\t\t\t\t\t\t\n
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos