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Letter to the Editor
Cervical myelopathy as a form of presentation of Whipple disease
Mielopatía cervical como forma de presentación de la enfermedad de Whipple
Á.I. Pérez Álvarez
Corresponding author
angelperez@telecable.es

Corresponding author.
, G. Morís de la Tassa
Servicio de Neurología, Hospital Universitario Central deAsturias, Oviedo, Asturias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Whipple disease is a multisystem disease caused by bacterial infection with <span class="elsevierStyleItalic">Tropheryma whipplei</span>&#46; It was first described by George H&#46; Whipple in 1907 as an &#8220;intestinal lipodystrophy&#8221; in a patient with weight loss&#44; polyarthritis&#44; diarrhoea&#44; malabsorption&#44; and mesenteric lymphadenitis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Presence of neurological symptoms in the absence of systemic manifestations is rare&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of Whipple disease manifesting with isolated symptoms of spinal cord involvement&#46; Our patient was a 66-year-old woman who consulted due to a one-year history of gait alterations&#44; with no associated symptoms&#46; The neurological examination revealed decreased deep sensitivity in the lower limbs&#44; with no pyramidal signs&#59; results were normal for all other areas&#46; A somatosensory evoked potentials study revealed injury to the somatosensory pathway at the level of the posterior column&#46; A non-contrast&#44; T2-weighted spinal cord MRI scan performed to rule out myelopathy revealed a hyperintense lesion in the posterior column between C2 and T1&#44; with no associated oedema &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#59; no brain lesions were identified&#46; A blood analysis including a complete biochemistry study and immunological tests found no evidence of autoimmune&#44; systemic&#44; or metabolic diseases&#44; nutritional deficiencies&#44; etc&#46; Given that differential diagnosis includes viral and bacterial infections&#44; we requested a microbiological analysis of a blood sample&#59; PCR findings were positive for <span class="elsevierStyleItalic">T&#46; whipplei</span>&#46; Biochemical&#44; microbiological&#44; immunological&#44; and cytological analyses of the CSF yielded normal results&#44; with the exception of positive PCR results for <span class="elsevierStyleItalic">T&#46; whipplei</span>&#46; The pathogen was not detected in the faeces or saliva&#46; An additional PCR test performed 15 days later also yielded positive results for <span class="elsevierStyleItalic">T&#46; whipplei</span>&#46; The patient received intravenous ceftriaxone for 14 days&#44; showing good clinical response&#46; Long-term treatment with oral trimethoprim-sulfamethoxazole achieved marked improvements in gait&#46; An MRI scan performed several months later revealed stability of the spinal cord lesion&#46; Subsequent blood and CSF PCR tests yielded negative results&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Whipple disease is an infectious disease associated with multisystem manifestations&#44; most frequently affecting the gastrointestinal system and joints&#46; Although the precise incidence is unknown&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> central nervous system involvement is frequent&#44; appearing in 43&#37; of cases<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#59; however&#44; presence of neurological symptoms in isolation occurs in only 5&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Neurological symptoms are nonspecific and highly variable&#44; ranging from impaired consciousness to cognitive impairment&#44; epileptic seizures&#44; myoclonus&#44; cerebellar or hypothalamic involvement&#44; cranial and peripheral neuropathies&#44; and extrapyramidal symptoms&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Oculomasticatory myorhythmia and oculofacial-skeletal myorhythmia are pathognomonic of Whipple disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Although some cases have been described of myelopathy associated with other inflammatory lesions in different parts of the central nervous system &#40;eg&#44; the brain&#44; optic chiasm&#44; posterior fossa&#41;&#44; as in the patient described by Kremer et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> presentation in the form of isolated myelopathy is even rarer&#46; The first case was reported by Clarke et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> in 1998 in a 62-year-old patient&#59; Messori