Letter to the Editor
Primary central nervous system lymphoma mimicking cerebellopontine angle lesion
Linfoma primario del sistema nervioso central aparentando lesión del ángulo pontocerebeloso
J. Berciano
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Servicio de Neurología, Hospital Universitario “Marqués de Valdecilla (IDIVAL)”, Universidad de Cantabria (UC), Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Santander
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Berciano" "autores" => array:1 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Berciano" "email" => array:2 [ 0 => "jaberciano@humv.es" 1 => "joseberciano51@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neurología, Hospital Universitario “Marqués de Valdecilla (IDIVAL)”, Universidad de Cantabria (UC), Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Santander" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Linfoma primario del sistema nervioso central aparentando lesión del ángulo pontocerebeloso" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">It was with great interest that we read the article by Berrocal-Izquierdo et al.,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> describing the case of a patient with primary central nervous system lymphoma (PCNSL) associated with symptoms of a left cerebellopontine angle lesion. According to the authors, prior to their report, 16 cases had previously been reported of PCNSL mimicking cerebellopontine angle masses.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In 1994, our research group reported the clinical-pathological case of a patient with PCNSL presenting as a left cerebellopontine angle lesion; at that time, 7 similar cases had been described.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> A literature search on PubMed (“cerebellopontine angle lymphoma,” on 29 November 2018) yielded 52 results; although not all references describe patients with PCNSL, these results do suggest that the association between cerebellopontine angle lesions and PCNSL may not be as rare as one may think.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our patient was a 39-year-old woman with one-year history of occipital headache showing poor response to analgesics.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> She was admitted due to exacerbation of headache, with vomiting, otalgia, hearing loss, and left-sided facial paraesthesia. A head CT scan revealed a contrast-enhancing tumour in the left cerebellopontine angle, obliteration and post-contrast enhancement of the basal cisterns, and ventricular dilation. Four CSF analyses revealed sterile lymphocytic pleocytosis, low glucose levels, and elevated adenosine deaminase levels; CSF cytology detected no malignant cells. The patient received tuberculostatic drugs and corticosteroids due to suspected tuberculous meningitis, but died 2 months later. The autopsy revealed PCNSL with leptomeningeal and perivascular infiltration, as well as microscopic subpial infiltration. In line with the macroscopic findings, subpial infiltration was more marked on the left side, affecting the pons and the middle cerebellar peduncle (see figures 2a and 2b in Berciano et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>).</p><p id="par0020" class="elsevierStylePara elsevierViewall">PCNSL is a subtype of non-Hodgkin lymphoma that exclusively affects the brain, eyes, spinal cord, and leptomeninges, without systemic involvement.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Symptoms depend on lesion topography, with most patients presenting symptoms including cognitive impairment, focal neurological signs, and symptoms of intracranial hypertension, developing over the course of several weeks or months. Around 20% of patients display concurrent leptomeningeal infiltration, which is frequently subclinical and only detectable with CSF analysis. In our case, 4 CSF analyses were insufficient to detect malignant cells; in fact, 3 analyses showed elevated adenosine deaminase levels, which led to suspicion of tuberculous meningitis.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In our patient, the histology study revealed mild, extensive perivascular infiltration of the Virchow-Robin spaces with subpial infiltration, occasionally extending to cover large areas of the brain parenchyma, visible on a macroscopic scale. Any lesion that reaches a critical size, including cerebellopontine angle lesions, may cause focal neurological symptoms.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">The study has not received any public or private funding.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-11-29" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Berciano J. Linfoma primario del sistema nervioso central aparentando lesión del ángulo pontocerebeloso. Neurología. 2020;35:506–507.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary central nervous system lymphoma mimicking cerebellopontine angle tumour" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Berrocal-Izquierdo" 1 => "F. Muñoz" 2 => "J. Bosch" 3 => "J. Molet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.nrl.2016.06.010" "Revista" => array:6 [ "tituloSerie" => "Neurologia." "fecha" => "2018" "volumen" => "33" "paginaInicial" => "614" "paginaFinal" => "616" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27452624" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary leptomeningeal lymphoma presenting as cerebellopontine angle lesion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Berciano" 1 => "C. Jiménez" 2 => "J. Figols" 3 => "J.C. Ferreres" 4 => "O. Combarros" 5 => "R. Arjona" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF00612120" "Revista" => array:6 [ "tituloSerie" => "Neuroradiology." 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"fecha" => "2017" "volumen" => "123" "paginaInicial" => "4314" "paginaFinal" => "4324" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28950405" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activity of adenosine deaminase in cerebrospinal fluid for the diagnosis and follow-up of tuberculous meningitis in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Ribera" 1 => "J.M. Martinez-Vazquez" 2 => "I. Ocaña" 3 => "R.M. Segura" 4 => "C. Pascual" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/infdis/155.4.603" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis." "fecha" => "1987" "volumen" => "155" "paginaInicial" => "603" "paginaFinal" => "607" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3102627" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735808/0000003500000007/v1_202009060847/S2173580820301425/v1_202009060847/en/main.assets" "Apartado" => array:4 [ "identificador" => "9409" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735808/0000003500000007/v1_202009060847/S2173580820301425/v1_202009060847/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580820301425?idApp=UINPBA00004N" ]
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