and Salvolini<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and Messori et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> subsequently described the case of a 65-year-old patient with relapsing-remitting cervico-thoracic myelopathy due to Whipple disease who subsequently developed brain lesions&#46; In 2005&#44; Schr&#246;ter et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> described the case of a 50-year-old patient with a cervical spinal cord lesion extending from the cervicomedullary junction to the upper thoracic region&#44; without cerebral involvement&#59; the patient responded well to antibiotic therapy against <span class="elsevierStyleItalic">T&#46; whipplei</span>&#44; which was detected in a blood PCR test&#46; To our knowledge&#44; our patient is the fourth reported case &#40;and the first in Spain&#41; of Whipple disease manifesting as isolated myelopathy affecting the posterior column&#46; The cases described bear certain similarities&#44; including age of presentation &#40;between the sixth and seventh decades of life&#41;&#44; symptoms of chronic progressive myelitis&#44; extensive cervical spinal cord involvement with MRI hyperintensity&#44; and marked improvement with antibiotics&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Differential diagnosis should include other bacterial&#44; viral&#44; and parasitic infections&#59; such demyelinating diseases as multiple sclerosis&#44; neuromyelitis optica&#44; and acute disseminated encephalomyelitis&#59; vascular disease &#40;ischaemia&#44; haemorrhage&#41;&#59; tumours or paraneoplastic syndromes&#59; and systemic &#40;eg&#44; systemic lupus erythematosus&#44; Beh&#231;et disease&#44; Sj&#246;gren syndrome&#44; sarcoidosis&#41; or deficiency diseases &#40;vitamin deficiency&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The limited published evidence on the topic and the nonspecific nature of the symptoms may hinder diagnosis and delay treatment&#46; Neurological symptoms may constitute the initial manifestation of Whipple disease&#44; with other more characteristic symptoms appearing at later stages&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> In any case&#44; the lack of microbiological confirmation should not delay treatment in cases of suspected Whipple disease&#46; Targeted antibiotic therapy for bacterial infection is recommended before spinal cord biopsy is performed&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; symptoms of spinal cord involvement are infrequent in Whipple disease&#46; Therefore&#44; infection with <span class="elsevierStyleItalic">T&#46; whipplei</span> should be considered in patients with isolated myelopathy of unknown cause&#44; even in the absence of systemic symptoms&#59; this requires a high level of clinical suspicion&#46; Early diagnosis enables the provision of effective treatment able to resolve symptoms and even to prevent lesions from spreading to other organs or regions of the nervous system&#59; Whipple disease is potentially fatal if the patient does not receive targeted treatment&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0045" class="elsevierStylePara elsevierViewall">This study has received no specific funding from any public&#44; private&#44; or non-profit organisation&#46;</p></span></span>"
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Article information
ISSN: 21735808
Original language: English
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2024 November 10 1 11
2024 October 36 9 45
2024 September 31 20 51
2024 August 50 6 56
2024 July 27 10 37
2024 June 31 1 32
2024 May 16 4 20
2024 April 27 1 28
2024 March 57 5 62
2024 February 52 8 60
2024 January 51 5 56
2023 December 48 13 61
2023 November 49 6 55
2023 October 63 7 70
2023 September 36 3 39
2023 August 38 7 45
2023 July 47 4 51
2023 June 49 3 52
2023 May 55 3 58
2023 April 64 5 69
2023 March 55 5 60
2023 February 41 8 49
2023 January 35 4 39
2022 December 26 14 40
2022 November 46 16 62
2022 October 41 7 48
2022 September 36 13 49
2022 August 31 7 38
2022 July 32 7 39
2022 June 25 6 31
2022 May 32 23 55
2022 April 35 12 47
2022 March 38 15 53
2022 February 49 9 58
2022 January 62 8 70
2021 December 36 11 47
2021 November 25 8 33
2021 October 43 13 56
2021 September 31 8 39
2021 August 35 6 41
2021 July 18 12 30
2021 June 25 13 38
2021 May 39 8 47
2021 April 94 21 115
2021 March 52 13 65
2021 February 26 13 39
2021 January 30 6 36
2020 December 21 12 33
2020 November 19 9 28
2020 October 18 10 28
2020 September 4 4 8
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos